Orthognathic Surgery

Number: 0095

Policy

Certain jaw and cranio-facial deformities may cause significant functional impairment.  These deformities include apertognathia (either lateral or anterior not correctable by orthodontics alone), significant asymmetry of the lower jaw, significant class 2 and class 3 occlusal discrepancies, and cleft palate.  Aetna considers orthognathic surgery medically necessary for correction of the following skeletal deformities of the maxilla or mandible when it is documented that these skeletal deformities are contributing to significant dysfunction, and where the severity of the deformities precludes adequate treatment through dental therapeutics and orthodontics alone:

  1. Maxillary and/or Mandibular Facial Skeletal Deformities Associated with Masticatory Malocclusion

    Aetna considers orthognathic surgery medically necessary for correction of skeletal deformities of the maxilla or mandible when it is documented that these skeletal deformities are contributing to significant masticatory dysfunction, and where the severity of the deformities precludes adequate treatment through dental therapeutics and orthodontics:

    1. Antero-posterior discrepancies

      1. Maxillary/mandibular incisor relationship: overjet of 5 millimeter (mm) or more, or a 0 to a negative value (norm 2 mm),
      2. Maxillary/mandibular antero-posterior molar relationship discrepancy of 4 mm or more (norm 0 to 1 mm).

      Note: These values represent 2 or more standard deviations (SDs) from published norms.

    2. Vertical discrepancies

      1. Presence of a vertical facial skeletal deformity which is 2 or more SDs from published norms for accepted skeletal landmarks
      2. Open Bite

        1. No vertical overlap of anterior teeth greater than 2 mm
        2. Unilateral or bilateral posterior open bite greater than 2 mm
      3. Deep overbite with impingement or irritation of buccal or lingual soft tissues of the opposing arch
      4. Supraeruption of a dento-alveolar segment due to lack of opposing occlusion creating dysfunction not amenable to conventional prosthetics.

    3. Transverse discrepancies

      1. Presence of a transverse skeletal discrepancy which is 2 or more SDs  from published norms.
      2. Total bilateral maxillary palatal cusp to mandibular fossa discrepancy of 4 mm or greater, or a unilateral discrepancy of 3 mm or greater, given normal axial inclination of the posterior teeth.
    4. Asymmetries

      1. Antero-posterior, transverse or lateral asymmetries greater than 3 mm with concomitant occlusal asymmetry.

  2. Facial Skeletal Discrepancies Associated with Documented Sleep Apnea, Airway Defects, and Soft Tissue Discrepancies

    Aetna considers orthognathic surgery medically necessary in cases where it is documented that mandibular and maxillary deformities are contributing to airway dysfunction, where such dysfunction is not amenable to non-surgical treatments, and where it is shown that orthognathic surgery will decrease airway resistance and improve breathing.

    For example, studies demonstrate that persons with vertical hyperplasia of the maxilla have an associated increase in nasal resistance, as do persons with maxillary hypoplasia with or without clefts.  Following orthognathic surgery, such individuals routinely demonstrate decreases in nasal airway resistance and improved respiration.

    Aetna considers orthognathic surgery medically necessary for members with underlying craniofacial skeletal deformities that are contributing to obstructive sleep apnea.  See CPB 0004 - Obstructive Sleep Apnea in Adults.  Before surgery, such individuals should be properly evaluated to determine the cause and site of their disorder and appropriate non-surgical treatments attempted when indicated.

  3. Temporomandibular Joint Pathology

    Aetna considers orthognathic surgery for correction of temporomandibular joint disease or myofascial pain dysfunction experimental and investigational because its effectiveness for these indications has not been established.  See CPB 0028 - Temporomandibular Disorders.

  4. Speech Impairments

    Aetna considers orthognathic surgery medically necessary for treatment of speech impairments accompanying severe cleft deformity.  Orthognathic surgery may help to reduce the flattening of the face that is characteristic of severe cleft deformity.  By using osteotomy techniques along with bone and cartilage grafts, the upper and lower jaws and facial skeletal framework are moved and appropriately reconstructed.  Pre-surgical orthodontic treatment is usually recommended.

    Aetna considers other orthognathic surgeries experimental and investigational for correction of articulation disorders and other impairments in the production of speech because there is inadequate evidence from prospective clinical studies in the peer-reviewed published medical literature of the effectiveness of orthognathic surgery for this indication.

    Aetna considers orthognathic surgery for correction of distortions within the sibilant sound class or for other distortions of speech quality (e.g., hyper-nasal or hypo-nasal speech) not medically necessary as these distortions do not cause functional impairment.

  5. Unaesthetic Facial Features and Psychological Impairments

    Aetna considers orthognathic surgery cosmetic for correction of unaesthetic facial features, regardless of whether these are associated with psychological disorders.

    Mentoplasty or genial osteotomies/ostectomies (chin surgeries) are always considered cosmetic when performed as an isolated procedure to address genial hypoplasia, hypertrophy, or asymmetry, and may be considered cosmetic when performed with other surgical procedures.

    No benefits are available for orthognathic surgery performed primarily for cosmetic purposes.  See Aetna CPB 0031 - Cosmetic Surgery.

