Compression Garments for the Legs

Number: 0482

Policy

Note: Aetna's standard benefit plans do not cover graded compression stockings or non-elastic binders because they are considered an outpatient consumable or disposable supply.  Please check benefit plan descriptions for details.  

Inflatable compression garmentsFootnotes*, non-elastic bindersFootnotes**, or individually fitted prescription graded compression stockingsFootnotes*** are considered medically necessary for members who have any of the following medical conditions:

  1. Treatment of any of the following complications of chronic venous insufficiency:

    • Lipodermatosclerosis
    • Stasis dermatitis (venous eczema)
    • Varicose veins (except spider veins)
    • Venous edema
    • Venous ulcers (stasis ulcers)
       
  2. Edema accompanying paraplegia, quadriplegia, etc.
  3. Edema following surgery, fracture, burns, or other trauma
  4. Persons with lymphedema (see CPB 0069 - Lymphedema)
  5. Post sclerotherapyFootnotes****
  6. Post-thrombotic syndrome (post-phlebitic syndrome)
  7. Postural hypotension
  8. Prevention of thrombosis in immobilized persons (e.g., immobilization due to surgery, trauma, general debilitation, etc.)
  9. Severe edema in pregnancy

These compression garments for the legs are considered experimental and investigational for all other indications (e.g., improvement of functional performance in individuals with Parkinson disease, improvement of knee proprioception in rehabilitation setting, and management of spasticity following stroke).

Footnotes* The above reference to inflatable compression garments (e.g., Flowtron Compression Garment, Jobst Pneumatic Compressor) also includes the pump needed to inflate the compression garment.  For Aetna's clinical policy on intermittent and sequential compression pumps for lymphedema, see CPB 0069 - Lymphedema, and CPB 0500 - Intermittent Pneumatic Compression Devices.

Footnotes**Aetna considers non-elastic leg binders (e.g., CircAid, LegAssist, Reid Sleeve) medically necessary for members who meet the selection criteria for pressure gradient support stockings listed above.  Non-elastic leg binders are similar to graded compression stockings in that they provide static compression of the leg, but unlike graded compression stockings, they do not use elastic, but use adjustable Velcro or buckle straps.

Footnotes***Applies only to pre-made or custom-made pressure gradient support stockings (e.g., Jobst, Juzo, SigVarus, Venes, etc.) that have a pressure of 18 mm Hg or more, that require a physician's prescription, and that require measurements for fitting.

Footnotes****Only pressure gradient support stockings are considered medically necessary for this indication; inflatable compression garments have no proven value for this indication.

Stockings purchased over the counter without a prescription which have a pressure of less than 20 mm Hg (e.g., elastic stockings, support hose, surgical leggings, anti-embolism stockings (Ted hose) or pressure leotards) are considered experimental and investigational because these supplies have not been proven effective in preventing thromboembolism.  Note: These OTC stockings are also not covered because they are not primarily medical in nature.

Silver impregnated compression stockings are considered not medically necessary because there is insufficient evidence that silver impregnated compression stockings are superior to standard compression stockings.

Replacements

Replacements are considered medically necessary when the compression garment can not be repaired or when required due to a change in the member's physical condition.  For pressure gradient support stockings, no more than 4 replacements per year are considered medically necessary for wear.

Two pairs of compression stockings are considered medically necessary in the initial purchase (the 2nd pair is for use while the 1st pair is in the laundry).

Contraindications

Compression garments are considered experimental and investigational for members with severe peripheral arterial disease or septic phlebitis because they are contraindicated in these conditions.

Background

Compression garments are usually made of elastic material, and are used to promote venous or lymphatic circulation.  Compression garments worn on the legs can help prevent deep vein thrombosis and reduce edema, and are useful in a variety of peripheral vascular conditions.  Compression garments can come in varying degrees of compression.  The higher degrees require a physician's prescription. 

Fabric support garments are stockings or sleeves, usually made of elastic that may be utilized for, but not limited to, cases of severe edema, prevention of deep vein thrombosis (DVT), venous insufficiency or for certain burn injuries to lessen swelling and/or to reduce scarring. Alternatives to fabric support garments include dietary changes, exercise, limb elevation and weight control.

