Age-related macular degeneration (ARMD), a progressive degenerative disease of the macula, is the leading cause of blindness in developed countries afflicting about 15 million people in the United States. The risk of ARMD increases with age, and usually affects people 60 years of age and older. Heavy alcohol consumption (more than 3 standard drinks per day) is associated with an increased risk of early ARMD (Chong et al, 2008). Early ARMD is characterized by the presence of a few (less than 20) medium-size drusen or retinal pigmentary abnormalities. Intermediate ARMD is characterized by at least one large druse, numerous medium-size drusen, or geographic atrophy that does not extend to the center of the macula. Late or advanced ARMD can be either neovascular (wet or exudative) or non-neovascular (dry, atrophic, or non-exudative). The neovascular form includes serous or hemorrhagic detachment of retinal pigment epithelium and choroidal neovascularization (CNV), which lead to leakage and scarring. It is responsible for the majority of cases of severe vision loss and is due to proliferation of abnormal blood vessels behind the retina. These blood vessels leak blood and fluid into the retina, resulting in visual abnormalities. The development of these abnormal blood vessels is due in part to the activity of vascular endothelial growth factor (VEGF), which induces angiogenesis, and increases vascular permeability and inflammation, all of which are thought to contribute to the progression of the neovascular form of ARMD. The non-neovascular form leads to a slow deterioration of the macula with a gradual loss of vision over a period of years. It does not involve leakage of blood or serum, and is characterized by drusen and geographic atrophy extending to the center of the macula. Patients with non-exudative ARMD can progress to the exudative form of ARMD, in which pathologic CNV membranes develop under the retina, leak fluid and blood, and ultimately cause a blinding disciform scar in a relatively short time. Approximately 10 to 20 % of patients with non-exudative ARMD eventually progress to the exudative form, which is responsible for most of the cases of advanced ARMD in the United States (AAO, 2006; Comer, 2006; Jager et al, 2008).
Various therapeutic approaches have been employed in the treatment of patients with ARMD. High-dose antioxidants are thought to be able to limit the damage caused by oxidative stress in the macula. However, this treatment only slows progression in some patients and does not reverse damage already present. After ARMD becomes exudative, laser photocoagulation, photodynamic therapy (PDT) with verteporfin (Visudyne), and intra-vitreal injections of pegaptanib sodium (Macugen), bevacizumab (Avastin) and ranibizumab (Lucentis) have been used to control CNV. Because of the limitations in current treatment, researchers are presently developing alternative therapies for wet ARMD including alternative types of PDT, irradiation, intra-ocular devices, intra-vitreal administration of bevasiranib (a small interfering RNA agent that inhibits intra-cellular transcription of VEGF), transpupillary thermotherapy, treatment with a variety of growth-factor modulators, and vitreo-retinal surgery (AAO, 2006; Comer, 2006; Jager et al, 2008).
Argon laser photocoagulation therapy was once the most common therapy for wet ARMD. It is now used only occasionally to treat CNV that extends by more than 200 µm from the center of the macula, since this treatment itself can create a large retinal scar associated with permanent visual loss (Jaeger, 2008). In a Cochrane review, Virgili and Bini (2007) examined the effects of laser photocoagulation for wet ARMD. A total of 15 trials were included in the review (2,064 subjects). Three types of photocoagulation were used in the trials: (i) direct photocoagulation of the entire CNV (11 trials), (ii) peri-foveal photocoagulation (1 trial) and (iii) grid photocoagulation (3 trials). In 12 trials the control group was observation only. One trial compared photocoagulation to submacular surgery and 2 trials compared different lasers. Data on the progression of visual loss could be extracted from 5 of the 8 trials of direct photocoagulation of the CNV versus observation. The treatment effect was in the direction of harm in all studies at 3 months follow-up (RR 1.41, 95% confidence intervals [CI]: 1.08 to 1.82). After 2 years the treatment effect was in the direction of benefit (RR 0.67, 95 % CI: 0.53 to 0.83). These studies were clinically heterogeneous with participants having CNV lesions in different locations and different baseline visual acuity (VA). There was little evidence of statistical heterogeneity at 3 months but substantial statistical heterogeneity at 2 years. However, all treatment effects in the individual trials were in the direction of benefit. One study comparing perifoveal photocoagulation or observation of subfoveal CNV found benefits that were statistically significant only at 2 years (RR 0.36, 95 % CI: 0.18 to 0.72). Other comparisons did not demonstrate differences. The authors concluded that in the medium to long-term, laser photocoagulation of CNV slows the progression of visual loss in people with wet ARMD. However, it is associated with an increased risk of visual loss immediately after treatment and this period may be longer in people with subfoveal ARMD. With the advent of pharmacotherapies, and concern for the impact of iatrogenic scotoma in subfoveal CNV, laser photocoagulation of subfoveal CNV is not recommended. No studies have compared photocoagulation with modern pharmacological agents for ARMD for non-subfoveal CNV.
In a Cochrane review on laser treatment of drusen to prevent progression to advanced ARMD, Parodi and colleagues (2009) stated that the trials included in this review confirm the clinical observation that laser photocoagulation of drusen leads to their disappearance. However, there is no evidence that this subsequently results in a reduction in the risk of developing CNV, geographic atrophy or visual acuity loss.
