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Clinical Policy Bulletin:
Electroencephalographic (EEG) Video Monitoring
Number: 0322


Policy

  1. Aetna considers electroencephalographic (EEG) video monitoring medically necessary for the following indications, where the diagnosis can not be made by neurological examination, standard EEG studies, and ambulatory EEG monitoring, and non-neurological causes of symptoms (e.g., syncope, cardiac arrhythmias) have been ruled out:

    1. To differentiate epileptic events from psychogenic seizures; or
    2. To establish the first diagnosis of a seizure disorder; or
    3. To establish the specific type of epilepsy in poorly characterized seizure types where such characterization is medically necessary to select the most appropriate therapeutic regimen.

    In addition, upon individual case review, EEG video monitoring may be considered medically necessary to establish the diagnosis of epilepsy in very young children with clinical symptoms consistent with epilepsy, and abnormal routine EEG consistent with epilepsy.

    Note: Once the cause of seizures and specific type of epilepsy has been established, continued video EEG monitoring (e.g., for monitoring response to therapy or titrating medication dosages) is considered not medically necessary.  In these cases, response to therapy can be assessed using standard EEG monitoring or ambulatory EEG monitoring.

  2. Aetna considers EEG video monitoring medically necessary for identification and localization of a seizure focus in persons with intractable epilepsy who are being considered for surgery.  See also CPB 0394 - Epilepsy Surgery.

  3. Aetna considers EEG video monitoring experimental and investigational for all other indications (e.g., assessment of the effectiveness of drug treatment in epilepsies, and prognosis of (i) cardiac arrest treated with hypothermia, and (ii) newborns with hypoxic-ischemic encephalopathy treated with hypothermia; not an all inclusive list) because its efefctiveness for these indications has not been established.

Note: The medically necessary level of care a member requires should be addressed individually according to the member's clinical needs.  An acute level of care is not considered medically necessary for many persons requiring video EEG monitoring.

See also CPB 0221 - Quantitative EEG (Brain Mapping)CPB 0289 - Grid Monitoring: Presurgical Evaluation for Persons with Intractable Seizures, and CPB 0425 - Ambulatory Electroencephalography.



Background

The Agency for Health Care Policy and Research has stated that information provided by video electroencephalographic (EEG) monitoring has improved patient outcome by permitting accurate diagnoses and modified therapy.  Furthermore, the American EEG Society has noted that this procedure is widely regarded as safe and effective for evaluating seizures disorders.  The American Epilepsy Society has stated that this technique is the method of choice for the evaluation of intractable and/or undiagnosed seizure disorders.  Additionally, many studies have reported the usefulness of this technique, and recommended its use for the diagnosis of psychogenic seizures.

An evidence report prepared for AHRQ (Ross et al, 2001) concluded that EEG video monitoring was useful for diagnosis of epilepsy if the EEG, CT, and MRI are non-diagnostic, and in diagnosis in very young children, in patients with poorly characterized seizure types, and in those with suspected psychogenic seizures.  The report concluded that video EEG has a role subsequent to a new diagnosis if the diagnosis is or becomes uncertain or if surgery is considered.  "In summary ... [t]he literature suggests that ambulatory and video EEGs are useful in a first diagnosis if standard EEG, CT, and MRI are non-diagnostic.  Video EEGs are also useful in diagnosis in very young children, in patients with poorly characterized seizure types, and in those with suspected psychogenic seizures, especially if episodes are frequent."  The report continued: "[T]he evidence, although scant, suggests there is no role for standard EEG in routine monitoring of patients after a new diagnosis of epilepsy.  Video EEG has a role subsequent to a new diagnosis if the diagnosis is or becomes uncertain or if surgery is considered" (Ross et al, 2001).

The role of video and ambulatory EEG is confined to refining or changing an uncertain diagnosis or in preoperative evaluations for seizure surgery (Ross et al, 2001).  When seizures are frequent and features are atypical or uncertain, these EEGs may well contribute information necessary to correct a misdiagnosis.  The literature describing these EEGs appears confined to specialists in academic centers.

An assessment of EEG video monitoring by the Institute for Clinical Effectiveness and Health Policy (Pichon Riviere, et al., 2011) concluded: "In patients with refractory epilepsy who have previously been studied using the standard diagnostic tests, telemetry video electroencephalography (V-EEG) seems to be an adequate diagnostic test to: differentiate a crisis from a pseudocrisis, characterize the different types of crises and localize the epileptic area. Continuous video-EEG monitoring is not considered medically necessary to monitor the antiepileptic drug response or drug titration."

Stefan et al (2011) stated that a reliable method for the estimation of seizure frequency and severity is of value in assessing the effectiveness of drug treatment in epilepsies.  These quantities are usually deduced from subjective patient reports, which may cause considerable problems due to insufficient or false descriptions of seizures and their frequency.  In a feasibility study, these researchers presented data from 2 difficult-to-treat patients with intractable epilepsy.  Patient 1 has had an unknown number of complex partial (CP) seizures.  A prolonged outpatient video-EEG monitoring over 160-hr and 137-hr (over an interval of 3 months) was performed with an automated seizure detection method.  Patient 2 suffered exclusively from nocturnal seizures originating from the frontal lobe.  In this case, an objective quantification of the effectiveness of drug treatment over a time period of 22 weeks was established.  For the reliable quantification of seizures, a prolonged outpatient video/video-EEG monitoring was appended after a short-term inpatient monitoring period.  Patient 1: The seizure detection algorithm was capable of detecting 10 out of 11 seizures.  The number of false-positive events was less than 0.03/hr.  It was clearly demonstrated that the patient showed more seizures than originally reported.  Patient 2: The add-on medication of lacosamide led to a significant reduction in seizure frequency and to a marked decrease in the mean duration of seizures.  The severity of seizures was reduced from numerous hyper-motoric seizures to few mild, head-turning seizures.  The authors concluded that outpatient monitoring may be helpful to guide treatment for severe epilepsies and offers the possibility to more reliably quantify the effectiveness of treatment in the long-term, even over several months.  The findings of this feasibility study need to be validated by well-designed studies.

Therapeutic hypothermia (TH) is becoming standard of care in newborns with hypoxic-ischemic encephalopathy (HIE).  The prognostic value of the EEG and the incidence of seizures during TH are uncertain.  Nash and colleagues (2011) described evolution of EEG background and incidence of seizures during TH, and identified EEG patterns predictive for MRI brain injury.  A total of 41 newborns with HIE who underwent TH were included in this study.  Continuous video-EEG was performed during hypothermia and re-warming.  EEG background and seizures were reported in a standardized manner.  Newborns underwent MRI after re-warming.  Sensitivity and specificity of EEG background for moderate-to-severe MRI brain injury was assessed at 6-hr intervals during TH and re-warming.  EEG background improved in 49 %, remained the same in 38 %, and worsened in 13 %.  A normal EEG had a specificity of 100 % upon initiation of monitoring and 93 % at later time points.  Burst suppression and extremely low voltage patterns held the greatest prognostic value only after 24 hrs of monitoring, with a specificity of 81 % at the beginning of cooling and 100 % at later time points.  A discontinuous pattern was not associated with adverse outcome in most patients (73 %).  Electrographic seizures occurred in 34 % (14/41), and 10 % (4/41) developed status epilepticus.  Seizures had a clinical correlate in 57 % (8/14) and were subclinical in 43 % (6/14).  The authors concluded that continuous video-EEG monitoring in newborns with HIE undergoing TH provides prognostic information about early MRI outcome and accurately identifies electrographic seizures, nearly 50 % of which are subclinical.  The findings of this small study need to be validated by well-designed studies.

Rosetti et al (2010) examined if continuous EEG (cEEG) may predict outcome of patients with coma after cardiac arrest (CA), particularly in the setting of TH.  From April 2009 to April 2010, these researchers prospectively studied 34 consecutive comatose patients treated with TH after CA who were monitored with cEEG, initiated during hypothermia and maintained after rewarming.  EEG background reactivity to painful stimulation was tested.  They analyzed the association between cEEG findings and neurologic outcome, assessed at 2 months with the Glasgow-Pittsburgh Cerebral Performance Categories (CPC).  Continuous EEG recording was started 12 +/- 6 hours after CA and lasted 30 +/- 11 hours.  Non-reactive cEEG background (12 of 15 (75 %) among non-survivors versus none of 19 (0) survivors; p < 0.001) and prolonged discontinuous "burst-suppression" activity (11 of 15 (73 %) versus none of 19; p < 0.001) were significantly associated with mortality.  EEG seizures with absent background reactivity also differed significantly (7 of 15 (47 %) versus none of 12 (0); p = 0.001).  In patients with non-reactive background or seizures/epileptiform discharges on cEEG, no improvement was seen after TH.  Non-reactive cEEG background during TH had a positive predictive value of 100 % (95 % confidence interval (CI): 74 to 100 %) and a false-positive rate of 0 (95 % CI: 0 to 18 %) for mortality.  All survivors had cEEG background reactivity, and the majority of them (14 of 19 (74 %)) had a favorable outcome (CPC 1 or 2).  The authors concluded that cEEG monitoring showing a non-reactive or discontinuous background during TH is strongly associated with unfavorable outcome in patients with coma after CA.  Moreover, they stated that these data warrant larger studies to confirm the value of cEEG monitoring in predicting prognosis after CA and TH.

The National Institute for Health and Clinical Excellence’s clinical guideline on “The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care” (NICE, 2012) stated that  “Long-term video or ambulatory EEG may be used in the assessment of children, young people and adults who present diagnostic difficulties after clinical assessment and standard EEG”.

 
CPT Codes / HCPCS Codes / ICD-9 Codes
CPT codes covered if selection criteria are met:
95951
Other CPT codes related to the CPB:
95816 - 95822
95950
95953
95956
99481
99482
ICD-9 codes covered if selection criteria are met:
300.11 Conversion disorder [psychogenic seizure]
345.00 - 345.91 Epilepsy and recurrent seizures [EEG video monitoring is not covered for the assessment of the effectiveness of drug treatment in epilepsies]
779.0 Convulsions in newborn
780.02 Transient alteration of awareness
780.32 Complex febrile convulsions
780.33 Post traumatic seizures
780.39 Other convulsions (e.g., seizure NOS)
781.0 Abnormal involuntary movements
ICD-9 codes not covered for indications listed in the CPB (not all-inclusive):
427.5 Cardiac arrest
768.70 - 768.73 Hypoxic-ischemic encephalopathy
Other ICD-9 codes related to the CPB:
427.0 - 427.42
427.60 - 427.89
Cardiac dysrhythmias
780.2 Syncope and collapse


The above policy is based on the following references:
  1. Erlichman M. Electroencephalographic (EEG) video monitoring. DHHS Publication No. (PHS) 91-3471. Rockville, MD: Agency for Healthcare Policy and Research (AHCPR); December 1990:1-14.
  2. Wyllie E, Friedman D, Rothner AD, et al. Psychogenic seizures in children and adolescents: Outcome after diagnosis by ictal video and electroencephalographic recording. Pediatrics. 1990;85(4):480-484.
  3. Meierkord H, Will B, Fish D, Shorvon S. The clinical features and prognosis of pseudoseizures diagnosed using video-EEG telemetry. Neurology. 1991;41(10):1643-1646.
  4. Boon PA, Williamson PD. The diagnosis of pseudoseizures. Clin Neurol Neurosurg. 1993;95(1):1-8.
  5. Leis AA. Psychogenic seizures. The Neurologist. 1996;2:141-149.
  6. Sundaram M, Sadler RM, Young GB, et al. EEG in epilepsy: Current perspectives. Can J Neuro Sci. 1999;26:255-262.
  7. Cascino GD. Use of routine and video electroencephalography. Neurol Clin. 2001;19(2):271-287.
  8. Sheth RD. Intractable pediatric epilepsy: Presurgical evaluation. Semin Pediatr Neurol. 2000;7(3):158-165.
  9. Bowman ES, Coons PM. The differential diagnosis of epilepsy, pseudoseizures, dissociative identity disorder, and dissociative disorder not otherwise specified. Bull Menninger Clin. 2000;64(2):164-180.
  10. Cascino GD. Clinical indications and diagnostic yield of video-electroencephalographic monitoring in patients with seizures and spells. Mayo Clin Proc. 2002;77(10):1111-1120.
  11. Cascino GD. Video-EEG monitoring in adults. Epilepsia. 2002;43 Suppl 3:80-93.
  12. Cragar DE, Berry DT, Fakhoury TA, et al. A review of diagnostic techniques in the differential diagnosis of epileptic and nonepileptic seizures. Neuropsychol Rev. 2002;12(1):31-64.
  13. Ross SD, Estok R, Chopra S, et al. Management of newly diagnosed patients with epilepsy: A systematic review of the literature. Evidence Report/Technology Assessment No. 39. Prepared by MetaWorks, Inc. for the Agency for Healthcare Research and Quality (AHRQ). AHRQ Publication No. 01-E038. Rockville, MD: AHRQ; September 2001. Available at: http://www.ahrq.gov/clinic/evrptfiles.htm#trepilep. Accessed May 5, 2004.
  14. Chapell R, Reston J, Snyder D, et al. Management of treatment-resistant epilepsy. Evidence Report/Technology Assessment No. 77. Prepared by the ECRI Evidence-based Practice Center for the Agency for Healthcare Research and Quality (AHRQ). AHRQ Publication Number 03-0028. Rockville, MD: AHRQ; May 2003. Available at: http://www.ahrq.gov/clinic/evrptfiles.htm#trepilep. Accessed May 5, 2004.
  15. Scottish Intercollegiate Guidelines Network (SIGN). Diagnosis and management of epilepsy in adults. A national clinical guideline. SIGN Publication No. 70. Edinburgh, Scotland: SIGN; April 2003.
  16. National Institute for Clinical Excellence (NICE). The diagnosis and management of the epilepsies in adults and children in primary and secondary care. Clinical Guideline 20. London, UK: NICE; October 2004.
  17. Valente KD, Freitas A, Fiore LA, et al. The diagnostic role of short duration outpatient V-EEG monitoring in children. Pediatr Neurol. 2003;28(4):285-291.
  18. Wood BL, Haque S, Weinstock A, Miller BD. Pediatric stress-related seizures: Conceptualization, evaluation, and treatment of nonepileptic seizures in children and adolescents. Curr Opin Pediatr. 2004;16(5):523-531.
  19. Scottish Intercollegiate Guidelines Network (SIGN). Diagnosis and management of epilepsies in children and young people. SIGN Publication No. 81. Edinburgh, Scotland: SIGN; March 2005.
  20. Alsaadi TM, Marquez AV. Psychogenic nonepileptic seizures. Am Fam Physician. 2005;72(5):849-856.
  21. Cossu M, Cardinale F, Colombo N, et al. Stereoelectroencephalography in the presurgical evaluation of children with drug-resistant focal epilepsy. J Neurosurg. 2005;103(4 Suppl):333-343.
  22. Abubakr A, Wambacq I. Seizures in the elderly: Video/EEG monitoring analysis. Epilepsy Behav. 2005;7(3):447-450.
  23. Krumholz A, Hopp J. Psychogenic (nonepileptic) seizures. Semin Neurol. 2006;26(3):341-350.
  24. Papacostas SS, Myrianthopoulou P, Papathanasiou E. Epileptic seizures followed by nonepileptic manifestations: A video-EEG diagnosis. Electromyogr Clin Neurophysiol. 2006;46(6):323-327.
  25. Singapore Ministry of Health. Epilepsy in adults. Guidelines. Singapore: Singapore Ministry of Health; January 2007.
  26. No authors listed. Indications for long term EEG and video EEG monitoring. National Association of Epilepsy Centers. September 9, 2008. (Katie Kuechenmeister, American Academy of Neurology, personal communication).
  27. Marchetti RL, Kurcgant D, Neto JG, et al. Psychiatric diagnoses of patients with psychogenic non-epileptic seizures. Seizure. 2008;17(3):247-253.
  28. Falip M, Carreño M, Donaire A, et al. Postictal psychosis: A retrospective study in patients with refractory temporal lobe epilepsy. Seizure. 2009;18(2):145-149.
  29. Alving J, Beniczky S. Diagnostic usefulness and duration of the inpatient long-term video-EEG monitoring: Findings in patients extensively investigated before the monitoring. Seizure. 2009;18(7):470-473.
  30. Moien-Afshari F, Griebel R, Sadanand V, et al. Safety and yield of early cessation of AEDs in video-EEG telemetry and outcomes. Can J Neurol Sci. 2009;36(5):587-592.
  31. Stefan H, Kreiselmeyer G, Kasper B, et al. Objective quantification of seizure frequency and treatment success via long-term outpatient video-EEG monitoring: A feasibility study. Seizure. 2011;20(2):97-100.
  32. Nash KB, Bonifacio SL, Glass HC, et al. Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. Neurology. 2011;76(6):556-562.
  33. Pichon Riviere A, Augustovski F, Garcia Marti S, et al. Usefulness of video EEG for the assessment of patients with refractory epilepsy. Summary. IRR No. 220. Buenos Aires, Argentina: Institute for Clinical Effectiveness and Health Policy (IECS); 2011.
  34. Rossetti AO, Urbano LA, Delodder F, et al. Prognostic value of continuous EEG monitoring during therapeutic hypothermia after cardiac arrest. Crit Care. 2010;14(5):R173.
  35. Van Loo P, Carrette E, Meurs A, et al. Surgical successes and failures of invasive video-EEG monitoring in the presurgical evaluation of epilepsy. Panminerva Med. 2011;53(4):227-240.
  36. National Institute for Health and Clinical Excellence (NICE). The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care. London, UK: National Institute for Health and Clinical Excellence (NICE); January 2012.


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Copyright Aetna Inc. All rights reserved. Clinical Policy Bulletins are developed by Aetna to assist in administering plan benefits and constitute neither offers of coverage nor medical advice. This Clinical Policy Bulletin contains only a partial, general description of plan or program benefits and does not constitute a contract. Aetna does not provide health care services and, therefore, cannot guarantee any results or outcomes. Participating providers are independent contractors in private practice and are neither employees nor agents of Aetna or its affiliates. Treating providers are solely responsible for medical advice and treatment of members. This Clinical Policy Bulletin may be updated and therefore is subject to change.
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