Aetna considers pyrophosphate muscle scan in the evaluation of myalgia and myositis experimental and investigational because there is no clinical evidence to support the use of pyrophosphate muscle scan in the evaluation of myalgia and myositis.
Aetna considers the Myoglobinuria Test Panel experimental and investigational because there is no clinical evidence to support the use of the Myoglobinuria Test Panel.
For myositis antibody panel, see CPB 0866 - Rheumatic Diseases: Selected Tests.
Myalgia is muscular pain or tenderness. Muscle pain can also involve ligaments, tendons and fascia, the soft tissues that connect muscles, bones and organs together. Myositis is an inflammation or swelling of the muscles and may be caused by injury, infection or an autoimmune disorder.
The Myoglobinuria Test Panel is used for individuals with exercise intolerance related weakness, pain, cramping and idiopathic myoglobulinuria. The test, using muscle tissue, detects specific enzymes related to metabolic function. Diseases tested for include Phosphofructokinase deficiency (PFK), McArdle's disease, Tarui's disease, Phosphoglycerate kinase deficiency (PGK), Phosphoglycerate mutase deficiency (PGAM), Lactate Dehydrogenase deficiency (LDH), Glycogen, Phosphorylase A+ total deficiency (Ph), Phosphorylase B kinase deficiency (PhK), Carnitine Palmitoyltransferase 2 deficiency (CPT2) and Myoadenylate Deaminase deficiency (MAD). The Myoglobinuria Test Panel is a proprietary test of Athena Diagnostics. There is no clinical evidence to support the use of the Myoglobinuria Test Panel.
The pyrophosphate muscle scan or scintigraphy, is a nuclear imaging technique evaluating the uptake of technetium-99m pyrophosphate to reflect muscle viability and activity. According to Rider and colleagues, 2002, several types of scintigraphy have been used to image the muscles of patients with idiopathic inflammatory myopathies, including antimyosin, 99mtechnetium pyrophosphate, and 67gallium, each demonstrating uptake in inflamed, but not atrophied, muscles. The clinical usefulness of scintigraphy in the assessment of myositis is not clear.