In an outcome-blinded, randomized controlled trial, Dennis et al (2009) evaluated the effectiveness of thigh-length graduated compression stockings (GCS) to reduce deep vein thrombosis (DVT) following stroke.  A total of 2,518 patients who were admitted to hospital within 1 week of an acute stroke and who were immobile were enrolled from 64 centers in the United Kingdom, Italy, and Australia.  Patients were allocated via a central randomization system to routine care plus thigh-length GCS (n = 1,256) or to routine care plus avoidance of GCS (n = 1,262).  A technician who was blinded to treatment allocation undertook compression Doppler ultrasound of both legs at about 7 to 10 days and, when practical, again at 25 to 30 days after enrolment.  The primary outcome was the occurrence of symptomatic or asymptomatic DVT in the popliteal or femoral veins.  Analyses were by intention-to-treat.  All patients were included in the analyses.  The primary outcome occurred in 126 (10.0 %) patients allocated to thigh-length GCS and in 133 (10.5 %) allocated to avoid GCS, resulting in a non-significant absolute reduction in risk of 0.5 % (95 % confidence interval [CI]: -1.9 % to 2.9 %).  Blisters, ulcers, skin breaks, and skin necrosis were significantly more common in patients allocated to GCS than in those allocated to avoid their use (64 [5 %] versus 16 [1 %]; odds ratio 4.18, 95 % CI: 2.40 to 7.27).  The authors concluded that these findings do not lend support to the use of thigh-length GCS in patients admitted to hospital with acute stroke.  National guidelines for stroke might need to be revised on the basis of these results.

The National Comprehensive Cancer Network's clinical practice guideline on venous thromboembolic disease (2010) states that GCS can be used in conjunction with a venous compression device as a method of mechanical prophylaxis.

Ibuki and colleagues (2010) examined the effect of 3 tone-reducing devices (dynamic foot orthosis, muscle stretch, and orthokinetic compression garment) on soleus muscle reflex excitability while standing in patients with spasticity following stroke.  A repeated measures intervention study was conducted on 13 patients with stroke selected from a sample of convenience.  A custom-made dynamic foot orthosis, a range of motion walker to stretch the soleus muscle and class 1 and class 2 orthokinetic compression garments were assessed using the ratio of maximum Hoffmann reflex amplitude to maximum M-response amplitude (Hmax:Mmax) to determine their effect on soleus muscle reflex excitability.  Only 10 subjects were able to complete the testing.  There were no significant treatment effects for the interventions (F = 1.208, df = 3.232, p = 0.328); however, when analyzed subject-by-subject, 2 subjects responded to the dynamic foot orthosis and 1 of those 2 subjects also responded to the class 1 orthokinetic compression garment.  Overall, the results demonstrated that the tone-reducing devices had no significant effect on soleus reflex excitability suggesting that these tone-reducing orthotic devices have no significant neurophysiologic effect on spasticity.

Jaccard and colleagues (2007) noted that silver fiber-containing compression stockings for the use in patients with chronic venous insufficiency (CVI) were introduced to the market.  In order to gain some first insight into the effects of these fabrics on the cutaneous microcirculation, a double-blind, randomized cross-over trial was performed in 10 healthy volunteers.  A 3 days run-in phase preceded the (2 x 10 days) treatment phases and was used to assess the reproducibility of the primary endpoint, which was the transcutaneous partial oxygen pressure (tcpO(2)) measured at a probe temperature of 44 degrees C in the peri-malleolar region of the reference leg in supine and dependent leg positions.  Coefficients of variation for double measured tcpO(2) values were 4.2 % (3.1 SD) and 5.8 % (6.0 SD) for the leg in supine and dependent position.  The intra-individual comparison of the effects from both treatment phases (value end of treatment - start of treatment) resulted in a negative tcpO(2) net balance for the regular hosiery (-0.93 (2.7 SD) mm Hg, supine; -1.1 (3.5 SD) mm Hg, dependent) but a positive net balance for the silver fibers containing stockings (0.25 (4.0 SD) mm Hg, supine; 1.7 (3.9 SD) mm Hg, dependent).  The inter-treatment differences were statistically significant for the leg in a dependent position.  The trial provides first evidence that interweaving silver threads into regular compression stockings may result in a positive effect regarding the nutritive skin perfusion.  This was a small study done with healthy subjects; it is unclear whether these findings can be extrapolated to patients who require compression stockings.

