Aetna considers kidney transplantation medically necessary when all of the following criteria below are met:
Member has completed an evaluation and been accepted by the kidney transplant committee at the kidney transplantation center; andNote: Frequently requests for evaluation for transplantation are confused with requests for the transplantation itself. While the transplant evaluation of persons with kidney disease may be indicated, the medical necessity for transplantation itself depends on the results of the evaluation.
Member meets transplanting institution's protocol eligibility criteria regarding age; and
Absence of malignancy or the malignancy has had curative therapy (e.g., surgical resection of non-invasive squamous cell or basal cell skin cancer) or the estimated risk of recurrence of the malignancy is less than 10 % within the next 2 years. For example, renal cell carcinoma treated by nephrectomy with no evidence of metastatic disease 2 years after the nephrectomy, prostate cancer with negative prostate-specific antigen levels after treatment, surgically treated colon cancer, thyroid cancer with normal thyroglobulin levels after therapy, and others. Women should have a negative Pap smear within the past 3 years and mammography, where indicated, within the past 2 years; and
Absence of systemic infection; and
Absence of symptomatic HIV infection, as defined by all of the following:
CD4 count greater than 200 cells/mm3 for more than 6 months; and
HIV-1 RNA (viral load) undetectable; and
On stable anti-viral therapy for more than 3 months; and
No other complications from AIDS, such as opportunistic infection (e.g., aspergillus, coccidiomycosis, resistant fungal infections, tuberculosis), Kaposi's sarcoma or other neoplasms.
Attending physician determines that there is no prohibitive cardiovascular risk; and
Attending physician determines that there is no prohibitive pulmonary risk; and
Attending physician determines that there is no prohibitive hepatic risk; and
Severity of disease
Member is already on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD); or
Member has chronic renal failure with anticipated deterioration to end stage renal disease, where member is seeking precertification for cadaveric kidney transplantation**; or
Member has end stage renal disease, evidenced by a creatinine clearance below 20 ml/min or development of symptoms of uremia, and member is seeking precertification for a living donor kidney transplantation.
** Note: Given waiting periods for cadaveric donors averaging 1 to 4 years, kidney transplantation is considered medically necessary for persons with severe chronic renal failure with anticipated progression to end stage renal disease. Severe chronic renal failure is defined as a creatinine clearance of less than 30 ml/min.
Kidney transplant is not considered medically necessary for persons who do not meet the transplanting institution's protocol selection criteria, or in the absence of a protocol, for persons who have any of the following (not an all-inclusive list):
Active vasculitis; or
Age over 70 years with severe co-morbidities; or
Life threatening extra-renal congenital abnormalities; or
Ongoing alcohol or drug abuse; or
Severe neurological or mental impairment, in persons without adequate social support, such that the person is unable to adhere to the regimen necessary to preserve the transplant; or
Untreated coagulation disorder
Combined Kidney/Pancreas Transplantation
For persons undergoing kidney transplantation due to diabetic nephropathy, a combined kidney/pancreas transplantation may be considered medically necessary under some circumstances (see CPB 0587 - Pancreas Kidney Transplantation). Other multi-organ transplants (e.g., kidney/heart, liver/kidney) should be referred to Aetna's National Medical Excellence Program for review.
Renal Autotransplantation and Ex-Vivo Bench Surgery
Aetna considers autotransplantation and ex-vivo repair medically necessary where repair of the kidney, renal artery or its branches are not amenable to in-situ reconstruction.
Gene Microarrays for Diagnosis of Rejection
Aetna considers the use of gene microarrays in diagnosis of rejection of kidney transplantation experimental and investigational because of insufficient evidence of their effectiveness.
Evaluation of Urine Immunocytology
Aetna considers evaluation of urine immunocytology for T cells experimental and investigational for the diagnosis of acute kidney rejection because of insufficient evidence of its effectiveness.
Aetna considers the use of belatacept (Nulojix) medically necessary for the prevention of acute rejection in kidney transplant recipients who are sero-positive for the Epstein Barr virus (EBV).
