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Clinical Policy Bulletin:
Melodic Intonation Therapy
Number: 0284


Policy

  1. Aetna considers melodic intonation therapy medically necessary for members with Broca's aphasia (also known as expressive or non-fluent aphasia) when all of the following selection criteria are met.

    1. Member has good auditory comprehension; and
    2. Member is well-motivated, emotionally stable, and has a good auditory span; and
    3. Member's repetition is poor, even for single words; and
    4. There is no evidence of bilateral brain involvement; and
    5. Verbal production is non-fluent, with diminished articulator agility and effortful initiation of speech production.
       
  2. Aetna considers melodic intonation therapy experimental and investigational for dysarthria, verbal apraxia, other types of aphasia, and for all other indications because its effectiveness for these indications has not been established.

  3. Aetna considers combinational use of transcranial magnetic stimulation/transcranial brain stimulation and melodic intonation therapy for the treatment of aphasia experimental and investigational because the effectiveness of this approach has not been established.

Notes: Melodic intonation therapy should be administered by a speech pathologist who is trained and qualified to work with individuals with aphasia and is experienced with the melodic intonation therapy techniques.  Melodic intonation therapy is best given in short, frequent sessions (30-min sessions) over a short time span (3 to 6 weeks).

See also CPB 0469 - Transcranial Magnetic Stimulation and Cranial Electrical Stimulation



Background

Aphasia refers to a degraded language capability due to lesions in the cortical language areas or association pathways.  Expressive aphasia (also known as non-fluent, anterior, or motor aphasia) affects spoken language (Broca's area) while receptive aphasia (also known as fluent, posterior, or sensory aphasia) affects language interpretation and memory (Wernicke's area).  Total (or global) aphasia is the consequence of large lesion(s) in the perisylvian area, extending deep into the subjacent white matter.  It can involve the frontal, temporal, and parietal lobes, resulting in the loss of all of nearly all speech and language functions.  Transcortical motor aphasia (also called anterior isolation syndrome) is caused by damage in the cortical areas around Broca's area, but sparing the arcuate fasciculus and Wernicke's area while transcortical sensory aphasia (also called posterior isolation syndrome) results from damage in the cortical areas around Wernicke's area, but sparing the arcuate fasciculus and Broca's area.

Melodic intonation therapy (MIT) is a type of speech-language therapy that has been used to treat non-fluent aphasia.  During MIT sessions a person with non-fluent aphasia is encouraged to hum, and then to sing words or phrases they find hard to recall, while tapping out a rhythm (NHS, 2011).  Melodic intonation therapy typically consists of speaking with a simplified and exaggerated prosody, characterized by a melodic component (2 notes, high and low) and a rhythmic component (2 durations, long and short).  This technique has been shown to increase the number of words a person can recall.  This may be due to the fact that the part of the brain we use to recall song lyrics and music is different from the part of the brain we use to recall spoken language.  Thus, MIT teaches a person with non-fluent aphasia an alternative way to recall words and phrases.  However, most aphasic patients do not respond to MIT.  This includes those with global and transcortical aphasia and almost all with evidence of significant posterior language area involvement.

There is some evidence that MITis effective for treating the speech-related problems of children and adults when diagnosed with Broca's aphasia (AAN, 1994).  However, the technique is now being used with children diagnosed with developmental apraxia of speech, which is defined as a speech articulation disorder not involving sensory or motor paralysis. 

A systematic review of the evidence by Roper (2003) concluded that “there is little to no evidence available supporting the effectiveness of Melodic Intonation Therapy (MIT) for children with apraxia.”  Based on this evidence-review, the Center for Evidence-Based Practices of the Orelena Hawks Puckett Institute (2003) made the following recommendation: "Use of modified forms of melodic intonation therapy to assist the speech development of young children who have apraxia of speech can not be recommended as a beneficial intervention until the practice is studied more carefully and thoroughly."

