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Aetna Aetna
Clinical Policy Bulletin:
Brachytherapy
Number: 0371


Policy

  1. Aetna considers brachytherapy (also known as interstitial radiation, intracavitary radiation, internal radiation therapy) medically necessary for the following conditions:

    1. Breast cancer (such as the MammoSite Radiation Therapy System (Proxima Therapeutics, Alpharetta, GA)); and
    2. Eye tumors (e.g., choroidal melanoma); and
    3. Genitourinary cancers other than bladder cancer (including cervical cancer, endometrial cancer, penile cancer, prostate cancer, urethral cancer, vaginal cancer); and
    4. Head and neck cancers (including buccal mucosa cancer, esophageal cancer, lip cancer, mouth cancer, nasopharyngeal cancer, salivary gland cancer, soft palate cancer, tonsillar fossa/pillar cancer); and
    5. Respiratory and digestive tract cancers (including lung cancer (for palliation of obstructive symptoms due to intraluminal tumor), pelvic recurrence of colorectal cancer, pleural mesotheliomas, rectal (anal) cancer); and
    6. Soft tissue sarcomas; and
    7. Stenotic obstruction post lung transplantation refractory to other treatments such as balloon dilation, laser debridement, or stent placement.
       
  2. Aetna considers brachytherapy experimental and investigational for all other indications (e.g., brain tumors, bladder cancer, subfoveal choroidal neovascularization secondary to age-related macular degeneration) because its effectiveness for indications other than the ones listed above has not been established.

  3. Aetna considers electronic brachytherapy experimental and investigational for breast cancer and all other indications (e.g., non-melanoma skin cancer) because its effectiveness has not been established.

  4. Aetna considers endovascular/intravascular brachytherapy to reduce re-stenosis following percutaneous femoropopliteal angioplasty/peripheral vascular disease experimental and investigational because its effectiveness has not been established.

  5. The combination of brachytherapy and external beam radiation therapy (ProstRcision) has not been proven to be more effective than other established alternatives for the treatment of prostate cancer.

Notes:

Brachytherapy may be used in conjunction with surgery.  Tumors close to critical structures that can not be resected with adequate surgical margins may also be treated by interstitial brachytherapy.

Brachytherapy may be used either alone or in combination with external beam radiation.

See also CPB 0491 - Coronary Artery Brachytherapy and Other Adjuncts to Coronary Interventions.



Background

Brachytherapy is a type of radiation therapy in which the radiation device is placed within or close to the target site, in contrast to teletherapy which uses a device removed from the patient.  In general, any solid tumor that is sufficiently localized may be treated by interstitial brachytherapy.  A variety of radioactive isotopes are employed in brachytherapy including lower energy sources usually for permanent implantation such as Palladium-103 and Iodine-125, as well as higher energy sources such as Iridium-192, Gold-198, and Cesium-137, which, except for Gold-198, are used for limited periods of time via after loading catheters.

Traditionally, brachytherapy has been employed in the treatment of gynecologic tumors (uterine cervix and endometrium) employing Radium-226 (Ra-226), Cobalt-60 (Co-60), and Cesium-137 (Cs-137).  Similarly, therapy of oropharyngeal tumors may require interstitial brachytherapy, such as radium needles, Cs-137 or Iridium-192 (Ir-192) in selected carcinomas of the lip, nasal vestibule or floor of mouth lesions, radium in oral tongue cancers, Gold-198 (Au-198) seeds or Ir-192 ribbons or catheters for base of tongue lesions (3) or tonsillar malignancies (radon or gold seeds).  In pelvic recurrences of colorectal tumors or in anal or bile duct cancers, interstitial Ir-192 or Iodine-125 (I-125) boosts may be combined with external beam radiation therapy (EBRT).  In superficial bladder tumors, penile cancers and small tumors of the female urethra, interstitial implantation with Ra-226, Cs-137 or Ir-192 may be necessary.

Interstitial brachytherapy is indicated for stages A2 and B prostatic cancer and for malignant brain tumors.  A variety of other tumors have been treated by this technique, including ophthalmic malignancies of the choroid or retina, hepatocellular carcinomas, unresectable esophageal cancers, pulmonary malignancies, as well as an adjunct to surgical treatment of neoplasms in varying anatomic locations, when tumors attached or adjacent to critical structures can not be completely excised or resected with adequate surgical margins.

The MammoSite Radiation Therapy System (Proxima Therapeutics, Alpharetta, GA) is an alternative to interstitial brachytherapy with either seeds or needles to treat the intact breast lumpectomy site.  With the MammoSite technique, the lumpectomy cavity is dilated by a balloon and a single high-dose radiation source is positioned within the central portion of the balloon to deliver a uniform dose to the walls of the lumpectomy cavity.  Although the MammoSite technique may offer a more uniform dose distribution over older techniques of interstitial brachytherapy implants, it has not been shown to offer any appreciable improvement in dosimetry over conventional external beam radiation.  The primary justification for breast brachytherapy is a lack of patient compliance with conventional post-operative external beam radiotherapy.  The MammoSite offers the convenience of a short course of treatment, usually 10 high-dose radiation applications done twice-daily over 5 days.  By contrast, external beam radiotherapy usually requires 5 to 7 weeks of treatment post-operatively.  Another system that has been cleared by the Food and Drug Administration (FDA) for interstitial breast brachytherapy is the MammoTest Breast Biopsy System (Fischer Imaging Corporation, Denver, CO).

Electronic brachytherapy (EBT) has been developed to offer advantages over standard radioactive brachytherapy in the areas of radiation safety both to the patient as well as the personnel administering the treatment.  The Axxent Electronic Brachytherapy System uses disposable miniature X-ray radiation sources to deliver electronically generated ionizing radiation directly to tumor beds.  Electronic brachytherapy is intended to minimize exposure of the patient's healthy tissue to unnecessary radiation.  Electronic brachytherapy uses X-ray energy to allow more flexibility than radioisotope-based brachytherapy systems that are currently in use.  Electronic brachytherapy does not require a heavily shielded environment, so that it has potential for use in a broad array of clinical settings.  The Axxent Electronic Brachytherapy System was cleared for use in breast cancer by the FDA based on a 510(k) application.  Electronic brachytherapy has potential for use in administering high-dose rate brachytherapy for breast cancer (BCBSA, 2007; CTAF, 2006).  However, there is insufficient evidence in the peer-reviewed published medical literature comparing outcomes of EBT with standard radioisotope-based brachytherapy.

