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Guided tissue regeneration (GTR) (002)

Number: 002


Subject: Guided tissue regeneration (GTR) in conjunction with bone replacement Grafts and/or in edentulous sites


Reviewed: July 12, 2023


Important note


This Clinical Policy Bulletin determines whether certain services or supplies are medically necessary, experimental, and investigational, or cosmetic. Aetna® has reached these conclusions based upon a review of currently available clinical information (including clinical outcome studies in the peer-reviewed published medical literature, regulatory status of the technology, evidence -based guidelines of public health and health research agencies, evidence-based guidelines and positions of leading national health professional organizations, views of physicians practicing in relevant clinical areas, and other relevant factors). 


Aetna makes no representations and accepts no liability with respect to the content of any external information cited or relied upon in the Bulletin.  The discussion, analysis, conclusions, and positions reflected in this Bulletin, including any reference to a specific provider, product, process or service by name, trademark, manufacturer, constitute an opinion by Aetna and are made without any intent to defame. 


Aetna expressly reserves the right to revise these conclusions as clinical information changes, and welcomes further relevant information including correction of any factual error. CPBs include references to standard HIPAA compliant code sets to assist with search functions and to facilitate billing and payment for covered services. New and revised codes are added to the CPBs as they are updated. When billing, you must use the most appropriate code as of the effective date of the submission. Unlisted, unspecified and nonspecific codes should be avoided.


Each benefit plan defines which services are covered, which are excluded, and which are subject to dollar caps or other limits. Members and their providers will need to consult the member's benefit plan to determine if there are any exclusions or other benefit limitations applicable to this service or supply.


The conclusion that a particular service or supply is medically necessary does not constitute a representation or warranty that this service or supply is covered (for example, will be paid for by Aetna) for a particular member. The member's benefit plan determines coverage. Some plans exclude coverage for services or supplies that Aetna considers medically necessary. If there is a discrepancy between this policy and a member's plan of benefits, the benefits plan will govern. In addition, coverage may be mandated by applicable legal requirements of a State, the Federal government or CMS for Medicare and Medicaid members.


Visit the CMS coverage database




We consider this surgical procedure to be dental-in-nature (DIN) oral surgery. DIN oral surgery procedures may be covered under either medical or dental plans.




GTR is a surgical procedure that aims to regenerate the periodontal tissues when the periodontal disease is advanced and could overcome some of the limitations of conventional therapy. A membrane is placed over the root surfaces or defect area following surgical exposure and debridement. The mucoperiosteal flaps are then adapted over the membrane and sutured. The membrane is placed to exclude epithelium and gingival connective tissue from the healing wound. This procedure may require subsequent surgical procedures to correct the gingival contours. Guided tissue regeneration may also be carried out in conjunction with bone replacement grafts or to correct deformities resulting from inadequate faciolingual bone width in an edentulous site. The CDT defines an edentulous site in the heading of the 4000 section.


According to the article “Periodontal Regeneration — Intrabony Defects: Practical Applications” from the 2015 AAP Regeneration Workshop: important patient-related factors (e.g., smoking) and defect/site-related factors (e.g., defect morphology and gingival biotype) can influence the potential to achieve periodontal regeneration. The regeneration of intrabony defects generally becomes more challenging with increasing loss of height, proximity, and number of bony walls.




D4266 - Guided tissue regeneration, natural teeth - resorbable barrier, per site

D4267 - Guided tissue regeneration, natural teeth - nonresorbable barrier, per site (includes membrane removal)

D4286 - Removal of non-resorbable barrier

D6106 - Guided Tissue Regeneration - Resorbable Barrier, Per Implant

D6107 - Guided Tissue Regeneration - Non-Resorbable Barrier, Per Implant

D7956 - Guided Tissue Regeneration, Edentulous Area - Resorbable Barrier, Per Site

D7957 - Guided Tissue Regeneration, Edentulous Area - Edentulous Area - Non-Resorbable Barrier, Per Site


Revision dates


Original policy: September 13, 2004
Updated: September 4, 2007; December 29, 2008; December 21, 2009; February 28, 2011; July 12, 2012; August 13,2013; June 9, 2014; June 22, 2015; May 23, 2016; June 26, 2017; February 12, 2020; April 5, 2021; August 2, 2022; July 12, 2023
Revised: December 5, 2005


The above policy is based on the following references:


Reynolds, Mark et al (2015). Periodontal regeneration — intrabony defects: practical applications from the AAP Regeneration Workshop. Clinical Advances in Periodontics. 5. 21-29. 10.1902/cap.2015.140062.


American Dental Association. CDT 2023 Dental Procedure Codes.


Copyright 2023 American Dental Association. All rights reserved.


Property of Aetna. All rights reserved. Dental Clinical Policy Bulletins are developed by Aetna to assist in administering plan benefits and constitute neither offers of coverage nor medical/dental advice. This Dental Clinical Policy Bulletin contains only a partial, general description of plan or program benefits and does not constitute a contract. Aetna does not provide health care services and, therefore, cannot guarantee any results or outcomes. Participating health care professionals are independent contractors in private practice and are neither employees nor agents of Aetna or its affiliates. Treating health care professionals are solely responsible for medical/dental advice and treatment of members. This Clinical Policy Bulletin may be updated and therefore is subject to change.

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