In a Cochrane review, Giansanti et al (2009) evaluated the effectiveness of submacular surgery for preserving or improving vision in patients with ARMD. These investigators searched CENTRAL, MEDLINE, EMBASE and LILACS. There were no language or date restrictions in the search for trials. The electronic databases were last searched on 11 February 2009. They included randomized or quasi-randomized controlled trials comparing submacular surgery with any other treatment or observation. Two authors independently extracted the data. The risk ratio of visual loss and visual gain was estimated at 1 year. Two multi-center studies with a similar design were conducted between 1997 and 2003 and compared submacular surgery with observation in people affected by subfoveal neovascular ARMD with (n = 336) or without (n = 454) extensive blood in the macula. At 1 year, there was high quality evidence of no benefit for preventing visual loss (risk ratio: 0.96; 95 % CI: 0.84 to 1.09). No difference could be demonstrated regarding the chance of visual gain (risk ratio: 1.06; 95 % CI: 0.75 to 1.51), although this evidence was of low quality because of imprecision. The risk difference was -2 % (95 % CI: -10 % to 5 %) and 1 % (95 % CI: -4 % to 6 %) for visual loss and visual gain, respectively, thus excluding a large benefit with surgery in terms of absolute risk in this sample. There was high quality evidence that cataract needing surgery (risk ratio: 8.69; 95 % CI: 4.06 to 18.61) and retinal detachment (risk ratio: 6.13; 95 % CI: 2.81 to 13.38) were more common among operated patients, and detachment occurred in 5 % of patients with no extensive blood and in 18 % of those with extensive blood beneath the macula. A pilot study compared submacular surgery with laser photocoagulation in 70 patients. No difference between the 2 treatments could be demonstrated for any outcome measure, but estimates were very imprecise because of small sample size. The authors concluded that there is no benefit with submacular surgery in most people with subfoveal CNV due to ARMD in terms of prevention of visual loss. Furthermore, the risk of developing cataract and retinal detachment increases after surgery.
A systematic evidence review published in BMJ Clinical Evidence (Arnold and Heriot, 2006) also concluded that submacular surgery for ARMD "is likely to be ineffective or harmful."
Ocular PDT entails the use of an intravenously administered, light-sensitive dye, verteporfin, which preferentially concentrates in new blood vessels. Visudyne is activated with the use of a 689-nm laser beam focused over the macula, causing localized choroidal neovascular thrombosis through a non-thermal chemotoxic reaction. Although it generally does not improve vision and its use as monotherapy appears to be less effective than other treatments, PDT does limit visual loss in wet ARMD, and its repeated use over a 5-year period appears to be safe, with minimal, infrequent side effects including dye extravasation at the injection site, back pain, and photosensitivity (Jager et al, 2008).
Kaiser (2007) discussed the rationale for combining anti-angiogenic treatment with Visudyne PDT in the management of CNV due to ARMD and evaluated available evidence for the therapeutic benefits of such approaches. Treatments for CNV due to ARMD can be directed at either the vascular component of CNV or the angiogenic component that leads to the development of the condition. Verteporfin targets the vascular component, whereas anti-angiogenic agents (such as pegaptanib and ranibizumab) target key mediators of the angiogenic cascade. The different mechanisms of action of these approaches offer the potential for additive or synergistic effects with combination therapy. In addition, anti-angiogenic agents might counteract up-regulation of angiogenic factors (including VEGF) that occur after verteporfin PDT. Results from pre-clinical and clinical studies of the combination of ranibizumab or pegaptanib with verteporfin warrant continued investigation. The author concluded that the use of anti-angiogenic agents in combination with verteporfin may have the potential to improve visual outcomes and reduce the number of treatments in eyes with CNV due to ARMD, and requires further evaluation in randomized, controlled clinical trials.
The first intra-vitreal agent approved by the Food and Drug Administration (FDA) for wet ARMD was pegaptanib, a messenger RNA aptamer and VEGF antagonist. Pegaptanib binds to VEGF and inhibits its binding to cellular receptors; its anti-VEGF activity is expected to inhibit abnormal blood vessel proliferation and thus decrease the vision loss associated with the proliferation of abnormal blood vessels. However, the number of patients whose VA improved with pegaptanib was limited, so the agent is no longer widely used (Jager et al, 2008).
Currently, the most common treatments for wet ARMD are intra-vitreal bevacizumab and ranibizumab. Bevacizumab, a monoclonal antibody to VEGF is being used off-label for wet ARMD. Although data from long-term studies are not yet available, several short-term studies of intra-vitreal bevacizumab have shown improvement in VA that is similar to the improvement with ranibizumab. Intra-vitreal bevacizumab appears to have systemic adverse events similar to those of ranibizumab, which is designed to block new blood vessel growth and leakiness, and is the first treatment which, when given monthly, can maintain the vision of more than 90 % of patients with wet ARMD. In contrast to pegaptanib, ranibizumab is a recombinant humanized monoclonal antibody fragment with specificity for all isoforms of human VEGF. Ranibizumab exhibits high affinity for human VEGF and exerts its neutralizing effects by inhibiting the VEGF-receptor interaction. Unlike the larger whole antibody, ranibizumab can penetrate the internal limiting membrane and reach the subretinal space following intra-vitreal injection (van Wijngaarden et al, 2005).
In an editorial on the use of intra-vitreal bevacizumab as the low cost alternative to ranibizumab published in the American Journal of Ophthalmology, Rosenfeld (2006) stated that "[c]urrently, there appears to be a global consensus that the treatment strategy using intra-vitreal Avastin is logical, the potential risks to our patients are minimal, and the cost-effectiveness is so obvious that the treatment should not be withheld". On March 20, 2006, a survey by the American Society of Retinal Specialists of its membership was completed. It found that 92 % of 289 respondents felt intra-vitreal bevacizumab was "somewhat better" or "much better" than other FDA-approved or covered therapies. Only 4 % of respondents had seen any thromboembolic complications thought to be related to the intra-vitreal bevacizumab, and 96 % thought intra-vitreal bevacizumab was the same or better in terms of overall safety compared to other FDA-approved or covered therapies.
