This CPB has been revised to state that the following are considered medically necessary: (i) real-time quaking-induced conversion (RT-QuIC) for evaluation of individuals with a rapidly progressive dementia suspected of having prion disease (e.g., Creutzfeldt-Jakob disease); and (ii) testing for syphilis using a non-treponemal test (e.g., Venereal Disease Research Laboratory (VDRL) or rapid plasma reagin (RPR) test) and/or a treponemal antibody detection test for the following – (a) screening of all pregnant women, (b) screening of persons who are at risk of syphilis infection, and (c) diagnostic testing of individuals with signs and symptoms of syphilis.

This CPB has also been revised to state that the following are considered experimental, investigational, or unproven: (i) ciprofloxacin resistance (gyrA S91F point mutation) testing; (ii) macrolide (clarithromycin) sensitivity (23S rRNA point mutation) testing; and (iii) Mayo Clinic Laboratories Metagenomic Sequencing, CSF, also known as the “MSCSF Test".