Aetna considers intestinal transplantation medically necessary for persons who have failed total parenteral nutrition (TPN) when the selection criteria below are met.
Parenteral nutrition (see CPB 0061 - Nutritional Support) entails the administration of micronutrients and macronutrients via catheters in central or peripheral veins. In most cases, the central venous route is used. For long-term TPN, a central catheter (e.g., Hickman, Broviac, PIC) is placed subcutaneously in the anterior chest. Indicators of failed TPN are liver failure, thrombosis, frequency of infection, and dehydration as demonstrated in the following clinical situations:
Selection Criteria: Aetna considers intestinal transplant medically necessary for the indications listed above for persons who meet the transplanting institution's protocol eligibility criteria. In the absence of a protocol, Aetna considers intestinal transplant medically necessary for the indications listed above when all of the following selection criteria are met:
A combined intestinal and liver transplant is considered medically necessary for persons with advanced liver disease necessitating liver transplantation (see CPB 0596 - Liver Transplantation) who meet the medical necessity criteria above (other than the requirement for adequate liver function). Note: In candidates for a combined transplant, adequacy of renal function should be assessed with a measured glomerular filtration rate (GFR), as a calculated GFR is inaccurate in advanced liver disease.
Contraindications: Intestinal transplant is considered not medically necessary for persons with the following contraindications:
Aetna considers multi-visceral transplants from deceased donors medically necessary for adults and children who meet criteria for the combined small bowel/liver transplant and require 1 or more abdominal visceral organs to be transplanted due to concomitant organ failure or anatomical abnormalities that preclude a small bowel/liver transplant.
Aetna considers multi-visceral transplants experimental and investigational for individuals with neuroendocrine pancreatic tumors.
Aetna considers measurement of fecal calprotectin experimental and investigational as a test for intestinal allograft rejection because its clinical value has not been established.
Intestinal transplantation has become the treatment of choice for patients with chronic intestinal failure whose illness can not be maintained on total parenteral nutrition (TPN). The term "intestinal failure" refers to gastro-intestinal (GI) function insufficient to meet body fluid and nutrient requirements; it includes short bowel syndrome (SBS) and severe motility disorders (e.g., chronic intestinal pseudo-obstruction syndrome in children and congenital intractable intestinal mucosa disorders). Short bowel (also known as short gut) syndrome is a condition in which the absorbing surface of the small intestine is inadequate as a result of extensive disease or surgical removal of a large segment of the small intestine. Patients with SBS are unable to obtain adequate nutrition from enteral feeding.
In infants, SBS is generally due to congenital anomalies. Common causes of a SBS in infants and children include microvillus atrophy, intestinal atresia, midgut volvulus, complicated gastroschisis, aganglion syndrome, and necrotizing enterocolitis. In adults, severe SBS usually occurs following a massive small bowel resection, which results in rapid intestinal transit and loss of absorptive function. Common causes of SBS in adults include Crohn's disease, desmoid tumors (familial polyposis with Gardner’s syndrome), radiation enteritis, iatrogenic jejunal-ileal bypass (for morbid obesity), mesenteric venous thrombosis, superior mesenteric artery thrombosis, and traumatic mesenteric transection (blunt abdominal trauma).
Parenteral nutrition and home parenteral nutrition are the mainstay of therapy for children with SBS and other causes of intestinal failure. Most infants with SBS eventually wean from parenteral nutrition, and most of those who do not wean tolerate parenteral nutrition for an extended period of time. However, a subgroup of patients with intestinal failure who remain dependent on parenteral nutrition will develop life-threatening complications as a consequence of standard therapy. The literature indicates that intestinal transplantation is recommended for this select group. The majority of intestinal transplantation recipients are children, especially those under the age of 5.
Indications for intestinal transplantation include parenteral nutrition-associated liver disease, recurrent sepsis, and threatened loss of central venous access. The literature suggests children with liver dysfunction should be considered for isolated intestinal transplantation before irreversible, advanced bridging fibrosis or cirrhosis supervenes, for which a combined liver and intestinal transplant is necessary. Irreversible liver disease is suggested by hyperbilirubinemia persisting beyond 3 to 4 months of age combined with features of portal hypertension such as splenomegaly, thrombocytopenia, or prominent superficial abdominal veins.