On April 20, 2006, the American Academy of Ophthalmology (AAO) wrote to the Centers for Medicare and Medicaid Services supporting the reimbursement for treating ARMD with intra-vitreal injections of bevacizumab to meet the medical needs of patients who have not responded to Visudyne PDT or intra-vitreal pegaptanib. The AAO's support for reimbursement is limited to "such patients who are deemed by their treating physician to have failed FDA-approved therapies, or in the judgment of their treating physician, based on his/her experience, are likely to have greater benefit from the use of intra-vitreal bevacizumab". On October 5, 2006, the National Institutes of Health's National Eye Institute said it will fund a multi-center clinical trial to compare ranibizumab with bevacizumab in the treatment of ARMD (NIH, 2006).
In a Cochrane review, Vedula and Krzystolik (2008) examined the effects of anti-VEGF modalities for treating neovascular ARMD. These investigators concluded that pegaptanib and ranibizumab reduce the risk of VA loss in patients with neovascular ARMD. Ranibizumab causes gains in VA in many eyes. Other agents blocking VEGF are being tested in ongoing trials.
In a multi-center, randomized controlled trial (RCT), the Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research Group (2012) described (i) the effects of ranibizumab and bevacizumab when administered monthly or as needed for 2 years, and (ii) the impact of switching to as-needed treatment after 1 year of monthly treatment. Subjects (n = 1,107) were those who were followed-up during year-2 among 1,185 patients with neovascular ARMD who were enrolled in the clinical trial. At enrollment, patients were assigned to 4 treatment groups defined by drug (ranibizumab or bevacizumab) and dosing regimen (monthly or as needed). At 1 year, patients initially assigned to monthly treatment were re-assigned randomly to monthly or as-needed treatment, without changing the drug assignment. Main outcome measure was mean change in VA. Among patients following the same regimen for 2 years, mean gain in VA was similar for both drugs (bevacizumab-ranibizumab difference, -1.4 letters; 95 % CI: -3.7 to 0.8; p = 0.21). Mean gain was greater for monthly than for as-needed treatment (difference, -2.4 letters; 95 % CI: -4.8 to -0.1; p = 0.046). The proportion without fluid ranged from 13.9 % in the bevacizumab-as-needed group to 45.5 % in the ranibizumab monthly group (drug, p = 0.0003; regimen, p < 0.0001). Switching from monthly to as-needed treatment resulted in greater mean decrease in vision during year 2 (-2.2 letters; p = 0.03) and a lower proportion without fluid (-19 %; p < 0.0001). Rates of death and arterio-thrombotic events were similar for both drugs (p > 0.60). The proportion of patients with 1 or more systemic serious adverse events was higher with bevacizumab than ranibizumab (39.9 % versus 31.7 %; adjusted risk ratio, 1.30; 95 % CI: 1.07 to 1.57; p = 0.009). Most of the excess events have not been associated previously with systemic therapy targeting VEGF. The authors concluded that ranibizumab and bevacizumab had similar effects on VA over a 2-year period. Treatment as needed resulted in less gain in VA, whether instituted at enrollment or after 1 year of monthly treatment. There were no differences between drugs in rates of death or arterio-thrombotic events. The interpretation of the persistence of higher rates of serious adverse events with bevacizumab is uncertain because of the lack of specificity to conditions associated with inhibition of VEGF.
In a prospective, double-masked, placebo-controlled, randomized clinical study, Lee and colleagues (2007) examined the effect of intra-vitreal injection of high-dose triamcinolone acetonide on minimally classic or occult CNV secondary to ARMD. The treatment group (21 eyes) received intra-vitreal injection (20 to 25 mg) of triamcinolone acetonide and the control group (18 eyes) received intra-vitreal injection (500 mug) of dexamethasone at 6-month intervals. Best-corrected Early Treatment Diabetic Retinopathy Study (ETDRS) score, contrast sensitivity score, and central macular volume were measured at 1 month, 3 months, 6 months, and 12 months. Mean baseline best-corrected VA (BCVA [logarithm of the minimal angle of resolution]) was 0.64 (Snellen equivalent, 20/80) in each group. At 1 month, 3 months, and 6 months after the injection, neither group had a significant change in BCVA. At 12 months, mean BCVA +/- SD significantly decreased to 1.06 +/- 0.34 (Snellen equivalent, 20/200) in the treatment group (paired t-test, p < 0.001), whereas it was 0.78 +/- 0.52 (Snellen equivalent, 20/125) in the control group (p = 0.23). The difference was marginally significant (p = 0.06, Student's t-test). All phakic eyes in the treatment group developed marked cataract progression. The authors concluded that intra-vitreal injection of high-dose triamcinolone had no beneficial effect on eyes with minimally classic or occult CNV secondary to ARMD and was associated with outcomes similar to those associated with intra-vitreal injection of dexamethasone, which was used as placebo.
