This CPB is revised to state that prophylactic plasmapheresis is considered medically necessary for Waldenstrom's macroglobulinemia, in persons with IgM greater than or equal to 5000 mg/dL while on rituximab or ofatumumab mg/dL, to avoid aggravation of serum viscosity on the basis of IgM flare related to rituximab or ofatumumab. This CPB is revised to state that plasmapheresis is considered medically necessary for acute humoral rejection of renal transplants.