A Medicare National Coverage Determination (1983) states that MIT is a covered service only for nonfluent aphasic patients unresponsive to conventional therapy, and only when the conditions for coverage of speech pathology services are met.

In a pilot study, Tamplin (2008) examined the effects of vocal exercises and singing on intelligibility and speech naturalness for subjects with acquired dysarthria following traumatic brain injury or stroke.  A multiple case study design was used, involving pre-, mid-, and post-treatment assessments of intelligibility, rate, naturalness, and pause time for 4 subjects with dysarthria.  Each subject participated in 24 individual music therapy sessions over 8 weeks involving oral motor respiratory exercises, rhythmic and melodic articulation exercises, rhythmic speech cuing, vocal intonation therapy, and therapeutic singing using familiar songs.  Results were measured using a standardized dysarthric speech assessment -- the Sentence Intelligibility Test, waveform analysis, and ratings of speech naturalness.  Statistically significant improvements in functional speech intelligibility were achieved but improvements in rate of speech were insignificant.  Speech naturalness improved post-treatment and a reduction in the number and length of pauses was verified via waveform analysis.  The author stated that these preliminary findings suggested that a program of vocal exercises and singing may facilitate more normative speech production for people with acquired dysarthria and supported the need for further research in this area.

Vines et al (2011) noted that research has suggested that a fronto-temporal network in the right hemisphere may be responsible for mediating MIT’s positive effects on speech recovery.  These researchers investigated the potential for a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), to augment the benefits of MIT in patients with non-fluent aphasia by modulating neural activity in the brain during treatment with MIT.  The polarity of the current applied to the scalp determines the effects of tDCS on the underlying tissue: anodal-tDCS increases excitability, whereas cathodal tDCS decreases excitability.  These investigators applied anodal-tDCS to the posterior inferior frontal gyrus of the right hemisphere, an area that has been shown both to contribute to singing through the mapping of sounds to articulatory actions and to serve as a key region in the process of recovery from aphasia, particularly in patients with large left hemisphere lesions.  The stimulation was applied while patients were treated with MIT by a trained therapist.  A total of 6 patients with moderate-to-severe non-fluent aphasia underwent 3 consecutive days of anodal-tDCS + MIT, and an equivalent series of sham-tDCS + MIT.  The 2 treatment series were separated by 1 week, and the order in which the treatments were administered was randomized.  Compared to the effects of sham-tDCS + MIT, anodal-tDCS + MIT led to significant improvements in fluency of speech.  The authors concluded that these results support the hypothesis that, as the brain seeks to re-organize and compensate for damage to left hemisphere language centers, combining anodal-tDCS with MIT may further recovery from post-stroke aphasia by enhancing activity in a right hemisphere sensorimotor network for articulation.  These preliminary findings need to be validated by well-designed studies.

Chrysikou and Hamilton (2011) stated that aphasia is a common consequence of unilateral stroke, typically involving perisylvian regions of the left hemisphere.  The course of recovery from aphasia after stroke is variable, and relies on the emergence of neuroplastic changes in language networks.  Recent evidence suggested that rehabilitation interventions may facilitate these changes.  Functional re-organization of language networks following left-hemisphere stroke and aphasia has been proposed to involve multiple mechanisms, including intra-hemispheric recruitment of peri-lesional left-hemisphere regions and transcallosal inter-hemispheric interactions between lesioned left-hemisphere language areas and homologous regions in the right hemisphere.  Moreover, it is debated whether inter-hemispheric interactions are beneficial or deleterious to recovering language networks.  Transcranial magnetic stimulation (TMS) and tDCS are non-invasive procedures that can be applied clinically to modulate cortical excitability during post-stroke language recovery.  Intervention with these non-invasive brain stimulation techniques also allows for inferences to be made regarding mechanisms of recovery, including the role of intra-hemispheric and inter-hemispheric interactions.  The authors reviewed recent evidence that suggests that TMS and tDCS are promising tools for facilitating language recovery in aphasic patients.