On November 18, 2011, the FDA approved aflibercept ophthalmic solution (Eylea, Regeneron Pharmaceuticals Inc.) for the treatment of neovascular (wet) ARMD. The FDA's approval of Eylea was based on positive results from the 2 phase III VEGF Trap-Eye: Investigation of Efficacy and Safety in Wet AMD (VIEW) trials. Both found the drug non-inferior to ranibizumab, which is currently the most potent FDA-approved treatment option for wet ARMD. The most commonly reported adverse events in patients receiving aflibercept included eye pain, conjunctival hemorrhage, vitreous floaters, cataract, and an increase in eye pressure. Aflibercept should not be used in those who have an active eye infection or active ocular inflammation. It has not been studied in pregnant women, so the treatment should be used only in pregnant women if the potential benefits of the treatment outweigh any potential risks. Age-related macular degeneration does not occur in children and aflibercept has not been studied in children. The recommended dose is 2 mg every 4 weeks (monthly) for the first 12 weeks, followed by 2 mg every 8 weeks (2 months).
In a review, Jager and colleagues (2008) discussed several evolving methods in the treatment of neovascular ARMD. Intra-vitreal administration of bevasiranib, a small interfering RNA agent, inhibits intra-cellular transcription of VEGF. This agent appears to inhibit CNV; phase III clinical trials are underway to ascertain its effectiveness in treating ARMD (Chappelow and Kaiser, 2008). The implantation of artificial intra-ocular devices might benefit patients who are refractory to pharmacotherapies. Implantable miniature telescopes might improve the quality of life of patients with severe visual loss from end-stage ARMD. Surgical implantation of optic nerve, cortical (visual cortex), subretinal, and epiretinal electrically stimulated devices have all led to the perception of phosphenes (discrete, reproducible perceptions of light) in humans. These devices may help restore functional vision in the future but are primitive at present.
Artificial lens systems usually consist of a single miniature telescope prosthesis or a combination of individual lenses implanted separately. Implantation is performed under local anesthesia. The natural lens is removed through a small incision at the limbus and the new lens system is inserted. An iridectomy is performed to prevent pupillary block. The exact technique for implantation may vary according to the system being used.
On July 6, 2010, the FDA approved the implantable miniature telescope (IMT) (VisionCare Ophthalmic Technologies, Saratoga, CA) for patients aged 75 years and older with stable, untreatable, severe-to-profound vision impairment (when vision impairment has not changed over time) caused by blind spots (bilateral central scotoma) associated with end-stage ARMD with evidence of a visually significant cataract.
In October 2014, the FDA expanded approval of IMT to patients 65 years of age or older. FDA approval to expand access to those age 65 and older was based on clinical data provided by the pivotal safety and efficacy study, IMT-002, and long-term studies IMT-002-LTM and IMT-002-LTME, which followed patients to 5 and 8 years, respectively.
The IMT device is a compound telescope system that consists of a glass cylinder (4.4 mm in length and 3.6 mm in diameter) housing wide-angle micro-optics. The height of the glass cylinder approximately equals that of 13 stacked intraocular lenses (IOLs). The device is heavier (115 mg in air and 60 mg in aqueous) and the carrier haptics are less flexible than those found on 1-piece polymethylmethacrylate IOLs. The IMT device is surgically implanted in the posterior chamber of the eye after removal of the eye’s lens and is designed to be implanted in 1 eye only; the implanted eye provides central vision, while the non-implanted eye is used for peripheral vision. The IMT protrudes 0.1 to 0.5 mm through the papillary plane, leaving a minimum of 2.0 mm of corneal clearance. When properly implanted in eyes with anterior chamber depths of 2.5 mm or more, the face of the optic should not touch the corneal endothelium. The device provides higher resolution images to the central retina and its telephoto effect also allows more to be seen in the central visual field. The device is used for both near and distance activities, with objects being brought into focus by standard spectacles. Prior to implantation, patients must agree to undergo training with an external telescope with a low vision specialist to determine whether adequate improvement in vision with the external telescope can be obtained and to verify if the patient has adequate peripheral vision in the eye that would not be implanted. Patients must also agree to participate in a post-operative visual training program. The device is available in 2 models: one provides 2.2 x magnification and the other provides 2.7 x magnification.
The IMT-002 clinical trial (Hudson et al, 2006) evaluated the safety and efficacy of VisionCare’s IMT in patients with bilateral, end-stage ARMD in a prospective, open-label, multi-center clinical trial with fellow eye controls. A total of 217 patients (mean age of 76 years) with ARMD and moderate to profound bilateral central VA loss (20/80 to 20/800) resulting from bilateral untreatable geographic atrophy, disciform scars, or both were enrolled; however, 11 eyes did not receive the device because of an aborted procedure. The IMT was implanted monocularly in the capsular bag after lens extraction. Fellow eyes were not implanted to provide peripheral vision and served as controls. Study patients participated in 6 visual rehabilitation visits after surgery. The majority of patients (90 %) met or exceeded the VA end-point defined as an improvement in 2 lines or more in either near or distance BCVA at the 1-year follow-up. Change in VA was not related to lesion type. Mean quality-of-life scores from the National Eye Institute 25-item Visual Function Questionnaire (NEI VFQ-25) and the Activities of Daily Life scale, a secondary outcome measure, improved by more than 7 points from baseline on 7 of 8 relevant subscales (e.g., social functioning, mental health, role difficulties, and dependency); at 12 months, 51.8 % (100/193) of patients gained at least 5 points, 25.9 % (50/193) of patients reported no change (i.e., change within +/- 5 points), and 22.3 % of patients (43/193) lost at least 5 points in VFQ-25 composite score from baseline. Mean endothelial cell density (ECD) loss at 3 months was 20 % and 25 % at 12 months. The decrease in ECD was correlated with post-surgical edema, and there was no evidence that endothelial cell loss accelerated by ongoing endothelial trauma after implantation. The authors concluded that the IMT can improve VA and quality of life in patients with moderate-to-profound visual impairment caused by bilateral, end-stage ARMD.