In children, the 1- and 3-year graft survival rates for isolated small bowel and combined small bowel and liver transplantations range from 40 to 50 %, while the 1- and 3-year patient survival rates range from 80 to 100 %, depending on the age range of the patient. Successful transplant recipients resume unrestricted oral diets. Despite the use of potent immunosuppressive agents, rejection rates are still 50 % or higher. Sepsis rates are also higher for patients who have had intestinal transplantation than for those who have received other organs because of bacterial translocation from the gut secondary to preservation injury and graft rejection. Graft and patient survival rates after intestinal transplantation are comparable to rates after lung transplantation.
In addition to rejection and infection (bacterial, fungal, and viral), other complications of intestinal transplantation are graft-versus-host disease, cytomegalovirus infection as well as post-transplant lymphoproliferative disease associated with aggressive immunosuppression and Epstein-Barr virus.
Multi-visceral transplantation entails the simultaneous transplantation of multiple abdominal viscera including the stomach, duodenum, pancreas, and small intestine, with (multi-visceral transplant [MVT]) or without the liver (modified MVT, [MMVT]).
Abu-Elmgagd et al (2009) evaluated the evolution of visceral transplantation in the milieu of surgical technical modifications, new immunosuppressive protocols, and other management strategies. Divided into 3 eras, a total of 453 patients received 500 visceral transplants. The primary used immunosuppression was tacrolimus-steroid-only during Era I (5/90 to 5/94), adjunct induction with multiple drug therapy during Era II (1/95 to 6/01), and recipient pre-treatment with tacrolimus monotherapy during Era III (7/01 to 11/08). During era II/III, donor bone marrow was given (n = 79), intestine was ex-vivo irradiated (n = 44), and Epstein-Barr-Virus (EBV)/cytomegalovirus (CMV) loads were monitored. Actuarial patient survival was 85 % at 1-year, 61 % at 5-years, 42 % at 10-years, and 35 % at 15-years with respective graft survival of 80 %, 50 %, 33 %, and 29 %. With a 10 % re-transplantation rate, second/third graft survival was 69 % at 1-year and 47 % at 5-years. The best outcome was with intestine-liver allografts. Era III rabbit anti-thymocyte globulin or alemtuzumab pre-treatment-based strategy was associated with significant (p < 0.0001) improvement in outcome with 1- and 5-year patient survival of 92 % and 70 %. The authors concluded that survival has greatly improved over time as management strategies evolved. The current results justified elevating the procedure level to that of other abdominal organs with the privilege to permanently reside in a respected place in the surgical armamentarium. Meanwhile, innovative tactics are still required to conquer long-term hazards of chronic rejection of liver-free allografts and infection of multi-visceral recipients
Vianna et al (2012) evaluated the clinical outcomes of MVT in the setting of diffuse thrombosis of the porto-mesenteric venous system. A database of intestinal transplant patients was maintained with prospective analysis of outcomes. The diagnosis of diffuse porto-mesenteric thrombosis (PMT) was established with dual-phase abdominal computed tomography or magnetic resonance imaging with venous reconstruction. A total of 25 patients with grade IV PMT received 25 MVT. Eleven patients underwent simultaneous cadaveric kidney transplantation. Biopsy-proven acute cellular rejection was noted in 5 recipients, which was treated successfully. With a median follow-up of 2.8 years, patient and graft survival were 80 %, 72 %, and 72 % at 1, 3, and 5 years, respectively. To date, all survivors have good graft function without any signs of residual/recurrent features of portal hypertension. The authors concluded that MVT can be considered as an option for the treatment of patients with diffuse PMT. They stated that MVT is the only procedure that completely reverses portal hypertension and addresses the primary disease while achieving superior survival results in comparison to the alternative options.
Trevizol et al (2013) stated that intestinal transplantation (IT)/MVT is the gold standard treatment for patients with intestinal failure and complications related to TPN, gastro-intestinal inoperable indolent tumors, or diffuse portal thrombosis. Currently, the reported 1-year patient survival rate is around 80 %, similar to other solid organ abdominal transplantations. Unfortunately, the patient survival decreases after the first year with the 5-year rate not close to 70 % yet. Acute cellular rejection (ACR) is the main cause of graft loss. Its early diagnosis may make it possible to improve survival of re-transplantations. These investigators analyzed the reported results published in the last 5 years by leading transplant centers to evaluate IT/MVT re-transplantation results. They performed a literature review using PubMed focusing on multi-visceral and intestinal re-transplantation in articles published between 2006 and 2012. In relation to the first transplantation, these researchers analyzed demographics, immunosuppression, rejection, infection as well as graft and patient survival rates. Two centers reported results on intestinal and multi-visceral re-transplantations. Mazariegos et al reported their experience with 15 intestinal re-transplantations in 14 pediatric recipients. Four patients died from post-transplant lympho-proliferative disease, severe ACR, fungal sepsis, or bleeding from a pseudo-aneurysm at a mean time of 5.7 months post-transplantation. Total parenteral nutrition was weaned at a median time of 32 days. Abu-Elmaged et al reported 47 cases with a 5-year survival of 47 % for all re-transplant modalities. Re-transplantation with liver-contained visceral allograft achieved a 5-year survival rate of 61 % compared with 16 % for liver-free visceral grafts. The authors concluded that despite those huge improvements, some transplanted patients develop severe ACR, culminating in graft loss and re-transplantation. Reports on multi-visceral and intestinal re-transplantation outcomes suggested that it is a viable procedure with appropriate patient survival after primary graft loss.
