Magnetic Resonance Imaging (MRI) of the Extremities

Number: 0171

Policy

1. Aetna considers magnetic resonance imaging (MRI) studies of the knee medically necessary when any of the following criteria is met:

   1. Detection, staging, and post-treatment evaluation of tumor of the knee; or
   2. Persistent knee pain/swelling and/or instability (giving way) not associated with an injury and not responding to at least 3 weeks of conservative therapy; or 
   3. Persistent knee pain/swelling and/or instability (giving way) secondary to an injury and not responding to conservative therapy when multi-view x-rays have ruled out a fracture or loose body in the knee and the clinical picture remains uncertain.  Conservative therapy consists of a combination of rest, ice, compression, elevation, non-steroidal anti-inflammatory drugs (NSAIDs), crutches, and range of motion (ROM) exercises; or
   4. Persistent true locking of the knee indicative of a torn meniscus or loose body.  (True locking is defined as more than a momentary locking of the joint with the knee in a flexed position, as compared to the sensation of momentary “catching” that many individuals experience in extension.); or
   5. Suspected bone infection (i.e., osteomyelitis); or
   6. Suspected osteochondritis dissecans or suspected osteonecrosis, if the clinical picture, including x-rays, is not confirmatory.

2. Aetna considers knee MRI experimental and investigational for all other indications, including any of the following circumstances because its effectiveness for indications other than the ones listed above has not been established:

   1. Fitting of implants for total knee arthroplasty; or
   2. If arthroscopy or ligament reconstruction is definitely planned and the MRI findings are unlikely to change the planned treatment; or
   3. If the clinical picture (i.e., history, physical examination, x-rays, etc.) is diagnostic with high degree of certainty of a torn meniscus, loose body, or osteochondritis dessicans; or
   4. To diagnose or evaluate rheumatoid arthritis or degenerative joint disease.

3. Aetna considers MRI medically necessary for the diagnosis of CLOVES syndrome and for the diagnosis of osteomyelitis in the foot.
   

4. Aetna considers whole-body MRI medically necessary for screening of malignancy in adults (aged 18 years or older) with Li-Fraumeni syndrome.

5. Aetna considers MRI for Morton neuroma medically necessary for pre-operative planning when symptomatic neuroma has been identified by plain X-ray and non-surgical treatments (e.g., metatarsal support, padded shoe insert, and steroid/local anesthetic injections) have failed.
   

6. Aetna considers MRI of the extremities (e.g., hands, knees, feet, etc.) experimental and investigational for diagnosing or monitoring arthritis because its effectiveness for these indications has not been established.

7. Aetna considers MRI of the extremities experimental and investigational for the following because its effectiveness for these indications has not been established:

   1. Assessment of perfusion in diabetic foot ulcer;
   2. Diagnosis or prognosis of spinal cord injury and whiplash associated disorder;
   3. Diagnosis of chronic exertional compartment syndrome;
   4. Diagnosis suspected upper extremity deep vein thrombosis;
   5. Evaluation and/or monitoring of disease progression in facioscapulohumeral muscular dystrophy.

Background

Magnetic resonance imaging (MRI) has become the premier orthopedic diagnostic tool used in detecting meniscal and anterior cruciate ligament (ACL) tears and has virtually replaced both arthrography and arthroscopy as the diagnostic test of choice.

According to established guidelines from the American College of Rheumatology (2002), disease progression in rheumatoid arthritis (RA) should be followed using standard X-rays of the extremities. There is no adequate evidence from prospective clinical studies that clinical outcomes are improved by using MRI over standard X-rays for this indication. Although several studies have shown that MRI can detect early osseous changes, prospective clinical studies are needed to determine how well these early changes can predict development of clinically significant disease, and to determine whether clinical outcomes are improved by initiating therapy in persons with normal X-rays based on MRI findings. McQueen et al (2001) found that only 25% of changes detected by MRI progressed to X-ray erosions. These results raise questions about the nature and pathophysiologic basis of the osseous changes detected by MRI, whether one can predict which of these osseous changes will progress to X-ray erosions, and about the nature of the changes detected by MRI that do not progress to X-ray erosions.

In addition, prospective clinical studies are necessary to determine whether clinical outcomes are improved by using MRI over standard X-rays to monitor disease progression in persons with RA. Goldbach-Mansky et al (2003) of the National Institute of Arthritis and Musculoskeletal Diseases concluded that “[c]areful validation of MRI findings and the evaluation of MRI as a tool to follow the effect of therapy remain to be performed before MRI may be used as a clinical tool to follow therapy or as a surrogate for evaluating osseous changes over time.”  Boutry et al (2005) evaluated prospectively the use of MRI for differentiating true RA from systemic lupus erythematosus (SLE) or primary Sjogren syndrome in patients who have inflammatory polyarthralgia of the hands but no radiographic evidence of RA. They concluded that it may be impossible to distinguish between patients with early RA and those without RA (namely those with SLE or primary Sjogren syndrome) by means of MRI. Graham et al (2005) reported that determining synovial volume in the hand and wrist in patients (n = 10) with juvenile rheumatoid arthritis by MRI is feasible and correlates with total hand swelling assessed on physical examination. However, these investigators stated that inconsistent or poor correlation with other clinical variables and the clinical definition of improvement requires further study.

Extremity MRI is not considered medically necessary to monitor the progression of arthritis. The American College of Rheumatology (ACR) Guidelines for the Management of Rheumatoid Arthritis (2002) lists X-rays as the appropriate method of monitoring disease progression. MRI of the arms and legs may be appropriate for the evaluation of masses, localized infections, non-healing fractures of long bones, and in certain cases, preoperative planning. Furthermore, the report on extremity MRI in RA by the ACR Extremity MRI Task Force (2006) stated that most of the literature assessing the utility of peripheral joint MRI has used high-field, not low-field extremity MRI; therefore, actual sensitivity, specificity, and predictive value of the low-field scanners available for the practicing rheumatologists are not known. The report also noted that the marginal benefit of low-field extremity MRI above and beyond standard measures of disease activity and severity (e.g., medical history, physical examination, selective laboratory testing, and radiography of the hands and wrists) has not been rigorously examined in studies published to date. In summary, the benefits of low-field strength extremity MRI for the diagnosis and management of RA are still being elucidated.