  6. Condylar Positioning Devices in Orthognathic Surgery

    Aetna considers the use of condylar positioning devices in orthognathic surgery experimental and investigational because their effectiveness in orthognathic surgery has not been established.

  7. Orthognathic Surgery Experimental Indications

    Aetna considers orthognathic surgery experimental and investigational for all indications other than those listed above because their effectiveness for indications other than the ones listed above has not been established.

  8. Three-Dimensional Virtual Treatment Planning

    Aetna considers three-dimensional virtual treatment planning of orthognathic surgery experimental and investigational because its effectiveness has not been established.

  9. Low-level Laser Therapy

    Aetna considers low-level laser therapy for the management of neurosensory disorders and post-operative pain/paresthesia following orthognathic surgery experimental and investigational because its effectiveness has not been established.

  10. Use of Kinesio Taping

    Aetna considers the use of Kinesio taping for reduction of swelling in persons after orthognathic surgery experimental and investigational because the effectiveness of this approach has not been established.

Note: Precertification requests or claims for orthognathic surgery are subject to review by Aetna's Oral and Maxillofacial Surgery Unit.

Orthodontic Treatment Prior to Orthognathic Surgery

Note: Expenses associated with the orthodontic phase of care (both pre- and post-surgical) are considered dental in nature and are not covered under Aetna's medical plans.  See CPB 0082 - Dental Services and Oral and Maxillofacial Surgery: Coverage Under Medical Plans.

Orthodontic treatment may be needed prior to orthognathic surgery to position the teeth in a manner that will provide for an adequate occlusion following surgical repositioning of the jaws.  For plans that require precertification, orthognathic surgery must be precertified prior to pre-surgical orthodontic treatment.  The interim occlusion that is achieved by orthodontic treatment may be dysfunctional prior to the completion of the orthognathic surgical phase of the treatment plan.  Therefore, all requests for orthognathic surgery must be reviewed/precertified by an the Aetna Oral and Maxillofacial Surgery Unit prior to the initiation of pre-surgical orthodontic care.  Failure to obtain precertification of orthognathic surgery prior to orthodontic care may result in the denial of benefits.

Documentation Requirements

Note: Orthognathic surgery may be subject to precertification review in plans that include precertification requirements.  The following documentation should be forwarded to Aetna's Oral and Maxillofacial Surgery Unit for review: a written explanation of the member's clinical course, including dates and nature of any previous treatment; physical evidence of a skeletal, facial or craniofacial deformity defined by study models and pre-orthodontic imaging; and a detailed description of the functional impairment considered to be the direct result of the skeletal abnormality.

See also CPB 0082 - Dental Services and Oral and Maxillofacial Surgery: Coverage Under Medical Plans.

Background

Orthognathic surgery is the revision by ostectomy, osteotomy or osteoplasty of the upper jaw (maxilla) and/or the lower jaw (mandible) intended to alter the relationship of the jaws and teeth.  These surgical procedures are intended
  1. to correct skeletal jaw and cranio-facial deformities that may be associated with significant functional impairment, and
  2. to reposition the jaws when conventional orthodontic therapy alone is unable to provide a satisfactory, functional dental occlusion within the limits of the available alveolar bone. 

Congenital or developmental defects can interfere with the normal development of the face and jaws. These birth defects may interfere with the ability to chew properly, and may also affect speech and swallowing. In addition, trauma to the face and jaws may create skeletal deformities that cause significant functional impairment. Functional deficits addressed by this type of surgery are those that affect the skeletal masticatory apparatus such that chewing, speaking and/or swallowing are impaired. 

During the procedure, an oral and maxillofacial surgeon repositions the affected areas (mentum, mandible and/or maxilla) to approximate normal alignment and structure; sometimes adding, removing or reshaping bone. Synthetic prosthetic materials may be used along with surgical plates, screws, wires and rubber bands to hold the jaws into the new position. The most common surgical technique is known as the LeFort I (though there are variations of this technique that may be performed, depending on the exact indications for the surgery).

There is a lack of evidence to support the use of condylar positioning devices in orthognathic surgery.  Costa et al (2008) stated that in the past few years, many devices have been proposed for preserving the pre-operative position of the mandibular condyle during bilateral sagittal split osteotomy.  The authors stated that accurate mandibular condyle re-positioning is considered important to obtain a stable skeletal and occlusal result, and to prevent the onset of TMD.  Condylar positioning devices (CPDs) have led to longer operating times, the need to keep inter-maxillary fixation as stable as possible during their application, and the need for precision in the construction of the splint or intra-operative wax bite.  The authors reviewed the literature concerning the use of CPDs in orthognathic surgery since 1990 and their application to prevent skeletal instability and contain TMD since 1995.  They concluded that there is no scientific evidence to support the routine use of CPDs in orthognathic surgery.

