This CPB has been revised to state that Rho-D immune globulin is also considered medically necessary for the suppression of Rh isoimmunization in Rho(D) negative persons transfused with Rho(D) positive red blood cells or blood components containing Rho(D) positive red blood cells. This CPB has been revised to state that post-exposure prophylaxis with varicella zoster immune globulin (VariZIG) is considered medically necessary in certain hematopoietic cell transplant (HCT) recipients (less than 24 months after HCT or greater than 24 months after HCT and on immunosuppressive therapy or has chronic graft-versus-host disease) following varicella zoster virus (VZV) exposure, including exposure to a VZV vaccinee having a varicella-like rash. This CPB has been revised for medical necessity for tetanus immune globulin with the following: specified for prevention of tetanus in remotely immunized persons (i.e., last complete vaccination 10 "or more" years ago "for clean and minor wounds or 5 or more years ago for dirty or major wounds [e.g., not limited to wounds contaminated with dirt, feces, soil, and saliva; puncture wounds; avulsions; and wounds resulting from missiles, crushing, burns and frostbite]") with neglected or tetanus-prone wounds (contaminated, necrotizing, or puncture wounds). This CPB has been revised for medical necessity criteria for vaccinia immune globulin with the following: added use for "vaccine infections in persons with skin disease (e.g., burns, eczema, impetigo, varicella-zoster)".