Transvaginal Ultrasonography for Ovarian and Endometrial Cancer Screening and Other Selected Indications

Number: 0530


Aetna considers transvaginal ultrasonography (TV-US) medically necessary for a number of indications:

  • Assessment of a pelvic mass (e.g., adenomyosis, cancer, cyst, and fibroid)
  • Diagnosis of bowel endometriosis
  • Evaluation of abnormal uterine bleeding
  • Evaluation of congenital uterine anomalies
  • Evaluation of infertility (see CPB 0327 - Infertility)
  • Evaluation for sequelae of pelvic infection (e.g., abscess, and hydrosalpinx)
  • Evaluation of women with new symptoms (bloating, difficulty eating or feeling full quickly, pelvic or abdominal pain, or urinary frequency and urgency) that have persisted for 3 or more weeks, and the clinician has performed a pelvic and rectal examination and suspects ovarian cancer
  • Evaluation of women with post-menopausal bleeding
  • Guidance during embryo transfer
  • Monitoring natural or stimulated follicular development during infertility therapy (see CPB 0327 - Infertility)
  • Monitoring of women with Lynch II syndrome (BRCA2 mutation) for ovarian cancer. (Note: The Doppler ultrasound mode is considered not medically necessary for TV-US monitoring of women with Lynch II syndrome)
  • Verifying position of intrauterine device if IUD string is not visible or if there is a suspicion that IUD is not in the correct position

Aetna considers TV-US experimental and investigational for screening for ovarian cancer, endometrial cancer, or other gynecologic cancers because of insufficient evidence of effectiveness for screening.


Pelvic ultrasound is considered to be clinically integral to the transvaginal examination and does not warrant separate reimbursement.  A transvaginal ultrasound (TV-US) provides superior detail in images of pelvic structures.  When TV-US is performed on a patient whose pelvic structures are within the bony pelvis, pelvic echography using an abdominal approach is duplicative of the TV-US.

Persadie (2002) stated that measurement of endometrial thickness with ultrasonography is a modality commonly used today.  Its clinical importance and applications extend throughout the phases of the reproductive lives of women.  In pre-menopausal women, endometrial thickness is used to monitor infertility treatment, while in post-menopausal women with abnormal uterine bleeding it is useful as an initial investigation for endometrial hyperplasia or cancer.  Moreover, endometrial thickness can vary with the menstrual cycle and with the use of hormone replacement therapy or selective estrogen receptor modulators.

Champaneria et al (2010) stated that adenomyosis is a common condition that causes substantial morbidity.  Until recently, the reference standard for a definitive diagnosis was histology of hysterectomy specimens.  Ultrasound and magnetic resonance imaging (MRI) may allow accurate non-invasive diagnosis.  In a systematic review with meta-analysis, these investigators compared the diagnostic accuracy of these techniques.  Subjects were women who had ultrasound and/or MRI, and whose results were compared with a reference standard.  Electronic searches were conducted in literature databases from database inception to 2010.  The reference lists of known relevant articles were searched for further articles.  Selected studies reported data on ultrasound and/or MRI with histological confirmation of diagnosis.  Two reviewers independently selected articles without language restrictions, and extracted data in the form of 2 × 2 tables.  They computed sensitivity and specificity for individual studies and pooled these results in a meta-analysis.  They also performed meta-regression to examine how the index tests compared on diagnostic accuracy.  A total of 23 articles (involving 2,312 women) satisfied the inclusion criteria.  Transvaginal ultrasound had a pooled sensitivity of 72 % (95 % confidence intervals [CI]: 65 to 79 %), specificity of 81 % (95 % CI: 77 to 85 %), positive likelihood ratio of 3.7 (95 % CI: 2.1 to 6.4) and negative likelihood ratio of 0.3 (95 % CI: 0.1 to 0.5); MRI had a pooled sensitivity of 77 % (95 % CI: 67 to 85 %), specificity of 89 % (95 % CI: 84 to 92 %), positive likelihood ratio of 6.5 (95 % CI: 4.5 to 9.3), and negative likelihood ratio of 0.2 (95 % CI: 0.1 to 0.4).  The results showed that a correct diagnosis was obtained more often with MRI.  The authors concluded that transvaginal ultrasound and MRI showed high levels of accuracy for the non-invasive diagnosis of adenomyosis.

The ACOG practice bulletin’s on “Diagnosis of abnormal uterine bleeding in reproductive-aged women” (2012) stated that some experts recommend transvaginal ultrasonography as the initial screening test for abnormal uterine bleeding and MRI as a second-line test to be used when the diagnosis is inconclusive, when further delineation would affect patient management, or when co-existing uterine myomas are suspected.

An UpToDate review on “Ultrasound examination in obstetrics and gynecology” (Shipp, 2013) states that gynecologic ultrasound examination has multiple uses, including but not limited to:

  • Evaluation of the menstrual cycle (endometrial thickness, follicular development)
  • Monitoring natural or stimulated follicular development during infertility therapy
  • Localization of an intrauterine device
  • Evaluation of abnormal uterine bleeding
  • Assessment of a pelvic mass (e.g., adenomyosis, fibroid, cancer, cysts)
  • Evaluation for sequelae of pelvic infection (e.g., abscess, hydrosalpinx)
  • Evaluation of congenital uterine anomalies
  • Screening for malignancy

Screening for Ovarian Cancer:

Ovarian cancer is among the deadliest types of cancer because diagnosis usually comes very late, after the cancer has spread. If the cancer is found and surgically removed before it spreads outside the ovary, the 5-year survival rate is 93 %.  However, only 19 % of cases are detected early enough for that kind of successful intervention.  It is estimated that 22,430 new cases and 15,280 deaths will be reported in 2007 (ACS, 2007).

A Committee Opinion by the American College of Obstetricians and Gynecologists has concluded that TV-US has not been proven as a screening test for ovarian cancer (ACOG, 2002).  The National Cancer Institute (NCI, 2004) has stated that there is insufficient evidence to establish that screening for ovarian cancer with TV-US would result in a decrease in mortality from ovarian cancer.  The NCI notes that a serious potential harm is the false-positive test result, which may lead to anxiety and invasive diagnostic procedures.  The NCI states that there is good evidence that screening for ovarian cancer with TV-US would result in more diagnostic laparoscopies and laparotomies than new ovarian cancers found.  Unnecessary oophorectomies may also result.

Transvaginal ultrasound may be medically necessary for monitoring women with Lynch II syndrome (BRCA2 mutation) for ovarian cancer.  Use of the Doppler mode, however, is not medically necessary for this indication.  Although transvaginal Doppler ultrasonography (TV-DUS) may improve upon the ability of other imaging methods (i.e., TV-US) in distinguishing benign from malignant ovarian neoplasms, it is not clear whether this improvement will have any impact on the management of patients with adnexal lesions.  Specifically, it is unknown whether the diagnostic abilities of TV-DUS are sufficient to confidently identify those patients who can forego surgery and be followed conservatively.  Furthermore, the diagnostic abilities of TV-DUS are probably different among pre- and post-menopausal patients due to the differing prevalence of malignancy between these 2 groups.  Unfortunately, studies of TV-DUS have included a mixture of pre- and post-menopausal patients.  It is unclear how TV-DUS will alter patient management in those patients with ovarian masses

Fields and Chevlen (2006) stated that currently available tests (CA-125, TV-US, or a combination of both) lack the sensitivity and specificity to be useful for screening ovarian cancer in the general population.