Mangus et al (2013) reviewed the changing indications and outcomes for this procedure over a 7-year period. This study was a retrospective case review of MVTs performed between 2004 and 2010 at a single center. All cases were either MVT or MMVT and included a simultaneous kidney transplant, if indicated. Graft failure was defined as loss of the graft or complete loss of function. Graft function was monitored by clinical function, laboratory values, and serial endoscopy with biopsy. During the study period, 95 patients received 100 transplants including 84 MVT and 16 MMVT. There were 19 patients who received a simultaneous kidney graft. There were 24 pediatric and 76 adult recipients (age range of 7 months to 66 years). Indications included intestinal failure alone, intestinal failure with cirrhosis, complete PMT, slow-growing central abdominal tumors, intestinal pseudo-obstruction, and frozen abdomen. All patients received antibody-based induction immunosuppression with calcineurin inhibitor-based maintenance immunosuppression. At a median mortality adjusted follow-up of 25 months, 1- and 3-year patient survival rates were 72 % and 57 %, respectively. There was a learning curve with this complex procedure resulting in a 48 % patient survival during the period from 2004 to 2007, followed by a 70 % patient survival during the period from 2008 to 2010. Post-transplant complications included rejection (50 % MMVT and 17 % MVT), infection (greater than 90 % first year), graft-versus-host disease (13 %), and post-transplant lymphoproliferative disorder (5 %). The authors concluded that indications for MVT and MMVT have broadened to include patients with terminal conditions not amenable to other medical therapies such as slow-growing tumors of the mesenteric root, complete PMT, and abdominal catastrophes/frozen abdomen. Outcomes have improved over time with many patients returning to full functional status and enjoying long-term survival.
Varkey et al (2013) stated that the current treatment of choice for patients with intestinal failure is parenteral nutrition, whereas medical therapy or resection is preferred for patients with neuroendocrine pancreatic tumors (NEPT) along with liver metastasis. As the survival of patients undergoing IT and MVT is improving, the discussion for expansion of treatment options has become a subject of debate. These researchers investigated the outcome for patients referred for IT and MVT and determined which patient group are the ones most likely to benefit the most from transplantation. The authors included all patients evaluated for IT and MVT at the Sahlgrenska University Hospital and The Queen Silvia Children's Hospital center between February 1998 and November 2009. Patients were classified according to proposed treatment strategy, and the outcome was evaluated. A total of 43 adults and 19 children with either intestinal failure or NEPT with liver metastases were evaluated for transplantation. Of these patients, 15 adults and 5 children were transplanted. Transplantation was life-saving for most children -- all the children survived after transplantation, but 70 % (4/6) died while awaiting transplantation. Among the adult patients with intestinal failure, the survival rate for patients considered to be stable on parenteral nutrition was higher than the transplanted adult patients. The survival rate of patients with NEPT was similar to the results seen among patients transplanted for intestinal failure. The authors concluded that the results confirmed the poor prognosis of patients with intestinal failure awaiting transplantation and indicated that different transplantation criteria may be applied for adults and children, especially when early transplantation is the preferred treatment. Moreover, they stated that the role of MVT in patients with NEPT remains uncertain.
Kubal et al (2015a) stated that intestinal failure and associated parenteral nutrition-induced liver failure cause significant morbidity, mortality, and health care burden. Intestine transplantation is now considered to be the standard of care in patients with intestinal failure who fail intestinal rehabilitation. Intestinal failure-associated liver disease is an important sequela of intestinal failure, caused by parenteral lipids, requiring simultaneous liver-intestine transplant. Lipid minimization and, in recent years, the emergence of fish oil-based lipid emulsions have been shown to reverse parenteral nutrition-associated hyper-bilirubinemia, but not fibrosis. Significant progress in surgical techniques and immunosuppression has led to improved outcomes after intestine transplantation. Intestine in varying combination with liver, stomach, and pancreas, also referred to as multi-visceral transplantation, is performed for patients with intestinal failure along with liver disease, surgical abdominal catastrophes, neuroendocrine and slow-growing tumors, and complete porto-mesenteric thrombosis with cirrhosis of the liver. Although acute and chronic rejections are major problems, long-term survivors have excellent quality of life and remain free of parenteral nutrition.