In an observational, non-randomized, multi-center study, Beitsch et al (2010) evaluated EBT as a post-surgical adjuvant radiation therapy for early stage breast cancer.  This study included women aged 50 years or more with invasive carcinoma or ductal carcinoma in situ, tumor size less than or equal to 3 cm, negative lymph node status, and negative surgical margins.  The end points were skin and subcutaneous toxicities, efficacy outcomes, cosmetic outcomes, and device performance.  In this interim report, 1-month, 6-month, and 1-year follow-up data were available on 68, 59, and 37 patients, respectively.  The EBT device performed consistently, delivering the prescribed 34 Gy to all 69 patients (10 fractions/patient).  Most adverse events were grade 1 and included firmness, erythema, breast tenderness, hyper-pigmentation, pruritis, field contracture, seroma, rash/desquamation, palpable mass, breast edema, hypo-pigmentation, telangiectasia, and blistering, which were anticipated. Breast infection occurred in 2 (2.9 %) patients.  No tumor recurrences were reported.  Cosmetic outcomes were excellent or good in 83.9 % to 100 % of evaluable patients at 1 month, 6 months, and 1 year.  The authors concluded that this observational, non-randomized, multi-center study demonstrated that this EBT device was reliable and well-tolerated as an adjuvant radiation therapy for early stage breast cancer.  These findings are limited by the length of follow-up, and longer follow-up data are needed.

Ahmad et al (2010) compared treatment plans for patients treated with EBT using the Axxent System as adjuvant therapy for early stage breast cancer with treatment plans prepared from the same CT image sets using an Ir-192 source.  Patients were implanted with an appropriately sized Axxent balloon applicator based on tumor cavity size and shape.  A CT image of the implanted balloon was utilized for developing both EBT and Ir-192 brachytherapy treatment plans.  The prescription dose was 3.4 Gy per fraction for 10 fractions to be delivered to 1 cm beyond the balloon surface.  Iridium plans were provided by the sites on 35 of the 44 patients enrolled in the study.  The planning target volume coverage was very similar when comparing sources for each patient as well as between patients.  There were no statistical differences in mean % V100.  The percent of the planning target volume in the high-dose region was increased with EBT as compared with Iridium (p < 0.001).  The mean maximum calculated skin and rib doses did not vary greatly between EBT and Iridium.  By contrast, the doses to the ipsilateral lung and the heart were significantly lower with eBx as compared with Iridium (p < 0.0001).  The total nominal dwell times required for treatment can be predicted by using a combination of the balloon fill volume and planned treatment volume (PTV).  This dosimetric comparison of EBT and Iridium sources demonstrated that both forms of balloon-based brachytherapy provide comparable dose to the planning target volume.  The authors concluded that EBT is significantly associated with increased dose at the surface of the balloon and decreased dose outside the PTV, resulting in significantly increased tissue sparing in the heart and ipsilateral lung.  This was a dosimetric comparison study with no clinical data on health outcomes.

Njeh and colleagues (2010) noted that breast conservation therapy (BCT) is the procedure of choice for the management of the early stage breast cancer.  However, its utilization has not been maximized because of logistics issues associated with the protracted treatment involved with the radiation treatment.  Accelerated partial breast irradiation (APBI) is an approach that treats only the lumpectomy bed plus a 1 to 2 cm margin, rather than the whole breast.  Hence, because of the small volume of irradiation, a higher dose can be delivered in a shorter period of time.  There has been growing interest for APBI and various approaches have been developed under phase I to III clinical studies; these include multi-catheter interstitial brachytherapy, balloon catheter brachytherapy, conformal external beam radiation therapy and intra-operative radiation therapy (IORT).  Balloon-based brachytherapy approaches include Mammosite, Axxent EBT and Contura, hybrid brachytherapy devices include SAVI and ClearPath.  The authors reviewed the different techniques, identifying the weaknesses and strength of each approach and proposed a direction for future research and development.  It is evident that APBI will play a role in the management of a selected group of early breast cancer.  However, the relative role of the different techniques is yet to be clearly identified.

Ivanov et al (2011) reported 1-year results and clinical outcomes of a trial that utilizes EBT to deliver IORT for patients with early-stage breast cancer.  A total of 11 patients were enrolled on an institutional review board (IRB)-approved protocol. Inclusion criteria were patient age greater than 45 years, unifocal tumors with infiltrating ductal or ductal carcinoma in situ (DCIS) histology, tumors less than or equal to 3 cm, and uninvolved lymph nodes.  Preloaded radiation plans were used to deliver radiation prescription dose of 20 Gy to the balloon surface.  The mean time for radiation delivery was 22 mins; the total mean procedure time was 1 hr 39 mins.  All margins of excision were negative on final pathology.  At mean follow-up of 12 months, overall cosmesis was excellent in 10 of 11 patients.  No infection, fat necrosis, desquamation, rib fracture or cancer recurrence has been observed.  There was no evidence of fibrosis at last follow-up.  The authors concluded that IORT utilizing EBT is emerging as a feasible, well-tolerated alternative to post-surgical APBI.  They stated that further research and longer follow-up data on EBT and other IORT methods are needed to establish the clinical efficacy and safety of this treatment.

Bhatnagar and Loper (2010) reported their initial experience of EBT for the treatment of non-melanoma skin cancer.  Data were collected retrospectively from patients treated from July 2009 through March 2010.  Pre-treatment biopsy was performed to confirm a malignant cutaneous diagnosis.  A CT scan was performed to assess lesion depth for treatment planning, and an appropriate size of surface applicator was selected to provide an acceptable margin.  An HDR EBT system delivered a dose of 40.0 Gy in 8 fractions twice-weekly with 48 hours between fractions, prescribed to a depth of 3 to 7 mm.  Treatment feasibility, acute safety, efficacy outcomes, and cosmetic results were assessed.  A total of 37 patients (mean age of 72.5 years) with 44 cutaneous malignancies were treated.  Of 44 lesions treated, 39 (89 %) were T1, 1 (2 %) Tis, 1 (2 %) T2, and 3 (7 %) lesions were recurrent.  Lesion locations included the nose for 16 lesions (36.4 %), ear 5 (11 %), scalp 5 (11 %), face 14 (32 %), and an extremity for 4 (9 %).  Median follow-up was 4.1 months.  No severe toxicities occurred.  Cosmesis ratings were good to excellent for 100 % of the lesions at follow-up.  The authors concluded that the early outcomes of EBT for the treatment of non-melanoma skin cancer appear to show acceptable acute safety and favorable cosmetic outcomes.  They stated that long-term follow-up is in progress to further assess efficacy and cosmesis.