More recently, guidance on the management of rheumatoid arthritis from the National Institute for Health and Clinical Excellence (NICE, 2009) recommended X-ray the hands and feet early in the course of the disease in people with persistent synovitis in these joints. The Scottish Intercollegiate Guidelines Network (SIGN, 2011) concluded that "[t]he evidence for additional imaging at diagnosis to assess disease activity in early RA [rheumatoid arthritis] is limited and methodologically poor. The evidence suggests that power Doppler ultrasound may be useful in assessing disease activity and may have predictive value on radiological outcome."  SIGN (2010) guidelines on psoriatic arthritis make no recommendation for magnetic resonance imaging of extremities.

This is consistent with the comments in a recent UpToDate review of the management of rheumatoid arthritis (Venables and Maini, 2011) which states that, although "magnetic resonance imaging (MRI) is a more sensitive technique than plain radiography for identifying bone erosions ... the clinical significance of erosions only detected by MRI awaits elucidation."  Another recent UpToDate review of management of rheumatoid arthritis by Schur et al (2011) stated that although "magnetic resonance imaging (MRI) [is] more sensitive for the detection of cartilage and bone abnormalities ... [it's] role in the process of making therapeutic decisions is presently under investigation."

There has been concern regarding the overuse of MRI. MRI has come to be perceived by many doctors and patients as the initial and the sine qua non diagnostic tool prior to surgical treatment. However, MRI should not be used as a routine screening tool in all knee injuries. Its use should be reserved for clinical situations in which the diagnosis remains in doubt. MRI does not replace a thorough history and physical examination and traditional multi-view x-rays as primary diagnostic tools. In a randomized controlled study (n = 87), Nikken and colleagues (2005) concluded that short MRI examination with a low-field-strength MRI system after radiography in initial evaluation of patients with acute wrist trauma has additional value in prediction of treatment need; however, it does not have value in identification of patients who can be discharged without further follow-up. In a randomized controlled study (n = 109), Oei and associates (2005) concluded that implementation of a dedicated extremity MRI examination, in addition to or instead of radiography, performed in patients with traumatic knee injury improves prediction of the need for additional treatment but does not significantly aid in identification of patients who can be discharged without further follow-up. They stated that value of a short MRI examination in the initial stage after knee trauma is limited.

Andrish (1996) stated that isolated meniscal injuries are rare in children under the age of 14, but the frequency increases thereafter. Meniscal tears in children are frequently associated with congenital meniscal abnormalities, while those in adolescents are often associated with ligamentous injuries of the knee. The combination of recurrent and often dramatic popping and intermittent episodes of locking has been termed the "snapping knee syndrome", and is almost invariably associated with a discoid meniscus. Although double-contrast arthrography has proved to be a reliable diagnostic technique, MRI is now the modality of choice. In this regard, Connolly et al (1996) had described the MRI appearance and associated abnormalities of discoid menisci in children. They noted that discoid meniscus commonly occurs bilaterally. High intra-meniscal signal is found, especially in symptomatic patients. The size criteria for diagnosing this condition in children are similar to those for adults.

In a prospective study, McNally et al (2002) examined if MRI of the acutely locked knee can alter surgical decision-making. The study group comprised patients with a clinical diagnosis of knee locking requiring arthroscopy. The decision to perform arthroscopy was made by an experienced consultant orthopedic surgeon specializing in trauma and recorded in the patient's notes prior to MRI. Pre-operative MRI was carried out using a 1.5 T system. The management was altered from surgical to conservative treatment in 20 (48%) patients on the basis of the MR findings. Arthroscopy was limited to patients with an MR diagnosis of a mechanical block, usually a displaced meniscal tear or loose body. Both patient groups were followed clinically until symptoms resolved. A total of 42 patients were entered into the study. MRI identified a mechanical cause for locking in 22 patients (21 avulsion meniscal tears and 1 loose body). All were confirmed at arthroscopy. Twenty patients were changed from operative to non-operative treatment on the basis of the MRI findings. One patient in this group required a delayed arthroscopy for an impinging anterior cruciate ligament stump. The sensitivity, specificity, and accuracy of MRI in identifying patients who require arthroscopy was 96, 100, and 98%, respectively. These investigators concluded that MRI can successfully segregate patients with a clinical diagnosis of mechanical locking into those who have a true mechanical block and those who can be treated conservatively. They stated that MRI should precede arthroscopy in this clinical setting.

Schurmann et al (2007) stated that complex regional pain syndrome type I (CRPS I) is difficult to diagnose in post-traumatic patients. As CRPS I is a clinical diagnosis the characteristic symptoms have to be differentiated from normal post-traumatic states. These researchers compared several diagnostic procedures for diagnosing post-traumatic CRPS I. A total of 158 patients with distal radial fracture were included in this study. A detailed clinical examination was carried out 2, 8, and 16 weeks after trauma in conjunction with bilateral thermography, plain radiographs of the hand skeleton, three phase bone scans (TPBSs), and contrast-enhanced magnetic resonance imaging (MRI). All imaging procedures were assessed blinded. At the end of the observation period, 18 patients (11%) were clinically identified as having CRPS I and 13 patients (8%) revealed an incomplete clinical picture which were defined as CRPS borderline cases. The sensitivity of all diagnostic procedures used was poor and decreased between the first and the last examinations (thermography: 45% to 29%; TPBS: 19% to 14%; MRI: 43% to 13%; bilateral radiographs: 36%). In contrast, a high specificity was observed in the TPBS and MRI at the 8th and 16th-week examinations (TPBS: 96%, 100%; MRI: 78%, 98%) and for bilateral radiographs 8 weeks after trauma (94%). Thermography presented a fair specificity that improved from the 2nd to the 16th week (50% to 89%). The authors concluded that the poor sensitivity of all tested procedures combined with a reasonable specificity produced a low positive predictive value (17% to 60%) and a moderate negative predictive value (79% to 86%). These results suggested that those procedures can not be used as screening tests. Imaging methods are not able to reliably differentiate between normal post-traumatic changes and changes due to CRPS I. Clinical findings remain the gold standard for the diagnosis of CRPS I and the procedures described above may serve as additional tools to establish the diagnosis in doubtful cases.

