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Specialty Pharmacy Clinical Policy Bulletins
Aetna Non-Medicare Prescription Drug Plan
Subject: Specialty Quantity Limit Fasenra 2468-H P2026a

Drug
FASENRA  (benralizumab)
Note:

Program Description

The standard limit is designed to allow a quantity sufficient for the most common uses of the medication. If the member’s plan allows a quantity limit exception review for the requested medication, coverage of an additional quantity may be provided up to the exception limit with prior authorization.

Covered Quantities

Coverage up to the exception limits may be provided with prior authorization via the Specialty Post Limit Quantity Exception Criteria for approval.

                                            Medication

                         Standard Limit

                     Exception Limit

Fasenra (benralizumab) 30 mg/mL single-dose prefilled syringe/autoinjector

1 syringe/autoinjector per 28 days

Not applicable

Fasenra (benralizumab) 10 mg/0.5 mL single-dose prefilled syringe

1 syringe per 56 days

3 syringes per 84 days

FDA-Recommended Dosing

Asthma

Adults and adolescent patients 12 years of age and older

30 mg every 4 weeks for the first 3 doses, followed by 30 mg every 8 weeks

Pediatric patients 6 to 11 years of age

Less than 35 kg

10 mg every 4 weeks for the first 3 doses, followed by 10 mg every 8 weeks

Greater than or equal to 35 kg

30 mg every 4 weeks for the first 3 doses, followed by 30 mg every 8 weeks

Eosinophilic Granulomatosis with Polyangiitis (EGPA)

30 mg every 4 weeks

Hypereosinophilic Syndrome (HES)

30 mg every 4 weeks




Place of Service:

Outpatient

The above policy is based on the following references:

1.      Fasenra [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; May 2026.

Copyright Aetna Inc. All rights reserved. Pharmacy Clinical Policy Bulletins are developed by Aetna to assist in administering plan benefits and constitute neither offers of coverage nor medical advice. This Clinical Policy Bulletin contains only a partial, general description of plan or program benefits and does not constitute a contract. Aetna does not provide health care services and, therefore, cannot guarantee any results or outcomes. Participating providers are independent contractors in private practice and are neither employees nor agents of Aetna or its affiliates. Treating providers are solely responsible for medical advice and treatment of members. This Clinical Policy Bulletin may be updated and therefore is subject to change.

August 16, 2026
Aetna
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