Aetna considers belatacept is experimental and investigational for the prophylaxis of organ rejection in other transplanted organs because its effectiveness for the prevention of acute rejection in organ transplant other than kidney has not been established.
Aetna considers measurement of pre-transplantation soluble CD30 level as a predictor of acute rejection in kidney transplantation experimental and investigational because its clinical value has not been established.
Chronic renal failure (CRF) occurs in approximately 2 out of 10,000 people. It results in the accumulation of fluid and waste products in the body, causing azotemia and uremia. Azotemia is the build-up of nitrogen waste products in the blood. It may occur without symptoms. Uremia is the state of ill health resulting from renal failure since most body systems are affected by CRF. Treatment of the underlying disorders may help prevent or delay development of CRF.
Chronic renal failure is slowly progressive over a number of years and most often results from any disease that causes gradual destruction of the internal structures of the kidneys. It can range from mild dysfunction to severe kidney failure, termed end stage renal disease (ESRD). In the early stages, there may be no symptoms. In fact, progression may be so gradual that symptoms do not occur until kidney function is less than 1/10 of normal. Because of the reversible nature of acute renal failure, all patients with this diagnosis should be supported with dialysis, at least for some period of time, to allow return of renal function.
The 3 diseases most commonly leading to CRF and treated by kidney transplantation are (i) type 1 diabetes mellitus, (ii) glomerulonephritis, and (iii) hypertensive nephrosclerosis, accounting for about 75 % of the total candidate population. Numerous subsets of patients in several study populations have shown that patients have a better survival if they receive a renal transplant than if they remain on dialysis therapy.
Patients with ESRD have 3 options for renal replacement therapy: (i) hemodialysis; (ii) chronic ambulatory peritoneal dialysis; or (iii) transplantation. The choice should be based on the relative risks and benefits. With the increasing appreciation that transplantation results are superior to those of chronic dialysis, the indications for transplantation have been broadened. Improvements in peri-operative care and immunosuppression have allowed many patients who would previously have been denied transplantation consideration as acceptable candidates. The best recipients for transplantation are young individuals whose renal failure is not due to a systemic disease that will damage the transplanted kidney or cause death from extra-renal causes.
The time a patient has spent on dialysis is an independent predictor of a poorer outcome from renal transplantation. Pre-emptive renal transplantation generally leads to better outcomes than transplantation after dialysis is initiated, and should be pursued in most cases for live donor transplants. The current shortage of cadaveric kidneys makes it unlikely that pre-emptive transplants will be a practical option for recipients of cadaveric kidney transplants.
No specific cause of intrinsic and irreversible renal failure is considered a contraindication to kidney transplantation. Nonetheless, all patients still should have reversible causes of renal dysfunction excluded before considering renal replacement therapy e.g., obstructive nephropathy has to be removed, chronic pyelonephritis secondary to recurrent infection has to be adequately treated, and reflux has to be fixed.
The evaluation of all transplant candidates, in addition to a standard medical work-up, should include cytomegalovirus (CMV) antibody titer; creatinine clearance; serology for syphilis, and hepatitis B (HBV) and C (HCV) viruses; evaluation of parathyroid status; coagulation profile; Pap smear; ABO and histocompatibility typing; urologic evaluation (including a voiding cystourethrogram in selected patients to assess outlet obstruction and reflux); gastro-intestinal evaluation (as warranted by history of ulcer, diverticulitis, or other symptoms); and psychosocial evaluation.
Patients with renal failure induced by diabetes (Kimmelstiel-Wilson disease) make up the greatest population of patients currently referred for transplantation. Actually, this has become the treatment of choice because persons with diabetes clearly do better with transplantation than with dialysis. In fact, both graft and patient survival for 1 to 2 years are reported to be as good in persons with diabetes as in other patients, whereas on chronic dialysis, less than 20 % of persons with diabetes survive 5 years. If diabetic patients can undergo transplantation before extensive damage occurs in other organs, such as the eye and heart, rehabilitation will be more satisfactory. Even patients with diseases in which the transplanted kidney may eventually be damaged by recurrent disease (e.g., lupus erythematosus, cystinosis, and amyloidosis) are often better palliated by transplantation than by dialysis. Indeed, the current results of transplantation mandate serious consideration of this therapy in virtually any patient with terminal renal disease. Not only is the quality of life far better with transplantation than with dialysis, but because the mortality of patients in the first year after transplantation is now less than 5 %, survival is also superior.