Lacey and colleagues (2006) examined the positive predictive values of CA-125 or TV-US screening for ovarian cancer according to family history of breast or ovarian cancer.  In the screening arm of a randomized controlled trial of screening compared with usual care, a total of 28,460 women with family history data received baseline and annual CA-125 and TV-US examinations.  These investigators analyzed CA-125 and TV-US results from the first 4 rounds of screening.  They classified women as average (n = 22,687), moderate (n = 2,572), or high (n = 2,163) risk based on family history, or high risk due to a personal history of breast cancer (n = 1,038).  Cancers were identified by active follow-up of women with abnormal screening results and annual questionnaires.  These researchers calculated positive predictive values for screening combinations.  Similar proportions (4.8 to 5.0 %) of women in each group had abnormal screening results.  Higher-risk women were more likely than lower-risk women to undergo biopsy after a positive screen.  Screening identified 43 invasive ovarian cancers.  The positive predictive values for abnormal screening results were 0.7 % in average-risk, 1.3 % in moderate-risk, and 1.6 % in high-risk groups; 1 ovarian cancer occurred among the breast cancer survivors.  The positive predictive values for post-baseline abnormal screening results were also higher in the higher-risk groups.  The positive-predictive values did not significantly differ across risk groups.  The authors concluded that the probabilities of abnormal annual CA-125 and TV-US screens were similar across groups based on family history of breast or ovarian cancer.  However, ovarian cancer was more likely to be diagnosed after an abnormal screening result among women at higher family history-based risk than among women at lower risk.

The authors noted that ongoing studies, including the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, will ascertain the efficacy of ovarian cancer screening.  Until the results of these studies are available, the findings of this analysis demonstrated that stratifying women into risk groups based on family history slightly enhanced the positive predictive values of a combined CA-125 and TV-US-based screening approach.  These researchers stated that whether these differences prove to be efficacious, cost-effective, or clinically useful in screened populations awaits the results of the PLCO and other cancer screening studies.

The Gynecologic Cancer Foundation, the Society of Gynecologic Oncologists, and the American Cancer Society have issued a consensus statement to promote early detection of ovarian cancer, which recommends that women who have symptoms -- specifically bloating, pelvic or abdominal pain, difficulty eating or feeling full quickly, and urinary frequency and urgency -- are urged to see a gynecologist if symptoms are new and persist for more than 3 weeks (ACS, 2007; SGO, 2007).  The consensus statement recommendations are based on studies that show the above symptoms appeared in women with ovarian cancer more than in other women (Goff et al, 2004; Daly and Ozols, 2004).  The recommendations acknowledge that there is not consensus on what physicians should do when patients present with these symptoms.  According to a consensus statement issued by the Gynecologic Cancer Foundation, patients should be evaluated with pelvic and rectal examinations.  If there is a suspicion of cancer, the clinician may chose to perform a TV-US to check the ovaries for signs of cancer.  Testing for CA-125 levels should also be considered.

Jokubkiene et al (2007) examined if tumor vascularity as assessed by 3-dimensional (3D) power Doppler ultrasound can be used to discriminate between benign and malignant ovarian tumors, if adding 3D power Doppler ultrasound to gray-scale imaging improves differentiation between benignity and malignancy, and if 3D power Doppler ultrasound adds more to gray-scale ultrasound than does 2-dimensional (2D) power Doppler ultrasound.  A total of 106 women scheduled for surgery because of an ovarian mass were examined with transvaginal gray-scale ultrasound as well as 2D and 3D power Doppler ultrasound.  The color content of the tumor scan was rated subjectively by the ultrasound examiner on a visual analog scale.  Vascularization index (VI), flow index (FI) and vascularization flow index (VFI) were calculated in the whole tumor and in a 5-cm(3) sample taken from the most vascularized area of the tumor.  Logistic regression analysis was used to build models to predict malignancy.  There were 79 benign tumors, 6 borderline tumors and 21 invasive malignancies.  A logistic regression model including only gray-scale ultrasound variables (the size of the largest solid component, wall irregularity, and lesion size) was built to predict malignancy.  It had an area under the receiver-operating characteristics (ROC) curve of 0.98, sensitivity of 100 %, false-positive rate of 10 %, and positive likelihood ratio (LR) of 10 when using the mathematically best cut-off value for risk of malignancy (0.12).  The diagnostic performance of the 3D flow index with the best diagnostic performance, i.e., VI in a 5-cm(3) sample, was superior to that of the color content of the tumor scan (area under ROC curve 0.92 versus 0.80, sensitivity 93 % versus 78 %, false-positive rate 16 % versus 27 % using the mathematically best cut-off value).  Adding the color content of the tumor scan or FI in a 5-cm(3) sample to the logistic regression model including the 3 gray-scale variables described above improved diagnostic performance only marginally, an additional 2 tumors being correctly classified.  The authors concluded that even though 2D and 3D power Doppler ultrasound can be used to discriminate between benign and malignant ovarian tumors, their use adds little to a correct diagnosis of malignancy in an ordinary population of ovarian tumors.  Objective quantitation of the color content of the tumor scan using 3D power Doppler ultrasound does not seem to add more to gray-scale imaging than does subjective quantitation by the ultrasound examiner using 2D power Doppler ultrasound.

Partridge and associates (2009) examined if annual screening with TV-US and CA-125 reduces ovarian cancer mortality.  Data from the first 4 annual screens, denoted T0-T3, were reported.  A CA-125 value at or above 35 units/ml or an abnormality on TV-US was considered a positive screen.  Diagnostic follow-up of positive screens was performed at the discretion of participants' physicians.  Diagnostic procedures and cancers were tracked and verified through medical records.  Among 34,261 screening arm women without prior oophorectomy, compliance with screening ranged from 83.1 % (T0) to 77.6 % (T3).  Screen positivity rates declined slightly with TV-US, from 4.6 at T0 to 2.9 to 3.4 at T1-T3; CA-125 positivity rates (range of 1.4 % to 1.8 %) showed no time trend.  A total of 89 invasive ovarian or peritoneal cancers were diagnosed; 60 were screen-detected.  The positive-predictive value (PPV) and cancer yield per 10,000 women screened on the combination of tests were similar across screening rounds (range of 1.0 % to 1.3 % for PPV and 4.7 to 6.2 for yield); however, the biopsy (surgery) rate among screen positives decreased from 34 % at T0 to 15 % to 20 % at T1-T3.  The overall ratio of surgeries to screen-detected cancers was 19.5:1.  A total of 72 % of screen-detected cases were late stage (III/IV).  The authors concluded that through 4 screening rounds, the ratio of surgeries to screen-detected cancers was high, and most cases were late stage.  However, the effect of screening on mortality is as yet unknown.