Because the IMT is large and non-foldable, it requires a much larger incision (12 mm) than phacoemlusification with foldable IOL. The risk of corneal endothelial cell loss during implantation is higher than conventional anterior segment procedures, but is comparable with that seen after large-incision cataract extraction (Colby et al, 2007). Significant losses in ECD may lead to corneal edema, corneal decompensation, and the need for corneal transplant. In the IMT-002 trial, 10 eyes had unresolved corneal edema, with 5 resulting in corneal transplants. The device was removed from 8 eyes post-operatively (4 subjects requested removal because they were dissatisfied with the device, 2 were removed due to condensation of the telescope portion, and 2 eyes underwent corneal transplantation as a result of corneal decompensation). The calculated 5-year risk for unresolved corneal edema, corneal decompensation, and corneal transplant are 9.2 %, 6.8 % and 4.1 %, respectively (FDA, 2010). Four device failures were reported during the IMT-002 trial.
According to the manufacturer's website, the IMT is intended for monocular implantation in patients aged 65 years and older with stable, untreatable, severe-to-profound vision impairment caused by blind spots (bilateral central scotoma) associated with end-stage ARMD as determined by fluorescein angiography when all of the following are met:
- Achieve at least a 5-letter improvement on the Early Treatment Diabetic Retinopathy Study (ETDRS) VA chart in the eye scheduled for surgery using an external telescope; and
- Adequate peripheral vision in the eye not scheduled for surgery; and
- Agree to undergo 2 to 4 pre-surgical training sessions with low vision specialist (optometrist or occupational therapist); and
- Evidence of a visually significant cataract (grade 2 or higher); and
- No active wet ARMD (no sign of active CNV in either eye); and
- No sign of eye disease other than well-controlled glaucoma; and
- Not been treated for wet ARMD in the previous 6 months; and
- Stable, untreatable ARMD disease present in both eyes (end-stage, geographic atrophy or disciform scar) as determined by fluorescein angiography; and
- Visual acuity poorer than 20/160, but not worse than 20/800 in both eyes; and
- Willingness to participate in a post-operative visual rehabilitation program.
As a condition of FDA approval, the manufacturer must conduct 2 post-approval studies: (i) VisionCare must continue follow-up on the subjects from its long-term follow-up cohort for an additional 2 years, and (ii) an additional study of 770 newly enrolled subjects will include an evaluation of the ECD and related adverse events for 5 years after implantation.
The IMT is contraindicated in patients with any of the following:
One of the internal components of the IMT implant containing stainless steel has been evaluated for magnetic resonance imaging (MRI) compatibility and determined to be MR-conditional.
The National Institute for Clinical Excellence's (NICE, 2008) guidance on implantable miniature lens systems for the treatment of ARMD stated that: "[e]vidence on the efficacy of implantation of miniature lens systems for advanced age-related macular degeneration (AMD) shows that the procedure can improve both vision and quality of life in the short-term. Short-term safety data are available for limited numbers of patients. There is currently insufficient long-term evidence on both efficacy and safety. Therefore this procedure should only be used with special arrangements for clinical governance, consent and audit or research." The National Institute for Clinical Excellence included a non-randomized study and a case series study as part of the evidence review. In the non-randomized study of 217 patients, 67 % (128/192) and 68 % (130/192) of eyes with an implanted lens system improved by 3 or more lines of best-corrected distance and near VA, respectively, compared with 13 % (24/192) and 33 % (64/192) of non-implanted fellow eyes (p less than 0.0001) at 1-year follow-up. Loss of 2 or more lines of best-corrected distance VA was reported in 2 % of implanted eyes and 9 % of fellow eyes at 1-year follow-up (p = 0.005). Two patients developed corneal decompensation and underwent device removal and corneal transplantation more than 1 year after the initial surgery and 5 % of the procedures were aborted due to complications (e.g., posterior capsule rupture and choroidal effusion/hemorrhage). In a case series study of 35 patients (40 eyes), best-corrected distance VA improved in all patients after a mean of 20 months. Other complications in the non-randomized study and case series study included increased IOP requiring treatment (28 % [57/206]) and corneal edema (25 % [9/36], 7 % [14/206]). Two specialist advisors reported corneal endothelial cell loss as an adverse event. They considered additional theoretical complications to include corneal decomposition and corneal and macular edema. One specialist advisor commented that the procedure has more risks than standard cataract surgery. Furthermore, the Committee noted that there are several different lens systems available and that the technique is still evolving.
An UpToDate review on “Age-related macular degeneration: Treatment and prevention” (Arroyo, 2014) states that “Two procedures have been tried, with limited success, for AMD: submacular surgery and macular translocation surgery. Submacular surgery involves the removal of abnormal subretinal neovascularization and large submacular hemorrhages, if present. Clinical trials have been largely disappointing, showing lack of benefit and high rates of retinal detachment. There may be a role for submacular surgery, however, in patients with large peripapillary membranes. Macular translocation surgery is experimental and involves moving the macula to a less diseased area of the retina in patients with subfoveal choroidal neovascularization. The advent of effective pharmacologic therapy has limited the use of this surgical modality to patients with large submacular hemorrhages. The surgical risks are substantial …. External beam radiation therapy has been studied in patients with AMD. A meta-analysis of randomized, controlled trials concluded that there was no consistent evidence of benefit. The long-term safety of radiation therapy is unknown”.