Tsai and Beredjiklian (2008) noted that arthritis of the thumb joints is a common problem and remains a significant cause of morbidity in the adult population. Careful physical examination is critical in the evaluation of these individuals, given the large differential diagnosis of conditions affecting the thumb and the radial side of the wrist. Because treatment should be specifically directed at the area of pathology, adequate diagnosis is vital. Plain radiograph examination remains the diagnostic modality of choice in the evaluation of patients with degenerative conditions regarding the hand and wrist.

The American College of Occupational and Environmental Medicine's clinical guideline on "Hand, wrist, and forearm disorders not including carpal tunnel syndrome" (2011) does not recommend MRI for diagnosing tuft fractures as well as phalangeal and metacarpal fractures.

Aweid et al (2012) stated that although all intra-compartmental pressure (ICP) measurement, MRI, and near-infrared spectroscopy seem to be useful in confirming the diagnosis of chronic exertional compartment syndrome (CECS), no standard diagnostic procedure is currently universally accepted.  These researchers reviewed systematically the relevant published evidence on diagnostic criteria commonly in use for CECS to address 3 main questions:

1. Is there a standard diagnostic method available?
2. What ICP threshold criteria should be used for diagnosing CECS? and
3. What are the criteria and options for surgical management? 

Finally, these investigators made statements on the strength of each diagnostic criterion of ICP based on a rigorous standardized process. The authors searched for studies that investigated ICP measurements in diagnosing CECS in the leg of human subjects, using PubMed, Score, PEDRO, Cochrane, Scopus, SportDiscus, Web of Knowledge, and Google Scholar.  Initial searches were performed using the phrase, "chronic exertional compartment syndrome".  The phrase "compartment syndrome" was then combined, using Boolean connectors ("OR" and "AND") with the words "diagnosis", "parameters", "levels", "localisation," or "measurement".  Data extracted from each study included study design, number of subjects, number of controls, ICP instrument used, compartments measured, limb position during measurements, catheter position, exercise protocol, timing of measurements, mean resting compartment pressures, mean maximal compartment pressures, mean post-exercise compartment pressures, diagnostic criteria used, and whether a reference diagnostic standard was used.  The quality of studies was assessed based on the approach used by the American Academy of Orthopaedic Surgeons in judging the quality of diagnostic studies, and recommendations were made regarding each ICP diagnostic criteria in the literature by taking into account the quality and quantity of the available studies proposing each criterion. A total of 32 studies were included in this review.  The studies varied in the ICP measurement techniques used; the most commonly measured compartment was the anterior muscle compartment, and the exercise protocol varied between running, walking, and ankle plantarflexion and dorsiflexion exercises.  Pre-exercise, mean values ranged from 7.4 to 50.8 mm Hg for CECS patients, and 5.7 to 12 mm Hg in controls; measurements during exercise showed mean pressure readings ranging from 42 to 150 mm Hg in patients and 28 to 141 mm Hg in controls.  No overlap between subjects and controls in mean ICP measurements was found at the 1-min post-exercise timing interval only showing values ranging from 34 to 55.4 mm Hg and 9 to 19 mm Hg in CECS patients and controls, respectively.  The quality of the studies was generally not high, and the researchers found the evidence for commonly used ICP criteria in diagnosing CECS to be weak. The authors concluded that studies in which an independent, blinded comparison is made with a valid reference standard among consecutive patients are yet to be undertaken.  There should also be an agreed ICP test protocol for diagnosing CECS because the variability here contributes to the large differences in ICP measurements and hence diagnostic thresholds between studies.  Current ICP pressure criteria for CECS diagnosis are therefore unreliable, and emphasis should remain on good history.  However, clinicians may consider measurements taken at 1 min after exercise because mean levels at this timing interval only did not overlap between subjects and controls in the studies that were analyzed.  Levels above the highest reported value for controls here (27.5 mm Hg) along with a good history, should be regarded as highly suggestive of CECS.  The authors stated that it is evident that to achieve an objective recommendation for ICP threshold, there is a need to set up a multi-center study group to reach an agreed testing protocol and modify the preliminary recommendations they have made.

Krabben et al (2013) stated that MRI is increasingly used to measure inflammation in rheumatoid arthritis (RA) research, but the correlation to clinical assessment is unexplored. This study determined the association and concordance between inflammation of small joints measured with MRI and physical examination. A total of 179 patients with early arthritis underwent a 68 tender joint count and 66 swollen joint count and 1.5T MRI of MCP (2-5), wrist and MTP (1-5) joints at the most painful side. Two readers scored synovitis and bone marrow edema (BME) according to the OMERACT RA MRI scoring method and assessed tenosynovitis. The MRI data were first analyzed continuously and then dichotomized to analyze the concordance with inflammation at joint examination. A total of 1,790 joints of 179 patients were studied. Synovitis and tenosynovitis on MRI were independently associated with clinical swelling, in contrast to BME. In 86% of the swollen MCP joints and in 92% of the swollen wrist joints any inflammation on MRI was present. In 27% of the non-swollen MCP joints and in 66% of the non-swollen wrist joints any MRI inflammation was present. Vice versa, of all MCP, wrist and MTP joints with inflammation on MRI 64%, 61% and 77%, respectively, were not swollen. Bone marrow edema, also in case of severe lesions, occurred frequently in clinically non-swollen joints. Similar results were observed for joint tenderness. The authors concluded that inflammation on MRI is not only present in clinically swollen but also in non-swollen joints. In particular BME occurred in clinically non-inflamed joints. The relevance of subclinical inflammation for the disease course is a subject for further studies.

Also, an UpToDate review on “Diagnosis and differential diagnosis of rheumatoid arthritis” (Venables and Maini, 2014) states that “MRI and ultrasound -- Magnetic resonance imaging (MRI) studies and ultrasonography do not have an established role in the routine evaluation of patients with polyarthritis. However, MRI and ultrasound are more sensitive than radiography at detecting changes resulting from synovitis and may be helpful in establishing the presence of synovitis in patients with normal radiographs and uncertainty regarding either the diagnosis or the presence of inflammatory changes, such as patients with obesity or subtle findings on examination”.