In a Cochrane review, O'Meara et al (2012) noted that the main treatment for venous (or varicose or stasis) ulcers is the application of a firm compression garment (bandage or stocking) in order to aid venous return.  There is a large number of compression garments available and it was unclear whether they are effective in treating venous ulcers and, if so, which method of compression is the most effective.  These researchers performed a systematic review of all randomized controlled trials (RCTs) evaluating the effects on venous ulcer healing of compression bandages and stockings.  Specific questions addressed by the review are: does the application of compression bandages or stockings aid venous ulcer healing? and which compression bandage or stocking system is the most effective?  For this second update these investigators searched: the Cochrane Wounds Group Specialised Register (May 31, 2012); the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 5, 2012); Ovid MEDLINE (1950 to May Week 4 2012); Ovid MEDLINE (In-Process & Other Non-Indexed Citations May 30, 2012); Ovid EMBASE (1980 to 2012 Week 21); and EBSCO CINAHL (1982 to May 30, 2012).  No date or language restrictions were applied.  Randomized controlled trials recruiting people with venous leg ulceration that evaluated any type of compression bandage system or compression stockings were eligible for inclusion.  Eligible comparators included no compression (e.g., primary dressing alone, non-compressive bandage) or an alternative type of compression.  Randomized controlled trials had to report an objective measure of ulcer healing in order to be included (primary outcome for the review). Secondary outcomes of the review included ulcer recurrence, costs, quality of life, pain, adverse events and withdrawals.  There was no restriction on date, language or publication status of RCTs.  Details of eligible studies were extracted and summarized using a data extraction table.  Data extraction was performed by 1 review author and verified independently by a 2nd review author.  A total of 48 RCTs reporting 59 comparisons were included (4,321 participants in total).  Most RCTs were small, and most were at unclear or high-risk of bias.  Duration of follow-up varied across RCTs.  Risk ratio (RR) and other estimates were shown below where RCTs were pooled; otherwise findings refer to a single RCT.  There was evidence from 8 RCTs (unpooled) that healing outcomes (including time to healing) are better when patients receive compression compared with no compression.  Single-component compression bandage systems are less effective than multi-component compression for complete healing at 6 months (1 large RCT).  A 2-component system containing an elastic bandage healed more ulcers at 1 year than one without an elastic component (1 small RCT).  Three-component systems containing an elastic component healed more ulcers than those without elastic at 3 to 4 months (2 RCTs pooled), RR 1.83 (95 % CI: 1.26 to 2.67), but another RCT showed no difference between groups at 6 months.  An individual patient data meta-analysis of 5 RCTs suggested significantly faster healing with the 4-layer bandage (4LB) than the short stretch bandage (SSB): median days to healing estimated at 90 and 99 respectively; hazard ratio 1.31 (95 % CI: 1.09 to 1.58).  High-compression stockings were associated with better healing outcomes than SSB at 2 to 4 months: RR 1.62 (95 % CI: 1.26 to 2.10), estimate from 4 pooled RCTs.  One RCT suggested better healing outcomes at 16 months with the addition of a tubular device plus single elastic bandage to a base system of gauze and crepe bandages when compared with 2 added elastic bandages.  Another RCT had 3 arms; when 1 or 2 elastic bandages were added to a base 3-component system that included an outer tubular layer, healing outcomes were better at 6 months for the 2 groups receiving elastic bandages.  There is currently no evidence of a statistically significant difference for the following comparisons: alternative single-component compression bandages (2 RCTs, unpooled); 2-component bandages compared with the 4LB at 3 months (3 RCTs pooled); alternative versions of the 4LB for complete healing at times up to and including 6 months (3 RCTs, unpooled); 4LB compared with paste bandage for complete healing at 3 months (2 RCTs, pooled), 6 months or 1 year (1 RCT for each time point); adjustable compression boots compared with paste bandages for the outcome of change in ulcer area at 3 months (1 small RCT); adjustable compression boots compared with the 4LB with respect to complete healing at 3 months (1 small RCT); single-layer compression stocking compared with paste bandages for outcome of complete healing at 4 months (1 small RCT) and 18 months (another small RCT); low compression stocking compared with SSB for complete healing at 3 and 6 months (1 small RCT);⋅compression stockings compared with a 2-component bandage system and the 4LB for the outcome of complete healing at 3 months (1 small, 3-armed RCT); and tubular compression compared with SSB (1 small RCT) for complete healing at 3 months.  Secondary outcomes: 4LB was more cost-effective than SSB.  It was not possible to draw firm conclusions regarding other secondary outcomes including recurrence, adverse events and health-related quality of life.  The authors concluded that compression increases ulcer healing rates compared with no compression.  Multi-component systems are more effective than single-component systems.  Multi-component systems containing an elastic bandage appear to be more effective than those composed mainly of inelastic constituents.  Two-component bandage systems appear to perform as well as the 4LB.  Patients receiving the 4LB heal faster than those allocated the SSB.  More patients heal on high-compression stocking systems than with the SSB.  They stated that further data are required before the difference between high-compression stockings and the 4LB can be established.