Stokbro et al (2014) stated that numerous publications regarding virtual surgical planning protocols have been published, most reporting only 1 or 2 case reports to emphasize the hands-on planning.  None had systematically reviewed the data published from clinical trials.  This systematic review analyzed the precision and accuracy of three-dimensional (3D) virtual surgical planning of orthognathic procedures compared with the actual surgical outcome following orthognathic surgery reported in clinical trials.  These researchers performed a systematic search of the current literature to identify clinical trials with a sample size of more than 5 patients, comparing the virtual surgical plan with the actual surgical outcome.  Search terms revealed a total of 428 titles, out of which only 7 articles were included, with a combined sample size of 149 patients.  Data were presented in 3 different ways: intra-class correlation coefficient, 3D surface area with a difference less than 2mm, and linear and angular differences in 3D.  Success criteria were set at 2 mm mean difference in 6 articles; 125 of the 133 patients included in these articles were regarded as having had a successful outcome.  Due to differences in the presentation of data, meta-analysis was not possible.  The authors concluded that virtual planning appears to be an accurate and reproducible method for orthognathic treatment planning; a more uniform presentation of the data is necessary to allow the performance of a meta-analysis.  Moreover, they stated that currently the software system most often used for 3D virtual planning in clinical trials is SimPlant (Materialise); more independent clinical trials are needed to further validate the precision of virtual planning.

Adolphs et al (2014) stated that within the domain of craniomaxillofacial surgery, orthognathic surgery is a special field dedicated to the correction of dentofacial anomalies resulting from skeletal malocclusion.  Generally, in such cases, an inter-disciplinary orthodontic and surgical treatment approach is needed.  After initial orthodontic alignment of the dental arches, skeletal discrepancies of the jaws can be corrected by distinct surgical strategies and procedures in order to achieve correct occlusal relations, as well as facial balance and harmony within individualized treatment concepts.  To transfer the pre-operative surgical planning and re-position the mobilized dental arches with optimal occlusal relations, surgical splints are typically used.  For this purpose, different strategies have been described which use 1 or more splints.  Traditionally, these splints are manufactured by a dental technician based on patient-specific dental casts; however, computer-assisted technologies have gained increasing importance with respect to pre-operative planning and its subsequent surgical transfer.  In a pilot study of 10 patients undergoing orthognathic corrections by a 1-splint strategy, 2 final occlusal splints were produced for each patient and compared with respect to their clinical usability. One splint was manufactured in the traditional way by a dental technician according to the preoperative surgical planning. After performing a CBCT scan of the patient's dental casts, a second splint was designed virtually by an engineer and surgeon working together, according to the desired final occlusion.  For this purpose, RapidSplint, a custom-made software platform, was used.  After post-processing and conversion of the datasets into .stl files, the splints were fabricated by the PolyJet procedure using photo polymerization.  During surgery, both splints were inserted after mobilization of the dental arches then compared with respect to their clinical usability according to the occlusal fitting.  Using the workflow described above, virtual splints could be designed and manufactured for all patients in this pilot study.  Eight of 10 virtual splints could be used clinically to achieve and maintain final occlusion after orthognathic surgery.  In 2 cases virtual splints were not usable due to insufficient occlusal fitting, and even two of the traditional splints were not clinically usable. In five patients where both types of splints were available, their occlusal fitting was assessed as being equivalent, and in one case the virtual splint showed even better occlusal fitting than the traditional splint.  In 1 case where no traditional splint was available, the virtual splint proved to be helpful in achieving the final occlusion.  The authors concluded that the findings of this pilot study demonstrated that clinically usable splints for orthognathic surgery can be produced by computer-assisted technology.  Virtual splint design was realized by RapidSplint®, an in-house software platform which might contribute in future to shorten pre-operative workflows for the production of orthognathic surgical splints.  The preliminary findings from this pilot study need to be validated by well-designed studies.

Swennen (2014) evaluated the timing for 3D virtual treatment planning of orthognathic surgery in the daily clinical routine.  A total of 350 consecutive patients were included in this study.  All patients were scanned following the standardized "Triple CBCT Scan Protocol" in centric relation.  Integrated 3D virtual planning and actual surgery were performed by the same surgeon in all patients.  The authors concluded that although clinically acceptable, still software improvements especially toward 3D virtual occlusal definition are mandatory to make 3D virtual planning of orthognathic surgery less time-consuming and more user-friendly to the clinician.

Austin et al (2015) compared the effectiveness of distraction osteogenesis to orthognathic surgery (OS) for the treatment of maxillary hypoplasia in individuals with cleft lip and palate.  These investigators performed a systematic review of prospective randomized, quasi-randomized or controlled clinical trials.  Medline, Embase, Scopus, Web of Science, CINAHL, CENTRAL, trial registers and grey literature were searched.  Hand-searching of 5 relevant journals was completed.  Two reviewers independently completed inclusion assessment.  Data extraction and risk of bias assessment were completed by a single reviewer and checked by a second reviewer.  A total of 5 publications all reporting different outcomes of a single RCT were included within the review.  The quality of the evidence was low with a high risk of bias.  Both surgical interventions produced significant soft tissue improvement.  Horizontal relapse of the maxilla was statistically significantly greater following OS.  There was no statistically significant difference in speech and velo-pharyngeal function between the interventions.  Maxillary distraction initially lowered social self-esteem, but this improved with time resulting in higher satisfaction with life in the long-term.  The authors concluded that the low quality of evidence included within the review meant there is insufficient evidence to conclude whether there is a difference in effectiveness between maxillary distraction and osteotomy for the treatment of cleft-related maxillary hypoplasia.  They stated that there is a need for further high-quality RCTs to allow conclusive recommendations to be made.