Menon and colleagues (2009) noted that the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) is a randomized controlled trial designed to assess the effect of screening on mortality.  These investigators summarised the outcome of the prevalence (initial) screen in UKCTOCS.  Between 2001 and 2005, a total of 202,638 post-menopausal women aged 50 to 74 years were randomly assigned to no treatment (control; n = 101,359); annual CA-125 screening (interpreted using a risk of ovarian cancer algorithm) with TV-US scan as a second-line test (multi-modal screening [MMS]; n = 50,640); or annual screening with TV-US (USS; n = 50,639) alone in a 2:1:1 ratio using a computer-generated random number algorithm.  All women provided a blood sample at recruitment.  Women randomized to the MMS group had their blood tested for CA-125 and those randomized to the USS group were sent an appointment to attend for a TV-US.  Women with abnormal screens had repeat tests.  Women with persistent abnormality on repeat screens underwent clinical evaluation and, where appropriate, surgery.  In the prevalence screen, 50,078 (98.9 %) women underwent MMS, and 48,230 (95.2 %) underwent USS.  The main reasons for withdrawal were death (2 MMS, 28 USS), non-ovarian cancer or other disease (none MMS, 66 USS), removal of ovaries (5 MMS, 29 USS), relocation (none MMS, 39 USS), failure to attend 3 appointments for the screen (72 MMS, 757 USS), and participant changing their mind (483 MMS, 1,490 USS).  Overall, 4,355 of 50,078 (8.7 %) women in the MMS group and 5,779 of 48,230 (12.0 %) women in the USS group required a repeat test, and 167 (0.3 %) women in the MMS group and 1,894 (3.9 %) women in the USS group required clinical evaluation.  A total of 97 of 50,078 (0.2 %) women from the MMS group and 845 of 48,230 (1.8 %) from the USS group underwent surgery; 42 (MMS) and 45 (USS) primary ovarian and tubal cancers were detected, including 28 borderline tumors (8 MMS, 20 USS).  28 (16 MMS, 12 USS) of 58 (48.3 %; 95 % confidence inetrval [CI]: 35.0 to 61.8) of the invasive cancers were stage I/II, with no difference (p = 0.396) in stage distribution between the groups.  A further 13 (5 MMS, 8 USS) women developed primary ovarian cancer during the year after the screen.  The sensitivity, specificity, and PPV for all primary ovarian and tubal cancers were 89.4 %, 99.8 %, and 43.3 % for MMS, and 84.9 %, 98.2 %, and 5.3 % for USS, respectively.  For primary invasive epithelial ovarian and tubal cancers, the sensitivity, specificity, and PPV were 89.5 %, 99.8 %, and 35.1 % for MMS, and 75.0 %, 98.2 %, and 2.8 % for USS, respectively.  There was a significant difference in specificity (p < 0.0001) but not sensitivity between the 2 screening groups for both primary ovarian and tubal cancers as well as primary epithelial invasive ovarian and tubal cancers.  The authors concluded that the sensitivity of the MMS and USS screening strategies is encouraging.  Specificity was higher in the MMS than in the USS group, resulting in lower rates of repeat testing and surgery.  This in part reflects the high prevalence of benign adnexal abnormalities and the more frequent detection of borderline tumors in the USS group.  The prevalence screen has established that the screening strategies are feasible.  The results of ongoing screening are awaited so that the effect of screening on mortality can be determined.

Nelson and colleagues (2009) stated that the National Breast and Ovarian Cancer Center's position statement on population screening and early detection of ovarian cancer in asymptomatic women was developed and agreed following a Forum in February 2009 attended by key Australian stakeholders.  The final position statement and supporting background information have been endorsed by key Australian colleges and agencies.  Position statement on population screening and early detection of ovarian cancer in asymptomatic women noted that (i) currently there is no evidence that any test, including pelvic examination, CA-125 or other biomarkers, ultrasound (including TV-US), or combination of tests, results in reduced mortality from ovarian cancer, and (ii) there is no evidence to support the use of any test, including pelvic examination, CA-125 or other biomarkers, ultrasound (including TV-US), or combination of tests, for routine population-based screening for ovarian cancer.

The Royal Australian College of General Practitioners’ guidelines on “Preventive activities in general practice” (2012) stated that “There is no evidence to support the use of any test -- including pelvic examination, CA125, or other biomarkers, ultrasound (including transvaginal ultrasound), or combination of tests -- for routine population-based screening for ovarian cancer …. The specificity of transvaginal ultrasound is low.  The low prevalence of ovarian cancer means that even screening tests that have very high sensitivity and specificity have a low positive predictive value for disease detection”.

Screening for Endometrial Cancer:

Montgomery et al (2004) noted that endometrial hyperplasia is a precursor to the most common gynecological cancer diagnosed in women: endometrial cancer of endometrioid histology.  It is most often diagnosed in post-menopausal women, but women at any age with unopposed estrogen from any source are at an increased risk for developing endometrial hyperplasia.  Hyperplasia with cytological atypia represents the greatest risk for progression to endometrial carcinoma and the presence of concomitant carcinoma in women with endometrial hyperplasia.  Abnormal uterine bleeding is the most common presenting symptom of endometrial hyperplasia.  Specific Pap smear findings and endometrial thickness per ultrasound could also suggest the diagnosis.  Epstein and Valentin (2004) stated that a measurement of endometrial thickness is a simple and accurate method for estimating the risk of endometrial cancer.  However, the reliability of ultrasound evaluation of endometrial morphology and/or vascularization for risk estimation of endometrial malignancy remains to be determined.

In addressing whether TV-US should be performed at annual examination in asymptomatic women, Cohen (2003) stated that there is little evidence that death rates from either endometrial or ovarian cancer would improve with this approach.  If TV-US is to be used in screening asymptomatic women, it should be as part of a controlled study and at no cost to the patient.  This is in agreement with Robertson (2003) who stated that routine screening for endometrial carcinoma is currently not justified.  Post-menopausal women need to be educated about the importance of seeking attention if any vaginal bleeding occurs.  All post-menopausal bleeding requires review and appropriate investigation.  Women taking tamoxifen have a higher risk of endometrial cancer and should report any bleeding or spotting; however, ultrasound screening is not recommended for asymptomatic women taking tamoxifen.  Families with hereditary non-polyposis colon cancer have a higher risk of endometrial cancer and require counseling about this risk.  A Pap test is not a screening test for endometrial cancer, but the incidental finding of endometrial cells on a Pap smear in a post-menopausal woman requires investigation.

The National Cancer Institute (NCI, 2004) has stated that there is insufficient evidence to establish whether a decrease in mortality from endometrial cancer occurs with screening by TV-US.  The NCI notes that risks associated with false-positive test results include anxiety and additional diagnostic testing and surgery.  In addition, endometrial cancers may be missed by ultrasound.