Improvement of Functional Performance in Individuals with Parkinson Disease

Southard and colleagues (2016) noted that symptoms of Parkinson's disease (PD) include bradykinesia, gait abnormalities, balance deficits, restless leg syndrome, and muscular fatigue.  Compression garments (CG) have been shown to improve performance in athletes by increasing venous return and reduce lactic acid.  These researchers evaluated the effect of CG on the performance of 3 standardized functional tests in persons with PD.  The functional tests selected represented strength, endurance, and mobility measures in individuals with PD.  A total of 19 males and 2 females (aged 48 to 85 years) with PD participated in this cross-over design study.  Subjects were randomly assigned to test under 2 conditions on 2 separate days:
  1. wearing below knee CG, and
  2. wearing sham stockings.
 Outcome measures included 5 Times Sit to Stand (5XSTS), gait speed, and 6 Minute Walk Test (6MWT).  There were 7 days between trials.  A paired t-test was used for each dependent variable.  Significance was set at p < 0.05.  There were no significant differences found between the CG and sham socks for all outcome measures.  Paired t-tests for the dependent variables were gait speed (p = 0.729); 5XSTS (p = 0.880); 6MWT (p = 0.265); and rate of perceived exertion (RPE) (p = 1.00).  The authors concluded that data to support the use of CG for enhanced proprioception, muscle power, speed, and endurance is in need of further study with the PD population.  In particular, it is recommended that future studies evaluate the possible physiological benefits of CG when worn during exercise interventions.

Improvement of Knee Proprioception in Rehabilitation Setting

In a counter-balanced, single-blinded, cross-over study, Ghai and associates (2016) examined the influence of below-knee CG on proprioception accuracy under differential information processing constraints designed to cause high or low conscious attention to the task.  A total of 44 healthy participants (26 males/18 females) with a mean age of 22.7 ± 6.9 years performed an active joint re-positioning task using their non-dominant and their dominant leg, with and without below-knee CG and with and without conducting a secondary task.  Analysis of variance revealed no main effect of leg dominance and no interactions (p's > 0.05).  However, a main effect was evident for both compression (F1, 43 = 84.23, p < 0.001, ηp2 = 0.665) and secondary task (F1, 43 = 4.391, p = 0.04, ηp2 = 0.093).  The authors concluded that this study was the first to evaluate the effects of a below knee CG on knee proprioception under differential information processing constraints.  They stated that proprioception accuracy of the knee joint is significantly enhanced post application of below-knee CG and when a secondary task is conducted concurrently with active joint re-positioning.  They noted that these findings suggested that below-knee CG may improve proprioception of the knee, regardless of leg dominance, and that secondary tasks that direct attention away from proprioceptive judgments may also improve proprioception, regardless of the presence of compression.  The authors discussed clinical implications with respect to proprioception in modern sports and rehabilitation settings.