Careful attention must be given to eradication of all infections including those of the urinary tract, lungs, teeth, and skin. Since cardiovascular complications are as common as infection as a cause of post-transplantation mortality, the patient's cardiovascular status should be carefully evaluated and optimized. In older patients and diabetic patients, this might require stress testing, cardiac catheterization, or even pre-transplant coronary artery bypass. Age is never an absolute contraindication for kidney transplantation. Although infants have had successful transplantations, most centers maintain infants on dialysis until body size is increased to 10 to 20 kg. Older patients are becoming more numerous in transplant clinics. Older age (greater than 65 years) never precludes transplantation, but it increases the risk of complications. Transplant centers usually encourage older patients who have multiple medical problems (rather than isolated kidney failure) to remain on dialysis. On both ends of the age spectrum, however, transplantation is becoming more common. Malignancy is considered a contraindication for kidney transplantation, as is severe atherosclerotic or pulmonary disease. Patients with active liver disease are also usually excluded. Both hepatitis B and C can result in eventual liver failure in some patients after transplantation.
The proper timing of transplantation is a delicate decision because the progression of renal dysfunction is variable and premature imposition of the risks of transplantation is not justified. However, dialysis or transplantation should not be withheld until advanced uremic symptoms, such as pericarditis, cardiac failure, severe anemia, osteodystrophy and neuropathy, ensure because these complications may become irreversible.
There are 3 sources of donor kidneys for kidney transplantation: (i) living related donors; (ii) cadaver donors; and (iii) living unrelated donors. A donor left kidney is usually transplanted to the right iliac fossa, with the renal artery anastomosed end-to-end to the hypogastric artery, and the renal vein end-to-end to the common iliac vein. The ureter is implanted into the bladder and under special conditions a uretero-ureteral anastomosis or uretero-pyelostomy may be performed. Autotransplantation has developed as an outgrowth of the technique used in renal transplantation. The simultaneous development of an apparatus that could preserve kidneys extracorporeally for long periods of time and of preservation solutions led to extracorporeal renal repair (work-bench surgery) and subsequent autotransplantation for conditions mentioned above.
On rare occasions, kidneys with lesions of the renal artery or its branches are not amenable to in-situ reconstruction. In these circumstances, temporary removal of the kidney, ex-vivo preservation, microvascular repair (work-bench surgery), and autotransplantation may permit salvage.
Some examples of clinical conditions where the renal artery or its branches are not amenable to in-situ reconstruction such that a person might benefit from autotransplantation and/or ex-vivo repair include but are not limited to:
Abdominal aortic aneurysms that involve the origin of the renal arteries; or
Disease of the major vessels extends beyond the bifurcation of the main renal artery into the segmental branches; or
Extensive atheromatous aortic disease when an operation on the aorta itself may prove hazardous; or
Multiple vessels supplying the affected kidney are involved; or
Persons who have large aneurysms, arteriovenous fistulas, or malformations of the kidney; or
Traumatic arterial injuries.
Patients with chronic kidney disease have significant abnormalities of bone remodeling and mineral homeostasis and are at increased risk of fracture. The fracture risk for kidney transplant recipients is 4 times that of the general population and higher than for patients on dialysis. Ebeling (2007) noted that organ transplant candidates should be assessed and pre-transplantation bone disease should be treated. Preventive therapy initiated in the immediate post-transplantation period is indicated in patients with osteopenia or osteoporosis, as further bone loss will occur in the first several months following transplantation. Long-term organ transplant recipients should also have bone mass measurement and treatment of osteoporosis. Bisphosphonates are the most promising approach for the management of transplantation osteoporosis. Active vitamin D metabolites may have additional benefits in reducing hyper-parathyroidism, particularly after kidney transplantation. The author stated that large, multi-center treatment trials with oral or parenteral bisphosphonates and calcitriol are recommended.