Measurement of Fecal Calprotectin:
Sudan et al (2007) stated that protocol endoscopy with biopsy is currently the gold standard of small bowel transplantation (SBTx) monitoring, however it is invasive, costly, needs skilled operator, may require anesthesia and may cause complications. These researchers investigated fecal calprotectin level (FCL) as a candidate non-invasive marker for monitoring patients after SBTx. Ileostomy effluents were collected at various post-operative days before endoscopy and biopsy. Fecal calprotectin levels were measured by enzyme-linked immunosorbent assay and a cut-off level of 100 ng/mg was considered positive. Results were retrospectively evaluated in combination with clinical, endoscopic, and histopathological findings. Fecal calprotectin levels were presented as median ng/mg. Fecal calprotectin levels were measured in 122 samples that were obtained from 29 patients after SBTx. Only 1 of 69 positive FCL did not accompany abnormal findings. Retrospective evaluation showed that 11 samples from 6 patients (FCL: 217) coincided with rejection episodes, 6 samples from 3 patients (FCL: 125) coincided with viral enteritis, 51 samples from 21 patients (FCL: 207) coincided with non-specific inflammation, 11 samples from 2 patients (FCL: 998) coincided with chronic intestinal ulceration, and finally 50 samples from 19 patients (FCL: 43) coincided with normal findings. No significant FCL difference was found between rejection, infection, and inflammation. Evolution in FCL in transplant recipients showed that FCL can predict rejection days before histopathological diagnosis. The authors concluded that FCL is a promising clinical screening test for intestinal allograft rejection. The major drawback of this study was that it was a retrospective study of selected patient samples with known diagnosis. If the clinical utility of FCL is confirmed by prospective validation studies, its use may avoid unnecessary protocol endoscopy with biopsy.
Monitoring of Donor-Specific Anti-HLA Antibodies after Intestine/Multi-visceral Transplantation:
Kaneku and Wozniak (2014) noted that early outcomes following intestinal transplantation (ITx) have markedly improved in recent years. However, there has been a lack of improvement in long-term outcomes. Increasing amounts of data suggested the humoral immune system is a major contributor to rejection and late allograft loss. These investigators summarized the available data on donor-specific human leukocyte antigen antibodies (DSAs) in ITx, with a focus on the clinical significance of DSAs, diagnosis of antibody-mediated rejection (AMR), and available treatment modalities. They stated that mounting evidence showed that pre- and/or post-transplant DSAs are associated with rejection and allograft loss following ITx. Preformed DSAs are present in nearly 1/3 of ITx recipients, and de-novo DSAs develop in up to 40 % of patients. Diagnosis and treatment of AMR remains challenging, but reports indicated that when optimal induction and maintenance immunosuppressive agents are used, the impact of DSAs may be negligible. The authors concluded that although data are limited due to center differences with regard to patient population, induction and maintenance immunosuppression protocols, and monitoring strategies, DSAs are associated with poor outcomes following ITx. They stated that a consensus to define AMR and optimal treatment strategies is needed.
Kubal et al (2015b) stated that presence of circulating DSA may be associated with worse clinical outcomes after ITx/multi-visceral transplantation. In 79 ITx/multi-visceral recipients, sera were prospectively screened for DSA by Luminex Single antigen test at 1, 3, 6, 9, 12, 18, 24, and 36 months after transplantation. Standard immunosuppression included thymoglobulin-rituximab induction and tacrolimus-prednisone maintenance. C4d staining was performed retrospectively on biopsies in patients that developed acute rejection (AR). A total of 22 (28 %) patients developed de novo DSA at a median post-transplant period of 3 (1 to 36) months. De novo DSA were observed in 10 of 40 liver-including and 12 of 39 liver-excluding transplants (p = 0.57). Occurrence of AR was slightly higher in patients with de novo DSA (45 % versus 33 %, respectively; p = 0.41). Similarly, chronic rejection (14 % versus 5 %; p = 0.21) and graft loss due to AR (18 % versus 7 %; p = 0.14) were numerically higher in patients with de novo DSA. Only 35 % patients experiencing AR had circulating de novo DSA at the time of AR. Antibody-mediated rejection was diagnosed in 6 patients based on C4d staining, of these 2 patients had circulating de novo DSA at the time of biopsy. The authors concluded that de novo DSA formation, particularly early in the post-transplant course may be associated with trends toward worse outcomes. However, its significance in the pathophysiology of AR remains uncertain. They stated that studies focusing mechanisms of DSA-related graft injury and intra-graft DSA detection might provide further insight into this issue.