Meyer et al (2009) stated that about 2 % to 5 % of endometrial cancers may be due to an inherited susceptibility.  Lynch syndrome (also known as hereditary non-polyposis colorectal cancer syndrome), an autosomal-dominant inherited cancer susceptibility syndrome caused by a germline mutation in one of the DNA mismatch repair genes, accounts for the majority of inherited cases.  Lynch syndrome is associated with early onset of cancer and the development of multiple cancer types, especially colon and endometrial cancer.  These researchers reviewed the current status of knowledge regarding Lynch syndrome-associated endometrial cancer and methods for diagnosis, screening, and prevention of cancers.  The lifetime cumulative risk of endometrial cancer for women with Lynch syndrome is 40 % to 60 %, which equals or exceeds their risk of colorectal cancer.  No current evidence suggests either a survival advantage or disadvantage to endometrial cancer that is associated with Lynch syndrome when these cases are compared with sporadic cases.  A combination of family and personal medical history and tumor testing provides an efficient basis for diagnosing Lynch syndrome in women with endometrial cancer.  Current gynecologic cancer screening guidelines for women with Lynch syndrome include annual endometrial sampling and TV-US beginning at age 30 to 35 years.  The authors concluded that diagnosing endometrial cancer patients with Lynch syndrome has important clinical implications for the individual and family members.  Screening and prevention practices can decrease the likelihood of developing additional cancers. 

Screening for Other Gynecological Cancers:

Sharma and Menon (2006) noted that the role of screening in gynecological cancers is being studied.  With mass screening proven effective in significantly lowering cervical cancer mortality, there is an intense interest in developing other screening methods to detect gynecological cancers early.  These researchers reviewed advances in cervical cancer screening, strategies being investigated in ovarian cancer screening and the lack of justification in screening for endometrial, vaginal and vulvar cancers.  A Medline-based literature search was performed for studies relating to screening for different gynecological malignancies.  Additional papers cited in those identified by the initial search were also reviewed.  Advances in cervical cancer screening include liquid-based cytology and human papillomavirus testing.  Results of ongoing trials are awaited before these can be fully implemented.  The results of the 2 large, multi-center, randomized controlled trials being conducted in the United Kingdom and United States (UKCTOCS and PLCO study, respectively) to evaluate the impact of screening on ovarian cancer mortality will shed some light on the need to implement screening for ovarian cancer in the general population.  Novel markers, serum proteomic profiles and Doppler ultrasonography are some of the other technologies being examined.  Presently, screening for endometrial cancer is not advocated since most women present with symptoms in early disease exhibit good survival outcomes.  Vaginal and vulval cancers are too rare to justify mass screening.  The authors concluded that methods to screen for various gynecological malignancies need further evaluation before implementation in the general population; results of large multi-center trials are awaited.  They stated that currently, screening for endometrial, vaginal and vulval cancers is not justified.

Evaluation of Post-Menopausal Bleeding:

The ACOG's Committee Opinion on the role of TV-US in the evaluation of women with post-menopausal bleeding (2009) stated that the clinical approach to post-menopausal bleeding requires prompt and efficient evaluation to exclude or diagnose carcinoma.  Women with post-menopausal bleeding may be evaluated initially with either endometrial biopsy or TV-US; this initial evaluation does not require performance of both tests.  Transvaginal ultrasonography can be useful in the triage of patients in whom endometrial sampling was performed but tissue was insufficient for diagnosis.  When TV-US is performed for patients with post-menopausal bleeding and an endometrial thickness of less than or equal to 4 mm is found, endometrial sampling is not required.  Meaningful assessment of the endometrium by ultrasonography is not possible in all patients.  In such cases, alternative assessment should be completed.  When bleeding persists despite negative initial evaluations, additional assessment usually is indicated.

Confirmation of Placement of an Intra-Uterine Device Following Insertion:

In a prospective comparative study, de Kroon and colleagues (2003) evaluated the accuracy of clinical evaluation of intra-uterine device (IUD) position.  The clinical evaluation was compared with the TV-US measurement of IUD position both immediately after insertion and 6 weeks after insertion.  The primary outcome measures were the positive- and negative-predictive values (PPV and NPV) of the clinical evaluation of IUD position.  A total of 195 women were included consecutively, 181 women (92.8 %) were available for follow-up.  The PPV and NPV of clinical evaluation of IUD position immediately after insertion were 0.60 (95 % CI: 0.39 to 0.81) and 0.98 (95 % CI: 0.96 to 1.0), respectively.  The prevalence of an abnormally positioned IUD was 7.7 % (95 % CI: 3.9 to 11.4).  The PPV and NPV of the clinical evaluation at follow-up were 0.54 (95 % CI: 0.26 to 0.81) and 1.0 (95 % CI: 0.98 to 1.0), respectively.  The prevalence of abnormal position was 4.0 % (95 % CI: 1.7 to 7.1).  The authors concluded that clinical evaluation is an excellent test for the evaluation of the position of an IUD and routine TV-US is not indicated for this purpose.

Diagnosis of Bowel Endometriosis:

Bazot et al (2007) compared the accuracy of TV-US and rectal endoscopic sonography (RES) for the diagnosis of deep infiltrating endometriosis (DIE), with respect to surgical and histological findings.  This was a longitudinal study of 81 consecutive patients referred for surgical management of DIE, who underwent both TV-US and RES pre-operatively.  The diagnostic criteria were identical for TV-US and RES, and were based on visualization of hypoechoic areas in specific locations (utero-sacral ligaments, vagina, recto-vaginal septum and intestine).  These investigators calculated the sensitivity, specificity, predictive values and accuracy of TV-US and RES for the diagnosis of DIE.  Endometriosis was confirmed histologically in 80/81 (98.7 %) patients.  Endometriomas and DIE were present in 43.2 % and 97.5 % of the women, respectively.  For the diagnosis of DIE overall, TV-US and RES, respectively, had a sensitivity of 87.3 % and 74.7 %, a PPV of 98.6 % and 98.3 %, and an accuracy of 86.4 % and 74 %.  For the diagnosis of utero-sacral endometriosis, they had a sensitivity of 80.8 % and 46.6 %, a specificity of 75 % and 50.0 %, a PPV of 96.7 % and 89.5 % and a NPV of 30 % and 9.3 %.  For the diagnosis of intestinal endometriosis, they had a sensitivity of 92.6 % and 88.9 %, a specificity of 100 % and 92.6 %, a PPV of 100 % and 96 % and a NPV of 87 % and 80.6 %.  The authors concluded that TV-US is apparently more accurate than RES for predicting DIE in specific locations, and should thus be the first-line imaging technique in this setting.

Hudelist and Keckstein (2009) noted that over the past years, additional diagnostic tools such as TV-US and/or magnetic resonance imaging have been recommended as an appropriate investigation to diagnose ovarian endometriomas or adenomyosis.  Several lines of recent evidence strongly suggests that the use of TV-US also has an important role in detecting DIE of the pelvis not only involving the ovaries but also structures such as the vagina, the recto-vaginal space, the utero-sacral ligaments, the bladder or the rectal wall.