In a Cochrane review, Palmer et al (2007) assessed the use of interventions for treating bone disease following kidney transplantation. Randomized controlled trials (RCTs) and quasi-RCTs comparing different treatments for kidney transplant recipients of any age were selected. All other transplant recipients, including kidney-pancreas transplant recipients were excluded. Two authors independently evaluated trial quality and extracted data. Statistical analyses were performed using the random effects model and the results expressed as relative risk (RR) with 95 % confidence intervals (CI) for dichotomous variables and mean difference (MD) for continuous outcomes. A total of 24 trials (n = 1,299) were included. No individual intervention (bisphosphonates, vitamin D sterol or calcitonin) was associated with a reduction in fracture risk compared with placebo. Combining results for all active interventions against placebo demonstrated any treatment of bone disease was associated with a reduction in the RR of fracture (RR 0.51, 95 % CI: 0.27 to 0.99). Bisphosphonates (any route), vitamin D sterol, and calcitonin all had a beneficial effect on the bone mineral density (BMD) at the lumbar spine. Bisphosphonates and vitamin D sterol also had a beneficial effect on the BMD at the femoral neck. Bisphosphonates were more effective in preventing BMD loss when compared head-to-head with vitamin D sterols. Few or no data were available for combined hormone replacement, testosterone, selective estrogen receptor modulators, fluoride or anabolic steroids. Other outcomes including all-cause mortality and drug-related toxicity were reported infrequently. The authors concluded that treatment with bisphosphonates, vitamin D sterol or calcitonin after kidney transplantation may protect against immunosuppression-induced reductions in BMD and prevent fracture. However, they state that adequately powered clinical studies are needed to ascertain if bisphosphonates are better than vitamin D sterols for fracture prevention in this population. Moreover, the optimal route, timing, and duration of administration of these interventions remains unknown.
Acute rejection is an immune process that begins with the recognition of the allograft as non-self and ends in graft destruction. Histological features of the allograft biopsy are currently used for the differential diagnosis of allograft dysfunction. In view of the safety and the opportunity for repetitive sampling, development of non-invasive biomarkers of allograft status is an important objective in transplantation. Khatri and Sarwal (2009) stated that in the past 10 years, microarray technology has revolutionized biological research by allowing the screening of tens of thousands of genes simultaneously. These investigators reviewed recent studies in organ transplantation using microarrays and highlighted the issues that should be addressed in order to use microarrays in the diagnosis of rejection. Microarrays have been useful in identifying potential biomarkers for chronic rejection in peripheral blood mononuclear cells, novel pathways for induction of tolerance, and genes involved in protecting the graft from the host immune system. Microarray analysis of peripheral blood mononuclear cells from chronic antibody-mediated rejection has identified potential non-invasive biomarkers. In a recent study, correlation of pathogenesis-based transcripts with histopathological lesions is a promising step towards inclusion of microarrays in clinics for organ transplants. The authors concluded that despite promising results in diagnosis of histopathological lesions using microarrays, the low dynamic range of microarrays and large measured expression changes within the probes for the same gene continue to cast doubts on their readiness for diagnosis of rejection. They stated that more studies are needed to resolve these issues. Dominating expression of globin genes in whole blood poses another challenge for identification of non-invasive biomarkers. In addition, studies are also needed to demonstrate effects of different immunosuppression therapies and their outcomes.
Hartono et al (2010) noted that urinary cell and peripheral blood cell mRNA profiles have been associated with acute rejection of human renal allografts. Emerging data support the idea that development of non-invasive biomarkers predictive of antibody-mediated rejection is feasible. The demonstration that intra-graft microRNA expression predicts renal allograft status suggests that non-invasively ascertained microRNA profiles may be of value. These researchers stated that they are pleased with the progress to date, and anticipate clinical trials investigating the hypotheses that non-invasively ascertained mRNA profiles will minimize the need for invasive biopsy procedures, predict the development of acute rejection and chronic allograft nephropathy, facilitate preemptive therapy capable of preserving graft function, and facilitate personalization of immunosuppressive therapy for the allograft recipient.