Olsen et al (2016) evaluated the effectiveness of hemostatic adjuncts on intra-operative blood loss (IOBL) in OS detected by RCTs of the highest quality.  A search of the Medline, Cochrane, Embase, and Web of Science databases was performed in January 2015, and the risk of bias was assessed using the Jadad and Delphi scales.  The predictor variable was the hemostatic measures, and the main outcome variable was the total IOBL volume.  The secondary outcome variables were the hemoglobin and hematocrit and operating time.  A total of 11 trials were included for review.  The individual trials demonstrated the effects on IOB from hypotensive anesthetic regimens, the use of aprotinin, and the herbal medicine Yunnan Baiyao.  Six studies of tranexamic acid (TXA), with 288 patients, were suitable for a meta-analysis of continuous data.  Tranexamic acid reduced IOBL by an average of 171 ml (95 % confidence interval [CI]: -230 to -112; p < 0.00001).  Its topical use yielded similarly significant results (mean difference -197, 95 % CI: -319 to -76; p < 0.001).  A subgroup analysis showed a decreased operating time in the TXA groups by an average of 15 minutes (mean difference -14.78, 95 % CI: -22.21 to -7.35; p < 0.0001).  The authors concluded that efficient hemostatic adjuncts exist for OS.  The findings of this meta-analysis showed that TXA significantly reduced IOBL by an average of 1/3, regardless of whether it was given intravenously (IV) or applied topically.  They stated that additional RCTs are needed to confirm the effect of topical TXA in OS, and larger studies of intravenous administration are needed before any routine recommendations.  No hemostatic effect of hypotensive anesthesia was found, mainly owing to imprecise descriptions of the blinding procedures.  Transparent and uniform trial reporting is thus encouraged in future studies.

Borba and colleagues (2016) stated that the sequencing of bi-maxillary orthognathic surgery remains controversial, although the traditional maxilla-first approach is performed routinely.  The se investigators presented a systematic review of the mandible-first sequence in bi-maxillary orthognathic surgery, provided data that may assist in the decision as to which jaw should undergo osteotomy first in bi-maxillary orthognathic surgery cases.  A literature search was conducted for articles published in the English language, reporting the use of the altered sequence for bi-maxillary orthognathic surgery (mandible-first), using the following descriptors: “orthognathic” and “double-jaw”, “orthognathic” and “two-jaw”, “orthognathic” and “mandible-first”, “orthognathic” and “bi-maxillary”.  A total of 887 abstracts were initially identified and were evaluated for inclusion according to the proposed inclusion criteria.  After evaluation of these abstracts and relevant references, 6 publications met the criteria for consideration.  Performing mandible-first surgery in bi-maxillary orthognathic cases dated back to the 1970s; however the decision regarding the jaw to be operated on first appeared to rely on accurate pre-operative planning based upon the surgeon's experience and preference.  While there appeared to be significant theoretical advantages to support the use of the altered orthognathic sequence (mandible-first), future prospective studies on its reliability, accuracy, and short- and long-term outcomes are needed.

Posnick et al (2016) examined operative time, peri-operative airway management, early post-operative cardio-pulmonary health, need for blood transfusion, and in-hospital stay associated with simultaneous bi-maxillary, intra-nasal, and osseous genioplasty surgery.  These investigators performed a retrospective cohort study derived from patients treated by 1 surgeon at a single institution from 2009 through 2014.  The sample consisted of a consecutive series of patients with symptomatic chronic obstructed nasal breathing and a dento-facial deformity (DFD).  All underwent at least a Le Fort I osteotomy, sagittal ramus osteotomies, septoplasty, inferior turbinate reduction, and osseous genioplasty.  For each patient, the design of the osteotomies and the fixation techniques were consistent.  The outcome variables included need for blood transfusion, operating time, success of naso-tracheal intubation, time and place of extubation, early post-operative cardio-pulmonary health, length of in-hospital stay, and need for re-admission after surgery.  For the 166 patients studied, the average age was 25 years (range of 13 to 65; 87 female patients [52 %]).  The primary patterns of presenting DFD included long face (43 of 166, 26 %), maxillary deficiency (41 of 166, 25 %), asymmetric mandibular excess (37 of 166, 22 %), short face (28 of 166, 17 %), and mandibular deficiency (15 of 166, 9 %); 42 patients (25 %) were confirmed to have symptomatic obstructive sleep apnea (OSA).  The open wound operating time averaged 2 hours 59 minutes (SD = 32 minutes).  Only 3 of the 166 patients (1.8 %) received blood transfusions.  All patients underwent successful naso-tracheal intubation; 96 % of patients were extubated in the operating room and the remaining 4 % were extubated in the recovery room.  No patients required re-intubation or tracheostomy; 137 patients (83 %) were discharged after a 1- or 2-night in-hospital stay; 25 (15 %) required a 3-night stay; and 4 (2 %) required a 4-night hospital stay to achieve adequate oral intake; none of the patients required re-admission.  The authors concluded that the findings of this study confirmed efficient surgical and anesthesia care for patients undergoing simultaneous bi-maxillary orthognathic, intra-nasal, and osseous genioplasty, and anticipating safe naso-tracheal intubation with extubation soon after surgery and a limited need for blood transfusion has proved to be the norm.  They stated that this study confirmed an average in-hospital stay of 2 nights after complex orthognathic surgery without need for re-admission.