In a multi-center clinical study, Dickler et al (2010) evaluated the success of treatment delivery, safety and toxicity of EBT in patients with endometrial cancer.  A total of 15 patients with stage I or II endometrial cancer were enrolled at 5 sites.  Patients were treated with vaginal EBT alone or in combination with external beam radiation.  The prescribed doses of EBT were successfully delivered in all 15 patients.  From the first fraction through 3 months follow-up, there were 4 common toxicity criteria (CTC) grade 1 adverse events and 2 CTC grade II adverse events reported that were EBT-related.  The mild events reported were dysuria, vaginal dryness, mucosal atrophy, and rectal bleeding.  The moderate treatment related adverse events included dysuria, and vaginal pain.  No grade III or IV adverse events were reported.  The EBT system performed well and was associated with limited acute toxicities.  The authors concluded that EBT shows acute results similar to HDR brachytherapy.  They stated that additional research is needed to further assess the clinical efficacy and safety of EBT in the treatment of endometrial cancer.

The American Society for Therapeutic Radiology and Oncology (ASTRO) Emerging Technology Committee's report on EBT (Park et al, 2010) stated that "advantages of EBT over existing technologies are as yet unproven in terms of efficacy or patient outcomes".  The report explains the impact of clinical use of electronic brachytherapy could be far-reaching, and if used improperly, potentially harmful to patients.  The report explains that electronic brachytherapy is currently an unregulated treatment delivery modality for cancer therapy, with minimal clinical data available from small single institution, studies, none with significant follow-up.  It also noted that there are currently no accepted calibration standards for EBT.  Thus, there can be large uncertainties associated with absorbed dose measurement at low energies.  Furthermore, the report stated that the effects of EBT on tumor and normal tissues are not yet well understood, given the paucity of clinical studies.

Published data on electronic brachytherapy comes from studies which are small, mostly single center studies with limited follow-up.  Much of this evidence is from low-quality retrospective studies.  Other evidence comes from dosimetric planning studies rather than studies reporting actual clinical outcomes.  The TARGET-A study is an exception in that it is a large, multi-center prospective study (Vaidya et al, 2011).  This study, however, did not employ direct comparisons between electronic brachytherapy and established methods of high-dose rate brachytherapy using radioactive isotopes.

Avila and colleagues (2009) assessed the short-term safety and feasibility of epiretinal strontium-90 brachytherapy delivered concomitantly with intra-vitreal bevacizumab for the treatment of subfoveal choroidal neovascularization (CNV) due to age-related macular degeneration (AMD) for 12 months.  A 3-year follow-up is planned.  In this prospective, non-randomized, multi-center study, 34 treatment-naïve patients with predominantly classic, minimally classic and occult subfoveal CNV lesions received a single treatment with 24 Gy beta radiation (strontium-90) and 2 injections of the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab.  Adverse events were observed.  Best corrected visual acuity (BCVA) was measured using standard Early Treatment Diabetic Retinopathy Study (ETDRS) vision charts.  Twelve months after treatment, no radiation-associated adverse events were observed.  In the intent-to-treat (ITT) population, 91 % of patients lost less than 3 lines (15 ETDRS letters) of vision at 12 months, 68 % improved or maintained their BCVA at 12 months, and 38 % gained greater than or equal to 3 lines.  The mean change in BCVA observed at month 12 was a gain of 8.9 letters.  The authors concluded that the safety and effectiveness of intra-ocular, epiretinal brachytherapy delivered concomitantly with anti-VEGF therapy for the treatment of subfoveal CNV secondary to AMD were promising in this small study population.  They stated that long-term safety will be assessed for 3 years.  This regimen is being evaluated in a large, multi-center, phase III study.

In a multi-center, randomized, active-controlled, phase III clinical trial, Dugel et al (2013) evaluated the safety and effectiveness of epi-macular brachytherapy (EMBT) for the treatment of neovascular AMD.  A total of 494 participants with treatment-naïve neovascular AMD were enrolled in this study.  Participants with classic, minimally classic, and occult lesions were randomized in a 2:1 ratio to EMBT or a ranibizumab monotherapy control arm.  The EMBT arm received 2 mandated, monthly loading injections of 0.5 mg ranibizumab.  The control arm received 3 mandated, monthly loading injections of ranibizumab then quarterly injections.  Both arms also received monthly as needed (pro re nata) re-treatment.  Main outcome measures were the proportion of participants losing fewer than 15 ETDRS letters from baseline VA and the proportion gaining more than 15 ETDRS letters from baseline VA.  At 24 months, 77 % of the EMBT group and 90 % of the control group lost fewer than 15 letters.  This difference did not meet the pre-specified 10 % non-inferiority margin.  This end-point was non-inferior using a 20 % margin and a 95 % CI for the group as a whole and for classic and minimally classic lesions, but not for occult lesions.  The EMBT did not meet the superiority end-point for the proportion of participants gaining more than 15 letters (16 % for the EMBT group versus 26 % for the control group): this difference was statistically significant (favoring controls) for occult lesions, but not for predominantly classic and minimally classic lesions.  Mean VA change was -2.5 letters in the EMBT arm and +4.4 letters in the control arm.  Participants in the EMBT arm received a mean of 6.2 ranibizumab injections versus 10.4 in the control arm.  At least 1 serious adverse event occurred in 54 % of the EMBT arm, most commonly post-vitrectomy cataract, versus 18 % in the control arm.  Mild, non-proliferative radiation retinopathy occurred in 3 % of the EMBT participants, but no case was vision threatening.  The authors concluded that the 2-year effectiveness data do not support the routine use of EMBT for treatment-naive wet AMD, despite an acceptable safety profile.  They stated that further safety review is needed.

Ashida and Chang (2009) stated that since the curved linear array echo-endoscope (linear EUS) was developed in the 1990s, EUS has evolved from EUS imaging, to EUS-guided fine needle aspiration (FNA), and now to EUS-guided fine needle injection, giving EUS even wider application.  This advancement has brought "interventional EUS" into the pancreato-biliary field.  Interventional EUS for pancreatic cancer includes delivery of contrast agents, drainage/anastomosis, celiac neurolysis (including ganglion neorolysis), radiofrequency ablation, photodynamic therapy, brachytherapy, as well as delivery of a growing number of anti-tumor agents.  Al-Haddad and Eloubeidi (2010) noted that coupled with FNA, EUS provides high accuracy for the diagnosis and staging of pancreatic cancer.  Novel EUS-based techniques have emerged as a safe minimally invasive alternative to the surgical or radiological approaches.  By allowing better pain control, delivering anti-tumor therapies or draining obstructed bile ducts, such techniques hold a big promise to improve the quality of life of patients with unresectable pancreatic cancer.

