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Aetna Aetna
Clinical Policy Bulletin:
Osteoarthritis of the Knee: Selected Treatments
Number: 0673


  1. Aetna considers arthroscopic lavage for osteoarthritis of the knee experimental and investigational because its effectiveness has not been established.

  2. Aetna considers arthroscopic debridement experimental and investigational for persons with osteoarthritis presenting with knee pain only or with severe osteoarthritis (Outerbridge classification III or IV*) because its effectiveness for these indications has not been established.

  3. Aetna considers arthroscopic debridement medically necessary for persons presenting with mild-to-moderate (Outerbridge classification I and II) osteoarthritis with knee pain plus mechanical symptoms due to loose bodies and meniscal tears.

  4. Aetna considers intra-articular injections of infra-patellar fat pad-derived mesenchymal stem cell for the treatment of osteoarthritis of the knee experimental and investigational because the effectiveness of this approach has not been established.

  5. Aetna considers patellofemoral replacement (arthroplasty) experimental and investigational in the treatment of isolated osteoarthritis of the knee.


*The most commonly used instrument to classify the severity of osteoarthritis in study patients was the Outerbridge scale.  The Outerbridge scale classifies the articular degeneration of the knee by compartment in four grades.  Grade I refers to softening or blistering of the articular cartilage.  Grade II describes fragmentation or fissuring in an area less than 1 cm, while those with an area greater than 1 cm are considered Grade III.  Finally, Grade IV refers to cartilage erosion down to the bone.

See also: CPB 0009 - Orthopedic Casts, Braces and SplintsCPB 0179 - ViscosupplementationCPB 0247 - Autologous Chondrocyte ImpantationCPB 0364 - Allograft Transplants of the ExtremitiesCPB 0545 - Electrothermal ArthroscopyCPB 0637 - Osteochondral Autografts (Mosaicplasty, OATS), and CPB 0660 - Unicompartmental, Bicompartmental, and Bi-unicompartmental Knee Arthroplastyies.


Osteoarthritis (OA) is a non-inflammatory degenerative joint disease that occurs mainly in middle-aged and older individuals.  Osteoarthritis of the knee occurs when the elastoviscous properties of the synovial fluid in the knee joint becomes diminished, resulting in less protection and shock absorption.  Osteoarthritis of the knee is often characterized by pain that frequently requires medical and/or surgical intervention.  In general, the pain associated with OA develops gradually, although sudden onset is also possible.  The joint may become stiff and swollen, making it difficult to bend or straighten the knee.  Pain and swelling are worse in the morning or after a period of inactivity.  Pain may also increase after activities such as walking, stair climbing or kneeling.  The pain may often cause a feeling of weakness in the knee, resulting in a "locking" or "buckling".  Many arthritic patients note that changes in the weather also affect the degree of pain from arthritis.

Based on the criteria of the American College of Rheumatology (Altman et al, 1986), a diagnosis of OA of the knee can be rendered if patients experience knee pain and at least 5 of the following:

  • Bony enlargement
  • Bony tenderness
  • Crepitus (noisy, grating sound) on active motion
  • Erythrocyte sedimentation rate (ESR) less than 40 mm/hr
  • Less than 30 minutes of morning stiffness
  • No palpable warmth of synovium
  • Over 50 years of age
  • Rheumatoid factor less than 1:40 titer (agglutination method)
  • Synovial fluid signs.

The severity of OA is often described according to the Outerbridge scale, which classifies the articular degeneration of the knee by compartment in 4 grades: (i) Grade I refers to softening or blistering of the articular cartilage, (ii) Grade II describes fragmentation or fissuring in an area less than 1 cm, (iii) Grade III describes fragmentation or fissuring in an area greater than 1 cm, and (iv) Grade IV refers to cartilage erosion down to the bone.

Treatment of mild symptomatic OA entails patient education, non-pharmacological approaches such as exercises, lifestyle modifications, and use of supportive devices, as well as pharmacotherapies including non-opioid oral and topical analgesics.  In patients who are unresponsive to this regimen, the use of non-steroidal anti-inflammatory drugs (NSAIDs) is appropriate.  Intra-articular injections of steroids or viscosupplementation may be used for patients who fail conservative management.  Patients with severe symptomatic OA of the knee may require surgical intervention, e.g., arthroscopic surgery, osteotomy, abrasion arthroplasty, subchondral penetration procedures, and laser/thermal chondroplasty.