Si and colleagues (2014) compared the safety and effectiveness of combination of ranibizumab with PDT versus ranibizumab monotherapy in the treatment of ARMD. The Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, PubMed, and Embase were searched. There were no language or data restrictions in the search for trials. Only RCTs were included. Methodological quality of the literatures was evaluated according to the Jadad Score. RevMan 5.2.6 software was used to do the meta-analysis. A total of 7 studies were included in this systematic review, among which 4 of them were included in quantitative analysis. The result showed that the ranibizumab monotherapy group had a better mean BCVA change versus baseline at month 12 compared with that of the combination treatment group, and the statistical difference was significant (WMD, -2.61; 95 % CI: -5.08 to -0.13; p = 0.04). However, after the removal of 1 study, the difference between the 2 groups showed no significant difference (WMD, -2.29; 95 % CI: -4.81 to 0.23; p = 0.07). Meanwhile, no significant central retinal thickness (CRT) reduction was found in the combination treatment group and the ranibizumab monotherapy group at 12 months follow-up. Nevertheless, the combination group tended to have a greater reduction in CRT (WMD, -4.13 µm; 95 % CI: -25.88 to 17.63, p = 0.71). The proportion of patients gaining more than 3 lines at month 12 in the ranibizumab group was higher than in the combination group and there was a significant difference (RR, 0.72; 95 % CI: 0.54 to 0.95; p = 0.02). Whereas there was no significant difference for the proportion of patients gaining more than 0 line at month 12 between the 2 groups (RR, 0.93; 95 % CI: 0.76 to 1.15; p = 0.52). The general tendency showed a reduction in ranibizumab re-treatment number in the combination treatment group compared with the ranibizumab monotherapy group. As major adverse events, the differences in the number of eye pain, endophthalmitis, hypertension and arterial thromboembolic events were not significant between the 2 groups, and the incidence of serious adverse events in the 2 groups was very low. The authors concluded that for the maintenance of vision, the comparison of the combination of ranibizumab with PDT versus ranibizumab monotherapy showed no apparent difference. Compared with the combination of ranibizumab and PDT, patients treated with ranibizumab monotherapy may gain more VA improvement. The combination treatment group had a tendency to reduce the number of ranibizumab re-treatment. Both treatment strategies were well-tolerated.
Jiang et al (2014) noted that ranibizumab is used monthly or as-needed (PRN) for the treatment of ARMD. However, which treatment regimen is more effective remains unknown. These investigators compared the effectiveness of monthly versus as-needed quarterly treatment; and the effectiveness of ranibizumab 0.5 mg treatment with: (a) no anti- VEGF; (b) ranibizumab 0.3 mg; and (c) bevacizumab. This was a systematic meta-analytic review of RCTs of ranibizumab in neovascular AMD. Weighted multiple regression analyses were used to compare the monthly versus PRN/quarterly treatment. A total of 8 RCTs met inclusion criteria. Patients on the monthly ranibizumab treatment had higher VA letter gains (β = 0.441, p < 0.05) compared with patients on as-needed/quarterly treatment. More patients on the monthly treatment gained greater than or equal to 15 letters than as-needed/quarterly treatment (β = 0.582, p < 0.05). Ranibizumab produced significantly higher improvement in VA (d = 1.20, z = 7.14, p < 0.05) and led to a higher proportion of patients gaining greater than or equal to 15 letters (OR: 6.67; 9 5% CI: 3.16 to 14.06; p < 0.05) when compared with non-anti-VEGF. Ranibizumab did not show any advantage in VA compared with bevacizumab. No significant differences were found between ranibizumab 0.3 mg and 0.5 mg. The authors concluded that this was the first meta-analysis to systematically evaluate the effectiveness of different treatment regimens for anti-VEGF therapy. Ranibizumab 0.3 or 0.5 mg monthly treatment was more effective for neovascular AMD than non-anti-VEGF treatments; but is no better than bevacizumab.
MacLaren et al (2014) examined the effects of retinal gene therapy with an adeno-associated viral (AAV) vector encoding REP1 (AAV.REP1) in patients with choroideremia. In a multi-center clinical trial, a total of 6 male patients (aged 35 to 63 years) with choroideremia were administered AAV.REP1 (0.6 to 1.0×10(10) genome particles, subfoveal injection). Visual function tests included BCVA, microperimetry, and retinal sensitivity tests for comparison of baseline values with 6 months after surgery. Despite undergoing retinal detachment, which normally reduces vision, 2 patients with advanced choroideremia who had low baseline BCVA gained 21 letters and 11 letters (more than 2 and 4 lines of vision). Four other patients with near normal BCVA at baseline recovered to within 1 to 3 letters. Mean gain in VA overall was 3.8 letters (SE 4.1). Maximal sensitivity measured with dark-adapted microperimetry increased in the treated eyes from 23.0 dB (SE 1.1) at baseline to 25.3 dB (1.3) after treatment (increase 2.3 dB [95 % CI: 0.8 to 3.8]). In all patients, over the 6 months, the increase in retinal sensitivity in the treated eyes (mean 1.7 [SE 1.0]) was correlated with the vector dose administered per mm(2) of surviving retina (r = 0.82, p = 0.04). By contrast, small non-significant reductions (p > 0.05) were noted in the control eyes in both maximal sensitivity (-0.8 dB [1.5]) and mean sensitivity (-1.6 dB [0.9]). One patient in whom the vector was not administered to the fovea re-established variable eccentric fixation that included the ectopic island of surviving retinal pigment epithelium that had been exposed to vector. The authors concluded that the initial results of this retinal gene therapy trial are consistent with improved rod and cone function that overcome any negative effects of retinal detachment. They stated that these findings lend support to further assessment of gene therapy in the treatment of choroideremia and other diseases, such as ARMD, for which intervention should ideally be applied before the onset of retinal thinning.