Lim et al (2013) examined the therapeutic effect of neurologic music therapy (NMT) and speech language therapy (SLT) through improvement of the aphasia quotient (AQ) in post-stroke aphasic patients.  A total of 21 post-stroke, non-fluent aphasia patients who had ischemic/hemorrhagic stroke on radiologic evaluation were divided into the NMT and SLT groups.  They received NMT and SLT for 1 month.  Language function was assessed by Korean version-Western Aphasia Battery before and after therapy.  Neurologic music therapy consisted of therapeutic singing and MIT, and SLT consisted of language-oriented therapy.  Significant improvements were revealed in AQ, repetition, and naming after therapy in the NMT group and improvements in repetition in the SLT group of chronic stroke patients (p < 0.05).  There were significant improvements in language ability in the NMT group of subacute stroke patients.  However, there was no significant improvement in the SLT group of subacute stroke patients.  The authors concluded that the NMT as well as SLT are effective treatments in the chronic stage of stroke; and NMT is effective in subacute post-stroke aphasic patients.

van der Meulen et al (2014) examined if language production treatment with MIT is effective in subacute severe non-fluent aphasia.  A multi-center, randomized controlled trial was conducted in a waiting-list control design: Patients were randomly allocated to the experimental group (MIT) or the control group (control intervention followed by delayed MIT).  In both groups, therapy started at 2 to 3 months post-stroke and was given intensively (5 hrs/wk) during 6 weeks.  In a second therapy period, the control group received 6 weeks of intensive MIT.  The experimental group resumed their regular treatment.  Assessment was done at baseline (T1), after the first intervention period (T2), and after the second intervention period (T3).  Effectiveness was evaluated at T2.  The impact of delaying MIT on therapy outcome was also examined.  A total of 27 participants were included (n = 16 in the experimental group and n = 11 in the control group).  A significant effect in favor of MIT on language repetition was observed for trained items, with mixed results for untrained items.  After MIT there was a significant improvement in verbal communication but not after the control intervention.  Finally, delaying MIT was related to less improvement in the repetition of trained material.  The authors concluded that in patients with subacute severe non-fluent aphasia, language production treatment with MIT was effective; and earlier treatment may lead to greater improvement.

Zumbansen et al (2014) critically reviewed the literature on MIT, one of the most formalized treatments used by speech-language therapist in Broca's aphasia.  These investigators suggested basic clarifications to enhance the scientific support of this promising treatment.  First, therapeutic protocols using singing as a speech facilitation technique are not necessarily MIT.  The goal of MIT is to restore propositional speech.  The rationale is that patients can learn a new way to speak through singing by using language-capable regions of the right cerebral hemisphere.  Eventually, patients are supposed to use this way of speaking permanently but not to sing overtly.  These researchers argued that many treatment programs covered in systematic reviews on MIT's efficacy do not match MIT's therapeutic goal and rationale.  Critically, these researchers identified 2 main variations of MIT: (i) the French thérapie mélodique et rythmée (TMR) that trains patients to use singing overtly as a facilitation technique in case of speech struggle and palliative versions of MIT that help patients with the most severe expressive deficits produce a limited set of useful, ready-made phrases; (ii) distinguishing between the immediate effect of singing on speech production and the long-term effect of the entire program on language recovery.  Many results in the MIT literature can be explained by this temporal perspective.  The authors proposed that MIT can be viewed as a treatment of apraxia of speech more than aphasia.  They stated that this issue should be explored in future experimental studies.