Arthroscopy involves direct visualization of the joint by a videofiberoptic device.  Arthroscopic lavage and/or debridement is often recommended when medical therapy fails to reduce osteoarthritic knee pain and improve functioning.  Lavage entails either large or small volume saline irrigation of the knee.  Debridement covers many types of arthroscopic surgery and may include but is not limited to variable amounts of the following treatments: partial synovectomy, decompression and resection of plicae/adipose tissue, partial menisectomy, chondroplasty, loose body removal, and/or osteophyte removal.  In clinical practice, debridement is generally performed with low volume lavage or washout.  The available evidence supporting the use of arthroscopic surgery for the treatment of symptomatic OA of the knee is largely retrospective and lacks validated health-related quality-of-life measures.  In this regard, the reports by Baumgaertner and colleagues (1990), Ogilvie-Harris and Fitsialos (1991), Yang and Nisonson (1995), as well as Jackson and Dieterichs (2003) were case series studies, while that by Fond et al (2002) was a cohort observational study. 

In contrast, findings of many randomized controlled studies indicate that arthroscopic lavage and/or debridement did not result in pain relief and improvement of functioning.  Gibson et al (1992) studied the effect of arthroscopic lavage and debridement of the osteoarthritic knee.  A total of 20 patients were randomly assigned to receive (i) lavage, or (ii) debridement.  The primary outcome was objective evaluation of thigh muscle function in the affected quadriceps compared to that of the non-affected quadriceps before and after operation.  There was some improvement in quadriceps isokinetic torque at 6 and 12 weeks after joint lavage but not after debridement.  However, neither method significantly relieved patients' symptoms.

In a multi-center, randomized, controlled study, Ravaud et al (1999) assessed the effectiveness of joint lavage and intra-articular steroid injection, alone and in combination, in the treatment of patients with symptomatic knee OA.  A total of 98 patients were randomly assigned to 4 treatment groups: (i) intra-articular placebo (1.5 ml of 0.9 % normal saline), (ii) intra-articular corticosteroids (3.75 mg of cortivazol in 1.5 ml), (iii) joint lavage and intra-articular placebo, and (iv) joint lavage and intra-articular corticosteroid.  Outcome measures including severity of pain (100-mm visual analog scale [VAS]), global status (100-mm VAS), and Lequesne's functional index were evaluated at baseline, week 1, week 4, week 12, and week 24.  There was no interaction between steroid injection and joint lavage.  Patients who had undergone joint lavage had significantly improved pain VAS scores at week 24 (p < 0.020).  In contrast, corticosteroid injection had no long-term effect (p < 0.313); corticosteroid injection was associated with a decrease in pain only at week 1 (p < 0.003) and week 4 (p < 0.020).  However, there was no significant improvement in function at week 4 regardless of the assigned treatment as indexed by Lequesne's functional index.

In a multi-center, randomized, controlled study, Kalunian and associates (2000) examined if visually-guided arthroscopic irrigation is an effective therapeutic intervention in patients with early knee OA.  A total of 90 patients were randomly assigned in a double-blind fashion to receive (i) arthroscopic irrigation with 3,000 ml of saline (treatment group), or (ii) the minimal amount of irrigation (250 ml) needed to perform arthroscopy (placebo group).  The primary outcome variable was aggregate Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score.  The study did not demonstrate an effect of irrigation on arthritis severity as measured by aggregate WOMAC scores, the primary outcome variable.  The mean change in aggregate WOMAC score at 12 months was 15.5 (95 % confidence interval [CI]: 7.7 to 23.4) for the full irrigation group compared to 8.9 (95 % CI: 4.9 to 13.0) for the minimal irrigation group (p < 0.10).

In a prospective, randomized, placebo-controlled trial to determine whether a placebo effect might play a role in arthroscopic treatment of OA of the knee (Moseley et al, 1996), 5 subjects were randomized to a placebo arthroscopy group, 3 subjects were randomized to an arthroscopic lavage group, and 2 subjects were randomized to a standard arthroscopic debridement group.  Patients who received the placebo surgery reported decreased frequency, intensity, and duration of knee pain.  They also thought that the procedure was worthwhile and would recommend it to family and friends.  Thus, there may be a significant placebo effect for arthroscopic treatment of osteoarthritis of the knee.  The authors concluded that a larger study is needed to evaluate fully the effectiveness of an arthroscopic procedure for this condition.  Recent evidence published in the New England Journal of Medicine (Moseley et al, 2002) confirms this earlier finding that arthroscopic lavage and/or debridement in patients with OA of the knee without other specific indications is no better than placebo surgery.