Bioresorbable Fixation Following Orthognathic Surgery

Agnihotry and associates (2017) noted that recognition of some of the limitations of titanium plates and screws used for the fixation of bones has led to the development of plates manufactured from bioresorbable materials.  While resorbable plates appear to offer clinical advantages over metal plates in orthognathic surgery, concerns remain about the stability of fixation and the length of time required for their degradation and the possibility of foreign body reactions.  In an update of the Cochrane Review first published in 2007., these investigators compared the effects of bioresorbable fixation systems with titanium systems used during orthognathic surgery.  Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to January 20, 2017); the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 11) in the Cochrane Library (searched January 20, 2017); Medline Ovid (1946 to January 20, 2017); and Embase Ovid (1980 to January 20, 2017).  These investigators searched the US National Institutes of Health Ongoing Trials Register ClinicalTrials.gov (clinicaltrials.gov; searched January 20, 2017), and the World Health Organization International Clinical Trials Registry Platform (searched  January 20, 2017) for ongoing trials.  No restrictions were placed on the language or date of publication when searching the electronic databases; RCTs comparing bioresorbable versus titanium fixation systems used for orthognathic surgery in adults were selected for analysis.  Two review authors independently screened the results of the electronic searches, extracted data and assessed the risk of bias of the included studies.  They resolved disagreement by discussion.  Clinical heterogeneity between the included trials precluded pooling of data, and only a descriptive summary was presented.  This review included 2 trials, involving 103 participants, one comparing titanium with resorbable plates and screws and the other titanium with resorbable screws.  Both studies were at high risk of bias and provided very limited data for the primary outcomes of this review.  All participants in one trial suffered mild-to-moderate post-operative discomfort with no statistically significant difference between the 2 plating groups at different follow-up times.  Mean scores of patient satisfaction were 7.43 to 8.63 (range of 0 to 10) with no statistically significant difference between the 2 groups throughout follow-up.  Adverse effects reported in one study were 2 plate exposures in each group occurring between the 3rd and 9th months.  Plate exposures occurred mainly in the posterior maxillary region, except for 1 titanium plate exposure in the mandibular premolar region.  Known causes of infection were associated with loosened screws and wound dehiscence with no statistically significant difference in the infection rate between titanium (1.5 % [3/196]), and resorbable (1.8 % [3/165]) plates.  The authors concluded that they did not have sufficient evidence to determine if titanium plates or resorbable plates are superior for fixation of bones after orthognathic surgery.  They stated that this review provided insufficient evidence to show any difference in post-operative pain and discomfort, level of patient satisfaction, plate exposure or infection for plate and screw fixation using either titanium or resorbable materials.

Luo and colleagues (2018) stated that despite developments in bioresorbable fixation over recent decades, controversy remains regarding skeletal stability following the use of this material in orthognathic surgery.  This systematic review and meta-analysis examined evidence from the international literature from studies comparing skeletal stability between bioresorbable and titanium fixation in orthognathic surgery. Key words were searched in Medline, Embase, and Cochrane Library, and relevant journals and reference lists were searched for additional material, up to January 2017.  Study quality was assessed with the Newcastle-Ottawa scale.  The meta-analysis was performed using RevMan software; a total of 10 cohort studies were included.  The meta-analysis showed no statistically significant difference between bioresorbable and titanium fixation (SMD (95 % CI)) for maxillary horizontal relapse (maxillary advancement 0.09 (-0.16 to 0.33); maxillary setback -0.04 (-0.64 to 0.56)), maxillary vertical relapse (maxillary elongation 0.15 (-0.31 to 0.61); maxillary impaction -0.30 (-1.10 to 0.50)), mandibular horizontal relapse (mandibular advancement 0.16 (-0.72 to 1.03); short-term mandibular setback -0.33 (-0.82 to 0.15)), and mandibular angular relapse (mandibular clockwise rotation -0.39 (-0.79 to 0.00); mandibular counter-clockwise rotation 0.14 (-0.37 to 0.66)).  However, after mandibular setback, titanium fixation showed significantly less relapse in the long-term (0.97 (0.47 to 1.47)).  The authors concluded that with regard to skeletal stability, bioresorbable fixation was comparable to titanium fixation when used in maxillary setback and mandibular clockwise rotation; however titanium fixation may be preferable in mandibular setback.  Moreover, they stated that further high-quality studies are needed to draw more definitive conclusions.