Furthermore, Axelsen and colleagues (2014) examined the ability of whole-body MRI (WBMRI) to visualize inflammation [synovitis, BME and enthesitis] and structural damage in patients with RA. The 3T WBMR images were acquired in a head-to-toe scan in 20 patients with RA and at least 1 swollen or tender joint. Short Tau Inversion Recovery and pre- and post-contrast T1-weighted images were evaluated for readability and the presence/absence of inflammation (synovitis, BME and enthesitis) and structural damage (erosions and fat infiltrations) in 76 peripheral joints, 30 entheseal sites and in the spine. The readability was greater than 70% for all individual joints, except for the most peripheral joints of the hands and feet. Synovitis was most frequent in the wrist, first tarsometatarsal, first CMC joints and glenohumeral joints (67 to 61%); BME in the wrist, CMC, acromioclavicular and glenohumeral joints (45 to 35%) and erosions in the wrist, MTP and CMC joints (19 to 16%). Enthesitis at greater than or equal to 1 site was registered in 16 patients. Bone marrow edema was frequently seen in the cervical (20%) but not the thoracic and lumbar spine, while fat infiltrations and erosions were rare. The intra-reader agreement was high (85 to 100%) for all pathologies. The agreement between WBMRI and clinical findings was low. The authors concluded that peripheral and axial inflammation and structural damage at joints and entheses was frequently identified by WBMRI, and more frequently than by clinical examination. They stated that WBMRI is a promising tool for evaluation of the total inflammatory load of inflammation (an MRI joint count) and structural damage in RA patients.

Management of Diabetic Foot Ulceration

Forsythe and Hinchliffe (2016) noted that evaluation of foot perfusion is a vital step in the management of patients with diabetic foot ulceration, in order to understand the risk of amputation and likelihood of wound healing. Underlying peripheral artery disease (PAD) is a common finding in patients with foot ulceration and is associated with poor outcomes. Evaluation of foot perfusion should therefore focus on identifying the presence of PAD and to subsequently estimate the effect this may have on wound healing. Assessment of perfusion can be difficult because of the often complex, diffuse and distal nature of PAD in patients with diabetes, as well as poor collateralization and heavy vascular calcification. Conventional methods of evaluating tissue perfusion in the peripheral circulation may be unreliable in patients with diabetes, thus, it may therefore be difficult to determine the extent to which poor perfusion contributes to foot ulceration. Anatomical data obtained on cross-sectional imaging is important but must be combined with measurements of tissue perfusion (such as transcutaneous oxygen tension) in order to understand the global and regional perfusion deficit present in a patient with diabetic foot ulceration. Ankle-brachial pressure index is routinely used to screen for PAD, but its use in patients with diabetes is limited in the presence of neuropathy and medial arterial calcification. Toe pressure index may be more useful because of the relative sparing of pedal arteries from medial calcification but may not always be possible in patients with ulceration. Fluorescence angiography is a non-invasive technique that can provide rapid quantitative information about regional tissue perfusion; capillaroscopy, iontophoresis and hyper-spectral imaging may also be useful in assessing physiological perfusion but are not widely available. The authors concluded that there may be a future role for specialized perfusion imaging of these patients, including MRI techniques, single-photon emission computed tomography (SPECT) and positron emission tomography (PET)-based molecular imaging; however, these novel techniques require further validation and are unlikely to become standard practice in the near future.

Evaluation and/or Monitoring of Disease Progression in Facioscapulohumeral Muscular Dystrophy

Andersen and associates (2017) noted that there is no effective treatment available for facioscapulohumeral muscular dystrophy type 1 (FSHD1), but emerging therapies are underway that call for a better understanding of natural history in this condition. In a prospective, longitudinal study, these researchers used quantitative MRI to evaluate yearly disease progression in patients with FSHD1. Ambulatory patients with confirmed diagnosis of FSHD1 (25/20 men/women, age range of 20 to 75 years, FSHD score: 0 to 12) were tested with 359-560-day interval between tests. Using the MRI Dixon technique, muscle fat replacement was evaluated in para-spinal, thigh, and calf muscles. Changes were compared with those in FSHD score, muscle strength (hand-held dynamometry), 6-minute-walk-distance (6MWD), 14-step-stair-test, and 5-time-sit-to-stand-test. Composite absolute fat fraction of all assessed muscles increased by 0.036 (confidence interval [CI]: 0.026 to 0.046, p < 0.001), with increases in all measured muscle groups. The clinical severity FSHD score worsened (10%, p < 0.05), muscle strength decreased over the hip (8%), neck (8%), and back (17%) (p < 0.05), but other strength measures, 6MWD, 5-times-sit-to-stand-test, and 14-step-stair-test were unchanged. Changes in muscle strength, FSHD score, and fat fraction did not correlate. The authors concluded that this first study to systemically monitor quantitative fat replacement longitudinally in FSHD1 showed that MRI provided an objective measure of disease progression, often before changes can be appreciated in strength and functional tests. The study indicated that quantitative MRI can be a helpful end-point in follow-up and therapeutic trials of patients with FSHD1. These preliminary findings need to be validated by well-designed studies.

In a single-center study, Mui and colleagues (2017) examined if quantitative muscle MRI should be added to the clinical trial toolbox for(FSHD by correlating it to clinical outcome measures in a large cohort of genetically and clinically well-characterized patients with FSHD comprising the entire clinical spectrum. Quantitative MRI scans of leg muscles of 140 patients with FSHD1 and FSHD2 were assessed for fatty infiltration and TIRM hyper-intensities and were correlated to multiple clinical outcome measures. The mean fat fraction of the total leg musculature correlated highly with the motor function measure, FSHD clinical score, Ricci score, and 6MWD (correlation coefficients -0.845, 0.835, 0.791, -0.701, respectively).  Fat fraction per muscle group correlated well with corresponding muscle strength (correlation coefficients up to -0.82).  The hamstring muscles, adductor muscles, rectus femoris, and gastrocnemius medialis were affected most frequently, also in early stage disease and in patients without leg muscle weakness.  Muscle involvement was asymmetric in 20% of all muscle pairs and fatty infiltration within muscles showed a decrease from distal to proximal of 3.9%.  TIRM hyper-intense areas, suggesting inflammation, were found in 3.5% of all muscles, with and without fatty infiltration. The authors concluded that this study showed a strong correlation of quantitative muscle MRI with different clinical outcome measures, especially with the motor function measure.  Since quantitative muscle MRI also had good clinimetric properties, it is a promising biomarker representative of disease severity.  For clinical trials, these researchers proposed to include quantitative muscle MRI and the motor function measure in the FSHD trial toolbox. Moreover, they stated that while the single-center, single-evaluator design of this study avoided interrater variability and increased the reliability of correlations between fat fractions and clinical measures; however, a limitation of this design was the decrease in the external validity. Furthermore, results regarding disease duration should be interpreted with caution since age at disease onset was collected retrospectively.