Mitchell et al (2012) noted that re-stenosis is a fundamental weakness of percutaneous femoropopliteal angioplasty (PTA).  The potential of endovascular brachytherapy (EVBT) to reduce re-stenosis has been evaluated in randomized clinical trials (RCTs), but no pooled analysis has been undertaken.  These investigators performed a systematic review to identify RCTs in which PTA alone was compared to PTA plus EVBT.  The Pubmed and Medline databases, American Heart Association OASIS database and conference proceedings from the Peripheral Vascular Surgery Society and Vascular Society of Great Britain and Ireland were searched.  Eligible studies were RCTs comparing PTA to PTA plus EVBT in human subjects with at least 1 clinical outcome reported (re-stenosis, complications, patency).  Study quality was assessed by the Jadad score.  Random-effects modeling was used to generate pooled effect size estimates.  A total of 6 trials (687 patients) were identified.  Endovascular brachytherapy reduced 12-month re-stenosis rates (pooled odds ratio 0.50; 95 % confidence intervals [CI]: 0.301 to 0.836; p = 0.008).  The benefit disappeared by 24 months.  The short-term risk of new lesions elsewhere in the treated artery was significantly increased by EVBT (pooled odds ratio 8.65; 95 % CI: 2.176 to 34.391; p = 0.002).  The authors concluded that while limited by the small sample sizes in the included trials, this analysis suggests that the early benefit of EVBT is counter-balanced by the increased risk of new lesions and the lack of medium- to long-term reductions in re-stenosis risk.  Based upon the best available evidence, EVBT can not be recommended for routine clinical use.

The Alberta Health Services’ clinical guideline on “Penile cancer” (2012) listed brachytherapy as a management option for Tis, Ta N0 M0 (Stage 0); T1 N0 M0 (Stage I); as well as T2 N0 M0 (Stage II) and T3 N0 M0 (Early Stage III) penile cancers.

Mattiucci et al (2013) explored the role of radiotherapy in the extra-hepatic bile duct carcinoma, and examined if and when radiotherapy could be effective for this group of patients.  These investigators performed a systematic review of recently published literature.  Recent studies using radiotherapy with survival data, resection rates and quality of life data were analyzed.  There are no randomized trials regarding the treatment of extra-hepatic cholangiocarcinoma.  The bulk of available studies suggested that in some cases radio-chemotherapy can be used as adjuvant therapy.  Radiotherapy could also have a role in unresectable cholangiocarcinoma: external radiotherapy or intraluminal brachytherapy, alone or in combination, could improve the outcome in selected patients.  Finally, radiotherapy, and in particular intraluminal brachytherapy, could be used as a palliative treatment to improve the quality of life and in controlling symptoms.  The authors concluded that the role of radiotherapy in extra-hepatic cholangiocarcinoma remains undefined due to the lack of randomized trials or otherwise properly controlled studies.

Wiedmann and colleagues (2005) noted that carcinoma of the biliary tree are rare tumors of the gastro-intestinal tract with a rising incidence during the last years.  Biliary neoplasms are classified into intra- and extra-hepatic cholangiocarcinoma (Klatskin tumor, middle and distal extra-hepatic tumors), gallbladder cancer, and ampullary carcinoma.  Transformation of normal into malignant bile duct tissue requires a chain of consecutive gene mutations, similar to the adenoma-dysplasia-carcinoma-sequence in colon cancer.  Abdominal ultrasound, combined non-invasive magnetic resonance cholangiography/tomography (MRC/MRT), and facultatively endoscopic retrograde cholangiography (ERC) for unclear diagnosis, represent the gold standard for primary diagnosis.  For ampullary carcinoma, endosonography and endoscopic biopsy are the diagnostic tools of choice.  Cure is attainable only by formal curative radical surgical resection.  Increasing surgical radicality within the last years enabled clearly improved 5-year survival rates.  In contrast, there has been no clinical benefit for adjuvant and neoadjuvant therapies.  For palliation, bile duct stenting and photodynamic therapy are established methods.  Radio- and chemotherapy should be reserved for clinical studies.  New therapeutic approaches include brachytherapy, the use of modern chemotherapeutics, COX-2- and tyrosine kinase-receptor-inhibitors.

Also, the NCCN’s clinical practice guideline on “Hepatobiliary cancers” (Version 2.2013) does not mention the use of brachytherapy for gallbladder carcinoma.  Furthermore, an UpToDate review on “Treatment of advanced, unresectable gallbladder cancer” (Mehrotra, 2014) states that “For locoregionally advanced unresectable disease with or without obvious metastatic disease, guidelines from the National Comprehensive Cancer Network (NCCN) suggest 5-FU-based chemotherapy with radiation therapy, palliative chemotherapy, supportive care alone, or participation in a clinical trial as appropriate options for patients with an unresectable tumor without obvious metastatic disease”.  The review does not mention brachytherapy.