Mihovilovic and colleagues (2010) evaluated urine immunocytology for T cells as a method for non-invasive identification of patients with acute renal allograft rejection in comparison to renal biopsy. In this prospective study, a cohort of 56 kidney, or kidney-pancreas transplant recipients was included. Patients either received their transplant at the University Hospital "Merkur", or have been followed at the "Merkur" Hospital. Patients were subject to either protocol or indication kidney biopsy (a total of 70 biopsies), with simultaneous urine immunocytology (determination of CD3-positive cells in the urine sediment). Acute rejection was diagnosed in 24 biopsies; 23 episodes were T-cell mediated (6 grade IA, 5 grade IB, 1 grade IIA, 1 grade III and 10 borderline), while in 1 case acute humoral rejection was diagnosed. A total of 46 biopsies did not demonstrate acute rejection. CD3-positive cells were found in 21 % of cases with acute rejection and in 13 % of cases without rejection (non-significant). A finding of CD3-positive cells in urine had a sensitivity of 21 % and specificity of 87 % for acute rejection (including borderline), with positive predictive value of 45 % and negative predictive value of 68 %. The authors concluded that although tubulitis is a hallmark of acute T cell-mediated rejection, detection of T cells in urine sediment was insufficiently sensitive and insufficiently specific for diagnosing acute rejection in this cohort of kidney transplant recipients.
Belatacept, a selective T-cell co-stimulation blocker, is a cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin. It is designed to block CD28, a critical activating receptor on T cells, by binding and saturating its ligands B7-1 and B7-2. In phase II and III clinical trials, belatacept was compared with cyclosporine (in combination with basiliximab, mycophenolate mofetil, and steroids). Advantages observed with belatacept include superior graft function, preservation of renal structure and improved cardiovascular risk profile. Concerns associated with belatacept are a higher frequency of cellular rejection episodes and more post-transplant lymphoproliferative disorder (PTLD) cases especially in Epstein-Barr virus (EBV) sero-negative patients, who should be excluded from belatacept-based regimens (Wekerle and Grinyo, 2012).
On June 15, 2011, the Food and Drug Administration approved belatacept (Nulojix) for the prevention of acute rejection in adult kidney transplant recipient. Nulojix is approved for use with other immunosuppressants, specifically basiliximab, corticosteroids, and mycophenolate mofetil. The approval of Nulojix was base on 2 open-label, randomized, multi-center, controlled phase III clinical trials that enrolled more than 1,200 patients and compared 2 dose regimens of Nulojix with another immunosuppressant, cyclosporine. These trials demonstrated that the recommended Nulojix regimen is safe and effective for the prevention of acute organ rejection.
Nulojix carries a Boxed Warning for an increased risk of developing PTLD. The risk of PTLD is higher for transplant patients who have never been exposed to EBV. Transplant patients who have not been exposed to EBV have more difficulty mounting an effective immune response to the virus if they get infected after transplant; typically they get exposed to the virus at time of transplant, as it is carried in around 80 % of donated organs. Patients should be tested for EBV and should only receive Nulojix if the test shows they have already been exposed to EBV. Another Boxed Warning on the Nulojix label, as well as labels of other immunosuppressants, warns of an increased risk of serious infections and other cancers. Common adverse reactions observed in transplant patients in the trials included anemia, constipation, kidney or bladder infection, and swollen legs, ankles, or feet. Any transplant patients, including those receiving Nulojix, should limit the amount of time spent in sunlight because of the risk of skin cancer and should not get live vaccines because of the risk of infection.