Moseley and colleagues (2002) carried out a randomized, placebo-controlled study to examine the effectiveness of arthroscopy for OA of the knee.  A total of 180 patients with knee OA were randomly assigned to receive (i) arthroscopic debridement, (ii) arthroscopic lavage, or (iii) placebo surgery.  Patients in the placebo group received skin incisions and underwent a simulated debridement without insertion of the arthroscope.  Patients and assessors of outcome were blinded to the treatment-group assignment.  Outcomes were assessed at multiple points over a 24-month period with the use of 5 self-reported scores -- 3 on scales for pain and 2 on scales for function -- and 1 objective test of walking and stair climbing.  A total of 165 patients completed the trial.  At no point did either of the intervention groups report less pain or better function than the placebo group.  For example, mean (+/- SD) scores on the Knee-Specific Pain Scale (range of 0 to 100, with higher scores indicating more severe pain) were similar in the placebo, lavage, and debridement groups: 48.9 +/- 21.9, 54.8 +/- 19.8, and 51.7 +/- 22.4, respectively, at 1 year (p < 0.14 for the comparison between placebo and lavage; p < 0.51 for the comparison between placebo and debridement) and 51.6 +/- 23.7, 53.7 +/- 23.7, and 51.4 +/- 23.2, respectively, at 2 years (p < 0.64 and p < 0.96, respectively).  Furthermore, the 95 % CIs for the differences between the placebo group and the intervention groups exclude any clinically meaningful difference.  These researchers concluded that for patients with OA of the knee, the outcomes after arthroscopic lavage or arthroscopic debridement were no better than those after a placebo procedure.

In view of the findings of Moseley and associates, advocates of arthroscopic lavage and debridement suggest that may be these procedures are effective in subgroups of patients with knee OA including those at the early stages of OA, those with normal alignment as well as those with mechanical symptoms.  However, Moseley and co-workers stated that they have performed an extensive subgroup analysis and did not find any differences to support the claim that outcomes of arthroscopic surgery for OA of the knee may be related to the severity of arthritis or alignment (Wray et al, 2002).

In a sham-controlled, randomized, double-blinded study, Bradley et al (2002) evaluated the effectiveness of tidal irrigation (TI) in comparison with a well-matched sham irrigation (SI) procedure as a treatment for OA of the knee.  A total of 180 patients with knee OA were randomized to receive TI or SI, with clinical follow-up over the ensuing 12 months.  The primary outcomes of interest were changes in pain and function, as measured by the WOMAC.  Patients and the nurse assessor were blinded, and success of blinding was assessed.  Although the study groups were otherwise comparable, the baseline WOMAC pain and physical functioning scores were higher (worse) in the SI group.  After adjustment for baseline, there were no differences between the effects of SI and TI.  Blinding was successful with approximately 90 % of SI and TI patients stating that they had received the TI procedure.  The authors concluded that the improvement of these patients with knee OA following TI was due to a placebo effect.

Dervin and colleagues (2003) prospectively evaluated a cohort of patients (n = 126) with OA of the knee who were selected for arthroscopic debridement and determined which clinical criteria favor a sustained improvement in health-related quality of life after 2 years of follow-up.  These researchers found that the prospectively evaluated quality-of-life benefit from arthroscopic debridement of the osteoarthritic knee is less than that reported in previous retrospective surveys on satisfaction.  Additionally, clinical variables were only partially helpful for predicting a successful result after arthroscopic debridement.

The American College of Rheumatology (ACR) (2000) guidelines on OA of the hip and knee has concluded that “[n]o well-controlled trials of arthroscopic debridement with or without arthroplasty have been conducted, and the utility of this intervention for the treatment of knee osteoarthritis is unproven.”  The ACR guidelines state that routine arthroscopic lavage with or without debridement should not be routinely recommended to patients with knee OA who have failed medical therapy.  Arthroscopic removal of debris may, however, be useful for relief of pain and improvement in joint function in patients with mechanical symptoms due to loose bodies and meniscal tears.  However, further studies in these types of patients are needed. 