In a Cochrane review, Andras et al (2014) evaluated the effectiveness of, and complications associated with, intra-vascular brachytherapy (IVBT) for maintaining patency after angioplasty or stent insertion in native vessels or bypass grafts of the iliac or infra-inguinal arteries.  For this update, the Cochrane Peripheral Vascular Diseases Group Trials Search Co-ordinator searched their Specialised Register (last searched August 2013) and CENTRAL (2013, Issue 7).  Randomized controlled trials of the use of brachytherapy as an adjunct to the endovascular treatment of people with peripheral arterial disease (PAD) or stenosed bypass grafts of the iliac or infra-inguinal arteries versus the procedure without brachytherapy were selected for analysis.  Two review authors independently assessed trial quality and 2 other review authors independently extracted the data.  Adverse event information was collected from the trials.  A total of 8 trials with a combined total of 1,090 participants were included in this review.  All included studies used the femoro-popliteal artery.  These investigators did not identify any studies that used the iliac arteries.  All studies compared percutaneous transluminal angioplasty (PTA) with or without stenting plus IVBT versus PTA with or without stenting alone.  No trials were found comparing IVBT to technologies such as drug eluting stents or balloons, or cryoplasty.  Follow-up ranged from 6 months to 5 years.  The quality of the included trials was moderate with concerns relating to the difficulty of blinding due to the nature of the procedures and the small sample sizes for some studies.  Primary outcomes (patency or re-stenosis and need for re-intervention) were reported in the majority of the trials, but reporting at various time points and the use of multiple definitions of the outcomes by the included studies meant that not all data were available for pooling.  The secondary outcomes were not reported in many of the included studies.  For brachytherapy, cumulative patency was higher at 24 months (odds ratio (OR) 2.36, 95 % CI: 1.36 to 4.10, n = 222, p = 0.002).  A statistically significant difference was found for re-stenosis at 6 months (OR 0.27, 95 % CI: 0.11 to 0.66, n = 562, p = 0.004), 12 months (OR 0.44, 95 % CI: 0.28 to 0.68, n = 375, p = 0.0002) and 24 months (OR 0.41, 95 % CI: 0.21 to 0.78, n = 164, p = 0.007) in favor of IVBT.  No difference was found after 5 years as measured in 1 study.  The need for re-interventions was reported in 6 studies.  Target lesion re-vascularization was significantly reduced in trial participants treated with IVBT compared with angioplasty alone (OR 0.51, 95 % CI: 0.27 to 0.97, p = 0.04) at 6 months after the interventions.  No statistically significant difference was found between the procedures on the need for re-intervention at 12 and 24 months after the procedures.  A statistically significant lower number of occlusions was found in the control group at more than 3 months (OR 11.46, 95 % CI: 1.44 to 90.96, n = 363, p = 0.02) but no differences were found at less than 1 month nor at 12 months after the procedures making the clinical significance uncertain.  Ankle brachial index was statistically significantly better for IVBT at the 12 month follow-up (mean difference 0.08, 95 % CI: 0.02 to 0.14, n = 100, p = 0.02) but no statistically significant differences were found at 24 hours and at 6 months.  Quality of life, complications, limb loss, cardiovascular deaths, death from all causes, pain-free walking distance and maximum walking distance on a treadmill were similar for the 2 arms of the trials with no statistically significant difference found between the treatment groups.  The authors concluded that the evidence for using peripheral artery brachytherapy as an adjunct to PTA to maintain patency and for the prevention of re-stenosis in people with peripheral vascular disease is limited, mainly due to the inconsistency of assessment and reporting of clinically relevant outcomes.  They stated that more data are needed on clinically relevant outcomes such as health related quality of life (HRQOL) or limb salvage and longer-term outcomes, together with comparisons with other techniques such as drug eluting balloons and stents; adequately powered RCTs, health economics and cost-effectiveness data are needed before the procedure could be recommended for widespread use.

Brachytherapy is a constantly evolving field and the above recommendations are subject to modifications as new data become available.

 
CPT Codes / HCPCS Codes / ICD-9 Codes
CPT codes covered if selection criteria are met:
19296
+ 19297
19298
20555
41019
+49327
+49412
55875
55876
55920
57156
61770
77326 - 77328
77750
77761 - 77763
77776 - 77778
77785 - 77787
77789
77799
CPT codes not covered for indications listed in the CPB:
0182T
Other CPT codes related to the CPB:
37224 Revascularization, endovascular, open or percutaneous, femoral, popliteal artery(s), unilateral; with transluminal angioplasty
HCPCS codes covered if selection criteria are met:
A9527 Iodine I-125, sodium iodide solution, therapeutic, per millicurie
C1715 Brachytherapy needle
C1716 Brachytherapy source, non-stranded, gold-198, per source
C1717 Brachytherapy source, non-stranded, high dose rate iridium-192, per source
C1719 Brachytherapy source, non-stranded, non-high dose rate iridium-192, per source
C2616 Brachytherapy source, non-stranded, yttrium-90, per source
C2634 Brachytherapy source, non-stranded, high activity, iodine-125, greater than 1.01 mCi (NIST), per source
C2635 Brachytherapy source, non-stranded, high activity palladium-103, greater than 2.2 mCi (NIST), per source
C2636 Brachytherapy linear source, non-stranded, paladium-103, per 1 mm
C2637 Brachytherapy source, non-stranded, ytterbium-169, per source
C2638 Brachytherapy source, stranded, iodine-125, per source
C2639 Brachytherapy source, non-stranded, iodine-125, per source
C2640 Brachytherapy source, stranded, palladium-103, per source
C2641 Brachytherapy source, non-stranded, palladium-103, per source
C2642 Brachytherapy source, stranded, cesium-131, per source
C2643 Brachytherapy source, non-stranded, cesium-131, per source
C2698 Brachytherapy source, stranded, not otherwise specified, per source
C2699 Brachytherapy source, non-stranded, not otherwise specified, per source
C9725 Placement of endorectal intracavitary applicator for high intensity brachytherapy
C9726 Placement and removal (if performed) of applicator into breast for radiation therapy
Q3001 Radioelements for brachytherapy, any type, each
Other HCPCS codes related to the CPB:
A4648 Tissue marker, implantable, any type, each
A4650 Implantable radiation dosimeter, each
ICD-9 codes covered if selection criteria are met:
162.0 - 162.9 Malignant neoplasm of trachea, bronchus, and lung
197.0 Secondary malignant neoplasm of lung
212.3 Benign neoplasm of bronchus and lung
231.2 Carcinoma in situ of bronchus and lung
235.7 Neoplasm of uncertain behavior of trachea, bronchus, and lung
996.84 Complications of transplanted lungs [stenotic obstruction post lung transplantation]
ICD-9 codes not covered for indications listed in the CPB:
188.0 - 188.9 Malignant neoplasm of bladder
191.0 - 191.9 Malignant neoplasm of brain
223.3 Benign neoplasm of bladder
225.0 Benign neoplasm of brain
233.7 Carcinoma in situ of bladder
236.7 Neoplasm of uncertain behavior of bladder
237.5 Neoplasm of uncertain behavior of brain and spinal cord
239.4 Neoplasms of unspecified nature bladder
239.6 Neoplasms of unspecified nature brain
362.50 Macular degeneration (senile), unspecified
362.51 Nonexudative senile macular degeneration
362.52 Exudative senile macular degeneration
Other ICD-9 codes related to the CPB:
V42.6 Lung replaced by transplant
V58.0 Encounter for radiotherapy