 
CPT Codes / HCPCS Codes / ICD-9 Codes
CPT codes not covered if selection criteria are met:
90867
90868
90869
Other CPT codes related to the CPB:
92507
92508
Other HCPCS codes related to the CPB:
G0153 Services performed by a qualified speech-language pathologist in the home health or hospice setting, each 15 minutes
S9128 Speech therapy, in the home, per diem
ICD-9 codes covered if selection criteria are met:
438.11 Late effects of cerebrovascular disease, aphasia
784.3 Aphasia
ICD-9 codes not covered for indications listed in the CPB (not all-inclusive):
315.31 - 315.39 Developmental speech or language disorder
784.5 Other speech disturbance [dysarthria]
784.69 Other symbolic dysfunction


The above policy is based on the following references:
  1. National Coverage Determination (NCD) for Melodic Intonation Therapy (170.2). Effective March 11, 1983. 
  2. Naeser MA, Helm-Estabrooks N. CT scan localization and response to melodic intonation therapy with nonfluent aphasia cases. Cortex. 1985;21(2):203-223.
  3. Robey RR. The efficacy of treatment for aphasic persons: A meta-analysis. Brain Language. 1994;47(4):582-608.
  4. American Academy of Neurology (AAN), Assessment: Melodic intonation therapy. Report of the Therapeutic and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 1994;44(3 Pt 1):566-568.
  5. Belin P, Van Eeckhout P, Zilbovicius M, et al. Recovery from nonfluent aphasia after melodic intonation therapy: A PET study. Neurology. 1996;47(6):1504-1511.
  6. Roper N. Melodic intonation therapy with young children with apraxia. Bridges. 2003;1(8):1-7.
  7. Orelena Hawks Puckett Institute, Center for Evidence-Based Practices. The use of Melodic Intonation Therapy to treat apraxia of speech in young children. Bottomlines. 2003;1(8):1. Available at: http://www.researchtopractice.info/products.php. Accessed May 12, 2004.
  8. Tamplin J. A pilot study into the effect of vocal exercises and singing on dysarthric speech. NeuroRehabilitation. 2008;23(3):207-216.
  9. Norton A, Zipse L, Marchina S, Schlaug G. Melodic intonation therapy: Shared insights on how it is done and why it might help. Ann N Y Acad Sci. 2009;1169:431-436.
  10. Johansson BB. Current trends in stroke rehabilitation. A review with focus on brain plasticity. Acta Neurol Scand. 2011;123(3):147-159.
  11. NHS Institute for Innovation and Improvement. Aphasia. Treatment. CKS Clinical Knowledge Summaries. NHS Evidence. London, UK: National Institute for Health and Clinical Excellence (NICE); 2011. 
  12. Vines BW, Norton AC, Schlaug G. Non-invasive brain stimulation enhances the effects of melodic intonation therapy. Front Psychol. 2011;2:230.
  13. Chrysikou EG, Hamilton RH. Noninvasive brain stimulation in the treatment of aphasia: exploring interhemispheric relationships and their implications for neurorehabilitation. Restor Neurol Neurosci. 2011;29(6):375-394.
  14. Lim KB, Kim YK, Lee HJ, et al. The therapeutic effect of neurologic music therapy and speech language therapy in post-stroke aphasic patients. Ann Rehabil Med. 2013;37(4):556-562.
  15. van der Meulen I, van de Sandt-Koenderman WM, Heijenbrok-Kal MH, et al. The efficacy and timing of melodic intonation therapy in subacute aphasia. Neurorehabil Neural Repair. 2014 Jan 20. [Epub ahead of print]
  16. Zumbansen A, Peretz I, Hébert S. Melodic intonation therapy: Back to basics for future research. Front Neurol. 2014;5:7.


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Copyright Aetna Inc. All rights reserved. Clinical Policy Bulletins are developed by Aetna to assist in administering plan benefits and constitute neither offers of coverage nor medical advice. This Clinical Policy Bulletin contains only a partial, general description of plan or program benefits and does not constitute a contract. Aetna does not provide health care services and, therefore, cannot guarantee any results or outcomes. Participating providers are independent contractors in private practice and are neither employees nor agents of Aetna or its affiliates. Treating providers are solely responsible for medical advice and treatment of members. This Clinical Policy Bulletin may be updated and therefore is subject to change.
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