Diagnosis and/or Prognosis of Spinal Cord Injury and Whiplash Associated Disorder

McPherson and colleagues (2018) stated that diffusion-weighted MRI (DW-MRI) of skeletal muscle has the potential to be a sensitive diagnostic and/or prognostic tool in complex, enigmatic neuro-musculoskeletal conditions such as spinal cord injury (SCI) and whiplash associated disorder.  However, the reliability and reproducibility of clinically accessible DW-MRI parameters in skeletal muscle remains incompletely characterized -- even in individuals without neuro-musculoskeletal injury -- and these parameters have yet to be characterized for many clinical populations.  These researchers provided normative measures of the apparent diffusion coefficient (ADC) in healthy muscles of the lower limb; evaluate the rater-based reliability and short- and long-term reproducibility of the ADC in the same muscles; and quantify ADC of these muscles in individuals with motor incomplete SCI. A total of 20 individuals without neuro-musculoskeletal injury and 14 individuals with motor incomplete SCI participated in this study.  These investigators acquired bilateral DW-MRI of the lower limb musculature in all participants at 3-T using a multi-shot echo-planar imaging sequence with b-values of 0, 100, 300 and 500 s/mm2 and diffusion-probing gradients applied in 3 orthogonal directions.  Outcome measures included average ADC in the lateral and medial gastrocnemius, tibialis anterior, and soleus of individuals without neurological or musculoskeletal injury; intra- and inter-rater reliability, as well as short- and long-term reproducibility of the ADC; and estimation of average muscle ADC in individuals with SCI. Intra- and inter-rater reliability of the ADC averaged 0.89 and 0.79, respectively, across muscles.  Least significant change, a measure of temporal reproducibility, was 4.50 and 11.98% for short (same day) and long (9-month) inter-scan intervals, respectively.  Average ADC was significantly elevated across muscles in individuals with SCI compared to individuals without neurological or musculoskeletal injury (1.655 versus 1.615 mm2/s, respectively). The authors concluded that despite the promise of DW-MRI in skeletal muscle as an additional tool for clinical evaluation and basic scientific investigation, its utility has remained limited at least in part due to a lack of normative data and an incomplete assessment of its precision and reliability.  These results demonstrated that its reproducibility is excellent over short time scales, reinforcing the available literature.  They also extended these findings by providing insights into the stability of the approach over the longest inter-scan interval available to-date (9 months).  Although performance was expectedly lower over this time scale, ADC changes as small as 12% were still discernable.  Considering that ADC changes of approximately 24% have been reported in radiculopathy, approximately 35% following rotator cuff tear, and approximately 20% immediately following vigorous contraction of the same muscles included in this investigation, the authors stated that controlled experiments using DW-MRI of skeletal muscle are sufficiently reproducible for longitudinal analyses.  With evolving scanner and sequence technologies, DW-MRI may prove to be a highly sensitive measure of physiological changes to peripheral muscles after neurological injury and in any number of common, yet enigmatic, neuro-musculoskeletal conditions (e.g., low back pain, whiplash).  Such knowledge could help to improve clinical decision-making at a time when therapeutic intervention may have its largest effect.  These researchers stated that the findings of this  provided a foundation for future studies that track longitudinal changes in skeletal muscle ADC of the lower extremity and/or examine the mechanisms underlying ADC changes in cases of known or suspected pathology. 

The authors stated that this study had several drawbacks.  Unlike previous investigations, their ROI definition was performed by raters with minimal imaging experience yet an intimate knowledge of the relevant anatomical structures (Doctor of Physical Therapy students).  Although this choice was motivated by a desire to estimate a potential lower bound on rater-based reliability, it also complicated the interpretation of these findings by making it harder to decouple the sources of experimental, physiological, and rater-induced variability.  Another drawback was that these researchers used the same MRI scanner for all imaging sessions.  As a result, the ADC values, as well as their reliability estimates, should be interpreted only in this context.  In purest terms, these findings may over-estimate rater-based reliability and/or reproducibility and thus be much different if compared to results from multi-site investigations incorporating different community imaging centers.  Finally, these investigators did not control leg temperature in the cohort of individuals with SCI.  Thus, it was possible that subtle temperature differences existed between the SCI and control cohorts and/or between the more and less impaired legs of individuals with SCI.  Reduced temperature in the extremities, as has been reported in SCI, could change the estimates of ADC independently of SCI-induced alterations of muscle physiology.  It appeared unlikely that changes in temperature could explain the differences in ADC they found between individuals with and without SCI, however.  Specifically, leg temperature in individuals with SCI was generally lower than that of individuals without SCI, suggesting that ADC should be lower in SCI than controls.  However, the authors found a significantly elevated ADC across muscles in the SCI cohort compared to the control cohort, indicating that temperature was not the primary factor driving the observed ADC differences.  These researchers also found no significant differences in ADC between legs within the SCI cohort for any muscle.  This finding also suggested that the influence of leg temperature on these findings was likely minimal (although it was presumably a source of overall variability in the estimates of ADC). Nevertheless, future work investigating skeletal muscle ADC in individuals with SCI (or other neurological injuries) should systematically monitor and control extremity temperature to avoid undue experimental confounds.

Diagnosis of CLOVES syndrome

Alomari and colleagues (2011) stated CLOVES syndrome, characterized by Congenital Lipomatous Overgrowth, Vascular malformations, Epidermal nevi, and Skeletal anomalies, is a complex disorder of congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and skeletal/scoliosis/spinal anomalies. The authors reported the occurrence of spinal-paraspinal fast-flow lesions within or adjacent to the truncal over-growth or a cutaneous birthmark in 6 patients with CLOVES syndrome. The available imaging studies included MRI in 6 patients, CT in 4, and spinal angiography in 5.

Boston Children’s Hospital CLOVES Syndrome Work Group’s clinical practice guidelines on “CLOVES syndrome” (2014) stated that “CLOVES patients may benefit from an MRI of the chest, abdomen, pelvis and lower extremities performed in the neonatal or early infantile period or at the time of initial presentation. This help define deeper components of the syndrome that may require from intervention in early childhood (e.g., lymphatic and venous malformations, gastrointestinal and genitourinary involvement); as well as characterize overgrowth and extension into the retroperitoneum, peritoneum, superior and posterior mediastinum, pelvis, pleural spaces and paraspinal muscles, tethered spinal cord, neural tube defects. If the study requires general anesthesia, the scan can be delayed until the risk of anesthesia is reduced (i.e., greater than 6 months of age). Optimal timing of imaging best balances the risks of anesthesia with the information to be gained”.