Hudelist et al (2011) analyzed the diagnostic value of TV-US for non-invasive, pre-surgical detection of bowel endometriosis.  MEDLINE (1966 to 2010) and EMBASE (1980 to 2010) databases were searched for relevant studies investigating the diagnostic accuracy of TV-US for diagnosing deep infiltrating endometriosis involving the bowel.  Diagnosis was established by laparoscopy and/or histopathological analysis.  Likelihood ratios (LRs) were re-calculated in addition to traditional measures of effectiveness.  Out of 188 papers, a total of 10 studies fulfilled pre-defined inclusion criteria involving 1,106 patients with suspected endometriosis.  The prevalence of bowel endometriosis varied from 24 to 73.3 %.  LR+ ranged from 4.8 to 48.56 and LR- ranged from 0.02 to 0.36, with wide confidence intervals.  Pooled estimates of sensitivities and specificities were 91 and 98 %; LR+ and LR- were 30.36 and 0.09; and PPV and NPV were 98 and 95 %, respectively.  Three of the studies used bowel preparations to enhance the visibility of the rectal wall; 1 study directly compared the use of water contrast versus no prior bowel enema, for which the LR- was 0.04 and 0.47, respectively.  The authors concluded that TV-US with or without the use of prior bowel preparation is an accurate test for non-invasive, pre-surgical detection of DIE of the rectosigmoid.

Egekvist and colleagues (2012) evaluated the inter-observer variation of transvaginal ultrasonographic measurements of the size of DIE lesions in the recto-sigmoid wall performed by an experienced and a less experienced sonographer.  Fifteen outpatient women were seen for a gynecologic examination and 24 women were seen with recto-sigmoid endometriosis.  Transvaginal ultrasonography was performed independently by 2 observers with a focus on the presence and size of recto-sigmoid endometriosis.  The senior observer had several years of experience, whereas the junior observer was a medical student with no prior experience in TV-US.  The findings of the 2 observers were identical concerning the identification of recto-sigmoid endometriosis.  The probability of differences in size within 30 % of the mean was 0.81, 0.63 and 0.61 for length, width and depth, respectively.  The authors concluded that these findings suggested that fair skills in this technique can be acquired by inexperienced examiners within a short period of time.

Cervical Assessment for Prevention of Preterm Birth:

The Society of Obstetricians and Gynaecologists of Canada stated that routine transvaginal cervical length assessment was not indicated in women at low-risk (Lim et al, 2011).  The Institute for Clinical Systems Improvement’s clinical practice guideline on “Management of labor” (Creedon et al, 2013) recommended the use of transvaginal sonogram for cervical length for monitoring of patients with sign/symptoms of preterm labor and early cervical change.  However, this recommendation is based on low- quality evidence.

In a Cochrane review, Berghella et al (2013) evaluated the effectiveness of antenatal management based on transvaginal ultrasound of cervical length (TVU CL) screening for preventing preterm birth (PTB).  These investigators searched the Cochrane Pregnancy and Childbirth Group's Trials Register (August 31, 2012), reviewed the reference lists of all articles and contacted experts in the field for additional and ongoing trials.  Published and unpublished randomized controlled trials (RCTs) including pregnant women between the gestational ages of 14 to 32 weeks screened with TVU CL for risk of PTB were selected for analysis.  This review focused exclusively on studies based on knowledge versus no knowledge of TVU CL results.  All potential studies identified from the search were independently assessed for inclusion by 3 review authors.  They also analyzed studies for quality measures and extracted data.  Of the 13 trials identified, 5 were eligible for inclusion (n = 507).  Three included singleton gestations with preterm labor (PTL); 1 included singleton gestations with preterm premature rupture of membranes (PPROM); and 1 included twin gestations with or without PTL.  In the 3 trials of singleton gestations with PTL, 290 women were randomized; 147 to knowledge and 143 to no knowledge of TVU CL.  Knowledge of TVU CL results was associated with a non-significant decrease in PTB at less than 37 weeks (22.3 % versus 34.7 %, respectively; average risk ratio [RR] 0.59, 95 % CI: 0.26 to 1.32; 2 trials, 242 women) and at less than 34 weeks (6.9 % versus 12.6 %; RR 0.55, 95 % CI: 0.25 to 1.20; 3 trials, 256 women).  Delivery occurred at a later gestational age in the knowledge versus no knowledge groups (mean difference (MD) 0.64 weeks, 95 % CI: 0.03 to 1.25; 3 trials, 290 women).  For all other outcomes for which there were available data (PTB at less than 34 or 28 weeks; birth-weight less than 2,500 grams; perinatal death; maternal hospitalization; tocolysis; and steroids for fetal lung maturity), there was no evidence of a difference between groups.  The trial of singleton gestations with PPROM (n = 92) evaluated as its primary outcome safety of TVU CL in this population, and not its effect on management.  There was no evidence of a difference in incidence of maternal and neonatal infections between the TVU CL and no TVU CL groups.  In the trial of twin gestations with or without PTL (n = 125), there was no evidence of a difference in PTB at less than 36, 34, or 30 weeks, gestational age at delivery, and other perinatal and maternal outcomes between the TVU CL and the no TVU CL groups.  Life-table analysis revealed significantly less PTB at less than 35 weeks in the TVU CL group compared with the no TVU CL group (p = 0.02).  The authors concluded that currently, there is insufficient evidence to recommend routine screening of asymptomatic or symptomatic pregnant women with TVU CL.  Since there is a non-significant association between knowledge of TVU CL results and a lower incidence of PTB at less than 37 weeks in symptomatic women, the authors encouraged further research.  Future studies should look at specific populations separately (e.g., singleton versus twins; symptoms of PTL or no such symptoms), report on all pertinent maternal and perinatal outcomes, and include cost-effectiveness analyses.  Most importantly, they stated that future studies should include a clear protocol for management of women based on TVU CL results, so that it can be easily evaluated and replicated.

Transvaginal Ultrasonography for Guidance during Embryo Transfer:

Teixeira et al (2015) summarized the current evidence on the effect of using US guidance during embryo transfer (ET).  In this systematic review, these investigators included RCTs examining the effect of the use of US guidance during ET; data from studies using the same catheter type in study arms were not pooled with the results from studies that used different catheter types.  A total of 21 studies were included in the quantitative analysis: 18 compared “US guidance” with “clinical touch”, of which 1 was subsequently excluded from the quantitative meta-analysis owing to a lack of available data; 3 studies compared TVU guidance with trans-abdominal US guidance; and 1 study compared “hysterosonometry before ET” with US guidance.  Comparison of the use of US guidance with clinical touch, in studies that used the same catheter type in the study arms, indicated a benefit of using US guidance during ET on the rates of live-birth (RR, 1.48; 95 % CI: 1.16 to 1.87), based on 2 studies involving 888 women with moderate-quality evidence, and on the rates of clinical pregnancy (RR, 1.32; 95 % CI: 1.18 to 1.46), based on 13 studies involving 3,641 women with high-quality evidence.  However, when comparing the use of US guidance with clinical touch in studies that used different catheter types, the results suggest that using US guidance during ET has no effect on the rates of reproductive outcome: live-birth (RR, 0.99; 95 % CI: 0.83 to 1.19), based on 1 study involving 1,649 women with moderate-quality evidence; clinical pregnancy (RR, 1.04; 95 % CI: 0.89 to 1.21), based on 5 studies involving 2,949 women with moderate-quality evidence.  The estimates for the rate of miscarriage and for the other identified comparisons were imprecise.  The authors concluded that the available evidence suggested that there is a benefit of using US guidance during ET.  However, both US-guided transfer and clinical touch should be considered acceptable, as the benefit of US is not large and should be balanced against the increased cost and need to change the catheter type.  They stated that more studies are needed before conclusions can be drawn regarding the effect of other techniques on reproductive outcome.