An assessment of arthroscopic lavage for knee osteoarthritis conducted by the Wessex Institute for Health Research and Development (Algood, 2002) summarized the evidence on arthroscopic lavage and debridement for osteoarthritis: "We found evidence from one good quality RCT [randomized controlled trial] that arthroscopic debridement or lavage did not improve patient reported pain and function at 2 years compared with sham arthroscopy for men with osteoarthritis of the knee.  Two other, weaker, RCTs found that debridement and lavage did not improve symptoms compared with non-arthroscopic lavage.  Another RCT found that arthroscopic lavage with 3,000 ml saline slightly improved pain compared with arthroscopic lavage with 250 ml saline.  Another RCT found that arthroscopic debridement improved pain relief compared with arthroscopic lavage in people with isolated degenerative disease on the medial femoral condyle.  We found no evidence that arthroscopic debridement or lavage improves symptoms compared with non-arthroscopic treatments."

In the Patient-Oriented Evidence that Matters (POEMs) of the Journal of Family Practice, Bailey (2002) stated that arthroscopy does not provide any benefit over sham surgery in reducing pain or physical functioning of patients with knee OA.  In the Interpreting Key Trials section of the Cleveland clinic Journal of Medicine, Bernstein and Quach (2003) stated that the value of arthroscopy in treating patients with arthritic joints must be proved.  Furthermore, in the American College of Physicians Journal Club, Gillespie (2003) stated that the study by Moseley et al (2002) made a case for questioning the value of arthroscopic lavage and debridement in active men younger than 65 years of age with OA of the knee.  In addition, the Centers for Medicare and Medicaid Services (2003) will be issuing a national non-coverage determination stating that arthroscopic lavage alone is not reasonable and necessary for patients with OA of the knee; and that arthroscopic debridement is not reasonable and necessary for patients presenting with knee pain only or with severe OA (Outerbridge classification III or IV).

An assessment of arthroscopic lavage and debridement by the Medical Advisory Secretariat of the Ontario Ministry of Health and Long-term Care (2005) concluded: "Arthroscopic debridement of the knee has thus far only been found to be effective for medial compartmental OA.  All other indications should be reviewed with a view to reducing arthroscopic debridement as an effective therapy.  Arthroscopic lavage of the knee is not indicated for any stage of OA.  There is very poor quality evidence on the effectiveness of debridement with partial meniscectomy in the case of meniscal tears in OA of the knee."

A randomized study by Kirkley et al (2008) published in the New England Journal of Medicine found that arthroscopic lavage and debridement for OA of the knee provided no additional benefit to optimized physical and medical therapy.  The investigators conducted a single-center, randomized, controlled trial of arthroscopic surgery in patients with moderate-to-severe OA of the knee.  Patients were randomly assigned to surgical lavage and arthroscopic debridement together with optimized physical and medical therapy or to treatment with physical and medical therapy alone.  The primary outcome was the total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score at 2 years of follow-up.  Secondary outcomes included the Short Form-36 (SF-36) Physical Component Summary score.  Of the 92 patients assigned to surgery, 6 did not undergo surgery.  Of the 86 patients assigned to control treatment, all received only physical and medical therapy.  After 2 years, there were no statistically significant differences in WOMAC scores or the SF-36 Physical Component Summary scores for the surgery group as compared with the control group.  Analyses of WOMAC scores at interim visits and other secondary outcomes also failed to show superiority of surgery.

An accompanying study published in the New England Journal of Medicine found that incidental meniscal findings on MRI of the knee are common in the general population and increase with increasing age (Englund et al, 2008).  MRI of the knee is often performed in patients who have knee symptoms of unclear cause.  When meniscal tears are found, it is commonly assumed that the symptoms are attributable to them.  However, there is a paucity of data regarding the prevalence of meniscal damage in the general population and the association of meniscal tears with knee symptoms and with radiographical evidence of osteoarthritis.  Englund et al (2008) studied persons from Framingham, Massachusetts, who were drawn from census-tract data and random-digit telephone dialing.  Subjects were 50 to 90 years of age and ambulatory; selection was not made on the basis of knee or other joint problems.  The investigators assessed the integrity of the menisci in the right knee on 1.5-tesla MRI scans obtained from 991 subjects (57 % of whom were women).  Symptoms involving the right knee were evaluated by questionnaire.  The investigators found that the prevalence of a meniscal tear or of meniscal destruction in the right knee as detected on MRI ranged from 19 % among women 50 to 59 years of age to 56 % among men 70 to 90 years of age; prevalences were not materially lower when subjects who had had previous knee surgery were excluded.  Among persons with radiographical evidence of OA, the prevalence of a meniscal tear was 63 % among those with knee pain, aching, or stiffness on most days and 60 % among those without these symptoms.  The corresponding prevalences among persons without radiographical evidence of OA were 32 % and 23 %.  Sixty-one percent of the subjects who had meniscal tears in their knees had not had any pain, aching, or stiffness during the previous month.