Chen and colleagues (2012) stated that the question of whether high pre-transplantation soluble CD30 (sCD30) level can be a predictor of kidney transplant acute rejection (AR) is under debate. These investigators performed a meta-analysis on the predictive efficacy of sCD30 for AR in renal transplantation. PubMed (1966 to 2012), EMBASE (1988 to 2012), and Web of Science (1986 to 2012) databases were searched for studies concerning the predictive efficacy of sCD30 for AR after kidney transplantation. After a careful review of eligible studies, sensitivity, specificity, and other measures of the accuracy of sCD30 were pooled. A summary receiver operating characteristic curve was used to represent the overall test performance. A total of 12 studies enrolling 2,507 patients met the inclusion criteria. The pooled estimates for pre-transplantation sCD30 in prediction of allograft rejection risk were poor, with a sensitivity of 0.70 (95 % CI: 0.66 to 0.74), a specificity of 0.48 (95 % CI: 0.46 to 0.50), a positive likelihood ratio of 1.35 (95 % CI: 1.20 to 1.53), a negative likelihood ratio of 0.68 (95 % CI: 0.55 to 0.84), and a diagnostic odds ratio of 2.07 (95 % CI: 1.54 to 2.80). The area under curve of the summary receiver operating characteristic curve was 0.60, indicating poor overall accuracy of the serum sCD30 level in the prediction of patients at risk for AR. The authors concluded that the results of the meta-analysis showed that the accuracy of pre-transplantation sCD30 for predicting post-transplantation AR was poor. They stated that prospective studies are needed to clarify the usefulness of this test for identifying risks of AR in transplant recipients.
CPT Codes / HCPCS Codes / ICD-9 Codes
CPT codes covered if selection criteria are met:
Other CPT codes related to the CPB:
77051 - 77057
88141 - 88175
90918 - 90940
HCPCS code covered if selection criteria are met:
Simultaneous pancreas kidney transplantation
Other HCPCS codes related to the CPB:
Cervical or vaginal cancer screening; pelvic and clinical breast examination[female candidates should have a negative result within the past three years]
Screening cytopathology, cervical or vaginal (any reporting system), collected in preservative fluid, automated thin layer preparation; screening by cytotechnologist under physician supervision[female candidates should have a negative result within the past three years]
requiring interpretation by physician [female candidates should have a negative result within the past three years]
G0141 - G0148
Screening, cytopathology, other
G0202 - G0206
G0308 - G0327
End stage renal disease services
Home therapy, hemodialysis; administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing services coded separately), per diem
Home therapy; peritoneal dialysis, administrative services, professional pharmacy services, care coordination and all necessary supplies and equipment (drugs and nursing visits coded separately
ICD-9 codes covered if selection criteria are met:
Chronic kidney disease, Stage V
End stage renal disease
Other ICD-9 codes related to the CPB:
001.0 - 139.8
Infectious and parasitic diseases
140.0 - 208.91
250.00 - 250.93
Disturbances of amino-acid transport
390 - 459.9
Diseases of the circulatory system
460 - 519.9
Diseases of the respiratory system
570 - 573.9
Diseases of the liver
580.0 - 580.9
581.0 - 581.9
582.0 - 583.9
583.81 - 583.89
Other specified disorders of kidney
Systemic lupus erythematosus
866.00 - 866.13
Injury to kidney
902.40 - 902.49
Injury to renal blood vessels
Late effect of internal injury to intra-abdominal organs
Late effect of injury to blood vessel of thorax, abdomen, and pelvis
V10.0 - V10.9
Personal history of malignant neoplasm
Organ or tissue replaced by transplant, kidney
Organ or tissue replaced by other means, other
Renal dialysis status
ICD-9 codes contraindicated for this CPB:
286.0 - 286.9
Coagulation defects [untreated]
303.00 - 305.93
Alcohol dependence, drug dependence, nondependent abuse of drugs, and alcohol abuse [ongoing alcohol or drug abuse]
330.0 - 337.9
Hereditary and degenerative diseases of the central nervous system [severe neurological or mental impairment]
ICD-9 codes covered if selection criteria are met:
Complications of kidney transplant [for the prevention of acute rejection in kidney transplant recipients who are sero-positive for the Epstein Barr virus (EBV)] [not covered for the prophylaxis of organ rejection in other transplanted organs]
Organ or tissue replaced by transplant, kidney [for the prevention of acute rejection in kidney transplant recipients who are sero-positive for the Epstein Barr virus (EBV)] [not covered for the prophylaxis of organ rejection in other transplanted organs]
ICD-9 codes not covered for indications listed in the CPB:
996.82 - 996.89
Complications of transplanted organs [excludes kidney]
V42.1 - V42.9
Organ or tissue replaced by transplant [excludes kidney]
Other ICD-9 codes related to the CPB: :
Other CPT codes related to the CPB:
Immunoassay for analyte other than infectious agent antibody or infectious agent antigen; quantitative, not otherwise specified [not covered for measurement of pre-transplantation soluble CD30 level as a predictor of acute rejection in kidney transplantation]
The above policy is based on the following references:
Bay WH, Hebert LA. The living donor in kidney transplantation. Ann Intern Med. 1987;106:719-727.