CPT Codes / HCPCS Codes / ICD-10 Codes
Information in the [brackets] below has been added for clarification purposes.   Codes requiring a 7th character are represented by "+":
ICD-10 codes will become effective as of October 1, 2015:
CPT codes covered if selection criteria are met:
76830 Ultrasound, transvaginal (non-obstetrical) [except for confirmation of placement of an intrauterine device following insertion]
ICD-10 codes covered if selection criteria are met (not all-inclusive) :
C53.0 - C55 Malignant neoplasm of uterus
C56.1 - C56.9 Malignant neoplasm of ovary
C57.4 Malignant neoplasm of uterine adnexa, unspecified
C79.60 - C79.62 Secondary malignant neoplasm of ovary
C79.82 Secondary malignant neoplasm of genital organs
D07.0 Carcinoma in situ of endometrium
D25.0 - D25.9 Leiomyoma of uterus [fibroid
D26.1 Other benign neoplasm of corpus uteri
D27.0 - D27.9 Benign neoplasm of ovary
D39.0 Neoplasm of uncertain behavior of uterus
D39.10 - D39.12 Neoplasm of uncertain behavior of ovary
N39.3 Stress incontinence (female)
N70.01 - N77.1 Inflammatory diseases of female pelvic organs
N80.0 Endometriosis of uterus
N80.5 Endometriosis of intestine [bowel]
N83.20 - N83.29 Other and unspecified ovarian cysts
N91.0 - N94.9 Disorders of menstruation and other abnormal bleeding from female genital tract
N94.0 Mittelschmerz
N94.89 Other specified conditions associated with female genital organs and menstrual cycle [pelvic congestion syndrome]
N95.0 Postmenopausal bleeding
N97.0 - N97.9 Female infertility [for monitoring natural or stimulated follicular development during infertility therapy]
Q51.0 - Q51.5, Q51.810 - Q51.818, Q51.9 Congenital malformations of uterus
R10.0 - R10.829
R10.84 - R10.9
Abdominal and pelvic pain
R14.0 Abdominal distension (gaseous) [bloating]
R19.00 - R19.09 Intra-abdominal and pelvic swelling, mass and lump
R35.0 Frequency of micturition
R39.15 Urgency of urination
R68.81 Early satiety
T83.31x+ - T83.39x+ Mechanical complication of intrauterine contraceptive device
T83.81x+ - T83.9xx+ Other specified and unspecified complications of genitourinary prosthetic devices, implants and grafts
Z15.02 Genetic susceptibility to malignant neoplasm of ovary [Lynch II syndrome (BRCA2 mutation)]
Z30.431 Encounter for routine checking of intrauterine contraceptive device
ICD-10 codes not covered for indications listed in the CPB:
Z01.411 - Z01.419 Encounter for gynecological examination (general) (routine)
Z12.73 Special screening for malignant neoplasms of ovary
Z12.79 Encounter for screening for malignant neoplasm of other genitourinary organs [endometrium]
Z30.430 Encounter for insertion of intrauterine contraceptive device
Z97.5 Presence of (intrauterine) contraceptive device