An accompanying editorial by Marx (2008) in the New England Journal of Medicine concluded that the study by Kirkley et al (2008), combined with other evidence, indicates that OA of the knee (in the absence of a history and physical examination suggesting meniscal or other findings) is not an indication for arthroscopic surgery and indeed has been associated with inferior outcomes after arthroscopic knee surgery.  The editorialist stated, however, that OA is not a contraindication to arthroscopic surgery, and arthroscopic surgery remains appropriate in patients with arthritis in specific situations in which OA is not believed to be the primary cause of pain.

In a systematic review of outcomes of 3 treatments for OA of the knee: (i) intra-articular viscosupplementation, (ii) oral glucosamine, chondroitin or the combination, and (iii) arthroscopic lavage or debridement, Samson et al (2007) concluded that these 3 interventions are widely used in the treatment of OA of the knee, yet the best available evidence does not clearly demonstrate clinical benefit.  Uncertainty regarding clinical benefit can be resolved only by rigorous, multi-center randomized controlled trials.  Furthermore, a Cochrane review on arthroscopic debridement for knee OA, Laupattarakasem et al (2008) concluded that there is "gold" level evidence that arthroscopic debridement has no benefit for undiscriminated OA (mechanical or inflammatory causes).

In a review on surgical options for patients with OA of the knee, Lützner and colleagues(2009) stated that surgical treatments for knee OA include arthroscopy, osteotomy and knee arthroplasty; determining which of these procedures is most appropriate will depend on several factors, including the location and severity of OA damage, patient characteristics and risk factors.  Arthroscopic lavage and debridement do not alter disease progression, and should not be used as a routine treatment for the osteoarthritic knee.

The American Association of Orthopaedic Surgeons’ clinical practice guideline on the treatment of OA of the knee (AAOS, 2008) does not recommend performing arthroscopy with debridement or lavage.  Furthermore, it does not recommend performing needle lavage.  Also, a recent Agency for Healthcare Research and Quality's (AHRQ, 2009) report summarized the evidence on the safety and effectiveness of 3 treatments for OA of the knee: (i) use of the supplements glucosamine hydrochloride, chondroitin sulfate, or combination of both; (ii) viscosupplementation; and (iii) arthroscopic lavage and debridement of the knee joint.  The evidence evaluated comes mainly from comparisons of each therapeutic approach with a placebo.  The AHRQ guideline concluded that glucosamine and chondroitin, viscosupplementation, as well as arthroscopic lavage with or without debridement do not lead to clinically meaningful improvement.

In a Cochrane review, Reichenbach and colleagues (2010) compared joint lavage with sham intervention, placebo or non-intervention control in terms of effects on pain, function and safety outcomes in patients with knee OAs.  These investigators searched CENTRAL, MEDLINE, EMBASE, and CINAHL up to August 3, 2009, checked conference proceedings, reference lists, and contacted authors.  They included studies if they were randomized or quasi-randomized trials that compared arthroscopic and non-arthroscopic joint lavage with a control intervention in patients with OA of the knee.  Two independent review authors extracted data using standardised forms.  They contacted investigators to obtain missing outcome information, and calculated standardized mean differences (SMDs) for pain and function, and risk ratios for safety outcomes.  They combined trials using inverse-variance random-effects meta-analysis.  These researchers included 7 trials with 567 patients; 3 trials examined arthroscopic joint lavage, 2 non-arthroscopic joint lavage and 2 tidal irrigation.  The methodological quality and the quality of reporting was poor and these investigators identified a moderate-to-large degree of heterogeneity among the trials (I(2) = 65 %).  They found little evidence for a benefit of joint lavage in terms of pain relief at 3 months (SMD -0.11, 95 % CI: -0.42 to 0.21), corresponding to a difference in pain scores between joint lavage and control of 0.3 cm on a 10-cm VAS.  Results for improvement in function at 3 months were similar (SMD -0.10, 95 % CI: -0.30 to 0.11), corresponding to a difference in function scores between joint lavage and control of 0.2 cm on a WOMAC disability sub-scale from 0 to 10.  For pain, estimates of effect sizes varied to some degree depending on the type of lavage, but this variation was likely to be explained by differences in the credibility of control interventions: trials using sham interventions to closely mimic the process of joint lavage showed a null-effect.  Reporting on adverse events and drop-out rates was unsatisfactory, and they were unable to draw conclusions for these secondary outcomes.  The authors concluded that joint lavage does not result in a relevant benefit for patients with knee OA in terms of pain relief or improvement of function.