Najarian JS, Kaufman DB, Fryd DS, et al. Long-term survival following kidney transplantation in 100 type I diabetic patients. Transplantation. 1989;47:106-113.
Doyle SE, Matas AJ, Gillingham K, et al. Predicting clinical outcome in the elderly renal transplant recipient. Kidney Int. 2000;57:2144-2150.
Manske CL, Wilson RF, Wang Y, et al. Prevalence of, and risk factors for, angiographically determined coronary artery disease in type I-diabetic patients with nephropathy. Arch Intern Med. 1992;152:2450-2455.
Manske CL, Thomas W, Wang Y, et al. Screening diabetic transplant candidates for coronary artery disease: Identification of a low risk subgroup. Kidney Int. 1993;44:617-621.
Ratner LE, Ciseck LJ, Moore RG, et al. Laparoscopic live donor nephrectomy. Transplantation. 1995;60:1047-1049.
Terasaki PI, Cecka JM, Gjertson DW, Takemoto S. High survival rates of kidney transplants from spousal and living unrelated donors. N Engl J Med. 1995;333:333-336.
Najarian JS, Gillingham KJ, Sutherland DE, et al. The impact of the quality of initial graft function on cadaver kidney transplants. Transplantation. 1994;57:812-816.
Najarian JS, Chavers BM, McHugh LE, et al. 20 years or more of follow-up of living kidney donors. Lancet. 1992;340(8823):807-810.
Johnson EM, Anderson JK, Jacobs C, et al. Long-term follow-up of living kidney donors: Quality of life after donation. Transplantation. 1999;67:717-721.
Campistol JM, Grinyo JM. Exploring treatment options in renal transplantation: The problems of chronic allograft dysfunction and drug-related nephrotoxicity. Transplantation. 2001;71(11 Suppl):SS42-SS51.
Soderberg-Naucler C, Emery VC. Viral infections and their impact on chronic renal allograft dysfunction. Transplantation. 2001;71(11 Suppl):SS24-SS30.
Paul LC. Immunologic risk factors for chronic renal allograft dysfunction. Transplantation. 2001;71(11 Suppl):SS17-SS23.
Markmann JF, Campos L, Velidedeoglu E, et al. Annual literature review--clinical transplants 2000. Clin Transpl. 2000;411-465.
Viberti G. Diabetes mellitus: A major challenge in transplantation. Transplant Proc. 2001;33(5A Suppl):3S-7S.
Konig P. Living kidney donation--selection criteria, preparation and follow-up. Acta Med Austriaca. 2001;28(3):70-73.
Curtis JJ. End-stage renal disease patients: Referral for transplantation. J Am Soc Nephrol. 1998;9(12 Suppl):S137-S140.
Steinman TI, Becker BN, Frost AE, et al. Guidelines for the referral and management of patients eligible for solid organ transplantation. Transplantation. 2001;71(9):1189-1204.
Cameron JS. Renal transplantation in the elderly. Int Urol Nephrol. 2000;32(2):193-201.
Basu A, Greenstein SM, Clemetson S, et al. Renal transplantation in patients above 60 years of age in the modern era: A single center experience with a review of the literature. Int Urol Nephrol. 2000;32(2):171-176.
Fabrizii V, Horl WH. Renal transplantation in the elderly. Curr Opin Urol. 2001;11(2):159-163.
Thervet E, Anglicheau D, Legendre C. Recent issues concerning renal transplantation in systemic lupus erythematosus patients. Nephrol Dial Transplant. 2001;16(1):12-14.
Jardine AG. Pretransplant management of end-stage renal disease patients to minimize posttransplant risk. Transplantation. 2000;70(11 Suppl):SS46-SS50.