The above policy is based on the following references:
    1. Kurjak A, Predanic M. New scoring system for prediction of ovarian malignancy based on transvaginal color Doppler sonography. J Ultrasound Med. 1992;11:631-638.
    2. Weiner Z, Thaler I, Beck D. Differentiating malignant from benign ovarian tumors with transvaginal color flow imaging. Obstet Gynecol. 1992;79:159-162.
    3. Timor-Tritsch IE, Lerner JP, Monteagudo A, et al. Transvaginal ultrasonographic characterization of ovarian masses by means of color flow-directed Doppler measurements and a morphologic scoring system. Am J Obstet Gynecol. 1993;168:909-913.
    4. Fleischer AC, Rodgers WH, Rao BK. Assessment of ovarian tumor vascularity with transvaginal color Doppler sonography. J Ultrasound Med. 1991;10:563-568.
    5. Hamper U, Sheth S, Abbas FM, et al. Transvaginal color Doppler sonography of adnexal masses: Differences in blood flow impedance in benign and malignant lesions. AJR. 1993;160:1225-1228.
    6. Kawai M, Kano T, Kikkawa F, et al. Transvaginal Doppler ultrasound with color flow imaging in the diagnosis of ovarian cancer. Obstet Gynecol. 1992;79:163-167.
    7. Carlson KJ, Skates SJ, Singer DE. Screening for ovarian cancer. Ann Intern Med. 1994;121(2):124-132.
    8. Mackey SE, Creasman WT. Ovarian cancer screening. J Clin Oncol. 1995;13(3):783-793.
    9. Tekay A, Jouppila P. Controversies in assessment of ovarian tumors with transvaginal color Doppler ultrasound. Acta Obstet Gynecol Scand. 1996;75(4):316-329.
    10. Anandakumar C, Chew S, Wong YC, et al. Role of transvaginal ultrasound color flow imaging and Doppler waveform analysis in differentiating between benign and malignant ovarian tumors. Ultrasound Obstet Gynecol. 1996;7(4):280-284.
    11. Szabo I, Szantho A, Csabay L, et al. Color Doppler ultrasonography in the differentiation of uterine sarcomas from uterine leiomyomas. Eur J Gynaecol Oncol. 2002;23(1):29-34.
    12. Cohen L, Fishman DA. Ultrasound and ovarian cancer. Cancer Treat Res. 2002;107:119-132.
    13. New Zealand Guidelines Group (NZGG). Guidelines for the management of uterine fibroids. Wellington, NZ: NZGG; August 1999.
    14. Working Party for Guidelines for the Management of Heavy Menstrual Bleeding. An evidence-based guideline for the management of heavy menstrual bleeding. N Z Med J. 1999;112(1088):174-177.
    15. NHS Centre for Reviews and Dissemination. Screening for ovarian cancer: A systematic review. York, UK: Centre for Reviews and Dissemination (CRD); 1998.
    16. Laing F, Mendelson E, Bohm-Velez M, et al. Premature cervical dilatation. American College of Radiology. ACR Appropriateness Criteria. Radiology. 2000;215(Suppl):939-945.
    17. Scottish Intercollegiate Guidelines Network (SIGN). Investigation of post-menopausal bleeding. A national clinical guideline. SIGN Publication No. 61. Edinburgh, Scotland: SIGN; September 2002.
    18. Royal College of Obstetricians and Gynaecologists (RCOG). The management of menorrhagia in secondary care. Evidence-Based Clinical Guidelines, No. 5. London, UK: RCOG Press; July 1999.
    19. North American Menopause Society. Clinical challenges of perimenopause: Consensus opinion of The North American Menopause Society. Menopause. 2000;7(1):5-13.
    20. Gupta JK, Chien PF, Voit D, et al. Ultrasonographic endometrial thickness for diagnosing endometrial pathology in women with postmenopausal bleeding: A meta-analysis. Acta Obstet Gynecol Scand. 2002;81(9):799-816.
    21. Karlsson B, Granberg S, Wikland M, et al. Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding - A Nordic multicentre study. Am J Obstet Gynecol. 1995;172(5):1488-1494.
    22. Villanueva EVS. The diagnostic characteristics of transvaginal ultrasound in the detection of endometrial cancer in postmenopausal women taking hormone replacement therapy. Clayton, Victoria, Australia: Centre for Clinical Effectiveness (CCE); 2000.
    23. American College of Obstetricians and Gynecologists (ACOG). The role of the generalist obstetrician-gynecologist in the early detection of ovarian cancer. ACOG Committee Opinion No. 280. Washington, DC: ACOG; December 2002.
    24. American College of Obstetricians and Gynecologists (ACOG). Assessment of risk factors for preterm birth. ACOG Practice Bulletin No. 31. Washington, DC: ACOG; October 2001.
    25. American College of Obstetricians and Gynecologists (ACOG). Prophylactic oophorectomy. ACOG Practice Bulletin No. 7. Washington, DC: ACOG; September 1999.
    26. American College of Obstetricians and Gynecologists (ACOG). Management of infertility caused by ovulatory dysfunction. ACOG Practice Bulletin No. 34. Washington, DC: ACOG; February 2002.
    27. American College of Obstetricians and Gynecologists (ACOG). Management of anovulatory bleeding. ACOG Practice Bulletin No. 14. Washington, DC: ACOG; March 2000.
    28. Lewis S, Menon U. Screening for ovarian cancer. Expert Rev Anticancer Ther. 2003;3(1):55-62.
    29. Levavi H, Sabah G. BRCA susceptibility genes--a review of current conservative management of BRCA mutation carriers. Eur J Gynaecol Oncol. 2003;24(6):463-466.
    30. National Institutes of Health (NIH), National Cancer Institute (NCI). Ovarian cancer (PDQ): Screening. Health Professional Version. Bethesda, MD: NCI; updated February 20, 2004. Available at: Accessed August 6, 2004.
    31. Cohen L. Should transvaginal ultrasound be performed at annual examination in asymptomatic women? Int J Fertil Womens Med. 2003;48(4):150-153.
    32. Robertson G. Screening for endometrial cancer. Med J Aust. 2003;178(12):657-659.
    33. Montgomery BE, Daum GS, Dunton CJ. Endometrial hyperplasia: A review. Obstet Gynecol Surv. 2004;59(5):368-378.
    34. Epstein E, Valentin L. Managing women with post-menopausal bleeding. Best Pract Res Clin Obstet Gynaecol. 2004;18(1):125-143.
    35. American Cancer Society guidelines on testing for early endometrial cancer detection-Update 2001. CA Cancer J Clin. 2001;51(1):54-59.
    36. Finnish Medical Society Duodecim. Gynaecologic ultrasound examination. Helsinki, Finland: Duodecim Medical Publications Ltd.; March 21, 2001.
    37. Hricak H, Mendelson E, Bohm-Velez M, et al, Goldstein S. Endometrial cancer of the uterus. American College of Radiology. ACR Appropriateness Criteria. Radiology. 2000;215(Suppl):947-953.
    38. National Institutes of Health (NIH), National Cancer Institute (NCI). Endometrial cancer (PDQ): Screening. Health Professional Version. Bethesda, MD: NCI; updated February 20, 2004. Available at: Accessed August 6, 2004.
    39. American College of Obstetricians and Gynecologists (ACOG). Tamoxifen and endometrial cancer. ACOG Committee Opinion No. 232. Washington, DC: ACOG; April 2000.
    40. American College of Obstetricians and Gynecologists (ACOG), Committee on Gynecologic Practice. Primary and preventive care: Periodic assessments. ACOG Committee Opinion No. 292. Washington, DC: ACOG; November 2003.
    41. Smith RA, Cokkinides V, Eyre HJ. American Cancer Society guidelines for the early detection of cancer, 2003. CA Cancer J Clin 2003;53(1):27-43.
    42. Guven MA, Bese T, Demirkiran F. Comparison of hydrosonography and transvaginal ultrasonography in the detection of intracavitary pathologies in women with abnormal uterine bleeding. Int J Gynecol Cancer. 2004;14(1):57-63.
    43. Ferrazzi E, Leone FP. Investigating abnormal bleeding on HRT or tamoxifen: The role of ultrasonography. Best Pract Res Clin Obstet Gynaecol. 2004;18(1):145-156.
    44. Valentin L. Use of morphology to characterize and manage common adnexal masses. Best Pract Res Clin Obstet Gynaecol. 2004;18(1):71-89. Curr Opin Obstet Gynecol. 2004;16(4):305-311.
    45. Clark TJ. Outpatient hysteroscopy and ultrasonography in the management of endometrial disease. Curr Opin Obstet Gynecol. 2004;16(4):305-311.