Furthermore, an UpToDate review on “Overview of intestinal and multivisceral transplantation” (Khan and Selvaggi, 2015) does not mention monitoring of donor-specific anti-HLA antibodies as a management tool.
|CPT Codes / HCPCS Codes / ICD-10 Codes|
|Information in the [brackets] below has been added for clarification purposes.  Codes requiring a 7th character are represented by "+":|
|CPT codes covered if selection criteria are met:|
|44132||Donor enterectomy (including cold preservation), open; from cadaver donor|
|44133||partial, from living donor|
|44135||Intestinal allotransplantation; from cadaver donor|
|44136||from living donor|
|44137||Removal of transplanted intestinal allograft, complete|
|44715||Backbench standard preparation of cadaver or living donor intestine allograft prior to transplantation, including mobilization and fashioning of the superior mesenteric artery and vein|
|44720||Backbench reconstruction of cadaver or living donor intestine allograft prior to transplantation; venous anastamosis, each|
|44721||arterial anastamosis, each|
|CPT codes not covered for indications listed in the CPB:|
|Other CPT codes related to the CPB:|
|36555 - 36597||Central venous access procedures|
|47135||Liver allotransplantation; orthotopic; partial or whole, from cadaver or living donor, any age|
|47143||Backbench standard preparation of cadaver donor whole liver graft prior to allotransplantation, including cholecystectomy, if necessary, and dissection and removal of surrounding soft tissues to prepare the vena cava, portal vein, hepatic artery, and common bile duct for implantation; without trisegment or lobe split|
|47144||with trisegment split of whole liver graft into two partial liver grafts (ie, left lateral segment (segments II and III) and right trisegment (segments I and IV through VIII))|
|47145||with lobe split of whole liver graft into two partial liver grafts (ie, left lobe (segments II, III and IV) and right lobe (segments I and V through VIII))|
|47146||Backbench reconstruction of cadaver or living donor liver graft prior to allotransplantation; venous anastomosis, each|
|47147||arterial anastomosis, each|
|99601 - 99602||Home infusion/specialty drug administration|
|HCPCS codes covered if selection criteria are met:|
|S2053||Transplantation of small intestine, and liver allografts|
|S2054||Transplantation of multivisceral organs|
|S2055||Harvesting of donor multivisceral organs, with preparation and maintenance of allografts; from cadaver donor|
|Other HCPCS codes related to the CPB:|
|B4164 - B5200||Parenteral nutrition solutions and supplies|
|B9004, B9006||Parenteral nutrition infusion pump, portable or stationary|
|S9364 - S9368||Home infusion therapy, total parenteral nutrition (TPN)|
|ICD-10 codes covered if selection criteria are met:|
|A40.0 - A40.9||Streptococcal sepsis|
|E86.0 - E86.9||Volume depletion|
|I82.811 - I82.91||Embolism and thrombosis of other specified veins|
|K91.2||Postsurgical malabsorption, not elsewhere classified|
|Z90.49||Acquired absence of other specified parts of digestive tract|
|ICD-10 codes not covered for indications listed in the CPB:|
|B18.0||Chronic viral hepatitis B with delta-agent|
|B18.1||Chronic viral hepatitis B without delta-agent|
|B18.2||Chronic viral hepatitis C|
|C7A.094||Malignant carcinoid tumor of the foregut NOS|
|D12.0 - D12.6||Benign neoplasm of colon, rectum, anus and anal canal|
|D3A.020 - D3A.029||Benign carcinoid tumors of the appendix, large intestine, and rectum|
|D3A.094||Benign carcinoid tumor of the foregut NOS|
|D48.1||Neoplasm of uncertain behavior of connective and other soft tissue|
|G00.0 - G09||Bacterial meningitis, not elsewhere classified|
|I50.1 - I50.9||Heart failure|
|K27.0 - K27.9||Peptic ulcer, site unspecified|
|K57.00 - K57.93||Diverticular disease of intestine|