Low-Level Laser Therapy Following Orthognathic Surgery

In a systematic review, Bittencourt and associates (2017) examined scientific evidence concerning the effectiveness of laser to reduce pain or paresthesia related to orthognathic surgery.  An electronic search was performed in PubMed, Scopus, Science Direct, LILACS, SciELO, CENTRAL, Google Scholar, OpenGrey, and ClinicalTrials.gov, up to November 2016, with no restrictions on language or year of publication.  Additionally, a hand-search of the reference list of the selected studies was performed.  The PICOS strategy was used to define the eligibility criteria and only randomized clinical trials were selected.  Out of 1,257 identified citations, 3 papers fulfilled the criteria and were included in the systematic review.  The risk of bias was assessed according to the Cochrane Guidelines for Clinical Trials and results were exposed based on a descriptive analysis.  One study showed that laser therapy was effective to reduce post-operative pain 24 hours (p = 0.007) and 72 hours (p = 0.007) after surgery.  Other study revealed the positive effect of laser to improve neurosensory recovery 60 days after surgery, evaluated also by the 2-point discrimination (p = 0.005) and sensory (p = 0.008) tests.  The 3rd study reported an improvement for general sensibility of 68.75 % for laser group, compared with 21.43 % for placebo (p = 0.0095), 6 months following surgery.  The authors concluded that individual studies suggested a positive effect of low-level laser therapy on reduction of post-operative pain and acceleration of improvement of paresthesia related to orthognathic surgery.  However, they noted that due to the insufficient number and heterogeneity of studies, a meta-analysis evaluating the outcomes of interest was not performed, and a pragmatic recommendation about the use of laser therapy was not possible.  These investigators stated that further high-quality clinical trials are needed to increase the strength of evidence and to confirm the effectiveness of low-level laser for the treatment of neurosensory disorders after orthognathic surgery.

Orthognathic Surgery for the Treatment for Temporomandibular Disorders

There is limited evidence of the effectiveness of orthognathic surgery on temporomandibular disorders.  Abrahamsson et al (2007) examined if orthognathic surgery does affect the prevalence of signs and symptoms of temporomandibular disorders (TMDs).  A literature survey in the PubMed and Cochrane Library electronic databases was performed and covered the period from January 1966 to April 2006.  The inclusion criteria were controlled, prospective or retrospective studies comparing TMDs before and after orthognathic surgery in patients with malocclusion.  There were no language restrictions, and 3 reviewers selected and extracted the data independently.  The quality of the retrieved articles was evaluated by 4 reviewers.  The search strategy resulted in 467 articles, of which 3 met the inclusion criteria.  Because of few studies with unambiguous results and heterogeneity in study design, the scientific evidence was insufficient to evaluate the effects that orthognathic surgery had on TMD.  Moreover, the studies had problems with inadequate selection description, confounding factors, and lack of method error analysis.  The authors concluded that to obtain reliable scientific evidence, additional well-controlled and well-designed studies are needed to determine how and if orthognathic surgery alters signs and symptoms of TMD.

Lindenmeyer et al (2010) performed a systematic review of the best available research literature investigating the relation of oral and maxillofacial surgical procedures to the onset or relief of chronic painful TMD.  A comprehensive review of the databases CINAHL, Cochrane Library, Embase, Medline, NHS Evidence--Oral Health, PsycINFO, Web of Knowledge, and MetaLib was undertaken by 2 authors up to June 2009 using search terms appropriate to establishing a relation between orofacial surgical procedures and TMD.  The search was restricted to English-language publications.  Of the 1,777 titles reviewed, 35 articles were critically appraised, but only 32 articles were considered eligible.  These were observational studies that fell into 2 groups; 9 were seeking to establish a surgical cause for TMD.  Of these, only 2 of a series of 3 claimed that there was a significant link, but this claim was based on weak data (health insurance records) and was abandoned in a subsequent report.  Twenty-three studies were seeking to achieve relief by orthognathic surgical intervention.  These were also negative overall, with 7 articles showing varying degrees of mostly non-significant improvement, whereas 16 showed no change or a worse outcome.  No published report on the putative effect of implant insertion was found.  The authors concluded that these apparently contradictory approaches underline a belief that oral surgical trauma or gross malocclusion has a causative role in the onset of TMD.  However, there was no overall evidence of a surgical causal etiology or orthognathic therapeutic value.  This review emphasized that it is in the patients' best interest to carry out prospective appropriately controlled randomized trials to clarify the situation.