    46. Meeuwissen PA, Seynaeve C, Brekelmans CT, et al. Outcome of surveillance and prophylactic salpingo-oophorectomy in asymptomatic women at high risk for ovarian cancer. Gynecol Oncol. 2005;97(2):476-482.
    47. Eitan R, Saenz CC, Venkatraman ES, et al. Pilot study prospectively evaluating the use of the measurement of preoperative sonographic endometrial thickness in postmenopausal patients with endometrial cancer. Menopause. 2005;12(1):27-30.
    48. Mecklin JP, Jarvinen HJ. Surveillance in Lynch syndrome. Fam Cancer. 2005;4(3):267-271.
    49. Fields MM, Chevlen E. Ovarian cancer screening: A look at the evidence. Clin J Oncol Nurs. 2006;10(1):77-81.
    50. Lacey JV Jr, Greene MH, Buys SS, et al. Ovarian cancer screening in women with a family history of breast or ovarian cancer. Obstet Gynecol. 2006;108(5):1176-1184.
    51. van Nagell JR Jr, DePriest PD, Ueland FR, et al. Ovarian cancer screening with annual transvaginal sonography: Findings of 25,000 women screened. Cancer. 2007;109(9):1887-1896.
    52. Sharma A, Menon U. Screening for gynaecological cancers. Eur J Surg Oncol. 2006;32(8):818-824.
    53. Munkarah A, Chatterjee M, Tainsky MA. Update on ovarian cancer screening. Curr Opin Obstet Gynecol. 2007;19(1):22-26.
    54. Vasen HF, Moslein G, Alonso A, et al. Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). J Med Genet. 2007;44(6):353-362.
    55. American Cancer Society (ACS). Ovarian cancer has early symptoms. First national consensus on common warning signs. ACS News Center. Atlanta, GA: ACS; June 14, 2007. Available at: Accessed July 6, 2007.
    56. Berchuck A; Society for Gynecologic Oncologists. Ovarian cancer symptoms consensus statement. Chicago, IL: Society for Gynecologic Oncologists; 2007. Available at: Accessed July 6, 2007.
    57. Goff BA, Mandel LS, Melancon CH, Muntz HG. Frequency of symptoms of ovarian cancer in women presenting to primary care clinics. JAMA. 2004;291(22):2705-2712.
    58. Daly MB, Ozols RF. Symptoms of ovarian cancer--where to set the bar? JAMA. 2004;291(22):2755-2756. 
    59. Van Calster B, Timmerman D, Bourne T, et al. Discrimination between benign and malignant adnexal masses by specialist ultrasound examination versus serum CA-125. J Natl Cancer Inst. 2007;99(22):1706-1714.
    60. van Nagell JR Jr, DePriest PD, Ueland FR, et al. Ovarian cancer screening with annual transvaginal sonography: Findings of 25,000 women screened. Cancer. 2007;109(9):1887-1896.
    61. Jokubkiene L, Sladkevicius P, Valentin L. Does three-dimensional power Doppler ultrasound help in discrimination between benign and malignant ovarian masses? Ultrasound Obstet Gynecol. 2007;29(2):215-225.
    62. Meyer LA, Broaddus RR, Lu KH. Endometrial cancer and Lynch syndrome: Clinical and pathologic considerations. Cancer Control. 2009;16(1):14-22.
    63. Partridge E, Kreimer AR, Greenlee RT, et al; PLCO Project Team. Results from four rounds of ovarian cancer screening in a randomized trial. Obstet Gynecol. 2009;113(4):775-782.
    64. Menon U, Gentry-Maharaj A, Hallett R, et al. Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: Results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Lancet Oncol. 2009;10(4):327-340.
    65. American College of Obstetricians and Gynecologists. ACOG Committee Opinion No. 440: The role of transvaginal ultrasonography in the evaluation of postmenopausal bleeding. Obstet Gynecol. 2009;114(2 Pt 1):409-411.
    66. Cass I. The search for meaning-symptoms and transvaginal sonography screening for ovarian cancer: Silent no more. Cancer. 2009;115(16):3606-3608.
    67. Pavlik EJ, Saunders BA, Doran S, et al. The search for meaning-symptoms and transvaginal sonography screening for ovarian cancer: Predicting malignancy. Cancer. 2009;115(16):3689-3698.
    68. Nelson AE, Francis JE, Zorbas H; National Breast and Ovarian Cancer Centre. Population screening and early detection of ovarian cancer in asymptomatic women. Aust N Z J Obstet Gynaecol. 2009;49(5):448-450.
    69. de Kroon CD, van Houwelingen JC, Trimbos JB, Jansen FW. The value of transvaginal ultrasound to monitor the position of an intrauterine device after insertion. A technology assessment study. Hum Reprod. 2003;18(11):2323-2327.
    70. Marret H, Fauconnier A, Chabbert-Buffet N, et al; CNGOF Collège National des Gynécologues et Obstétriciens Français. Clinical practice guidelines on menorrhagia: Management of abnormal uterine bleeding before menopause. Eur J Obstet Gynecol Reprod Biol. 2010;152(2):133-137.
    71. American College of Obstetricians and Gynecologists Committee on Gynecologic Practice. Committee Opinion No. 477: The role of the obstetrician-gynecologist in the early detection of epithelial ovarian cancer. Obstet Gynecol. 2011;117(3):742-746.
    72. Bazot M, Malzy P, Cortez A, et al. Accuracy of transvaginal sonography and rectal endoscopic sonography in the diagnosis of deep infiltrating endometriosis. Ultrasound Obstet Gynecol. 2007;30(7):994-1001.
    73. Hudelist G, Keckstein J. The use of transvaginal sonography (TVS) for preoperative diagnosis of pelvic endometriosis. Praxis (Bern 1994). 2009;98(11):603-607.
    74. Hudelist G, English J, Thomas AE, et al. Diagnostic accuracy of transvaginal ultrasound for non-invasive diagnosis of bowel endometriosis: Systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2011;37(3):257-263.
    75. Egekvist AG, Forman A, Seyer-Hansen M. Transvaginal ultrasonography of rectosigmoid endometriosis: Interobserver variation of lesion size. Acta Obstet Gynecol Scand. 2012;91(2):264-268.
    76. No authors listed. ACOG Technical Bulletin. Gynecologic ultrasonography. Number 215 -- November 1995. Int J Gynaecol Obstet. 1996;52(3):293-304.
    77. Persadie RJ. Ultrasonographic assessment of endometrial thickness: A review. J Obstet Gynaecol Can. 2002;24(2):131-136.
    78. Champaneria R, Abedin P, Daniels J, et al. Ultrasound scan and magnetic resonance imaging for the diagnosis of adenomyosis: Systematic review comparing test accuracy. Acta Obstet Gynecol Scand. 2010;89(11):1374-1384.
    79. Wolfman W, Leyland N, Heywood M, et al; Society of Obstetricians and Gynaecologists of Canada. Asymptomatic endometrial thickening. J Obstet Gynaecol Can. 2010;32(10):990-999.
    80. Naftalin J, Hoo W, Pateman K, et al. How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum Reprod. 2012;27(12):3432-3439.
    81. American College of Obstetricians and Gynecologists (ACOG). Diagnosis of abnormal uterine bleeding in reproductive-aged women. ACOG Practice Bulletin No. 128. Washington, DC: ACOG; July 2012.
    82. Shipp TD. Ultrasound examination in obstetrics and gynecology. UpToDate [online serial]. Waltham, MA: UpToDate; reviewed April 2013.
    83. Lim K, Butt K, Crane JM. SOGC Clinical Practice Guideline. Ultrasonographic cervical length assessment in predicting preterm birth in singleton pregnancies. J Obstet Gynaecol Can. 2011;33(5):486-499.
    84. Creedon D, Akkerman D, Atwood L, et al. Management of labor. Bloomington, MN: Institute for Clinical Systems Improvement (ICSI); March 2013.
    85. Berghella V, Baxter JK, Hendrix NW. Cervical assessment by ultrasound for preventing preterm delivery. Cochrane Database Syst Rev. 2013;1:CD007235.
    86. Butt K, Lim K; Society of Obstetricians and Gynaecologists of Canada. Determination of gestational age by ultrasound. J Obstet Gynaecol Can. 2014;36(2):171-183.
    87. Screening tests of unproven benefit. In: Guidelines for preventive activities in general practice, 8th edition. East Melbourne (Australia): Royal Australian College of General Practitioners; 2012.
    88. Teixeira DM, Dassuncao LA, Vieira CV, et al. Ultrasound guidance during embryo transfer: A systematic review and meta-analysis of randomized controlled trials. Ultrasound Obstet Gynecol. 2015;45(2):139-148.

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