Panteliades and associates (2016) stated that CLOVES syndrome is a rare, newly described, and relatively unknown syndrome, related to somatic mutations of the PIK3CA gene. Clinical findings include adipose tissue over-growth, vascular malformations, epidermal nevi, scoliosis, and spinal deformities. These researchers addressed a characteristic phenotype case, highlighting peculiar cutaneous and radiological changes. A 2-year old child was referred to evaluate the increase in the soft parts in the lower back, left arm, and posterior portion of the lower limbs, which had been present since birth. The patient also presented with flat feet, epidermal nevi on the right arm, nodular plate with a cystic formation on the left arm, spacing between the 1st and 2nd toes, capillary malformation in the trunk, as well as epispadia and scoliosis of the thoracic-lumbar spine. Imaging examinations (CT of the abdomen and MRI of the abdomen and right upper limb) revealed confluent and heterogeneous lobes located in the subcutaneous adipose tissue of the abdomen, with a cystic aspect, suggestive of lymphangioma, an asymmetrical increase in the fat deposit on the retro-peritoneal posterior abdominal wall, as well as para-vertebral muscles, presence of scoliosis in the thoracic-lumbar spine, and complex vascular malformation in the left arm.

Mahajan and co-workers (2019) stated that CLOVES syndrome is a recently described sporadic syndrome from post-zygotic activating mutations in PIK3CA. These researchers presented the case of a 3-year old boy, born to non-consanguineous and healthy parents, had epidermal verrucous nevus, lower limb length discrepancy and bilateral genuvalgum, anterior abdominal wall lipomatous mass, central beaking of L2 and L3, and fibrous dysplasia of the left frontal bone. Ocular and dental abnormalities (ptosis, esotropia, delayed canine eruption, dental hypoplasia), ipsilateral asymmetrical deformity of skull, and large left cerebral hemisphere with mild ipsilateral ventriculomegaly were peculiar to him denoting an uncommon phenotype. The parents did not consent for MRI and genetic studies because of financial constraints. The authors noted that CLOVES syndrome has emerged as an uncommon yet distinct clinical entity with some phenotypic variations. Its diagnosis is usually from cutaneous, truncal, spinal, and foot anomalies in clinical and radio-imaging studies. 

Diagnosis of Osteomyelitis in the Foot

Jones and colleagues (2012) noted that the clinical presentation of acute Charcot arthropathy in the diabetic population usually follows the Eichenholtz classification. These researchers discussed 3 usual cases of Charcot arthropathy presenting with rapid primary bone resorption in the absence of subluxation, dislocation and/or fracture. They carried out a review of the literature. To their knowledge, Charcot arthropathy has not been previously described as primary bone resorption. Three cases encountered at the authors’ multi-disciplinary High Risk Foot Clinic (HRFC) presented with primary bony resorption without features of subluxation, dislocation and/or fracture. Aggressive primary bone resorption was initially thought due to infection; a diagnostic dilemma that delayed optimal treatment. Late bone resorption in typical Charcot is linked to un-regulated proinflammatory cytokines (IL-1β, IL-6 and TNFα) that lead to increased osteoclastic activity. The pathophysiology of osteolysis in aggressive primary bony resorption may relate to a disturbance in the balance between RANK-L and OPG. The authors concluded that primary resorption of bone without subluxation, dislocation and/or fracture could represent an active Charcot process. These investigators stated that prudent use of serial radiography and early MRI to look for the widespread bone and soft tissue edema is recommended.

Madan and Pai (2013) stated that MRI is becoming a popular investigation for a variety of foot problems. In chronic charcot neuroarthropathy (CN), MRI shows low signal intensity in subchondral bone on both T1 and T2 weighted images; this correlates with sclerosis on radiographs. In contrast, in osteomyelitis there is low signal intensity on T1‐weighted and high signal intensity on T2‐weighted images. However, differentiating acute Charcot foot from osteomyelitis remains a challenge. The very similar clinical presentation of these 2 entities causes confusion in the diagnosis and overlap of the MRI findings adds to this confusion. However, there are some clues that can help to clinch the diagnosis. On MRI, a Charcot foot will show localized juxta‐articular edema, whereas in osteomyelitis the edema is more on one side of the joint and is not confined to the juxta-articular area. Clinically, osteomyelitis affects a single bone in the fore-foot or hind-foot, whereas CN affects many bones, commonly in the mid-foot.

An UpToDate review on “Osteomyelitis in adults: Clinical manifestations and diagnosis” (Lalani and Schmitt, 2019) states that “If the patient is diabetic and has symptoms referable to the foot, magnetic resonance imaging (MRI) is the test of choice … Acute Charcot neuroarthropathy may present with localized erythema and warmth; it can be difficult to determine if such patients have Charcot arthropathy or osteomyelitis (or both). Furthermore, patients with Charcot arthropathy commonly develop skin ulcerations that can in turn lead to secondary osteomyelitis. Magnetic resonance imaging (MRI; contrast-enhanced) may be diagnostically useful if it shows a sinus tract, replacement of soft tissue fat, a fluid collection, or extensive marrow abnormalities … Patients with suspected osteomyelitis should undergo laboratory evaluation (including erythrocyte sedimentation rate, C-reactive protein, white blood cell count), blood cultures, and radiographic imaging. In patients with greater than or equal to 2 weeks of symptoms, conventional radiography is a reasonable initial imaging modality. In patients with less than 2 weeks of symptoms, an advanced imaging modality (magnetic resonance imaging, computed tomography, or nuclear imaging) should be pursued. Advanced imaging is also warranted for patients with diabetes, localized symptoms, and/or abnormal laboratory results whose plain radiographs are normal or suggestive of osteomyelitis without characteristic features. Osteomyelitis is unlikely in the absence of radiographic evidence on advanced imaging ”.

