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Clinical Policy Bulletin:
Contact Dissolution for Gallstones
Number: 0509


Policy

Aetna considers contact dissolution (also known as direct solvent dissolution or litholysis) experimental and investigational for the treatment of gallstones because none of the agents used for contact dissolution -- ethyl propionate, isopropyl acetate, methyl tertiary butyl ether -- has been approved by the U.S. Food and Drug Administration for this indication and the safety and effectiveness of this practice has not been established.



Background

Gallstone (cholelithiasis) is a common disease in this country and is associated with significant morbidity.  Open and laparoscopic cholecystectomy remains the mainstay in the methods of treating patients with symptomatic disease.  For selected patients, non-invasive treatment such as Actigall (ursodiol) therapy may be appropriate.  Contact dissolution by means of ethyl propionate (EP), isopropyl acetate (IA), or methyl tertiary butyl ether (MTBE), has also been used in high-risk patients such as the elderly, patients who are too ill to undergo surgery, and individuals with idiosyncratic reactions to anesthesia.

In contact dissolution of gallstones, the solvent is usually introduced through a percutaneous trans-hepatic catheter into the gallbladder.  A catheter is inserted through a small needle puncture into the gallbladder under fluoroscopic or ultrasonographic guidance.  The catheter is then connected to a computerized peristaltic pump that delivers small amounts of solvent continuously to slowly dissolve the stones and removes any remaining stone fragments.  Gallstones can usually be cleared in hours to days.  Care must be taken to limit the time of contact between instillation and drainage to avoid discharge of this potentially toxic agent into the bile duct or the duodenum.  Failure to do so may result in transient abdominal pain and duodenitis.

There is a significant risk of complications with contact dissolution of gallstones.  As one commentator noted, "none [of the several contact solvents available] is a simple, safe, and effective method of treating gallstones" (Lee, 1999).  Complications of use of contact solvents include those caused by the percutaneous puncture procedure and side effects if the solvent drains into the duodenum (e.g., hemolytic anemia, erosive or hemorrhagic duodenitis, aspiration pneumonia, and somnolence).

Although there is preliminary evidence that contact dissolution is effective in treating cholesterol gallstones, this is considered an investigational procedure.  None of the agents used (EP, IA, and MTBE) has been approved by the Food and Drug Adminsitration for the treatment of gallstones.  As one authority commented regarding direct contact dissolution of gallstones, "this investigational therapy has not gained sufficient acceptance" and, with the introduction of laparoscopic cholecystectomy, contact dissolution has been "practically abandoned" (Paumgartner, 1998).  In a review on cholesterol gallstone disease, Portincasa et al (2006) stated that the "contact" method for stone dissolution by MTBE via percutaneous puncture of the gallbladder or extracorporeal shockwave lithotripsy have been abandoned.

 
CPT Codes / HCPCS Codes / ICD-9 Codes
There are no specific codes for contact dissolution of gallstones:
ICD-9 codes not covered for indications listed in the CPB:
574.00 - 574.91 Cholelithiasis


The above policy is based on the following references:
  1. Thistle JL, May GR, Bender CE, et al. Dissolution of cholesterol gallbladder stones by methyl tert-butyl ether administered by percutaneous transhepatic catheter. N Engl J Med. 1989;320(10):633-639.
  2. Hellstern A, Leuschner M, Frenk H, et al. Gall stone dissolution with methyl tert-butyl ether: How to avoid complications. Gut. 1990;31(8):922-925.
  3. McNulty J, Chua A, Keating J, et al. Dissolution of cholesterol gall stones using methyltertbutyl ether: A safe effective treatment. Gut. 1991;32(12):1550-1553.
  4. Janowitz P, Schumacher KA, Swobodnik W, et al. Transhepatic topical dissolution of gallbladder stones with MTBE and EDTA. Results, side effects, and correlation with CT imaging. Dig Dis Sci. 1993;38(11):2121-2129.
  5. Hofmann AF, Amelsberg A, Esch O, et al. Successful topical dissolution of cholesterol gallbladder stones using ethyl propionate. Dig Dis Sci. 1997;42(6):1274-1282.
  6. Zakko SF, Scirica JC, Guttermuth MC, et al. Ethyl propionate is more effective and less cytotoxic than methyl tert-butyl ether for topical gallstone dissolution. Gastroenterology. 1997;113(1):232-237.
  7. Ransohoff DF, Gracie WA. Treatment of gallstones. Clinical Practice Guidelines. 1995 ed.  Philadelphia, PA: American College of Physicians; 1995: IV-22 - IV-37.
  8. Paumgartner G. Nonsurgical management of gallstone disease. In: Sleisenger & Fordtran's Gastrointestinal and Liver Disease. M Feldman, et al.,eds.  6th ed. Philadelphia, PA: WB Saunders Co; 1998: 98.
  9. Lee SP, Ko CW. Gallstones. In: Textbook of Gastroenterology. DH Alpers. et al. eds. 3rd ed.  Philadelphia, PA: Lippincott Williams & Wilkins; 1999: 2273.
  10. Patient Care Committee, Society for Surgery of the Alimentary Tract. Treatment of gallstone and gallbladder disease. SSAT patient care guidelines. J Gastrointest Surg. 2004;8(3):363-364.
  11. Bellows CF, Berger DH, Crass RA. Management of gallstones. Am Fam Physician. 2005;72(4):637-642.
  12. Portincasa P, Moschetta A, Palasciano G. Cholesterol gallstone disease. Lancet. 2006;368(9531):230-239.
  13. Hofmann AF. Bile acids: Trying to understand their chemistry and biology with the hope of helping patients. Hepatology. 2009;49(5):1403-1418.


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Copyright Aetna Inc. All rights reserved. Clinical Policy Bulletins are developed by Aetna to assist in administering plan benefits and constitute neither offers of coverage nor medical advice. This Clinical Policy Bulletin contains only a partial, general description of plan or program benefits and does not constitute a contract. Aetna does not provide health care services and, therefore, cannot guarantee any results or outcomes. Participating providers are independent contractors in private practice and are neither employees nor agents of Aetna or its affiliates. Treating providers are solely responsible for medical advice and treatment of members. This Clinical Policy Bulletin may be updated and therefore is subject to change.
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