Table: CPT Codes / HCPCS Codes / ICD-10 Codes
Code Code Description

Information in the [brackets] below has been added for clarification purposes.   Codes requiring a 7th character are represented by "+":

HCPCS codes covered if selection criteria are met:
A4465 Non-elastic binder for extremity
A6507 Compression burn garment, foot to knee length, custom fabricated
A6508 Compression burn garment, foot to thigh length, custom fabricated
A6530 - A6549 Gradient compression stocking
E0650 Pneumatic compressor, non-segmental home model
E0651 Pneumatic compressor, segmental home model without calibrated gradient pressure
E0652 Pneumatic compressor, segmental home model with calibrated gradient pressure
E0660 Non-segmental pneumatic appliance for use with pneumatic compressor, full leg
E0666 Non-segmental pneumatic appliance for use with pneumatic compressor, half leg
E0667 Segmental pneumatic appliance for use with pneumatic compressor, full leg
E0669 Segmental pneumatic appliance for use with pneumatic compressor, half leg
E0671 Segmental gradient pressure pneumatic appliance, full leg
E0673 Segmental gradient pressure pneumatic appliance, half leg

HCPCS codes not covered for indications listed in the CPB:
E0675 Pneumatic compression device, high pressure, rapid inflation/deflation cycle, for arterial insufficiency (unilateral or bilateral system)

ICD-10 codes covered if selection criteria are met:
G81.00 - G81.94 Hemiplegia and hemiparesis
G82.20 - G83.9 Paraplegia (paraparesis), quadriplegia (quadriparesis) and other paralytic syndromes
I80.00 - I80.209
I80.221 - I80.3		 Phlebitis and thrombophlebitis of superficial or deep vessels of lower extremities
I83.001 - I83.899 Varicose veins of lower extremities, with ulcer, with inflammation, with ulcer and inflammation, or with other complications
I87.00 - I87.099 Postthrombotic syndrome
I87.2 Venous insufficiency (chronic)(peripheral)
I89.0 - I89.9 Other noninfective disorders of lymphatic vessels and lymph nodes
I95.1 Orthostatic hypotension
O12.00 - O12.05 Gestational edema
O22.00 - O22.03, O87.4 Varicose veins of lower extremity in pregnancy
O90.89 Other complications of the puerperium, not elsewhere classified [postpartum edema]
Q82.0 Hereditary lymphedema
R60.0 - R60.9 Edema, not elsewhere classified
Z74.01 Bed confinement status

ICD-10 codes not covered for indications listed in the CPB:
G20 Parkinson's disease
I70.201 - I70.299 Atherosclerosis of native arteries of the extremities
I70.301 - I70.799 Atherosclerosis of bypass graft of the extremities
I73.00 - I73.9
I77.70 - I77.79		 Other peripheral vascular disease
I74.2 - I74.4 Embolism and thrombosis of arteries of the extremities
I77.1 Stricture of artery
I77.89 Other specified disorders of arteries and arterioles

The above policy is based on the following references:

  1. Herouy Y. Lipodermatosclerosis and compression stockings. J Am Acad Dermatol. 2000;42(2 Pt 1):307-308.
  2. Agnelli G, Sonaglia F. Prevention of venous thromboembolism. Thromb Res. 2000;97(1):V49-V62.
  3. Clement DL. Management of venous edema: Insights from an international task force. Angiology. 2000;51(1):13-17.
  4. Freedman MD. Clinical therapeutic conference: Recurrent venous thrombotic and thromboembolic disease. Am J Ther. 1998;5(1):51-56.
  5. Agu O, Hamilton G, Baker D. Graduated compression stockings in the prevention of venous thromboembolism. Br J Surg. 1999;86(8):992-1004.
  6. Buchtemann AS, Steins A, Yolkert B, et al. The effect of compression therapy on venous haemodynamics in pregnant women. Br J Obstet Gynaecol. 1999;106(6):563-569.
  7. Baker S, Fletcher A, Glanville J, et al. Compression therapy for venous leg ulcers. Effective Health Care. 1997;3(1).
  8. Phillips TJ. Successful methods of treating leg ulcers. The tried and true, plus the novel and new. Postgrad Med. 1999;105(5):159-161, 165-166, 173-174 passim.
  9. Neumann HA. Compression therapy with medical elastic stockings for venous diseases. Dermatol Surg. 1998;24(7):765-770.
  10. Greer IA. Epidemiology, risk factors and prophylaxis of venous thrombo-embolism in obstetrics and gynaecology. Baillieres Clin Obstet Gynaecol. 1997;11(3):403-430.
  11. Veraart JC, Daamen E, de Vet HC, et al. Elastic compression stockings: durability of pressure in daily practice. Vasa. 1997;26(4):282-286.
  12. Mohr DN, Silverstein MD, Murtaugh PA, et al. Prophylactic agents for venous thrombosis in elective hip surgery. Meta-analysis of studies using venographic assessment. Arch Intern Med. 1993;153(19):2221-2228.
  13. Alguire PC, Mathes BM. Chronic venous insufficiency and venous ulceration. J Gen Intern Med. 1997;12(6):374-383.
  14. Brandjes DP, Buller HR, Heijboer H, et al. Randomized trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis. Lancet. 1997;349(9054):759-762.
  15. Yashura H, Shigematsu, H, Muto T. A study of the advantages of elastic stockings for leg lymphedema. Int Angiol. 1996;15(3):272-277.
  16. Imperiale TF, Speroff T. A meta-analysis of methods to prevent venous thromboembolism following total hip replacement. JAMA. 1994;271(22):1780-1785.
  17. Wells PS, Lensing AW, Hirsh J. Graduated compression stockings in the prevention of postoperative venous thromboembolism. Arch Intern Med. 1994;154(1):67-72.
  18. Trinity Lymphedema Centers. LegAssist Non-Elastic Adjustable Limb Containment System [website]. Tampa, FL: Trinity Lymphedema Centers; 2002. Available at: http://www.trinitylc.com/cmpgarm1.html. Accessed April 26, 2002.
  19. Leduc O, Leduc A. Rehabilitation protocol in upper limb lymphedema. Ann Ital Chir. 2002;73(5):479-484.
  20. Spence RK, Cahall E. Inelastic versus elastic leg compression in chronic venous insufficiency: a comparison of limb size and venous hemodynamics. J Vasc Surg. 1996; 24(5):783-787.
  21. Bergan JJ, Sparks SR. Non-elastic compression: An alternative in management of chronic venous insufficiency. J Wound Ostomy Continence Nurs. 2000;27(2):83-89.
  22. Lund E. Exploring the use of CircAid(R) legging in the management of lymphoedema. Int J Palliat Nurs. 2000; 6(8):383-391.
  23. O'Meara S, Cullum NA, Nelson EA. Compression for venous leg ulcers. Cochrane Database Syst Rev. 2009;(1):CD000265.
  24. Nelson EA, Bell-Syer SEM, Cullum NA. Compression for preventing recurrence of venous ulcers. Cochrane Database Syst Rev. 2000;(4):CD002303.
  25. Kolbach DN, Sandbrink MWC, Hamulyak K, et al.  Non-pharmaceutical measures for prevention of post-thrombotic syndrome. Cochrane Database Syst Rev. 2003;(3):CD004174.
  26. Kolbach DN, Sandbrink MWC, Neumann HAM, Prins MH. Compression therapy for treating stage I and II (Widmer) post-thrombotic syndrome. Cochrane Database Syst Rev. 2003;(4):CD004177.
  27. Amaragiri SV, Lees TA. Elastic compression stockings for prevention of deep vein thrombosis. Cochrane Database Syst Rev. 2000;(1):CD001484.