Whole-Body MRI for Screening of Malignancy in Adults with Li-Fraumeni Syndrome

Huby and colleagues (2019) stated that Li-Fraumeni syndrome (LFS) is a rare inherited disease characterized by the early onset of multiple primary malignant tumors.  Sarcomas account for more than 30% of all malignant tumors occurring at pediatric age.  Furthermore, it was shown that the rates of 2nd cancer were higher in childhood cancer survivors.  These investigators reported the case of a patient with LFS who was referred to these researchers with 3 synchronous skeletal tumors.  This unique situation led to difficulties for the medical team regarding the diagnosis of malignancy and the surgical treatment to propose.  The discovery of multiple lesions in the extension assessment underlined the usefulness of whole-body imaging for the follow-up of patients with germline TP53 mutations.  Most recent guidelines now recommend annual whole-body MRI (WB-MRI) for screening for cancer patients carrying germline TP53.

Frebourg and associates (2020) noted that 50 years after the recognition of the LFS, the perception of cancers related to germline alterations of TP53 has drastically changed: germline TP53 alterations are often identified among children with cancers, in particular soft-tissue sarcomas, adrenocortical carcinomas, central nervous system (CNS) tumors, or among women with early breast cancers, without familial history.  This justifies the expansion of the LFS concept to a wider cancer predisposition syndrome designated heritable TP53-related cancer (hTP53rc) syndrome. The interpretation of germline TP53 variants remains challenging and should integrate epidemiological, phenotypical, bioinformatics prediction, and functional data.  The penetrance of germline disease-causing TP53 variants is variable, depending both on the type of variant (dominant-negative variants being associated with a higher cancer risk) and on modifying factors. These investigators stated that WB-MRI allows early detection of tumors in variant carriers; and in cancer patients with germline disease-causing TP53 variants, radiotherapy, and conventional genotoxic chemotherapy contribute to the development of subsequent primary tumors.  It is critical to perform TP53 testing before the initiation of treatment in order to avoid in carriers, if possible, radiotherapy and genotoxic chemotherapies.  In children, the recommendations are to perform clinical examination and abdominal ultrasound (US) every 6 months, annual WB-MRI and brain MRI from the 1st year of life, if the TP53 variant is known to be associated with childhood cancers.  In adults, the surveillance should include every year clinical examination, WB-MRI, breast MRI in women from 20 until 65 years and brain MRI until 50 years.

Hanson and colleagues (2020) stated that constitutional pathogenic variants in TP53 are associated with LFS or the more recently described heritable TP53-related cancer syndrome and are associated with increased lifetime risks of a wide spectrum of cancers.  Due to the broad tumor spectrum, surveillance for this patient group has been limited.  To-date, the only recommendation in the United Kingdom (UK) has been for annual breast MRI in women; however, more recently, a more intensive surveillance protocol including WB-MRI has been recommended by International Expert Groups.  To address the gap in surveillance for this patient group in the UK, the UK Cancer Genetics Group facilitated a 1-day consensus meeting to discuss a protocol for the UK.  Using a pre-workshop survey followed by structured discussion on the day, these researchers achieved consensus for a UK surveillance protocol for TP53 carriers to be adopted by UK Clinical Genetics services.  The key recommendations are for annual WB-MRI and dedicated brain MRI from birth, annual breast MRI from 20 years in women and three-four monthly abdominal US in children along with review in a dedicated clinic.

Concul and co-workers (2020) noted leukemia and tumors of the brain, soft tissues, breasts, adrenal glands, and bone are the most common cancers associated with LFS.  Patients with LFS are very susceptible to radiation; thus, the use of WB-MRI is recommended for regular cancer screening.  It is important to recognize the common tumors associated with LFS on MRI, and it is also important to be aware of the high rate of false-positive (FP) lesions.  The authors concluded that WB-MRI is useful for the detection of cancer in patients who come for regular screening; however, it is associated with pitfalls about which the radiologist must remain aware.

An UpToDate review on “Li-Fraumeni syndrome” (Evans, 2020) states that “Cancer surveillance strategy -- A heightened level of surveillance for cancer is required for individuals who are considered at risk, based upon a history of a Li-Fraumeni syndrome malignancy, the presence of a known TP53 mutation, or the presence of increased risk in a family with Li-Fraumeni syndrome but without an identifiable mutation or that has not undergone mutation testing.  Multiple centers have studied the role of whole-body MRI as a surveillance strategy.  A meta-analysis of 13 observational cohorts included 578 participants with germline TP53 mutations.  In baseline surveillance imaging, a total of 42 new cancers were diagnosed in 39 individuals (6.7% of the study population).  Of these, 35 were localized and treated with curative intent.  False-positive findings on whole-body MRI that required further evaluation (additional imaging or biopsy) were found in 173 people (29.9% of the cohort).  The value of baseline whole-body MRI needs to be balanced against the high frequency of false-positive results.  The long-term impact on outcome due to early diagnosis, and the optimal frequency of repeat scanning will require a longitudinal study. The National Comprehensive Cancer Network (NCCN) has defined guidelines that are useful in attempting to diagnose cancer early in patients with Li-Fraumeni syndrome, as has the American Association for Cancer Research (AACR) … whole-body MRI, perhaps on an annual basis, is now recommended by AACR guidance”.

Moreover, eviCore Imaging Guidelines (2020) notes that “Adults (≥ 18 years) with a diagnosis of Li-Fraumeni syndrome (LFS) may be screened for malignancy with a whole body MRI (CPT 76498) on an annual basis”.

