Subject: Guided Tissue Regeneration (GTR)
Reviewed: August 12, 2013
Important noteThis Clinical Policy Bulletin expresses our determination of whether certain services or supplies are medically necessary. We have reached these conclusions based on a review of currently available clinical information including:
Aetna considers this surgical procedure to be dental-in-nature (DIN) oral surgery. Coverage may be available for DIN oral surgery procedures under either medical or dental plans.
GTR is a surgical procedure that aims to regenerate the periodontal tissues when the periodontal disease is advanced and could overcome some of the limitations of conventional therapy. A membrane is placed over the root surfaces or defect area following surgical exposure and debridement. The mucoperiosteal flaps are then adapted over the membrane and sutured. The membrane is placed to exclude epithelium and gingival connective tissue from the healing wound. This procedure may require subsequent surgical procedures to correct the gingival contours. Guided tissue regeneration may also be carried out in conjunction with bone replacement grafts or to correct deformities resulting from inadequate faciolingual bone width in an edentulous area.
Per the American Academy of Periodontology (AAP) position paper (2005), Periodontal Regeneration, periodontal intraosseous defects, especially those characterized by three bony walls, respond favorably with substantial bone fill when treated with GTR techniques. Similar techniques applied to mandibular class II furcation defects have produced clinical improvements in terms of decreased probing depths and improved clinical attachment levels. Use of GTR in treating maxillary class II and mandibular class III defects has produced inconsistent results.1
D4266 -- Guided tissue regeneration -- resorbable barrier, per site
D4267 -- Guided tissue regeneration -- nonresorbable barrier, per site (includes membrane removal)
Revision DatesOriginal policy: September 13, 2004
The above policy is based on the following references:
1American Academy of Periodontology. AAP Position Paper; Periodontal regeneration, 2005: 1-22.
2American Dental Association. Current Dental Terminology, CDT-2013:32.*
3Needleman IG, Giedrys-Leeper E, Tucker RJ, Worthington HV. Guided tissue regeneration for periodontal infra-bony defects (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Accessed April 25, 2011. Available at:
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