Prevention of ARMD:
In a meta-analysis, Chuo and colleagues (2007) examined the effect of lipid-lowering agents in the development of ARMD. Case-control and cohort studies presenting relative risks and 95 % CI were identified through a literature review. Inclusion was limited to studies where both the exposure of interest (lipid-lowering agents) and outcome (ARMD) were explicitly defined. Pooled estimates were computed using the random effects model. To quantify heterogeneity, these researchers calculated the proportion of total variance of between study variance using the Ri statistic. The Q statistic for heterogeneity was also calculated. Eight studies were identified. The pooled relative risk (RR) for all studies was 0.74 (95 % CI: 0.55 to 1.00). When only those studies examining the use of statins were pooled (n = 7), the RR was 0.70 (95 % CI: 0.48 to 1.03). Using the Ri statistic, the heterogeneity between studies was found to be 0.85 for all studies and 0.89 for studies examining statins. The authors concluded that lipid-lowering agents, including statins, do not appear to lower the risk of developing ARMD, although clinically significant effects can not be excluded. The use of these agents in the prevention of ARMD can not be recommended until well-designed prospective studies with long-term follow-up have demonstrated a benefit.
Evans and Henshaw (2008) stated that some observational studies have suggested that people who eat a diet rich in antioxidant vitamins (e.g., carotenoids, vitamins C and E) or minerals (e.g., selenium and zinc) may be less likely to develop ARMD. In a Cochrane review, these researchers examined the evidence as to whether or not taking vitamin or mineral supplements prevents the development of ARMD. They included all randomized trials comparing an antioxidant vitamin and/or mineral supplement (alone or in combination) to control; and included only studies where supplementation had been given for at least 1 year. Three RCTs were included in this review (23,099 people randomized). These trials investigated alpha-tocopherol and beta-carotene supplements. There was no evidence that antioxidant vitamin supplementation prevented or delayed the onset of ARMD. The pooled risk ratio for any age-related maculopathy (ARM) was 1.04 (95 % CI: 0.92 to 1.18), for ARMD (late ARM) was 1.03 (95 % CI: 0.74 to 1.43). Similar results were seen when the analyses were restricted to beta-carotene and alpha-tocopherol. The authors concluded that there is no evidence to date that the general population should take antioxidant vitamin and mineral supplements to prevent or delay the onset of ARMD.
Oral supplementation with the Age-Related Eye Disease Study (AREDS) formulation (antioxidant vitamins C and E, beta carotene, and zinc) has been shown to reduce the risk of progression to advanced ARMD. Observational data suggested that increased dietary intake of lutein + zeaxanthin (carotenoids), omega-3 long-chain polyunsaturated fatty acids (docosahexaenoic acid [DHA] + eicosapentaenoic acid [EPA]), or both might further reduce this risk. The Age-Related Eye Disease Study 2 (AREDS2) RCT examined if adding lutein + zeaxanthin, DHA + EPA, or both to the AREDS formulation decreases the risk of developing advanced ARMD and evaluated the effect of eliminating beta carotene, lowering zinc doses, or both in the AREDS formulation. The AREDS2 is a multi-center, randomized, double-masked, placebo-controlled phase III study with a 2 × 2 factorial design, conducted in 2006 to 2012 and enrolling 4,203 participants aged 50 to 85 years at risk for progression to advanced ARMD with bilateral large drusen or large drusen in 1 eye and advanced ARMD in the fellow eye. Participants were randomized to receive lutein (10 mg) + zeaxanthin (2 mg), DHA (350 mg) + EPA (650 mg), lutein + zeaxanthin and DHA + EPA, or placebo. All participants were also asked to take the original AREDS formulation or accept a secondary randomization to 4 variations of the AREDS formulation, including elimination of beta carotene, lowering of zinc dose, or both. Main outcome measure was development of advanced ARMD. The unit of analyses used was by eye. Median follow-up was 5 years, with 1,940 study eyes (1,608 participants) progressing to advanced ARMD. Kaplan-Meier probabilities of progression to advanced ARMD by 5 years were 31 % (493 eyes [406 participants]) for placebo, 29 % (468 eyes [399 participants]) for lutein + zeaxanthin, 31 % (507 eyes [416 participants]) for DHA + EPA, and 30 % (472 eyes [387 participants]) for lutein + zeaxanthin and DHA + EPA. Comparison with placebo in the primary analyses demonstrated no statistically significant reduction in progression to advanced ARMD (hazard ratio [HR], 0.90 [98.7 % CI: 0.76 to 1.07]; p = 0.12 for lutein + zeaxanthin; 0.97 [98.7 % CI: 0.82 to 1.16]; p = 0.70 for DHA + EPA; 0.89 [98.7 % CI: 0.75 to 1.06]; p = 0.10 for lutein + zeaxanthin and DHA + EPA). There was no apparent effect of beta carotene elimination or lower-dose zinc on progression to advanced ARMD. More lung cancers were noted in the beta carotene versus no beta carotene group (23 [2.0 %] versus 11 [0.9 %], nominal p = 0.04), mostly in former smokers. The authors concluded that addition of lutein + zeaxanthin (Lutemax 2020), DHA + EPA, or both to the AREDS formulation in primary analyses did not further reduce risk of progression to advanced ARMD. However, because of potential increased incidence of lung cancer in former smokers, lutein + zeaxanthin could be an appropriate carotenoid substitute in the AREDS formulation.