Ronn et al (2011) noted that OA of the knee is common, and the chances of suffering from OA increase with age.  Its treatment should be initially non-operative-and requires both pharmacological and non-pharmacological treatment modalities.  If conservative therapy fails, surgery should be considered.  Surgical treatments for knee OA include arthroscopy, cartilage repair, osteotomy, and knee arthroplasty.  Determining which of these procedures is most appropriate depends on several factors, including the location, stage of OA, co-morbidities on the one side and patients suffering on the other side.  Arthroscopic lavage and debridement is often carried out, but does not alter disease progression.  If OA is limited to one compartment, uni-compartmental knee arthroplasty or unloading osteotomy can be considered.  They are recommended in young and active patients in regard to the risks and limited durability of total knee replacement.  Total arthroplasty of the knee is a common and safe method in the elderly patients with advanced knee OA.

In a cases-control study, Koh and Choi (2012) examined if isolated mesenchymal stem cells (MSCs) derived from the infra-patellar fat pad could effectively improve clinical results when percutaneously injected into arthritic knees.  A total of 25 stem cell injections combined with arthroscopic debridement were administered to patients with knee OA.  A mean of 1.89 × 10(6) stem cells were prepared with approximately 3.0 ml of platelet-rich plasma (PRP) and injected in the selected knees of patients in the study group.  The mean Lysholm, Tegner activity scale, and VAS scores of patients in the study group improved significantly by the last follow-up visit.  No major adverse events related to the injections were observed during the treatment and follow-up periods.  The results were compared between the study and control groups, in which the patients had undergone arthroscopic debridement and PRP injection without stem cells.  Although the pre-operative mean Lysholm, Tegner activity scale, and VAS scores of the study group were significantly poorer than those of the control group, the clinical results at the last follow-up visit were similar and not significantly different between the 2 groups.  The authors concluded that the short-term results of this study are encouraging and show that infra-patellar fat pad-derived MSC therapy with intra-articular injections is safe, and provides assistance in reducing pain and improving function in patients with knee OA.  These preliminary findings need to be validated by well-designed studies.

CPT Codes / HCPCS Codes / ICD-9 Codes
Other CPT codes related to the CPB:
Other HCPCS codes related to the CPB:
C1776 Joint device (implantable)
G0289 Arthroscopy, knee, surgical, for removal of loose body, foreign body, debridement/shaving of articular cartilage (chondroplasty) at the time of other surgical knee arthroscopy in a different compartment of the same knee
ICD-9 codes not covered for indications listed in the CPB:
715.16 Osteoarthrosis, localized, primary, lower leg
715.26 Osteoarthrosis, localized, secondary, lower leg
715.36 Osteoarthrosis, localized, not specific whether primary or secondary, lower leg
715.96 Osteoarthrosis, unspecified whether generalized or localized, lower leg
719.46 Pain in joint, lower leg
719.56 Stiffness of joint, not elsewhere classified, lower leg