In a Cochrane review, Luther et al (2010) examined the effectiveness of orthodontic intervention in reducing symptoms in patients with TMD (compared with any control group receiving no treatment, placebo treatment or reassurance) and investigated if active orthodontic intervention leads to TMD.  The Cochrane Oral Health Group's Trials Register, CENTRAL, MEDLINE and EMBASE were searched.  Hand-searching of orthodontic journals and other related journals was undertaken in keeping with the Cochrane Collaboration hand-searching program.  No language restrictions were applied.  Authors of any studies were identified, as were experts offering legal advice, and contacted to identify unpublished trials.  Most recent search was April 13, 2010.  All randomized controlled trials (RCTs) including quasi-randomized trials assessing orthodontic treatment for TMD were included.  Studies with adults aged equal to or above 18 years old with clinically diagnosed TMD were included.  There were no age restrictions for prevention trials provided the follow-up period extended into adulthood.  The inclusion criteria required reports to state their diagnostic criteria for TMD at the start of treatment and for participants to exhibit 2 or more of the signs and/or symptoms.  The treatment group included treatment with appliances that could induce stable orthodontic tooth movement.  Patients receiving splints for 8 to 12 weeks and studies involving surgical intervention (direct exploration/surgery of the joint and/or orthognathic surgery to correct an abnormality of the underlying skeletal pattern) were excluded.  The outcomes were: how well were the symptoms reduced, adverse effects on oral health and quality of life.  Screening of eligible studies, assessment of the methodological quality of the trials and data extraction were conducted in triplicate and independently by 3 review authors.  As no 2 studies compared the same treatment strategies (interventions) it was not possible to combine the results of any studies.  The searches identified 284 records from all databases.  Initial screening of the abstracts and titles by all review authors identified 55 articles that related to orthodontic treatment and TMD.  The full articles were then retrieved and of these articles only 4 demonstrated any data that might be of value with respect to TMD and orthodontics.  After further analysis of the full texts of the 4 studies identified, none of the retrieved studies met the inclusion criteria and all were excluded from this review.  The authors concluded that there are insufficient research data on which to base clinical practice on the relationship of active orthodontic intervention and TMD.  There is an urgent need for high quality RCTs  in this area of orthodontic practice.

Dolwick and Widmer (2018) stated that well-controlled clinical trials supporting orthognathic surgery as the primary management for TMDs are lacking.  Most published studies lack an adequate experimental design to minimize biases.  Studies that minimized some biases did support an overall reduction in the frequency of TMD signs and symptoms in some Class III and Class II patients who had orthognathic surgery.  However, Class II correction with counter-clockwise rotation of the mandible increased TMD.  The authors concluded that individual variability precluded the ability to predict TMD outcome after surgery.  They stated that irreversible therapies such as orthognathic surgery should not be primary treatments in the management or prevention of TMDs.

Minimally Invasive Orthognathic Surgery

AlAsseri and Swennen (2018) stated that minimally invasive techniques are currently applied in many oral and maxilla-facial surgical procedures, including orthognathic surgery.  These investigators carried out a systematic review on the application of potentially minimally invasive procedures in orthognathic surgery to provide a clear overview of the relevant published data.  Articles in English on minimally invasive orthognathic procedures, published in the scientific literature, were obtained from the PubMed, Embase, and Cochrane Library databases, and an additional manual search (revised December 31, 2016).  After screening the abstracts and applying the eligibility criteria, a total of 403 articles were identified.  All articles reporting the potential for minimally invasive orthognathic surgery were included (n = 44).  The full papers were evaluated in detail and categorized as articles on a minimally invasive surgical approach (n = 4), endoscopically assisted orthognathic procedures (n = 17), or the use of a piezoelectric device in orthognathic surgery (n = 25); 2 articles were each included in 2 categories.  Although a small incision and minimal dissection is the basic principle of a minimally invasive technique, most articles (90.9 %) reported the endoscope and piezoelectric instrument as important tools in minimally invasive orthognathic surgery.  The authors concluded that evidence from available studies suggested that patients undergoing minimally invasive orthognathic surgery had less morbidity and made a faster recovery.  Moreover, they stated that further research should aim to obtain higher levels of evidence.

Use of Kinesio Taping for the Reduction of Swelling in Patients after Orthognathic Surgery

Lietz-Kijak and colleagues (2018) noted that orthognathic surgery (OGS) is associated with extensive surgical intervention within the soft and hard tissues of the facial region of the skull leading to inflammatory reactions.  The presence of post-operative swelling indicates the accumulation of exudate or transudate; both these fluids occur in surgery.  Massive swelling is a significant problem, because the tension of tissues intensifies pain sensations.  In a pilot study, these researchers examined the effectiveness of the Kinesio taping (KT) in patients after OGS in the area of the facial skull in terms of eliminating post-operative swelling.  This trial was carried out in 16 patients who suffered from this complication after bilateral sagittal split osteotomy.  he swelling was shown to be reduced after KT; within the same study the differences were statistically significant between the left and right sides and for the same side (p < 0.05).  The application of the lymphatic KT led to the reduction of tension in the affected area and restoration of proper lymphatic circulation in the region covered by swelling.  This allowed for the improvement of the blood and lymph micro-circulation and activation of self-healing processes.  The authors concluded that the analysis of the impact of the practical use of the lymphatic KT on complications after OGS revealed that it had a beneficial effect on the reduction of swelling.  They stated that the use of the KT appeared promising because it is economical, non-traumatic, simple-to-perform, and rarely causes undesirable allergies.  Moreover, they stated that further research is needed to examine if KT can reduce or eliminate the need for additional drugs, such as steroids.