In a multi-center, phase III, RCT, Dugel et al (2013) evaluated the safety and effectiveness of epi-macular brachytherapy (EMBT; also known as epiretinal brachytherapy) for the treatment of neovascular ARMD. A total of 494 participants with treatment-naïve neovascular ARMD were included in this study. Participants with classic, minimally classic, and occult lesions were randomized in a 2:1 ratio to EMBT or a ranibizumab monotherapy control arm. The EMBT arm received 2 mandated, monthly loading injections of 0.5 mg ranibizumab. The control arm received 3 mandated, monthly loading injections of ranibizumab then quarterly injections. Both arms also received monthly as needed (pro re nata) re-treatment. Main outcome measures included the proportion of participants losing fewer than 15 ETDRS letters from baseline VA and the proportion gaining more than 15 ETDRS letters from baseline VA. At 24 months, 77 % of the EMBT group and 90 % of the control group lost fewer than 15 letters. This difference did not meet the pre-specified 10 % non-inferiority margin. This end-point was non-inferior using a 20 % margin and a 95 % CI for the group as a whole and for classic and minimally classic lesions, but not for occult lesions. The EMBT did not meet the superiority end-point for the proportion of participants gaining more than 15 letters (16 % for the EMBT group versus 26 % for the control group): this difference was statistically significant (favoring controls) for occult lesions, but not for predominantly classic and minimally classic lesions. Mean VA change was -2.5 letters in the EMBT arm and +4.4 letters in the control arm. Participants in the EMBT arm received a mean of 6.2 ranibizumab injections versus 10.4 in the control arm. At least 1 serious adverse event occurred in 54 % of the EMBT arm, most commonly post-vitrectomy cataract, versus 18 % in the control arm. Mild, non-proliferative radiation retinopathy occurred in 3 % of the EMBT participants, but no case was vision threatening. The authors concluded that the 2-year effectiveness data do not support the routine use of EMBT for treatment-naive wet ARMD, despite an acceptable safety profile. They stated that further safety review is needed.
Petrarca et al (2013) reported the optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) results of the MERITAGE (Macular Epiretinal Brachytherapy in Treated Age-Related Macular Degeneration) study. In this prospective, multi-center, interventional, non-controlled clinical trial, a total of 53 eyes of 53 participants with chronic, active neovascular ARMD requiring frequent anti-VEGF re-treatment were enrolled. Participants underwent pars plana vitrectomy with a single 24-gray dose of EMBT, delivered with an intra-ocular, hand-held, cannula containing a strontium 90/yttrium 90 source positioned over the active lesion. Participants were re-treated with ranibizumab administered monthly as needed, using pre-defined re-treatment criteria. Patients underwent FFA at baseline, month 1, and month 12. Patients underwent OCT at baseline and then monthly for 12 months. The FFA and OCT images were evaluated by independent, central reading facilities. Main outcome measures included change in OCT center-point thickness and angiographic lesion size 12 months after EMBT. Mean center-point thickness increased by 50 μm, from 186 to 236 μm (p = 0.292), but 70 % of participants had an increase of less than the mean, with a median increase of only 1.8 μm. The FFA total lesion size increased slightly by 0.79 mm(2), from 14.69 to 15.48 mm(2) (p = 0.710). Total CNV area increased by 1.17 mm(2), from 12.94 to 14.12 mm(2) (p = 0.556). The classic CNV area decreased substantially by 3.70 mm(2), from 3.90 to 0.20 mm(2) (p < 0.01). Predominantly classic lesions showed the greatest response, with mean ETDRS VA improving by 1.5 letters (versus -4.0 for all participants combined); mean center-point thickness decreased by 43 μm (p = 0.875). The angiographic and OCT response did not correlate with lesion size at baseline. The authors concluded that in chronic, active, neovascular ARMD, EMBT is associated with non-significant changes in center-point thickness and FFA total lesion size over 12 months. Moreover, they stated that “Although EMBT may be most appropriate for the treatment of classic ARMD, larger studies are needed”.
Ciliary Neurotrophic Factor:
Zhang and colleagues (2011) stated that there is no treatment available for vision loss associated with advanced dry ARMD or geographic atrophy (GA). In a pilot, proof of concept phase II study, these investigators evaluated ciliary neurotrophic factor (CNTF) delivered via an intra-ocular encapsulated cell technology implant for the treatment of GA. They designed a multi-center, 1-year, double-masked, sham-controlled dose-ranging study. Patients with GA were randomly assigned to receive a high- or low-dose implant or sham surgery. The primary endpoint was the change in BCVA at 12 months. Ciliary neurotrophic factor treatment resulted in a dose-dependent increase in retinal thickness. This change was followed by VA stabilization (loss of less than 15 letters) in the high-dose group (96.3 %) compared with low-dose (83.3 %) and sham (75 %) group. A subgroup analysis of those with baseline BCVA at 20/63 or better revealed that 100 % of patients in the high-dose group lost less than 15 letters compared with 55.6 % in the combined low-dose/sham group (p = 0.033). There was a 0.8 mean letter gain in the high-dose group compared with a 9.7 mean letter loss in the combined low-dose/sham group (p = 0.0315). Both the implant and the implant procedure were well-tolerated. The authors concluded that these findings suggested that CNTF delivered by the encapsulated cell technology implant appears to slow the progression of vision loss in GA, especially in eyes with 20/63 or better vision at baseline. The findings of this phase II clinical study need to be validated by well-designed studies.