The above policy is based on the following references:
  1. Shank B, Cunningham JD, Kelsen, DP. Cancer of the anal region. In: Cancer: Principles and Practice of Oncology. 5th ed. VT DeVita Jr, S Hellman, SA Rosenberg, eds. Philadelphia, PA: Lippincott-Raven; 1997:1244-1245. 
  2. Scher HI, Shipley WU, Herr HW. Cancer of the bladder. In: Cancer: Principles and Practice of Oncology. 5th ed.  VT DeVita Jr, S Hellman, SA Rosenberg, eds. Philadelphia, PA: Lippincott-Raven; 1997:1315. 
  3. Schantz SP, Harrison LB, Forastiere AA. Tumors of the nasal cavity and paranasal sinuses, nasopharynx, oral cavity, and oropharynx. In: Cancer: Principles and Practice of Oncology. 5th ed. VT DeVita Jr, S Hellman, SA Rosenberg, eds. Philadelphia, PA: Lippincott-Raven; 1997:749 
  4. Gaspar LE, Nag S, Herskovic A, et al. American Brachytherapy Society (ABS) consensus guidelines for brachytherapy of esophageal cancer. Clinical Research Committee, American Brachytherapy Society, Philadelphia, PA. Int J Radiat Oncol Biol Phys. 1997; 38(1):127-132. 
  5. McDermott MW, Snee PK, Gutin PH. Interstitial brachytherapy for malignant brain tumors. Semin Surg Oncol. 1998;14(1):79-87. 
  6. Sneed PK, McDermott MW, Gutin PH. Interstitial brachytherapy procedures for brain tumors. Semin Surg Oncol. 1997;13(3):157-166. 
  7. Smith T, Wazer DE, Robert NJ, et al. Local/regional therapy of primary breast cancer: A contemporary multimodal approach. Semin Oncol. 1992;19(3):230-238. 
  8. Cohen AM, Minsky BD, Schilsky RL. Cancer of the rectum. In: Cancer: Principles and Practice of Oncology. 5th ed. VT DeVita Jr, S Hellman, SA Rosenberg, eds. Philadelphia, PA: Lippincott-Raven; 1997:1228-1229. 
  9. Minna JD, Sekido, Y, Fong, K, et al. Cancer of the lung. In: Cancer: Principles and Practice of Oncology. 5th ed. VT DeVita Jr, S Hellman, SA Rosenberg, eds. Philadelphia, PA: Lippincott-Raven; 1997:882. 
  10. Raben A, Mychalczak B. Brachytherapy for non-small cell lung cancer and selected neoplasms of the chest. Chest. 1997;112(4 Suppl):276S-286S. 
  11. Nag S, Beyer D, Friedland J, et al. American Brachytherapy Society (ABS) recommendations for transperineal permanent brachytherapy of prostate cancer. Int J Radiat Oncol Biol Phys. 1999;44(4):789-799. 
  12. Vicini FA, Kini VR, Edmundson G, et al. A comprehensive review of prostate cancer brachytherapy: Defining an optimal technique. Int J Radiat Oncol Biol Phys. 1999;44(3):483-491. 
  13. Brennan MF, Casper ES, Harrison LB. Soft tissue sarcoma. In: Cancer: Principles and Practice of Oncology. 5th ed. VT DeVita Jr, S Hellman, SA Rosenberg, eds. Philadelphia, PA: Lippincott-Raven; 1997:1762-1764. 
  14. Hilaris BS, Bodner WR, Mastoras CA. Role of brachytherapy in adult soft tissue sarcomas. Semin Surg Oncol. 1997;13(3):196-203. 
  15. Pisters PW, Harrison LB, Leung DH, et al. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol. 1996;14(3):859-868. 
  16. Sahel JA, Steeves RA, Albert DM. Intraocular melanoma. In: Cancer: Principles and Practice of Oncology. 5th ed. VT DeVita Jr, S Hellman, SA Rosenberg, eds. Philadelphia, PA: Lippincott-Raven; 1997:2004-2005. 
  17. Eifel PJ, Berek JS, Thigpen JT. Cancer of the cervix, vagina, and vulva. In: Cancer: Principles and Practice of Oncology. 5th ed. VT DeVita Jr, S Hellman, SA Rosenberg, eds. Philadelphia, PA: Lippincott-Raven; 1997:1446-1450. 
  18. Burke TW, Eifel PJ, Muggia FM. Cancer of the uterine body. In: Cancer: Principles and Practice of Oncology. 5th ed. VT DeVita Jr, S Hellman, SA Rosenberg, eds. Philadelphia, PA: Lippincott-Raven; 1997:1487. 
  19. Waksman R. Intracoronary brachytherapy in the Cath Lab. Physics dosimetry, technology and safety considerations. Herz. 1998;23(6):401-406. 
  20. Costa MA, Sabat M, van der Giessen WJ, et al. Late coronary occlusion after intracoronary brachytherapy. Circulation. 1999;100(8):789-792. 
  21. Nori D, Bains M, Hilaris BS, et al. New intraoperative brachytherapy techniques for positive or close surgical margins. J Surg Oncol. 1989;42(1):54-59. 
  22. Wills F, Hailey D. Brachytherapy for prostate cancer. HTA-17. Edmonton, AB: Alberta Heritage Foundation for Medical Research (AHFMR); 1999.
  23. Conseil d'Evaluation des Technologies de la Sante du Quebec (CETS). Brachytherapy and prostate cancer. CETS 99-5 RF. Montreal, QC: CETS; 2000.
  24. Nag S, Cano ER, Demanes DJ, et al. The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for head-and-neck carcinoma. Int J Radiat Oncol Biol Phys. 2001;50(5):1190-1198. 
  25. Nag S, Shasha D, Janjan N, et al. The American Brachytherapy Society recommendations for brachytherapy of soft tissue sarcomas. Int J Radiat Oncol Biol Phys. 2001;49(4):1033-1043. 
  26. Patterson J. Brachytherapy for localised prostate cancer. STEER: Succinct and Timely Evaluated Evidence Reviews. Bazian, Ltd., eds. London, UK: Wessex Institute for Health Research and Development, University of Southampton; 2001;1(17).
  27. Johansen T B, Dahl O, Heikkila R, et al. Treating prostate cancer with brachytherapy. SMM-Report 2/2002. Oslow, Norway: The Norwegian Knowledge Centre for the Health Services (NOKC); 2002. 
  28. Nag S, Chao C, Erickson B, et al. The American Brachytherapy Society recommendations for low-dose-rate brachytherapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 2002;52(1):33-48. 
  29. Nag S, Chao C, Erickson B, et al. The American Brachytherapy Society recommendations for low-dose-rate brachytherapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 2002;52(1):33-48.
  30. BlueCross BlueShield Association (BCBSA), Technology Evaluation Center (TEC). Brachytherapy for accelerated partial breast irradiation after breast-conserving surgery for early stage breast cancer. TEC Assessment Program. Chicago IL: BCBSA; 2002;17(18).
  31. Canadian Coordinating Office for Health Technology Assessment (CCOHTA). Brachytherapy for prostate cancer. Pre-assessment. Ottawa, ON: CCOHTA; February 2002.
  32. Mathur PN, Edell E, Sutedja T, et al. Treatment of early stage non-small cell lung cancer. Chest. 2003;123(1 Suppl):176S-180S.
  33. Nag S, Quivey JM, Earle JD, et al. The American Brachytherapy Society recommendations for brachytherapy of uveal melanomas. Int J Radiat Oncol Biol Phys. 2003;56(2):544-555.
  34. Swedish Council on Technology Assessment in Health Care (SBU). Radiotherapy for cancer - update.  Stockholm, Sweden: SBU; 2003.
  35. BlueCross BlueShield Association (BCBSA), Technology Evaluation Center (TEC). Brachytherapy for the prevention of restenosis in peripheral arteries following PTA of the femoropopliteal system. TEC Assessment Program. Chicago IL: BCBSA; 2002;17(22).
  36. Hummel S, Paisley S, Morgan A, et al. Clinical and cost-effectiveness of new and emerging technologies for early localised prostate cancer: a systematic review. Health Technol Assess. 2003;7(33):1-170.
  37. Edmundson GK, Vicini FA, Chen PY, et al. Dosimetric characteristics of the MammoSite RTS, a new breast brachytherapy applicator. Int J Radiat Oncol Biol Phys. 2002;52(4):1132-1139.
  38. Keisch M, Vicini F, Kuske RR, et al. Initial clinical experience with the MammoSite breast brachytherapy applicator in women with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2003;55(2):289-293.
  39. Zannis VJ, Walker LC, Barclay-White B, Quiet CA. Postoperative ultrasound-guided percutaneous placement of a new breast brachytherapy balloon catheter. Am J Surg. 2003;186(4):383-385.
  40. Healthcare Sales & Marketing Network, LLC (HSMN). FDA clears use of Fischer MammoTest Breast Biopsy System as platform for interstitial breast brachytherapy. News Release. Healthcare Sales & Marketing Network News. Newtown Square, PA: HSMN: November 29, 2004. Available at: http://salesandmarketingnetwork.com/news_release.php?ID=2002089&key=RSNA. Accessed April 6, 2005.
  41. Pichon Riviere A, Augustovski F, Cernadas C, et al. Brachytherapy for prostate cancer treatment. Technology Assessment. Report IRR No. 10. Buenos Aires, Argentina: Institute for Clinical Effectiveness and Health Policy (IECS); October 2003.
  42. Zannis V, Beitsch P, Vicini F, et al. Descriptions and outcomes of insertion techniques of a breast brachytherapy balloon catheter in 1403 patients enrolled in the American Society of Breast Surgeons MammoSite breast brachytherapy registry trial. Am J Surg. 2005;190(4):530-538.
  43. Melia M, Moy CS, Reynolds SM, et al. Quality of life after iodine 125 brachytherapy vs enucleation for choroidal melanoma: 5-year results from the Collaborative Ocular Melanoma Study: COMS QOLS Report No. 3. Arch Ophthalmol. 2006;124(2):226-238.
  44. Shakespeare TP, Lim KH, Lee KM, et al; American Brachytherapy Society. Phase II study of the American Brachytherapy Society guidelines for the use of high-dose rate brachytherapy in the treatment of cervical carcinoma: Is 45-50.4 Gy radiochemotherapy plus 31.8 Gy in six fractions high-dose rate brachytherapy tolerable? Int J Gynecol Cancer. 2006;16(1):277-282.
  45. Niehoff P, Ballardini B, Polgar C, et al. Early European experience with the MammoSite radiation therapy system for partial breast brachytherapy following breast conservation operation in low-risk breast cancer. Breast. 2006;15(3):319-325.
  46. McDaid C, Hartley S, Bagnall A-M, et al. Systematic review of effectiveness of different treatments for childhood retinoblastoma. Health Technol Assess. 2005;9(48):1-162.
  47. Medical Services Advisory Committee (MSAC). Brachytherapy for the treatment of prostate cancer: Assessment report May 2005. MSAC Application No.1089. Canberra, ACT: MSAC; 2006.
  48. National Institute for Health and Clinical Excellence (NICE). High dose rate brachytherapy for carcinoma of the cervix. Interventional Procedure Guidance 160. London, UK: NICE; 2006.
  49. National Institute for Health and Clinical Excellence (NICE). High dose rate brachytherapy in combination with external-beam radiotherapy for localised prostate cancer. Interventional Procedure Guidance 174. London, UK: NICE; 2006.
  50. National Institute for Health and Clinical Excellence (NICE. Preoperative high dose rate brachytherapy for rectal cancer. Interventional Procedure Guidance 201. London, UK: NICE; 2006.
  51. National Institute for Clinical Excellence (NICE). Low dose rate brachytherapy for prostate cancer. Interventional Procedure Guidance 132. London, UK: NICE; 2005.
  52. Dickler A, Kirk MC, Seif N, et al. A dosimetric comparison of MammoSite high-dose-rate brachytherapy and Xoft Axxent electronic brachytherapy. Brachytherapy. 2007;6(2):164-168.
  53. Rivard MJ, Davis SD, DeWerd LA, et al. Calculated and measured brachytherapy dosimetry parameters in water for the Xoft Axxent X-Ray Source: An electronic brachytherapy source. Med Phys. 2006;33(11):4020-4032.
  54. U.S. Food and Drug Administration (FDA), Center for Devices and Radiologic Health (CDRH). Axxent Electronic Brachytherapy System. 510(k) No.K050843. Rockville, MD: FDA; December 22, 2005.
  55. Xoft Inc. Axxent Electronic Brachytherapy System [website]. Fremont, CA: Xoft; 2007. Available at: http://www.xoftmicrotube.com/. Accessed July 10, 2007.
  56. BlueCross BlueShield Association (BCBSA), Technology Evaluation Center (TEC). Accelerated partial breast irradiation as sole radiotherapy after breast-conserving surgery for early stage breast cancer. TEC Assessment Program. Chicago, IL: BCBSA; September 2007;22(4).
  57. California Technology Assessment Forum (CTAF). Brachytherapy for accelerated partial breast irradiation following conserving surgery. Technology Assessment. San Francisco, CA: CTAF; June 21, 2006. Available at: http://ctaf.org/content/general/detail/530. Accessed July 10, 2007.
  58. Liu D, Poon E, Bazalova M, et al. Spectroscopic characterization of a novel electronic brachytherapy system. Phys Med Biol. 2008;53(1):61-75.
  59. Denecke T, Lopez Hänninen E. Brachytherapy of liver metastases. Recent Results Cancer Res. 2008;177:95-104.
  60. Vicini F, Beitsch PD, Quiet CA, et al. Three-year analysis of treatment efficacy, cosmesis, and toxicity by the American Society of Breast Surgeons MammoSite Breast Brachytherapy Registry Trial in patients treated with accelerated partial breast irradiation (APBI). Cancer. 2008;112(4):758-766.