Table: CPT Codes / HCPCS Codes / ICD-10 Codes
Code Code Description

Information in the [brackets] below has been added for clarification purposes.   Codes requiring a 7th character are represented by "+":

CPT codes covered if selection criteria are met:

21083 Impression and custom preparation; palatal lift prosthesis
21084     speech aid prosthesis
21085     oral surgical splint
21088     facial prosthesis
21141 Reconstruction midface, Lefort I; single piece, segment movement in any direction (e.g., for Long Face Syndrome), without bone graft
21142     2 pieces, segment movement in any direction, without bone graft
21143     3 or more pieces, segment movement in any direction, without bone graft
21145     single piece, segment movement in any direction, requiring bone grafts (includes obtaining graft)
21146     2 pieces, segment movement in any direction, requiring bone grafts (includes obtaining autografts) (e.g., ungrafted unilateral alveolar cleft)
21147     3 or more pieces, segment movement in any direction, requiring bone grafts (includes obtaining autografts) (e.g., ungrafted bilateral alveolar cleft or multiple osteotomies)
21150 Reconstruction midface, Lefort II; anterior intrusion (e.g., Treacher-Collins Syndrome)
21151     any direction, requiring bone grafts (includes obtaining autografts)
21154 Reconstruction midface, Lefort III (extracranial), any type, requiring bone grafts (includes obtaining autografts); without Lefort I
21155     with Lefort I
21159 Reconstruction midface, Lefort III (extra and intracranial) with forehead advancement (e.g., mono bloc), requiring bone grafts (includes obtaining autografts): without Lefort I
21160     with Lefort I
21181 Reconstruction by contouring of benign tumor of cranial bones (e.g., fibrous dysplasia), extracranial
21182 Reconstruction of orbital walls, rims, forehead, nasoethmoid complex following intra- and extracranial excision of benign tumor of cranial bone (e.g., fibrous dysplasia) with multiple autografts (includes obtaining grafts); total area of bone grafting less than 40 sq cm
21183     total area of bone grafting greater than 40 sq cm but less than 80 sq cm
21184     total area of bone grafting greater than 80 sq cm
21188 Reconstruction midface, osteotomies (other than Lefort type) and bone grafts (includes obtaining autografts)
21193 Reconstruction of mandibular rami, horizontal, vertical, C, or L osteotomy; without bone graft
21194     with bone graft (includes obtaining graft)
21195 Reconstruction of mandibular rami and/or body, sagittal split; without internal rigid fixation
21196     with internal rigid fixation
21198 Osteotomy, mandible, segmental;
21199     with genioglossus advancement
21206 Osteotomy, maxilla, segmental (e.g., Wassmund or Schuchard)
21208 Osteoplasty, facial bones; augmentation (autograft, allograft, or prosthetic implant)
21209     reduction
21210 Graft, bone; nasal, maxillary or malar areas (includes obtaining graft)
21215     mandible (includes obtaining graft)
21230 Graft; rib cartilage, autogenous, to face, chin, nose or ear (includes obtaining graft)
21235     ear cartilage, autogenous, to nose or ear (includes obtaining graft)
21240 Arthroplasty, temporomandibular joint, with or without autograft (includes obtaining graft)
21242 Arthroplasty, temporomandibular joint, with allograft
21243 Arthroplasty, temporomandibular joint, with prosthetic joint replacement
21247 Reconstruction of mandibular condyle with bone and cartilage autografts (includes obtaining grafts) (e.g., for hemifacial microsomia)
21255 Reconstruction of zygomatic arch and glenoid fossa with bone and cartilage (includes obtaining autografts)
21270 Malar augmentation, prosthetic material
21275 Secondary revision of orbitocraniofacial reconstruction
21295 Reduction of masseter muscle and bone (e.g., for treatment of benign masseteric hypertrophy); extraoral approach
21296     intraoral approach
42200 - 42281 Repair of palate

CPT codes not covered for indications listed in the CPB:

21125 Augmentation, mandibular body or angle; prosthetic material
21127     with bone graft, onlay or interpositional (includes obtaining autograft)

Other CPT codes related to the CPB:

21110 Application of interdental fixation device for conditions other than fracture or dislocation, includes removal
21120 - 21123 Genioplasty

HCPCS codes covered if selection criteria are met:

D5954 - D5959 Palatal augmentation and lift prosthesis
D7940 - D7955 Other repair procedures

HCPCS codes not covered for indications listed in the CPB:

Kinesio taping - no specific code:

Other HCPCS codes related to the CPB:

D8010 - D8999 Orthodontics

ICD-10 codes covered if selection criteria are met:

G47.33 Obstructive sleep apnea (adult) (pediatric) [associate with facial skeletal deformitites]
M26.00 - M26.59, M26.70 - M26.9 Dentofacial anomalies [including malocclusion] and other disorders of jaw [except TMJ disorders]
Q35.1 - Q37.9 Cleft lip and cleft palate

ICD-10 codes not covered for indications listed in the CPB:

G89.18 Other acute postprocedural pain [neurosensory disorders]
G89.28 Other chronic postprocedural pain [neurosensory disorders]
M26.601 - M26.609 Temporomandibular joint disorders
R20.2 Paresthesia of skin [neurosensory disorders]
R60.0 - R60.9 Edema, not elsewhere classified
Z41.1 Encounter for cosmetic surgery
Z98.890 Other postprocedural states [post orthognathic surgery]

The above policy is based on the following references:

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