  28. CIGNA HealthCare Medicare Administration. Coverage of compression garments in the treatment of venous stasis ulcers. CMS News and Information. Philadelphia, PA: CIGNA; July 15, 2003. Available at: http://www.cignamedicare.com/articles/july03/cope636.html. Accessed November 7, 2003.
  29. Velmahos GC, Kern J, Chan L, et al. Prevention of venous thromboembolism after injury. Evidence Report/Technology Assessment No. 22. Rockville, MD: Agency for Healthcare Research and Quality (AHRQ); 2000.
  30. Byrne B. Deep vein thrombosis prophylaxis: The effectiveness and implications of using below-knee or thigh-length graduated compression stockings. Heart Lung. 2001;30(4):277-284.
  31. Johnston R. The effectiveness of below knee thromboembolic deterrent garments compared to full length garments in preventing deep vein thrombosis. Evidence Centre Evidence Report. Clayton, VIC: Centre for Clinical Effectiveness (CCE); 2001.
  32. Cullum N, Nelson EA, Flemming K, Sheldon T. Systematic reviews of wound care management: (5) beds; (6) compression; (7) laser therapy, therapeutic ultrasound, electrotherapy and electromagnetic therapy. Health Technol Assess. 2001;5(9):1-221.
  33. Mazzone C, Chiodo Grandi F, Sandercock P, et al. Physical methods for preventing deep vein thrombosis in stroke. Cochrane Database Syst Rev. 2004;(4):CD001922.
  34. Young G. Leg cramps. In: BMJ Clinical Evidence. London, UK: BMJ Publishing Group; September 2008.
  35. McManus R, Fitzmaurice D, Murray ET, Taylor C. Thromboembolism. In: BMJ Clinical Evidence. London, UK: BMJ Publishing Group; August 2009.
  36. Tisi P. Varicose veins. In: BMJ Clinical Evidence. London, UK: BMJ Publishing Group; May 2007.
  37. Nelson EA, Jones J. Venous leg ulcers. In: BMJ Clinical Evidence. London, UK: BMJ Publishing Group; September 2007.
  38. O'Brien JG, Chennubhotla SA, Chennubhotla RV. Treatment of edema. Am Fam Physician. 2005;71(11):2111-2117.
  39. Roderick P, Ferris G, Wilson K, et al. Towards evidence-based guidelines for the prevention of venous thromboembolism: Systematic reviews of mechanical methods, oral anticoagulation, dextran and regional anaesthesia as thromboprophylaxis. Health Technol Assess. 2005;9(49):1-78.
  40. Warren AG, Janz BA, Borud LJ, Slavin SA. Evaluation and management of the fat leg syndrome. Plast Reconstr Surg. 2007;119(1):9e-15e.
  41. Bamigboye AA, Smyth R. Interventions for varicose veins and leg oedema in pregnancy. Cochrane Database Syst Rev. 2007;(1):CD001066.
  42. Amsler F, Blattler W. Compression therapy for occupational leg symptoms and chronic venous disorders: A meta-analysis of randomised controlled trials. European J Vasc Endovasc Surg. 2008;35(3):366-372.
  43. CLOTS Trials Collaboration, Dennis M, Sandercock PA, Reid J, et al. Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): A multicentre, randomised controlled trial. Lancet. 2009;373(9679):1958-1965.
  44. National Comprehensie Cancer Network (NCCN). Venous thromboembolic disease. NCCN Clinical Practice Guidelines in Oncology, v.1.2010. Fort Washington, PA: NCCN; 2010.
  45. Ibuki A, Bach T, Rogers D, Bernhardt J. The effect of tone-reducing orthotic devices on soleus muscle reflex excitability while standing in patients with spasticity following stroke. Prosthet Orthot Int. 2010;34(1):46-57.
  46. Jaccard Y, Singer E, Degischer S, et al. Effect of silver-threads-containing compression stockings on the cutaneous microcirculation: A double-blind, randomized cross-over study. Clin Hemorheol Microcirc. 2007;36(1):65-73.
  47. Work Loss Data Institute. Knee & leg (acute & chronic). Encinitas, CA: Work Loss Data Institute; 2011. 
  48. O'Meara S, Cullum N, Nelson EA, Dumville JC. Compression for venous leg ulcers. Cochrane Database Syst Rev. 2012;11:CD000265.
  49. Wigg J, Lee N. Use of compression shorts in the management of lymphoedema and lipoedema. Br J Community Nurs. 2014;19 Suppl 10:S30-S35.
  50. Southard V, DiFrancisco-Donoghue J, Mackay J, et al. The effects of below knee compression garments on functional performance in individuals with Parkinson disease. Int J Health Sci (Qassim). 2016;10(3):373-380.
  51. Ghai S, Driller MW, Masters RS. The influence of below-knee compression garments on knee-joint proprioception. Gait Posture. 2016 Aug 9 [Epub ahead of print].