Morton Neuroma

An UpToDate review on “Evaluation and diagnosis of common causes of forefoot pain in adults” (Fields, 2021) states that “Morton neuroma -- Interdigital neuromas of the foot are often referred to as Morton neuroma.  The etiology of Morton neuroma is not fully understood but is thought to be similar to metatarsalgia,  involving collapse of the transverse arch that places traction and increased pressure on the interdigital nerve, ultimately leading to injury.  Overpronation and tight shoes are often associated with the condition.  Morton neuroma is a common problem in athletic and non-athletic populations.  Females are approximately 5 times more likely than males to develop Morton neuroma … Conservative treatment should precede expensive diagnostic procedures.  This approach involves decreasing pressure on the metatarsal heads by using a metatarsal support or bar or padded shoe insert … Treatment inserts are often placed in both shoes, even when symptoms are unilateral, to ensure that the patient walks evenly, but bilateral pads are not always needed.  Symptomatic relief often begins within a few days of insert use and pain may completely subside over several weeks.  A broad-toed shoe that allows spreading of the metatarsal heads may be helpful.  Proper shoe width should be determined while standing, using a professional shoe fitting device.  If width has changed, older shoes should be discarded … If conservative measures fail to relieve symptoms, a single injection of a glucocorticoid and local anesthetic into the site of tenderness can be performed using a dorsal, not plantar, approach.  A plantar approach is more likely to cause complications.  A number of combinations have been used.  We prefer to inject triamcinolone 0.5 mL (10 mg/mL solution) and lidocaine 0.5 mL (1 % solution).  In addition, we limit the total volume of the injection to 1 mL to minimize discomfort and reduce the risk of fat pad atrophy, although up to 2 mL total volume may be used.  Some study authors have used a combination of methylprednisolone (20 mg, or 0.5 mL) and 1 % lidocaine.  Ultrasound-guided injection is preferred by many practitioners to ensure accurate needle placement, although studies are limited, and injection guided by anatomic landmarks can be effective.  The majority of patients experience some benefit from glucocorticoid injection.  Relief can last 3 months or longer with ultrasound-guided injection according to one randomized trial and multiple case series.  In addition, the use of a glucocorticoid appears to give somewhat better relief than injection of a local anesthetic alone.  Complications are rare; metatarsal fat pad atrophy can be debilitating but may occur less often if a dorsal injection is used and injection is guided by ultrasound.  A range of nonsurgical therapies have been studied.  Meta-analyses of studies including 9 interventions reported that glucocorticoid injection had the strongest evidence for benefit.  Manipulation and mobilization showed benefit in 1 meta-analysis; alcohol injection showed short-term benefit in another.  Studies of extracorporeal shockwave therapy, injections of sclerosing substances or Botox, radiofrequency ablation, capsaicin, and cryoneurolysis consist primarily case series.  Other treatments, including injection of alcohol and radiofrequency therapy to ablate the neuroma, show promise in observational case series.  These interventions should be considered experimental until further study clarifies their efficacy”.

Moreover, eviCore's "Musculoskeletal Imaging Guidelines" (Version 1, 2021) allows MRI for Morton neuroma for pre-operative planning (positive result of an initial plain x-ray is needed before MRI can be approved).

Table: CPT Codes / HCPCS Codes / ICD-10 Codes

Code	Code Description
Information in the [brackets] below has been added for clarification purposes.   Codes requiring a 7th character are represented by "+":
Magnetic resonance of knee:
CPT codes covered if selection criteria are met:
73721 - 73723	Magnetic resonance (e.g., proton) imaging, any joint of lower extremity [not covered for fitting of implant for total knee arthroplasty]
Other CPT codes related to the CPB:
27427 - 27429	Ligamentous reconstruction (augmentation), knee
27437 - 27447	Arthroplasty, knee
29870 - 29889	Arthroscopy of knee
ICD-10 codes covered if selection criteria are met:
C49.20 - C49.22	Malignant neoplasm of connective tissue of lower limb, including hip
C76.50 - C76.52	Malignant neoplasm of lower limb
D21.20 - D21.22	Benign neoplasm of connective and other soft tissue of lower limb, including hip
D48.0	Neoplasm of uncertain behavior of bone and articular cartilage
M23.000 - M23.92	Internal derangement of knee
M25.261 - M25.269	Flail joint, knee
M25.361 - M25.369	Other instability, knee
M25.461 - M25.469	Effusion, knee
M25.561 - M25.569	Pain in knee
M86.361 - M86.369 M86.461 - M86.469 M86.561 - M86.569 M86.661 - M86.669	Chronic osteomyelitis of lower leg
M87.051 - M87.066 M87.151 - M87.166 M87.251 - M87.266 M87.351 - M87.366 M87.851 - M87.869	Osteonecrosis, lower leg
M93.261 - M93.269	Osteochondritis dissecans, knee
S83.200+ - S83.289+	Tear of meniscus, current injury
ICD-10 codes not covered for indications listed in the CPB:
M05.00 - M14.89	Rheumatoid arthritis and other inflammatory polyarthropathies
M17.0 - M17.9	Osteoarthritis, knee
M22.40 - M22.42	Chondromalacia of patella
M23.8x1 - M23.92	Other internal derangements of knee
Z46.89	Encounter for fitting and adjustment of other specified devices [orthopedic devices] [implant for TKA]
MRI of extremities:
CPT codes covered if selection criteria are met:
73218 - 73223	Magnetic resonance (e.g., proton) imaging, upper extremity
73718 - 73723	Magnetic resonance (e.g., proton) imaging; lower extremity
Other CPT codes related to the CPB:
64450	Injection(s), anesthetic agent(s) and/or steroid; other peripheral nerve or branch
Other HCPCS codes related to this CPB:
L3030	Foot, insert, removable, formed to patient foot, each
L3050	Foot, arch support, removable, premolded, metatarsal, each
ICD-10 codes covered if selection criteria are met:
G57.60 - G57.63	Lesion of plantar nerve
M86.8x7	Other osteomyelitis, ankle and foot
Q87.3	Congenital malformation syndromes involving early overgrowth [CLOVES syndrome]
ICD-10 codes not covered for indications listed in the CPB:
G71.00 - G71.09	Muscular dystrophy [facioscapulohumeral muscular dystrophy]
M05.00 - M14.89	Rheumatoid arthritis and other inflammatory polyarthropathies
M79.A11 - M79.A29	Nontraumatic compartment syndrome of upper and lower extremities
S13.4xxA-S13.4xxS	Sprain of ligaments of cervical spine
S14.0xxA-S14.9xxS	Unspecified injury of cervical spinal cord
S24.0xxA-S24.9xxS	Unspecified injury of thoracic spinal cord
S34.01xA-S34.139S	Unspecified injury to lumbar and sacral spinal cord
T79.A11 - T79.A29	Traumatic compartment syndrome of upper and lower extremities
Whole-body MRI:
CPT codes covered if selection criteria are met:
Whole-body MRI – no specific code:
ICD-10 codes covered if selection criteria are met:
Z12.0 - Z12.9	Encounter for screening for malignant neoplasm [screening of malignancy with Li-Fraumeni syndrome]
Z15.01	Genetic susceptibility to malignant neoplasm of breast [screening of malignancy with Li-Fraumeni syndrome]

The above policy is based on the following references: