Iontophoresis or electrophoresis, (e.g., Drionic® device) is ineffective (see CPB 0229 - Iontophoresis) (a trial of botulinum toxin can be substituted for iontophoresis in persons with predominantly axillary hyperhidrosis -- see CPB 0113 - Botulinum Toxin); and
Significant disruption of professional and/or social life has occurred because of excessive sweating; and
Topical aluminum chloride or other extra-strength antiperspirants are ineffective or result in a severe rash; and
Unresponsive or unable to tolerate pharmacotherapy prescribed for excessive sweating (e.g., anti-cholinergics, beta-blockers, benzodiazapines) if sweating is episodic.
Aetna considers thoracoscopic sympathectomy cosmetic for excessive spontaneous facial blushing. Facial blushing (flushing) is considered a cosmetic indication as it does not result in functional impairment.
Aetna considers thoracoscopic sympathectomy experimental and investigational for all other indications becasue its effectiveness for indications other than the ones listed above has not been established.
A report by the Finnish Office of Health Technology Assessment systematically evaluated the literature on the safety and effectiveness of thoracoscopic sympathectomy for treatment of sweating and for treatment of social phobia (Malmivaara et al, 2005). Thoracoscopic sympathectomy aims to reduce excessive sweating of the face and hands and facial flushing by interrupting stimulation of sweat glands by the sympathetic nervous system. The treatment is performed as an endoscopic procedure, where the upper thoracic chain of the sympathetic nerve trunk is transsected or clamped.
The authors stated that it is difficult to conduct even a qualitative synthesis of studies of thoracoscopic sympathectomy, due to poor reporting of patient characteristics and variation among studies in the reporting of outcomes (Malmivaara et al, 2005). In addition, the authors found most of the studies to be of poor methodologic quality. The authors stated, however, that available literature suggests that thoracoscopic sympathectomy reduces excessive sweating of the palms and facial flushing. Patient satisfaction was reported as good or moderately good. The authors identified only 1 study that followed subjects for more than 2 years.
The reported rates of acute post-operative complications following endoscopic thoracic sympathetomy varided widely among studies studies (Malmivaara et al, 2005). Acute post-operative complications, some severe, occurred in as many as 10 % of subjects. The most commonly reported chronic complication was compensatory sweating below the breast level, often with substantial resultant disability. Other chronic complications included dryness of the face or palms and gustatory sweating. The authors noted that, due to wide variation in the reporting of complications, it is probable that these complications have been under-reported in most series.
The authors concluded that "due to lack of controlled trials there is no reliable evidence for the effectiveness of endoscopic thoracic sympathectomy for excessive sweating in the face and hands or for flushing of the face" (Malmivaara et al, 2005). The authors also found no reliable evidence of the effectiveness of endoscopic thoracoscopic sympathectomy for social phobia. The authors concluded that endoscopic thoracic sympathectomy is associated with significant immediate and long-term adverse effects.
A follow-up article to the FinOHTA assessment (Malmivaara et al, 2007) re-affirmed these earlier findings, concluding that: "The evidence for the effectiveness of ETS [endoscopic thoracic sympathectcomy] is weak. The intervention is associated with severe immediate complications in some patients and persistent adverse effects for many." The methodological quality and the reporting of clinically relevant characteristics were poor. The quality scores of the included studies ranged from 0 to 8; only 3 studies scored 6 or more. The authors stated that blushing and excessive sweating decreased after ETS in all studies, but no further details were reported. Complications following ETS included pneumothorax and/or haemothorax and Horner's syndrome in some patients in almost all studies. Compensatory excessive sweating was observed in 50 % or more of patients in 13 of the 15 studies, and was considered to cause significant disability in 3 to 15 % of those who experienced it.
A review by the Royal Australasian College of Surgeons (Watt et al, 2009) concluded that "[a] lack of high quality randomised trial evidence on ETS means that it is difficult to make a judgment on the safety and effectiveness of this technique", and that "[t]here is potentially a number of safety issues associated with this procedure."
Patients with palmar hyperhidrosis who fail topical therapies and iontophoresis, and who do not tolerate or get relief from botulinum toxin, can be treated effectively with endoscopic thoracic sympathectomy (Smith, 2008). Side effects, especially compensatory hyperhidrosis in other parts of the body, may reduce long-term patient satisfaction with this procedure. Endoscopic thoracic sympathectmy can also be used for axillary hyperhidrosis, but the relapse rate is high.
CPT Codes / HCPCS Codes / ICD-9 Codes
CPT codes covered if selection criteria are met:
Other CPT codes related to the CPB:
Other HCPCS codes related to the CPB:
Botulinum toxin type A, per unit
Botulinum toxin type B, per 100 units
ICD-9 codes covered if selection criteria are met:
Causalgia of upper limb
Causalgia of lower limb
Primary focal hyperhidrosis [intractable, disabling - see criteria]
Secondary focal hyperhidrosis [intractable, disabling - see criteria]
ICD-9 codes not covered for indications listed in the CPB:
Other ICD-9 codes related to the CPB:
Unspecified disorder of the autonomic nervous system [shoulder-hand syndrome]
Unspecified circulatory system disorder [vascular occlusive disease]
The above policy is based on the following references:
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Copyright Aetna Inc. All rights reserved. Clinical Policy Bulletins are developed by Aetna to assist in administering plan benefits and constitute neither offers of coverage nor medical advice. This Clinical Policy Bulletin contains only a partial, general description of plan or program benefits and does not constitute a contract. Aetna does not provide health care services and, therefore, cannot guarantee any results or outcomes. Participating providers are independent contractors in private practice and are neither employees nor agents of Aetna or its affiliates. Treating providers are solely responsible for medical advice and treatment of members. This Clinical Policy Bulletin may be updated and therefore is subject to change.