  61. Cardona AF, Reveiz L, Ospina EG, et al. Palliative endobronchial brachytherapy for non-small cell lung cancer. Cochrane Database Syst Rev. 2008;(2):CD004284.
  62. Dickler A, Dowlatshahi K. Xoft Axxent electronic brachytherapy. Expert Rev Med Devices. 2009;6(1):27-31.
  63. Haffty BG, Vicini FA, Beitsch P, et al. Timing of Chemotherapy after MammoSite radiation therapy system breast brachytherapy: Analysis of the American Society of Breast Surgeons MammoSite breast brachytherapy registry trial. Int J Radiat Oncol Biol Phys. 2008;72(5):1441-1448.
  64. Vicini F, Beitsch PD, Quiet CA, et al. Three-year analysis of treatment efficacy, cosmesis, and toxicity by the American Society of Breast Surgeons MammoSite Breast Brachytherapy Registry Trial in patients treated with accelerated partial breast irradiation (APBI). Cancer. 2008;112(4):758-766.
  65. Avila MP, Farah ME, Santos A, et al. Twelve-month short-term safety and visual-acuity results from a multicentre prospective study of epiretinal strontium-90 brachytherapy with bevacizumab for the treatment of subfoveal choroidal neovascularisation secondary to age-related macular degeneration. Br J Ophthalmol. 2009;93(3):305-309.
  66. Viani GA, Manta GB, Stefano EJ, de Fendi LI. Brachytherapy for cervix cancer: Low-dose rate or high-dose rate brachytherapy - a meta-analysis of clinical trials. J Exp Clin Cancer Res. 2009;28:47.
  67. Sreedharan A, Harris K, Crellin A, et al. Interventions for dysphagia in oesophageal cancer. Cochrane Database Syst Rev. 2009;(4):CD005048.
  68. Ashida R, Chang KJ. Interventional EUS for the treatment of pancreatic cancer. J Hepatobiliary Pancreat Surg. 2009;16(5):592-597.
  69. Al-Haddad M, Eloubeidi MA. Interventional EUS for the diagnosis and treatment of locally advanced pancreatic cancer. JOP. 2010;11(1):1-7.
  70. Harper JL, Watkins JM, Zauls AJ. Six-year experience: Long-term disease control outcomes for partial breast irradiation using MammoSite balloon brachytherapy. Am J Surg. 2010;199(2):204-209.
  71. Mehta VK, Algan O, Griem KL, et al. Experience with an electronic brachytherapy technique for intracavitary accelerated partial breast irradiation. Am J Clin Oncol. 2010;33(4):327-335.
  72. Beitsch PD, Patel RR, Lorenzetti JD, et al. Post-surgical treatment of early-stage breast cancer with electronic brachytherapy: An intersociety, multicenter brachytherapy trial. Onco Targets Ther. 2010;3:211-218.
  73. Ahmad S, Johnson D, Hiatt JR, et al. Comparison of tumor and normal tissue dose for accelerated partial breast irradiation using an electronic brachytherapy eBx source and an Iridium-192 source. J Appl Clin Med Phys. 2010;11(94):3301.
  74. Njeh CF, Saunders MW, Langton CM. Accelerated Partial Breast Irradiation (APBI): A review of available techniques. Radiat Oncol. 2010;5:90.
  75. Bhatnagar A, Loper A. The initial experience of electronic brachytherapy for the treatment of non-melanoma skin cancer. Radiat Oncol. 2010;5:87.
  76. Dickler A, Puthawala MY, Thropay JP, et al. Prospective multi-center trial utilizing electronic brachytherapy for the treatment of endometrial cancer. Radiat Oncol. 2010;5:67.
  77. Park CC, Yom SS, Podgorsak MB, et al; Electronic Brachytherapy Working Group. American Society for Therapeutic Radiology and Oncology (ASTRO) Emerging Technology Committee report on electronic brachytherapy. Int J Radiat Oncol Biol Phys. 2010;76(4):963-972.
  78. Ivanov O, Dickler A, Lum BY, et al. Twelve-month follow-up results of a trial utilizing Axxent electronic brachytherapy to deliver intraoperative radiation therapy for early-stage breast cancer. Ann Surg Oncol. 2011;18(2):453-458.
  79. Vaidya JS, Baum M, Tobias JS, et al. Long-term results of targeted intraoperative radiotherapy (Targit) boost during breast-conserving surgery. Int J Radiat Oncol Biol Phys. 2011;81(4):1091-1097.
  80. Mitchell D, O'Callaghan AP, Boyle EM, et al. Endovascular brachytherapy and restenosis following lower limb angioplasty: Systematic review and meta-analysis of randomized clinical trials. Int J Surg. 2012;10(3):124-128.
  81. Alberta Provincial Genitourinary Tumour Team. Penile cancer. Edmonton (Alberta): Alberta Health Services, Cancer Care; February 2012. (Clinical practice guideline; no. GU-006). Available at: http://www.guideline.gov/content.aspx?id=38589&search=Brachytherapy. Accessed March 22, 2013.
  82. Wiedmann M, Schoppmeyer K, Witzigmann H, et al. Current diagnostics and therapy for carcinomas of the biliary tree and gallbladder. Z Gastroenterol. 2005;43(3):305-315.
  83. Dugel PU, Bebchuk JD, Nau J, et al; CABERNET Study Group. Epimacular brachytherapy for neovascular age-related macular degeneration: A randomized, controlled trial (CABERNET). Ophthalmology. 2013;120(2):317-327.
  84. National Comprehensive Cancer Network. Clinical practice guideline: Hepatobiliary cancers. Version 2.2013. NCCN: Fort Washington, PA.
  85. Mattiucci GC, Autorino R, D'Agostino GR, et al. Chemoradiation and brachytherapy in extrahepatic bile duct carcinoma. Crit Rev Oncol Hematol. 2013 Nov 2. [Epub ahead of print]
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Copyright Aetna Inc. All rights reserved. Clinical Policy Bulletins are developed by Aetna to assist in administering plan benefits and constitute neither offers of coverage nor medical advice. This Clinical Policy Bulletin contains only a partial, general description of plan or program benefits and does not constitute a contract. Aetna does not provide health care services and, therefore, cannot guarantee any results or outcomes. Participating providers are independent contractors in private practice and are neither employees nor agents of Aetna or its affiliates. Treating providers are solely responsible for medical advice and treatment of members. This Clinical Policy Bulletin may be updated and therefore is subject to change.
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