The above policy is based on the following references:
  1. Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986;29(8):1039-1049.
  2. Baumgaertner MR, Cannon WD Jr, Vittori JM, et al. Arthroscopic debridement of the arthritic knee. Clin Orthop. 1990;(253):197-202.
  3. Ogilvie-Harris DJ, Fitsialos DP. Arthroscopic management of the degenerative knee. Arthroscopy. 1991;7(2):151-157.
  4. Gibson JN, White MD, Chapman VM, Strachan RK. Arthroscopic lavage and debridement for osteoarthritis of the knee. J Bone Joint Surg Br. 1992;74(4):534-537.
  5. Yang SS, Nisonson B. Arthroscopic surgery of the knee in the geriatric patient. Clin Orthop. 1995;(316):50-58.
  6. Moseley JB Jr, Wray NP, Kuykendall D, et al. Arthroscopic treatment of osteoarthritis of the knee: A prospective, randomized, placebo-controlled trial. Results of a pilot study. Am J Sports Med. 1996;24(1):28-34.
  7. Ravaud P, Moulinier L, Giraudeau B, et al. Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee: Results of a multicenter, randomized, controlled trial. Arthritis Rheum. 1999;42(3):475-482.
  8. Kalunian KC, Moreland LW, Klashman DJ, et al. Visually-guided irrigation in patients with early knee osteoarthritis: A multicenter randomized, controlled trial. Osteoarthritis Cartilage. 2000;8(6):412-418.
  9. American College of Rheumatology, Subcommittee on Osteoarthritis Guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee. Arthritis Rheum. 2000;43(9):1905-1915.
  10. Outerbridge RE. The etiology of chondromalacia patellae. 1961. Clin Orthop. 2001;(389):5-8.
  11. Fond J, Rodin D, Ahmad S, Nirschl RP. Arthroscopic debridement for the treatment of osteoarthritis of the knee: 2- and 5-year results. Arthroscopy. 2002;18(8):829-834.
  12. Bradley JD, Heilman DK, Katz BP, et al. Tidal irrigation as treatment for knee osteoarthritis: A sham-controlled, randomized, double-blinded evaluation. Arthritis Rheum. 2002;46(1):100-108.
  13. Moseley JB, O'Malley K, Petersen NJ, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. 2002;347(2):81-88.
  14. Wray NP, Moseley JB, O'Malley K. Authors reply to comments on 'Arthroscopic surgery for osteoarthritis of the knee'. N Engl J Med. 2002;347(21):1718-1719.
  15. Bailey RE. Arthroscopic surgery ineffective for osteoarthritis of the knee. J Fam Pract. 2002;51(10):813.
  16. Bernstein J, Quach T. A perspective on the study of Moseley et al: Questioning the value of arthroscopic knee surgery for osteoarthritis. Cleve Clin J Med. 2003;70(5):401, 405-406, 408-410.
  17. Gillespie WJ. Arthroscopic surgery was not effective for relieving pain or improving function in osteoarthritis of the knee. ACP J Club. 2003;138(2):49.
  18. Jackson RW, Dieterichs C. The results of arthroscopic lavage and debridement of osteoarthritic knees based on the severity of degeneration: A 4- to 6-year symptomatic follow-up. Arthroscopy. 2003;19(1):13-20.
  19. Dervin GF, Stiell IG, Rody K, Grabowski J. Effect of arthroscopic debridement for osteoarthritis of the knee on health-related quality of life. J Bone Joint Surg Am. 2003;85-A(1):10-19.
  20. Centers for Medicare & Medicaid Services (CMS). Arthroscopy for the osteoarthritic knee (#CAG-00167N). National Coverage Analysis (NCA). Baltimore, MD: CMS; July 3, 2003. Available at: Accessed July 28, 2003.
  21. Allgood P. Arthroscopic lavage for knee osteoarthritis. In: Bazian, Ltd. Ed. STEER: Succinct and Timely Evaluated Evidence Reviews. Southampton, UK: Wessex Institute for Health Research & Development, University of Southampton; 2003; 3(3). Available at: Accessed August 28, 2003.
  22. Forster MC, Straw R. A prospective randomised trial comparing intra-articular Hyalgan injection and arthroscopic washout for knee osteoarthritis. Knee. 2003;10(3):291-293.
  23. Center for Medicare and Medicaid Services (CMS). National Coverage Determination (NCD) for arthroscopic lavage and arthroscopic debridement for the osteoarthritic knee. Medicare Coverage Database. CMS Pub. No. 100-3, Sec. 150.9. Baltimore, MD: CMS; effective June 11, 2004. Available at:
    2004/MM3281.pdf. Accessed June 21, 2004.
