Subject: Specialty Quantity Limit Otezla 2271-H P2025

Drug

OTEZLA  (apremilast)

Policy:

Program Description

The standard limit is designed to allow a quantity sufficient for the most common uses of the medication. The recommended dosing parameters for all FDA-approved indications fall within the standard limits. Coverage of an additional quantity may be reviewed on a case-by-case basis upon request.

Covered Quantities

Medication	Standard Limit
Otezla (apremilast) 10 mg/20 mg/30 mg 28-day starter pack	1 pack (55 tablets) per 28 days
Otezla (apremilast) 10 mg/20 mg 28-day starter pack	1 pack (55 tablets) per 28 days
Otezla (apremilast) 30 mg tablets	60 tablets per 30 days
Otezla (apremilast) 20 mg tablets	60 tablets per 30 days

FDA-recommended Dosing

Plaque Psoriasis (PsO), Psoriatic Arthritis (PsA), Behcet’s disease

Adults (PsO, PsA, Behcet’s disease) and Pediatrics (6-17 years old) PsO weighing at least 50 kg

Day 1 to day 5 dosage titration schedule:

• Day 1: 10 mg in morning
• Day 2: 10 mg in morning and 10 mg in evening
• Day 3: 10 mg in morning and 20 mg in evening
• Day 4: 20 mg in morning and 20 mg in evening
• Day 5: 20 mg in morning and 30 mg in evening

Day 6 and thereafter: 30 mg in morning and 30 mg in evening

Pediatrics (6-17 years old) PsO weighing 20 kg to less than 50 kg

Day 1 to day 5 dosage titration schedule:

• Day 1: 10 mg in morning
• Day 2: 10 mg in morning and 10 mg in evening
• Day 3: 10 mg in morning and 20 mg in evening
• Day 4: 20 mg in morning and 20 mg in evening
• Day 5: 20 mg in morning and 20 mg in evening

Day 6 and thereafter: 20 mg in morning and 20 mg in evening

Place of Service:

Outpatient

The above policy is based on the following references:

1. Otezla [package insert]. Thousand Oaks, CA: Amgen Inc.; April 2024.

Copyright Aetna Inc. All rights reserved. Pharmacy Clinical Policy Bulletins are developed by Aetna to assist in administering plan benefits and constitute neither offers of coverage nor medical advice. This Clinical Policy Bulletin contains only a partial, general description of plan or program benefits and does not constitute a contract. Aetna does not provide health care services and, therefore, cannot guarantee any results or outcomes. Participating providers are independent contractors in private practice and are neither employees nor agents of Aetna or its affiliates. Treating providers are solely responsible for medical advice and treatment of members. This Clinical Policy Bulletin may be updated and therefore is subject to change.

June 07, 2025