Bishop MC. Infections associated with dialysis and transplantation. Curr Opin Urol. 2001;11(1):67-73.
Kasiske BL, Cangro CB, Hariharan S, et al. The evaluation of renal transplantation candidates: Clinical practice guidelines. Am J Transplant. 2002;1 Suppl 2:1-95.
Swedish Council on Technology Assessment in Health Care. Xenotransplantation: Renal transplantation example - early assessment briefs (ALERT). Stockholm, Sweden: Swedish Council on Technology Assessment in Health Care (SBU); 1999.
Noorani HZ, McGahan L. Criteria for selection of adult recipients for heart, cadaveric kidney and liver transplantation. Technology Report Issue 6. Ottawa, ON: Canadian Coordinating Office for Health Technology Assessment; 1999.
Tooher RL, et al. A systematic review of laparoscopic live donor nephrectomy (2nd update and re-appraisal). North Adelaide, ACT: Australian Safety and Efficacy Register of New Interventional Procedures - Surgical (ASERNIP-S); 2003.50320277.3460 - 519.9
Corbillon E, Poullie A-I, Doublet J-D. Laparoscopic versus open surgery live-donor nephrectomy. Paris, France: L'Agence Nationale d'Accreditation d'Evaluation en Sante (ANAES); 2004.
Knoll G, Cockvield S, Blydt-Hansen T, et al; The Kidney Transplant Working Group of the Canadian Society of Transplantation. Canadian Society of Transplantation consensus guidelines on eligibility for kidney transplantation. CMAJ. 2005;173(10):1-25.
Bhagani S, Sweny P; The British HIV Association. Guidelines for kidney transplantation in patients with HIV disease. London, UK: British HIV Association; 2005.
National Health Service (NHS), UKTransplant. Kidney (renal) allocation. Organ Allocation. London, UK: UKTransplant; 2006. Available at: http://www.uktransplant.org.uk/ukt/about_transplants. Accessed June 6, 2006.
Health Council of the Netherlands Gezondheidsraad (GR). The benefit of HLA-matching in kidney transplantation [summary]. The Haag, Netherlands: GR; 2006.
Ebeling PR. Transplantation osteoporosis. Curr Osteoporos Rep. 2007;5(1):29-37.
Palmer SC, McGregor DO, Strippoli GF. Interventions for preventing bone disease in kidney transplant recipients. Cochrane Database Syst Rev. 2007;(3):CD005015.
Hodson EM, Craig JC, Strippoli GF, Webster AC. Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients. Cochrane Database Syst Rev. 2008;(2):CD003774.
Pascual J, Zamora J, Galeano C, et al. Steroid avoidance or withdrawal for kidney transplant recipients. Cochrane Database Syst Rev. 2009;(1):CD005632.
Navaneethan SD, Perkovic V, Johnson DW, et al. HMG CoA reductase inhibitors (statins) for kidney transplant recipients. Cochrane Database Syst Rev. 2009;(2):CD005019.
Khatri P, Sarwal MM. Using gene arrays in diagnosis of rejection. Curr Opin Organ Transplant. 2009;14(1):34-39.
Hartono C, Muthukumar T, Suthanthiran M. Noninvasive diagnosis of acute rejection of renal allografts. Curr Opin Organ Transplant. 2010;15(1):35-41.
Chen Y, Tai Q, Hong S, et al. Pretransplantation soluble CD30 level as a predictor of acute rejection in kidney transplantation: A meta-analysis. Transplantation. 2012;94(9):911-918.
Copyright Aetna Inc. All rights reserved. Clinical Policy Bulletins are developed by Aetna to assist in administering plan benefits and constitute neither offers of coverage nor medical advice. This Clinical Policy Bulletin contains only a partial, general description of plan or program benefits and does not constitute a contract. Aetna does not provide health care services and, therefore, cannot guarantee any results or outcomes. Participating providers are independent contractors in private practice and are neither employees nor agents of Aetna or its affiliates. Treating providers are solely responsible for medical advice and treatment of members. This Clinical Policy Bulletin may be updated and therefore is subject to change.