  24. Calvert GT, Wright RW. The use of arthroscopy in the athlete with knee osteoarthritis. Clin Sports Med. 2005;24(1):133-152.
  25. Pagnano MW, Clarke HD, Jacofsky DJ, et al. Surgical treatment of the middle-aged patient with arthritic knees. Instr Course Lect. 2005;54:251-259.
  26. Laupattarakasem W, Laopaiboon M, Sumananont C. Arthroscopic debridement for knee osteoarthritis (Protocol for Cochrane Review). Cochrane Database Syst Rev. 2005;(1):CD005118.
  27. Ontario Ministry of Health and Long-Term Care, Medical Advisory Secretariat (MAS). Arthroscopic lavage and debridement for osteoarthritis of the knee. Health Technology Literature Review. Toronto, ON: Ontario Ministry of Health and Long-Term Care; September 2005. Available at:
    pdf/rev_lavdeb_090105.pdf. Accessed October 12, 2006.
  28. Stuart MJ, Lubowitz JH. What, if any, are the indications for arthroscopic debridement of the osteoarthritic knee? Arthroscopy. 2006;22(3):238-239.
  29. Aaron RK, Skolnick AH, Reinert SE, Ciombor DM. Arthroscopic debridement for osteoarthritis of the knee. J Bone Joint Surg Am. 2006;88(5):936-943.
  30. Siparsky P, Ryzewicz M, Peterson B, Bartz R. Arthroscopic treatment of osteoarthritis of the knee: Are there any evidence-based indications? Clin Orthop Relat Res. 2007;455:107-112.
  31. Samson DJ, Grant MD, Ratko TA, et al. Treatment of primary and secondary osteoarthritis of the knee. Evid Rep Technol Assess (Full Rep). 2007;(157):1-157.
  32. Kirkley A, Birmingham TB, Litchfield RB, et al. A randomized trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. 2008;359(11):1097-1107.
  33. Englund M, Guermazi A, Gale D, et al. Incidental meniscal findings on knee MRI in middle-aged and elderly persons. N Engl J Med. 2008;359(11):1108-1115.
  34. Marx RG. Arthroscopic surgery for osteoarthritis of the knee? N Engl J Med. 2008;359(11):1169-1170.
  35. Laupattarakasem W, Laopaiboon M, Laupattarakasem P, Sumananont C. Arthroscopic debridement for knee osteoarthritis. Cochrane Database Syst Rev. 2008;(1):CD005118.
  36. American Academy of Orthopaedic Surgeons (AAOS). Clinical practice guideline on the treatment of osteoarthritis of the knee (non-arthroplasty). Rosemont, IL: American Academy of Orthopaedic Surgeons (AAOS); 2008. Available at: Accessed January 7, 2009.
  37. Agency for Healthcare Research and Quality (AHRQ). Three treatments for osteoarthritis of the knee: Evidence shows lack of benefit. Clinician’s Guide. Effective Health Care. AHRQ Pub. No. 09-EHC001-3. Rockville, MD: AHRQ; April, 2009. Available at: Accessed August 31, 2009.
  38. Samson DJ, Grant MD, Ratko TA, et al. Treatment of primary and secondary osteoarthritis of the knee. Evidence Report/Technology Assessment No. 157. Prepared for the Agency for Healthcare Research (AHRQ) by the Blue Cross and Blue Shield Association Technology Evaluation Center Evidence-based Practice Center (Contract No. 290-02-0026). AHRQ Publication No. 07-E012. Rockville, MD: AHRQ; September 2007. 
  39. Lützner J, Kasten P, Günther KP, Kirschner S. Surgical options for patients with osteoarthritis of the knee. Nat Rev Rheumatol. 2009;5(6):309-316.
  40. Campbell MK, Skea ZC, Sutherland AG, et al.; KORAL study group. Effectiveness and cost-effectiveness of arthroscopic lavage in the treatment of osteoarthritis of  the knee: A mixed methods study of the feasibility of conducting a surgical placebo-controlled trial (the KORAL study). Health Technol Assess. 2010;14(5):1-180.
  41. Reichenbach S, Rutjes AW, Nüesch E, et al. Joint lavage for osteoarthritis of the knee. Cochrane Database Syst Rev. 2010;(5):CD007320.
  42. Howell SM. The role of arthroscopy in treating osteoarthritis of the knee in the older patient. Orthopedics. 2010;33(9):652.
  43. Feeley BT, Gallo RA, Sherman S, Williams RJ. Management of osteoarthritis of the knee in the active patient. J Am Acad Orthop Surg. 2010;18(7):406-416.
  44. Ronn K, Reischl N, Gautier E, Jacobi M. Current surgical treatment of knee osteoarthritis. Arthritis. 2011;2011:454873.
  45. Koh YG, Choi YJ. Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis. Knee. 2012 May 12. [Epub ahead of print]

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